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The map label for this gene is atpB [H]

Identifier: 190571031

GI number: 190571031

Start: 675255

End: 675980

Strand: Reverse

Name: atpB [H]

Synonym: WPa_0623

Alternate gene names: 190571031

Gene position: 675980-675255 (Counterclockwise)

Preceding gene: 190571034

Following gene: 190571030

Centisome position: 45.6

GC content: 31.13

Gene sequence:

>726_bases
ATGGCGTTAAATCCGCTAGAACAATTTAAAGTATATACAATAATAGAACTACCAAAATTATTTGGGTATGACATAAACTT
TACCAACTCATCTCTTTTTATGATGATCTCGGTGATATTAATGGTACTGTTTTTGCTCCTTGGAATAAGAAAAGGTGCAG
TAATACCAGGATATTTGCAAGCTGCAGTTGAATATGTATATGATTTTGTTGTTTCAATAATAGAAAGTAACACTGGAAGC
AAAGGTTTGGAGCACATTCCTTTGATATTTACAGTATTTATTTTCATTTTATCGTGTAATTTAGTTGGTGTTCTTCCTTA
TAGTTTCACAGTTACAAGTCATGTGATAGTTACCTTCGCTTTATCAATGGTGGTTTTTACTTATATAACGATTGTTGGGT
TTAAAGAAAGAGGAGTAGAATTTTTACGCATATTGCTACCAAAAGGAACTCCTTCGTGGCTTGCACCTATAATCATCATT
ATTAAATTATTTGCTTATTTAGTAAGACCGATTAGTTTATCAATAAGGCTTGCAGCAAATATGATTGCGGGTCATACAAT
CATCAAAGTGATAGCAGGATTCGTCATAAATATGAACATATTTTTTACACCTGCACCTTTTTTGTTTATAATTGCACTAA
TAGGATTTGAAGTATTTGTTGCAGTTTTGCAAGCTTATATATTTACTATATTAACATGTGTATATTTGTCAGATGCAGTA
AAGTAA

Upstream 100 bases:

>100_bases
TAATGCTATAATAATACAGAGCTCCTTATCTTAATTCTTGACTTTATTTTATAAAATTTATACTTTATTTACTGCTGCAG
TTTAAGTATACAGGGTCAAA

Downstream 100 bases:

>100_bases
TTGACTTCCTTGCAGAATATTTTACAATTATATTATAAAGAAATAGTTAAAGGTAATATATGGATTTAGTGGCTTTAAAA
TTTATAGCAATTGGTTTGGC

Product: F0F1 ATP synthase subunit A

Products: ATP; H+; H2O [C]

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MALNPLEQFKVYTIIELPKLFGYDINFTNSSLFMMISVILMVLFLLLGIRKGAVIPGYLQAAVEYVYDFVVSIIESNTGS
KGLEHIPLIFTVFIFILSCNLVGVLPYSFTVTSHVIVTFALSMVVFTYITIVGFKERGVEFLRILLPKGTPSWLAPIIII
IKLFAYLVRPISLSIRLAANMIAGHTIIKVIAGFVINMNIFFTPAPFLFIIALIGFEVFVAVLQAYIFTILTCVYLSDAV
K

Sequences:

>Translated_241_residues
MALNPLEQFKVYTIIELPKLFGYDINFTNSSLFMMISVILMVLFLLLGIRKGAVIPGYLQAAVEYVYDFVVSIIESNTGS
KGLEHIPLIFTVFIFILSCNLVGVLPYSFTVTSHVIVTFALSMVVFTYITIVGFKERGVEFLRILLPKGTPSWLAPIIII
IKLFAYLVRPISLSIRLAANMIAGHTIIKVIAGFVINMNIFFTPAPFLFIIALIGFEVFVAVLQAYIFTILTCVYLSDAV
K
>Mature_240_residues
ALNPLEQFKVYTIIELPKLFGYDINFTNSSLFMMISVILMVLFLLLGIRKGAVIPGYLQAAVEYVYDFVVSIIESNTGSK
GLEHIPLIFTVFIFILSCNLVGVLPYSFTVTSHVIVTFALSMVVFTYITIVGFKERGVEFLRILLPKGTPSWLAPIIIII
KLFAYLVRPISLSIRLAANMIAGHTIIKVIAGFVINMNIFFTPAPFLFIIALIGFEVFVAVLQAYIFTILTCVYLSDAVK

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=163, Percent_Identity=34.3558282208589, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1790176, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6226527, Length=247, Percent_Identity=32.7935222672065, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14 [C]

Molecular weight: Translated: 26882; Mature: 26751

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure 
ALNPLEQFKVYTIIELPKLFGYDINFTNSSLFMMISVILMVLFLLLGIRKGAVIPGYLQ
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
AAVEYVYDFVVSIIESNTGSKGLEHIPLIFTVFIFILSCNLVGVLPYSFTVTSHVIVTFA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LSMVVFTYITIVGFKERGVEFLRILLPKGTPSWLAPIIIIIKLFAYLVRPISLSIRLAAN
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MIAGHTIIKVIAGFVINMNIFFTPAPFLFIIALIGFEVFVAVLQAYIFTILTCVYLSDAV
HHHHHHHHHHHHHHHHHCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ADP; H+; Phosphate [C]

Specific reaction: ADP + (4) H+ + Phosphate <==> ATP + (3) H+ + H2O [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA