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The map label for this gene is uvrD [H]

Identifier: 190571383

GI number: 190571383

Start: 1058198

End: 1060111

Strand: Reverse

Name: uvrD [H]

Synonym: WPa_0991

Alternate gene names: 190571383

Gene position: 1060111-1058198 (Counterclockwise)

Preceding gene: 190571384

Following gene: 190571380

Centisome position: 71.51

GC content: 35.01

Gene sequence:

>1914_bases
ATGAACGATTATCTCTCACTGTTAAATCCAGAACAGCAATTAGCTGTAACTAACATAAATGGGCCAGTTTTGATACTGGC
AGGAGCCGGAACCGGAAAAACAAGAACGATTACTTCAAGAATAGCACACATAATTAGAAACGGTCACGCTTATTCTGATG
AGATATTAGCAGTTACATTTACAAATAAAGCAGCAAATGAGATGGTATCAAGGGTACTTGAGCTAACGGGCACAAACATA
CCATGGCTTGGCACTTTCCATGCAATTGCAGCAAAAATTTTGCGCATGCACGCAGAAATTGTGGGCTTAAACCCCAATTT
TACAATCATTGGTGTGGATGACCAATTACAGGTAATAAAAAATATTATCAATGAAATAAATCCTGATTACCTATCAGAAA
AATATAAGACCATTATGAATATTATTCAGCAATGGAAAGAGAAGTGCTTATTGCCGTCTGAAGTGGAAGATGTTCAATCA
TTTAGGCCAGTTTACGTAACTGCACTTAAAGTCTATTACCAGTATCAGGAAAGGTTAAAATTCCTTAACTCTGTTGATTT
TGGTGACTTATTGTTATATAACATACAACTTTTTAATAAAAAGACCGAGGTTCTGTCCTACTACCAAAACAAGTTTAAGT
ATGTCATGGTAGATGAGTATCAAGATACAAATGCAATACAATATCTTTGGCTAAAATACCTTGCAAAAGAGCATTCAAAT
ATTTGCTGTGTAGGAGATGATGACCAGTCGATATACAGTTGGCGTGGTGCAGAAGTTGAAAATATTTTGAAATTTTCCGA
TGATTTTAAAAATGCAAAAACCGTTAAACTGGAGTGTAACTACAGGTCAACATCCCACATAATTGCAACTGCATCATATG
TGATCAATCACAATAAGACTCGCTTAGAAAAAAAATTGTGGACAACAAACATTGAAGGCGAAAAGGTAAATCTAATCAAA
TTGTGGGACGGAAAGGCTGAAGCAAGGTTCATAAGCGAACAGATATTAAAACTCAATAAATACAGATTTAGTGATATTGC
AGTGCTCGTCAGGGCTACTTTTCAAACTAGAGTTCTCGAAGAGTATTTTATAAAATATTCAATTCCCTATAAGATTATAA
GTGGCGTAAAATTCTACGAACGTCAAGAAGTAAGGGATATAATTGCATATTTGAGGCTTGTTACAAATAATAATGATGAT
CTCGCTTTTGAAAGGATCGTAAATCGTCCAAAAAGAAGCATAGGAGCTACAACTCTAAAGAAAATATACACGACTGCTCA
GGATAACAAAATTTCTTTTTTTGAGGCAGCAAAAATATTGGTTAATAGTGATCAAGTAACCGAAAGAATTAAACTCTCAC
TAAATGATTTTTTAAATAAAATTAAAGCTTGGGAAGAAATAGTAAGCGTAAAACCACTGCATGAATTTGTTAAAATCGTA
GCAAATCAATCAGGATATATGGAAATGCTTGAGAATGAAGGAGTGACGGGTTTAGCGCGAATAGAAAATGTTAAAGAGCT
CATTTCATCTTTGAAGAATTTTGACAGCACTATAACCTTCTTGGAGCATATTAGTTTGGTGATGGAAGTGGATAATATGA
ATAGCGATGACACTGTATATGTTATGACTCTTCATGCGGCTAAAGGGCTTGAATTCCCGTGCGTGTTTTTACCTGGTTGG
GAAGAAGGATTATTTCCTCATCAAAGATCTTTTGAAGATAAAAGTGGTAAAGCTTTGGAAGAAGAGAGAAGACTTGCATA
TGTTGGCATAACTAGAGCAAAAGAAAGGTTGATCATTTCATGTGCAGATAGGAGGGAAATTAATAATCAGTGGCAACCAA
TGAGCACTTCTCGATTTATTAAAGAATTGCCAAGAGAAAATGTTGAGGTGATCAAGAATAGTGCCTACTGTTGA

Upstream 100 bases:

>100_bases
TATCTAGTACTTGAATGAGTTGAATGTTATGTTCAATAAGACCTTTACAATATTTGGATCATAGGTTTAACTTTATAAAG
TTATAATCTATAGAGCTTCA

Downstream 100 bases:

>100_bases
AGCTATAACTGCAGCTCTTACGACAAACACATCTGAATTACTTCAATTATATATTTCTCCTGGCAAAAATTCTCTGATGG
TCTTAAATAAAATTTTCAGT

Product: helicase II, UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MNDYLSLLNPEQQLAVTNINGPVLILAGAGTGKTRTITSRIAHIIRNGHAYSDEILAVTFTNKAANEMVSRVLELTGTNI
PWLGTFHAIAAKILRMHAEIVGLNPNFTIIGVDDQLQVIKNIINEINPDYLSEKYKTIMNIIQQWKEKCLLPSEVEDVQS
FRPVYVTALKVYYQYQERLKFLNSVDFGDLLLYNIQLFNKKTEVLSYYQNKFKYVMVDEYQDTNAIQYLWLKYLAKEHSN
ICCVGDDDQSIYSWRGAEVENILKFSDDFKNAKTVKLECNYRSTSHIIATASYVINHNKTRLEKKLWTTNIEGEKVNLIK
LWDGKAEARFISEQILKLNKYRFSDIAVLVRATFQTRVLEEYFIKYSIPYKIISGVKFYERQEVRDIIAYLRLVTNNNDD
LAFERIVNRPKRSIGATTLKKIYTTAQDNKISFFEAAKILVNSDQVTERIKLSLNDFLNKIKAWEEIVSVKPLHEFVKIV
ANQSGYMEMLENEGVTGLARIENVKELISSLKNFDSTITFLEHISLVMEVDNMNSDDTVYVMTLHAAKGLEFPCVFLPGW
EEGLFPHQRSFEDKSGKALEEERRLAYVGITRAKERLIISCADRREINNQWQPMSTSRFIKELPRENVEVIKNSAYC

Sequences:

>Translated_637_residues
MNDYLSLLNPEQQLAVTNINGPVLILAGAGTGKTRTITSRIAHIIRNGHAYSDEILAVTFTNKAANEMVSRVLELTGTNI
PWLGTFHAIAAKILRMHAEIVGLNPNFTIIGVDDQLQVIKNIINEINPDYLSEKYKTIMNIIQQWKEKCLLPSEVEDVQS
FRPVYVTALKVYYQYQERLKFLNSVDFGDLLLYNIQLFNKKTEVLSYYQNKFKYVMVDEYQDTNAIQYLWLKYLAKEHSN
ICCVGDDDQSIYSWRGAEVENILKFSDDFKNAKTVKLECNYRSTSHIIATASYVINHNKTRLEKKLWTTNIEGEKVNLIK
LWDGKAEARFISEQILKLNKYRFSDIAVLVRATFQTRVLEEYFIKYSIPYKIISGVKFYERQEVRDIIAYLRLVTNNNDD
LAFERIVNRPKRSIGATTLKKIYTTAQDNKISFFEAAKILVNSDQVTERIKLSLNDFLNKIKAWEEIVSVKPLHEFVKIV
ANQSGYMEMLENEGVTGLARIENVKELISSLKNFDSTITFLEHISLVMEVDNMNSDDTVYVMTLHAAKGLEFPCVFLPGW
EEGLFPHQRSFEDKSGKALEEERRLAYVGITRAKERLIISCADRREINNQWQPMSTSRFIKELPRENVEVIKNSAYC
>Mature_637_residues
MNDYLSLLNPEQQLAVTNINGPVLILAGAGTGKTRTITSRIAHIIRNGHAYSDEILAVTFTNKAANEMVSRVLELTGTNI
PWLGTFHAIAAKILRMHAEIVGLNPNFTIIGVDDQLQVIKNIINEINPDYLSEKYKTIMNIIQQWKEKCLLPSEVEDVQS
FRPVYVTALKVYYQYQERLKFLNSVDFGDLLLYNIQLFNKKTEVLSYYQNKFKYVMVDEYQDTNAIQYLWLKYLAKEHSN
ICCVGDDDQSIYSWRGAEVENILKFSDDFKNAKTVKLECNYRSTSHIIATASYVINHNKTRLEKKLWTTNIEGEKVNLIK
LWDGKAEARFISEQILKLNKYRFSDIAVLVRATFQTRVLEEYFIKYSIPYKIISGVKFYERQEVRDIIAYLRLVTNNNDD
LAFERIVNRPKRSIGATTLKKIYTTAQDNKISFFEAAKILVNSDQVTERIKLSLNDFLNKIKAWEEIVSVKPLHEFVKIV
ANQSGYMEMLENEGVTGLARIENVKELISSLKNFDSTITFLEHISLVMEVDNMNSDDTVYVMTLHAAKGLEFPCVFLPGW
EEGLFPHQRSFEDKSGKALEEERRLAYVGITRAKERLIISCADRREINNQWQPMSTSRFIKELPRENVEVIKNSAYC

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=647, Percent_Identity=41.7310664605873, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI48994965, Length=644, Percent_Identity=36.3354037267081, Blast_Score=377, Evalue=1e-105,
Organism=Escherichia coli, GI1787196, Length=171, Percent_Identity=29.8245614035088, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322369, Length=459, Percent_Identity=32.6797385620915, Blast_Score=183, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6324477, Length=675, Percent_Identity=22.8148148148148, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 73588; Mature: 73588

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDYLSLLNPEQQLAVTNINGPVLILAGAGTGKTRTITSRIAHIIRNGHAYSDEILAVTF
CCCCHHHCCCCHHEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEE
TNKAANEMVSRVLELTGTNIPWLGTFHAIAAKILRMHAEIVGLNPNFTIIGVDDQLQVIK
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHHH
NIINEINPDYLSEKYKTIMNIIQQWKEKCLLPSEVEDVQSFRPVYVTALKVYYQYQERLK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHH
FLNSVDFGDLLLYNIQLFNKKTEVLSYYQNKFKYVMVDEYQDTNAIQYLWLKYLAKEHSN
HHHCCCCCHHHEEEEHHHCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC
ICCVGDDDQSIYSWRGAEVENILKFSDDFKNAKTVKLECNYRSTSHIIATASYVINHNKT
EEEECCCCCHHHEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHEEEEHHHCCCCHH
RLEKKLWTTNIEGEKVNLIKLWDGKAEARFISEQILKLNKYRFSDIAVLVRATFQTRVLE
HHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EYFIKYSIPYKIISGVKFYERQEVRDIIAYLRLVTNNNDDLAFERIVNRPKRSIGATTLK
HHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHH
KIYTTAQDNKISFFEAAKILVNSDQVTERIKLSLNDFLNKIKAWEEIVSVKPLHEFVKIV
HHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANQSGYMEMLENEGVTGLARIENVKELISSLKNFDSTITFLEHISLVMEVDNMNSDDTVY
HCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEE
VMTLHAAKGLEFPCVFLPGWEEGLFPHQRSFEDKSGKALEEERRLAYVGITRAKERLIIS
EEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEHHHCCCEEEEE
CADRREINNQWQPMSTSRFIKELPRENVEVIKNSAYC
ECCHHHCCCCCCCCCHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure
MNDYLSLLNPEQQLAVTNINGPVLILAGAGTGKTRTITSRIAHIIRNGHAYSDEILAVTF
CCCCHHHCCCCHHEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEE
TNKAANEMVSRVLELTGTNIPWLGTFHAIAAKILRMHAEIVGLNPNFTIIGVDDQLQVIK
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHHH
NIINEINPDYLSEKYKTIMNIIQQWKEKCLLPSEVEDVQSFRPVYVTALKVYYQYQERLK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHH
FLNSVDFGDLLLYNIQLFNKKTEVLSYYQNKFKYVMVDEYQDTNAIQYLWLKYLAKEHSN
HHHCCCCCHHHEEEEHHHCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC
ICCVGDDDQSIYSWRGAEVENILKFSDDFKNAKTVKLECNYRSTSHIIATASYVINHNKT
EEEECCCCCHHHEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHEEEEHHHCCCCHH
RLEKKLWTTNIEGEKVNLIKLWDGKAEARFISEQILKLNKYRFSDIAVLVRATFQTRVLE
HHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
EYFIKYSIPYKIISGVKFYERQEVRDIIAYLRLVTNNNDDLAFERIVNRPKRSIGATTLK
HHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHH
KIYTTAQDNKISFFEAAKILVNSDQVTERIKLSLNDFLNKIKAWEEIVSVKPLHEFVKIV
HHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANQSGYMEMLENEGVTGLARIENVKELISSLKNFDSTITFLEHISLVMEVDNMNSDDTVY
HCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEE
VMTLHAAKGLEFPCVFLPGWEEGLFPHQRSFEDKSGKALEEERRLAYVGITRAKERLIIS
EEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEEHHHCCCEEEEE
CADRREINNQWQPMSTSRFIKELPRENVEVIKNSAYC
ECCHHHCCCCCCCCCHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA