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The map label for this gene is ispA [H]

Identifier: 190571159

GI number: 190571159

Start: 823366

End: 824148

Strand: Reverse

Name: ispA [H]

Synonym: WPa_0757

Alternate gene names: 190571159

Gene position: 824148-823366 (Counterclockwise)

Preceding gene: 190571164

Following gene: 190571158

Centisome position: 55.59

GC content: 35.89

Gene sequence:

>783_bases
ATGCTAGACGAAACAACAAAAAATTTGCTTGTTGTAGAAGTGAATAAGCTCTTACCTGAAAATAGCGAGAATAAACTTAT
ATCAGCTATGCGTTATGTACTTCTTGCTCCTGCAAAACATATACGTTCTTTTTTAGTTATAGCATCTTCGTCGATATTCA
ACATAAAGGTTGAAAAAGCAATAACAGCAGCAGCAGCAATTGAATTTATTCATGCTTACTCCCTAATTCACGATGATCTG
CCATGTATGGATAACAGTGACACTCGAAGAGGCCAGCCAAGCTGCCACAAAAAATTTGGTGAAGCAACAGCAGTACTGGC
CGGAGATGCATTACTTACCCTGGCTTTTGAGGTATTATCTTTGTTAAATTGTGAGATCATAAAAGTGCTCTCTCAAGCAA
TAGGAATGAAGGGAATGGTGGGAGGGCAGATTTTAGATATAGGTGCAGATTTTGACAAAATAAAAGAAATTCATTTGATG
AAAACTGCAAAACTATTTGCAGCTTCATGTGAAATAGGGGCTATAATAGGAGGCGCTACAGACAAGGAGCGGGAAGCATT
ATATAACTATGGAATAAATCTAGGGCTTATTTTTCAAGCCAAGGATGATATCGAAGATTATGAGCAAGATAAAACAAACA
ATTTAATGTCCGTGCTTGGAAAAAATGAAATGGAAAACTATATAGATAGTCTCTTTAAACAGGCCTCAGATAATTTAAGT
ACGCTTTCAGGGAATACTAGTGACTTATATGATTTATTGAATCAAGTAAAAAAAGATGGTTAG

Upstream 100 bases:

>100_bases
GATGTTATAAGAAATTTTGATGTTTGCAATAGCTTTTATGATTATATAAACTATTAAAAACTTCCTATCTCTTAGCACTC
GATAGTTAATAAATTTAAAA

Downstream 100 bases:

>100_bases
AAAAATTATATTACAAATGTTTATCTCTGTAGTAATGATTCTCACTTTAGCTTCTGCTTTTATAATTACGATTGTTTATA
TAAACAAAGATAAACCAGAG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLDETTKNLLVVEVNKLLPENSENKLISAMRYVLLAPAKHIRSFLVIASSSIFNIKVEKAITAAAAIEFIHAYSLIHDDL
PCMDNSDTRRGQPSCHKKFGEATAVLAGDALLTLAFEVLSLLNCEIIKVLSQAIGMKGMVGGQILDIGADFDKIKEIHLM
KTAKLFAASCEIGAIIGGATDKEREALYNYGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKNEMENYIDSLFKQASDNLS
TLSGNTSDLYDLLNQVKKDG

Sequences:

>Translated_260_residues
MLDETTKNLLVVEVNKLLPENSENKLISAMRYVLLAPAKHIRSFLVIASSSIFNIKVEKAITAAAAIEFIHAYSLIHDDL
PCMDNSDTRRGQPSCHKKFGEATAVLAGDALLTLAFEVLSLLNCEIIKVLSQAIGMKGMVGGQILDIGADFDKIKEIHLM
KTAKLFAASCEIGAIIGGATDKEREALYNYGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKNEMENYIDSLFKQASDNLS
TLSGNTSDLYDLLNQVKKDG
>Mature_260_residues
MLDETTKNLLVVEVNKLLPENSENKLISAMRYVLLAPAKHIRSFLVIASSSIFNIKVEKAITAAAAIEFIHAYSLIHDDL
PCMDNSDTRRGQPSCHKKFGEATAVLAGDALLTLAFEVLSLLNCEIIKVLSQAIGMKGMVGGQILDIGADFDKIKEIHLM
KTAKLFAASCEIGAIIGGATDKEREALYNYGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKNEMENYIDSLFKQASDNLS
TLSGNTSDLYDLLNQVKKDG

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=206, Percent_Identity=33.9805825242718, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1786623, Length=217, Percent_Identity=42.8571428571429, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789578, Length=210, Percent_Identity=34.2857142857143, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=151, Percent_Identity=36.4238410596026, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319475, Length=195, Percent_Identity=31.7948717948718, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24651612, Length=158, Percent_Identity=32.9113924050633, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 28494; Mature: 28494

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDETTKNLLVVEVNKLLPENSENKLISAMRYVLLAPAKHIRSFLVIASSSIFNIKVEKA
CCCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEHHHH
ITAAAAIEFIHAYSLIHDDLPCMDNSDTRRGQPSCHKKFGEATAVLAGDALLTLAFEVLS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
LLNCEIIKVLSQAIGMKGMVGGQILDIGADFDKIKEIHLMKTAKLFAASCEIGAIIGGAT
HHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCC
DKEREALYNYGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKNEMENYIDSLFKQASDNLS
CHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHH
TLSGNTSDLYDLLNQVKKDG
HCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDETTKNLLVVEVNKLLPENSENKLISAMRYVLLAPAKHIRSFLVIASSSIFNIKVEKA
CCCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEHHHH
ITAAAAIEFIHAYSLIHDDLPCMDNSDTRRGQPSCHKKFGEATAVLAGDALLTLAFEVLS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
LLNCEIIKVLSQAIGMKGMVGGQILDIGADFDKIKEIHLMKTAKLFAASCEIGAIIGGAT
HHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCC
DKEREALYNYGINLGLIFQAKDDIEDYEQDKTNNLMSVLGKNEMENYIDSLFKQASDNLS
CHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHH
TLSGNTSDLYDLLNQVKKDG
HCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]