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The map label for this gene is lon

Identifier: 190570984

GI number: 190570984

Start: 616483

End: 618939

Strand: Direct

Name: lon

Synonym: WPa_0572

Alternate gene names: 190570984

Gene position: 616483-618939 (Clockwise)

Preceding gene: 190570983

Following gene: 190570987

Centisome position: 41.59

GC content: 34.84

Gene sequence:

>2457_bases
ATGAGTATTGGACGTGCTGTAAACTTTAATTCTACTGTATTACCAGTATTACCTCTAAGAGATGTAGTAATTTTTCCAAA
TATAATGTTGCCTTTATTCGTAGGTAGAGAAAAATCTGTTCATGCACTAGAATATGCAATAAGTAGCAGTAGTCACCAAA
ACGAGATTTTTCTCATAGCACAAAAAGATGGTTCTATTGATAATCCAGAGCCAGAGAATCTTTATGAAGTAGGCGTGTTA
GCAAACATTATACAACCATTAATAAAACTGCCTGACAATGCAGTAAAAGTCATGATTCATGGGGTAAGAAGGGGAAGAGT
TATAGAATATATTAGCTCTCACACTTTGTTACAGGCCAGAGTAGCGTTAGATGGTCATTATGAGTATGGAGAAAATGAAG
ATAATATTGATTTAGAAGCTTTAAGGCGTTCTGTTATAGATGCATTCGACAATTGGTGTAAACTAAGCAAGAAAAGTCGA
CCCGAGATTATTATTGACCCCATTGATCAAGTTAAAGAGGTTAATCAAATTGTAGATATGATAGCTTCGCACTTAAATAT
AAAGGTATCAGATAAGCAAAACATACTTGAAGTTTATAACCCAAAAGAACGTTTAAAAAAAGTTTTTGCTCTTATTGAGA
GAGAAATAAGTATTTTGAGTGCACAAAACCGCTTGTATAAGACAATTAAATCACAGGTTGAAAGTACTCAAAAAGTTTAC
TACCTTAATGAGCAATTAAAAGCTATACAGAAAGAATTAGGTGAGTTTGAAAATGGAGATGAAGGGAATATACTCAATGA
ATTTGAAAAAAAGATAAATGAAACAAAGCTTTCTGAGGAAGCAAAAGAGAAAGCCATAACTGACTTAAAGAGATATAAGA
AAATGAATCCCATTTCTCCTGAAGCAACAGTTATATCTAGTTACTTGCATTGGTTGCTTGATTTGCCATGGGGAAAGTAC
AAAGATGCAAAAATTAACTTAAATGCGGCTAAAAAAATCTTAGATGAAAATCATTATGGCATAGAGAAAGTAAAAGATAG
AATAATAGAATTTTTAGCAGTATTAAAGAGAGTAAAAGAGATAAAGGGTCCTATACTTTGCTTAGTTGGACCACCTGGTG
TTGGTAAAACTTCTTTAGCTAAGTCTATGGCAAAAGCAGTAGGAAGAGATTTTGTTCGCATATCTCTTGGTGGTATACGT
GATGAGTCTGAAATACGAGGACACAGGAAAACTTATATTGGCTCAATGCCTGGTAAAATCATTCAACACATGAAAAAAGC
TAATTCATGCAACCCGCTTTTCCTGCTTGATGAAATAGATAAGATGGGTTCTGATTCGCGTGGTGATCCTGCATCTGCAT
TACTTGAGGTTTTGGATACTGAGCACAATAAACATTTTACAGATCATTACTTGGAAGTTGAGTTTGATCTTTCAAGTGTA
ATGTTTGTAGCCACAGCAAATAGCTTAAATTTACCGCATCCTTTGCGTGATAGGATGGAAATTATACAATTATCTGGGTA
TACCGAAGACGAGAAGATCAGTATTGCTACACATCACCTTATTCCAAAATTAAAAAAAGAGCATGGTTTGCATCAGAAGG
AGTGGGAAATAACCAATGAAGCATTATACGAGTTGATACGTTTATATACACGTGAAAGCGGCGTGCGAAGCATGGAAAGG
GAACTTGCAAAACTCATGAGAAAGGCAGTTAAAGCAATATTAACTGATAAAAATAAGAAAATATCCGTAGAGACTGGTAA
TTTACAAGATTATCTAGGGGTACGTAAGTATACCTTTGGCATTGCAGAAAATGAGAGTTTGGTAGGGATAGTAACTGGTC
TTGCCTATACTGAAACAGGTGGTGATATTTTAATGATAGAGTCAGTCCTAATTCCGGGCAAGGGGGAAATAAAATACACA
GGAAAGCTTGGAGAGGTTATGCAAGAGTCTATAAAAGCTGCGTATAGTTATGTGCGATCAAATTGTTTATTTTTCGGTAT
AAAACCCGAAAAATTTCAAAATAATGATATACATTTGCATGTACCTGAGGGTGCTGTGCCAAAAGATGGTCCCTCTGCTG
GCAGTGCAGTATGTACATCTATTGTTTCTCTTATGACAAATATACCAGTTAACAAAAGTGTTGCTATGACAGGTGAAGTA
ACATTGCGTGGTAGAGTGTTGGCTATTGGGGGTTTGAGAGAAAAATTGCTTGCTGCGCTAAGAGGATCAATCAAAACTGT
GATTATACCAAGTGAAAATGAGAAAGATATGCAAGAGATTCCTGCAAATATAAAAGAAGAAATCAATGTAATTTTTGCTG
AGAATATTGATGAAGTTATAAAAGTTGCTTTGATGCACCCTATTACTTCAATTGATGATAATAACGAAATTAGTGTGTCT
ACCTCCATAGAAAATAAGGATAATACCTTCCCTTCATCAGAAACATTAAAGCACTAA

Upstream 100 bases:

>100_bases
AACGGTTACTAAGAAAATGGTAGAATTAGGCAAAGTGACGATTAATCATAATAATAAGGGTAGTGTTATAACGGTTAATG
ATTAATTTGAGGCATATATT

Downstream 100 bases:

>100_bases
ATTGAAAAGGTTTATGCAATTTTCGTTTCTTTTTTTTAACCTCAAAGCTCTGATTTGAATATATAAATTACAAGTAACAT
ATATGGCAATTTCATAAGTT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 818; Mature: 817

Protein sequence:

>818_residues
MSIGRAVNFNSTVLPVLPLRDVVIFPNIMLPLFVGREKSVHALEYAISSSSHQNEIFLIAQKDGSIDNPEPENLYEVGVL
ANIIQPLIKLPDNAVKVMIHGVRRGRVIEYISSHTLLQARVALDGHYEYGENEDNIDLEALRRSVIDAFDNWCKLSKKSR
PEIIIDPIDQVKEVNQIVDMIASHLNIKVSDKQNILEVYNPKERLKKVFALIEREISILSAQNRLYKTIKSQVESTQKVY
YLNEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSEEAKEKAITDLKRYKKMNPISPEATVISSYLHWLLDLPWGKY
KDAKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKEIKGPILCLVGPPGVGKTSLAKSMAKAVGRDFVRISLGGIR
DESEIRGHRKTYIGSMPGKIIQHMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSV
MFVATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLHQKEWEITNEALYELIRLYTRESGVRSMER
ELAKLMRKAVKAILTDKNKKISVETGNLQDYLGVRKYTFGIAENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYT
GKLGEVMQESIKAAYSYVRSNCLFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGSAVCTSIVSLMTNIPVNKSVAMTGEV
TLRGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPANIKEEINVIFAENIDEVIKVALMHPITSIDDNNEISVS
TSIENKDNTFPSSETLKH

Sequences:

>Translated_818_residues
MSIGRAVNFNSTVLPVLPLRDVVIFPNIMLPLFVGREKSVHALEYAISSSSHQNEIFLIAQKDGSIDNPEPENLYEVGVL
ANIIQPLIKLPDNAVKVMIHGVRRGRVIEYISSHTLLQARVALDGHYEYGENEDNIDLEALRRSVIDAFDNWCKLSKKSR
PEIIIDPIDQVKEVNQIVDMIASHLNIKVSDKQNILEVYNPKERLKKVFALIEREISILSAQNRLYKTIKSQVESTQKVY
YLNEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSEEAKEKAITDLKRYKKMNPISPEATVISSYLHWLLDLPWGKY
KDAKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKEIKGPILCLVGPPGVGKTSLAKSMAKAVGRDFVRISLGGIR
DESEIRGHRKTYIGSMPGKIIQHMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSV
MFVATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLHQKEWEITNEALYELIRLYTRESGVRSMER
ELAKLMRKAVKAILTDKNKKISVETGNLQDYLGVRKYTFGIAENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYT
GKLGEVMQESIKAAYSYVRSNCLFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGSAVCTSIVSLMTNIPVNKSVAMTGEV
TLRGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPANIKEEINVIFAENIDEVIKVALMHPITSIDDNNEISVS
TSIENKDNTFPSSETLKH
>Mature_817_residues
SIGRAVNFNSTVLPVLPLRDVVIFPNIMLPLFVGREKSVHALEYAISSSSHQNEIFLIAQKDGSIDNPEPENLYEVGVLA
NIIQPLIKLPDNAVKVMIHGVRRGRVIEYISSHTLLQARVALDGHYEYGENEDNIDLEALRRSVIDAFDNWCKLSKKSRP
EIIIDPIDQVKEVNQIVDMIASHLNIKVSDKQNILEVYNPKERLKKVFALIEREISILSAQNRLYKTIKSQVESTQKVYY
LNEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSEEAKEKAITDLKRYKKMNPISPEATVISSYLHWLLDLPWGKYK
DAKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKEIKGPILCLVGPPGVGKTSLAKSMAKAVGRDFVRISLGGIRD
ESEIRGHRKTYIGSMPGKIIQHMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSVM
FVATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLHQKEWEITNEALYELIRLYTRESGVRSMERE
LAKLMRKAVKAILTDKNKKISVETGNLQDYLGVRKYTFGIAENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYTG
KLGEVMQESIKAAYSYVRSNCLFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGSAVCTSIVSLMTNIPVNKSVAMTGEVT
LRGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPANIKEEINVIFAENIDEVIKVALMHPITSIDDNNEISVST
SIENKDNTFPSSETLKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=616, Percent_Identity=40.9090909090909, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI31377667, Length=654, Percent_Identity=40.9785932721713, Blast_Score=495, Evalue=1e-140,
Organism=Escherichia coli, GI1786643, Length=776, Percent_Identity=52.9639175257732, Blast_Score=827, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=650, Percent_Identity=40.1538461538462, Blast_Score=468, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17556486, Length=535, Percent_Identity=40.1869158878505, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=394, Percent_Identity=43.4010152284264, Blast_Score=347, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24666867, Length=656, Percent_Identity=39.9390243902439, Blast_Score=475, Evalue=1e-134,
Organism=Drosophila melanogaster, GI221513036, Length=656, Percent_Identity=39.9390243902439, Blast_Score=475, Evalue=1e-134,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_WOLPP (B3CLB3)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975342.1
- ProteinModelPortal:   B3CLB3
- MEROPS:   S16.001
- EnsemblBacteria:   EBWOLT00000000563
- GeneID:   6385144
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0572
- GeneTree:   EBGT00050000030952
- HOGENOM:   HBG566281
- OMA:   ENEDNID
- ProtClustDB:   CLSK749501
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 91810; Mature: 91679

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 692-692 ACT_SITE 735-735

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIGRAVNFNSTVLPVLPLRDVVIFPNIMLPLFVGREKSVHALEYAISSSSHQNEIFLIA
CCCCCCCCCCCCEEEECCCCCHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEE
QKDGSIDNPEPENLYEVGVLANIIQPLIKLPDNAVKVMIHGVRRGRVIEYISSHTLLQAR
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHEEEH
VALDGHYEYGENEDNIDLEALRRSVIDAFDNWCKLSKKSRPEIIIDPIDQVKEVNQIVDM
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHH
IASHLNIKVSDKQNILEVYNPKERLKKVFALIEREISILSAQNRLYKTIKSQVESTQKVY
HHHHCCEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
YLNEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSEEAKEKAITDLKRYKKMNPISP
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EATVISSYLHWLLDLPWGKYKDAKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKE
HHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IKGPILCLVGPPGVGKTSLAKSMAKAVGRDFVRISLGGIRDESEIRGHRKTYIGSMPGKI
HCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHHCCCCCHHH
IQHMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSV
HHHHHHCCCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECHHHE
MFVATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLHQKEWEITNE
EEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHH
ALYELIRLYTRESGVRSMERELAKLMRKAVKAILTDKNKKISVETGNLQDYLGVRKYTFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHEEE
IAENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYTGKLGEVMQESIKAAYSYVRS
CCCCCCEEEEEECCEEECCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHC
NCLFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGSAVCTSIVSLMTNIPVNKSVAMTGEV
CEEEEECCHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEE
TLRGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPANIKEEINVIFAENIDEVI
EEEEEEEEECCHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHHCCHHHHH
KVALMHPITSIDDNNEISVSTSIENKDNTFPSSETLKH
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHCCCC
>Mature Secondary Structure 
SIGRAVNFNSTVLPVLPLRDVVIFPNIMLPLFVGREKSVHALEYAISSSSHQNEIFLIA
CCCCCCCCCCCEEEECCCCCHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEEE
QKDGSIDNPEPENLYEVGVLANIIQPLIKLPDNAVKVMIHGVRRGRVIEYISSHTLLQAR
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHEEEH
VALDGHYEYGENEDNIDLEALRRSVIDAFDNWCKLSKKSRPEIIIDPIDQVKEVNQIVDM
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHH
IASHLNIKVSDKQNILEVYNPKERLKKVFALIEREISILSAQNRLYKTIKSQVESTQKVY
HHHHCCEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
YLNEQLKAIQKELGEFENGDEGNILNEFEKKINETKLSEEAKEKAITDLKRYKKMNPISP
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EATVISSYLHWLLDLPWGKYKDAKINLNAAKKILDENHYGIEKVKDRIIEFLAVLKRVKE
HHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
IKGPILCLVGPPGVGKTSLAKSMAKAVGRDFVRISLGGIRDESEIRGHRKTYIGSMPGKI
HCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCHHHHHCCCCCHHH
IQHMKKANSCNPLFLLDEIDKMGSDSRGDPASALLEVLDTEHNKHFTDHYLEVEFDLSSV
HHHHHHCCCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECHHHE
MFVATANSLNLPHPLRDRMEIIQLSGYTEDEKISIATHHLIPKLKKEHGLHQKEWEITNE
EEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHH
ALYELIRLYTRESGVRSMERELAKLMRKAVKAILTDKNKKISVETGNLQDYLGVRKYTFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHEEE
IAENESLVGIVTGLAYTETGGDILMIESVLIPGKGEIKYTGKLGEVMQESIKAAYSYVRS
CCCCCCEEEEEECCEEECCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHC
NCLFFGIKPEKFQNNDIHLHVPEGAVPKDGPSAGSAVCTSIVSLMTNIPVNKSVAMTGEV
CEEEEECCHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEE
TLRGRVLAIGGLREKLLAALRGSIKTVIIPSENEKDMQEIPANIKEEINVIFAENIDEVI
EEEEEEEEECCHHHHHHHHHCCCCEEEEECCCCCHHHHHCCCCHHHHHHHHHHCCHHHHH
KVALMHPITSIDDNNEISVSTSIENKDNTFPSSETLKH
HHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA