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The map label for this gene is icd [H]

Identifier: 190570962

GI number: 190570962

Start: 585832

End: 587250

Strand: Reverse

Name: icd [H]

Synonym: WPa_0547

Alternate gene names: 190570962

Gene position: 587250-585832 (Counterclockwise)

Preceding gene: 190570963

Following gene: 190570961

Centisome position: 39.61

GC content: 36.93

Gene sequence:

>1419_bases
ATGTCAACATCAGTCACAGTTGCGTATGGTGATGGTATCGGACCAGAAATTATGGAAGCGGTGCTGTCGATATTGCGTGA
AGCGAAAGCAGAGATCTCAATAGATATTATTGAAATAGGAGAGCGTGTTTATAGTAAGGAATGGTCTCATGGAATTTCTC
CGAGTGGTTGGGAATCTATCGAAAGGACAAAGATATTACTCAAATCTCCAACAACAACCCCTCAAGGTAAAGGGCACAAA
AGCTTAAACGTTGCACTCAGAAAGAACTTAGGGCTGTATGCAAACATTAGACCATGCATTTCGTATCACCCTGTTATAGA
AAATAAATTCGATAAATTTGATGTTGTTGTAATACGCGAAAATGAAGAGGACGTTTACACCGGAATAGAGCATAGGCTCA
CTGGTGACTCGTACCAATGCACTAAAATTATTACTAGATCTGGCTCAGAAAAAATATGCAGGTATGCTTTTGAATATGCG
AAAAAACATAACAGAAAGAAAGTAACTTGCCTGACTAAAGACAACATAATGAAAATGACTGACGGCGCTTTTCATGCAGC
GTTTGATCGTATTGCAAAAGAATATCCGGATATAAAGGCGGAACATTATATAGTTGATATTGGAATGGCACGTGTTGCCA
CAGAACCCGAGAATTTCGATGTTATAGTAACTGAAAATCTATATGGCGACATATTATCAGACATAGTAGCACAAACCTCA
GGTTCTGTAGGGCTTGCAGGAAGTAGCAATATAGGTAATGAATATGCAATGTTTGAAGCGGTTCACGGCTCTGCTCCTGA
TATTGCAGGAAAAAATATAGCTAATCCTTCTGGTCTTTTAAATGCCGCAGTACATATGTTGGTCTATATTGGTCAAGTGA
GTACTGCAAAACTAATCTACGATGCATGGCTCAAGACTTTGGAAGATGGAGTACATACCGCTGATTTATATAAGGAGAAA
AAGAGTAAACAAAAGGTTGGAACAAAAGAATTTGCAAAAGCTGTTATAGATAATCTAGGGAAAAAACCCACAACGTTATC
TGAGCTTATAATTAGCAGTGATTCGGATAGTAAAATAAATAAAGTACAAGACAATTACGAACAAGATTACAAAGTTAAAA
AGCTAGTGGGTAGTGATATAACGCTTGCTTGGGACAAATCCAACAATTTTGATCAAATAGTTAGGTTATTTGAATCGAGT
AATCTGAAAATGATAGCAATATACTCAAAAGGACTTGCAATTTGGCCAGGAGGCTCAAAGTCTTCAAGTGACCAAATAAT
CTGCAGGTTTATTGCAAATAATGAAATTACAAATAGTGATGTGAATAACTTGCTAATCAAATTTGAGGAACACAATTTTG
ATGTGGTGAGAATGGATAAGTTGTATTTGTATGATGGGAAAGAGGGTTTCTTCTCTTAG

Upstream 100 bases:

>100_bases
TAAAAGTTCATTATTAAATAACCGTAAATATGCTATTTTAGCAACATTGACCCACTTTATTATTTGAATTAACATTAAAT
CATTTACAGTTAAGGAAGTT

Downstream 100 bases:

>100_bases
TGGTTGCTTGATATTTTTATGCTTGTGTGAAACATTAAATATATTATACTAATAGCATCGTGTATTTATGTGAGGTGTAG
TAATGAGTCAACATTTTAAG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSTSVTVAYGDGIGPEIMEAVLSILREAKAEISIDIIEIGERVYSKEWSHGISPSGWESIERTKILLKSPTTTPQGKGHK
SLNVALRKNLGLYANIRPCISYHPVIENKFDKFDVVVIRENEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYA
KKHNRKKVTCLTKDNIMKMTDGAFHAAFDRIAKEYPDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTS
GSVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLVYIGQVSTAKLIYDAWLKTLEDGVHTADLYKEK
KSKQKVGTKEFAKAVIDNLGKKPTTLSELIISSDSDSKINKVQDNYEQDYKVKKLVGSDITLAWDKSNNFDQIVRLFESS
NLKMIAIYSKGLAIWPGGSKSSSDQIICRFIANNEITNSDVNNLLIKFEEHNFDVVRMDKLYLYDGKEGFFS

Sequences:

>Translated_472_residues
MSTSVTVAYGDGIGPEIMEAVLSILREAKAEISIDIIEIGERVYSKEWSHGISPSGWESIERTKILLKSPTTTPQGKGHK
SLNVALRKNLGLYANIRPCISYHPVIENKFDKFDVVVIRENEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYA
KKHNRKKVTCLTKDNIMKMTDGAFHAAFDRIAKEYPDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTS
GSVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLVYIGQVSTAKLIYDAWLKTLEDGVHTADLYKEK
KSKQKVGTKEFAKAVIDNLGKKPTTLSELIISSDSDSKINKVQDNYEQDYKVKKLVGSDITLAWDKSNNFDQIVRLFESS
NLKMIAIYSKGLAIWPGGSKSSSDQIICRFIANNEITNSDVNNLLIKFEEHNFDVVRMDKLYLYDGKEGFFS
>Mature_471_residues
STSVTVAYGDGIGPEIMEAVLSILREAKAEISIDIIEIGERVYSKEWSHGISPSGWESIERTKILLKSPTTTPQGKGHKS
LNVALRKNLGLYANIRPCISYHPVIENKFDKFDVVVIRENEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYAK
KHNRKKVTCLTKDNIMKMTDGAFHAAFDRIAKEYPDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTSG
SVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLVYIGQVSTAKLIYDAWLKTLEDGVHTADLYKEKK
SKQKVGTKEFAKAVIDNLGKKPTTLSELIISSDSDSKINKVQDNYEQDYKVKKLVGSDITLAWDKSNNFDQIVRLFESSN
LKMIAIYSKGLAIWPGGSKSSSDQIICRFIANNEITNSDVNNLLIKFEEHNFDVVRMDKLYLYDGKEGFFS

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=312, Percent_Identity=42.6282051282051, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI4758582, Length=327, Percent_Identity=34.8623853211009, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI28178838, Length=309, Percent_Identity=35.9223300970874, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI28178821, Length=308, Percent_Identity=34.0909090909091, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI28178816, Length=308, Percent_Identity=34.0909090909091, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI28178819, Length=166, Percent_Identity=39.7590361445783, Blast_Score=122, Evalue=7e-28,
Organism=Escherichia coli, GI1787381, Length=388, Percent_Identity=31.701030927835, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788101, Length=304, Percent_Identity=33.8815789473684, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI87081683, Length=340, Percent_Identity=30.8823529411765, Blast_Score=143, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71986051, Length=315, Percent_Identity=43.1746031746032, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI25144293, Length=347, Percent_Identity=37.463976945245, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17505779, Length=319, Percent_Identity=36.9905956112853, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17550882, Length=347, Percent_Identity=33.7175792507205, Blast_Score=182, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324709, Length=344, Percent_Identity=40.1162790697674, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6324291, Length=315, Percent_Identity=38.7301587301587, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6322097, Length=352, Percent_Identity=34.0909090909091, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319830, Length=248, Percent_Identity=29.4354838709677, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24643270, Length=321, Percent_Identity=43.613707165109, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24643268, Length=321, Percent_Identity=43.613707165109, Blast_Score=255, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24661184, Length=342, Percent_Identity=40.9356725146199, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI161078637, Length=317, Percent_Identity=36.2776025236593, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI161078635, Length=317, Percent_Identity=36.2776025236593, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI161078633, Length=317, Percent_Identity=36.2776025236593, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24650122, Length=317, Percent_Identity=36.2776025236593, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI161078639, Length=311, Percent_Identity=36.3344051446945, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI281362242, Length=345, Percent_Identity=33.0434782608696, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24648872, Length=345, Percent_Identity=33.0434782608696, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20130355, Length=340, Percent_Identity=30, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI45550436, Length=307, Percent_Identity=23.4527687296417, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52574; Mature: 52443

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSVTVAYGDGIGPEIMEAVLSILREAKAEISIDIIEIGERVYSKEWSHGISPSGWESI
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCCCCCCHHHH
ERTKILLKSPTTTPQGKGHKSLNVALRKNLGLYANIRPCISYHPVIENKFDKFDVVVIRE
HHCEEEEECCCCCCCCCCCCCEEHEECCCCCEEEECCCCCCCCCHHCCCCCCEEEEEEEC
NEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYAKKHNRKKVTCLTKDNIMKMT
CCCHHHHCHHHEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
DGAFHAAFDRIAKEYPDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTS
CCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCC
GSVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLVYIGQVSTAKLIY
CCEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
DAWLKTLEDGVHTADLYKEKKSKQKVGTKEFAKAVIDNLGKKPTTLSELIISSDSDSKIN
HHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHH
KVQDNYEQDYKVKKLVGSDITLAWDKSNNFDQIVRLFESSNLKMIAIYSKGLAIWPGGSK
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCEEEECCCCC
SSSDQIICRFIANNEITNSDVNNLLIKFEEHNFDVVRMDKLYLYDGKEGFFS
CCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEECCCCCCC
>Mature Secondary Structure 
STSVTVAYGDGIGPEIMEAVLSILREAKAEISIDIIEIGERVYSKEWSHGISPSGWESI
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCCCCCCHHHH
ERTKILLKSPTTTPQGKGHKSLNVALRKNLGLYANIRPCISYHPVIENKFDKFDVVVIRE
HHCEEEEECCCCCCCCCCCCCEEHEECCCCCEEEECCCCCCCCCHHCCCCCCEEEEEEEC
NEEDVYTGIEHRLTGDSYQCTKIITRSGSEKICRYAFEYAKKHNRKKVTCLTKDNIMKMT
CCCHHHHCHHHEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEC
DGAFHAAFDRIAKEYPDIKAEHYIVDIGMARVATEPENFDVIVTENLYGDILSDIVAQTS
CCHHHHHHHHHHHHCCCCCCCEEEEEECHHHHCCCCCCCEEEEECCHHHHHHHHHHHHCC
GSVGLAGSSNIGNEYAMFEAVHGSAPDIAGKNIANPSGLLNAAVHMLVYIGQVSTAKLIY
CCEEECCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
DAWLKTLEDGVHTADLYKEKKSKQKVGTKEFAKAVIDNLGKKPTTLSELIISSDSDSKIN
HHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCHHH
KVQDNYEQDYKVKKLVGSDITLAWDKSNNFDQIVRLFESSNLKMIAIYSKGLAIWPGGSK
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCEEEECCCCC
SSSDQIICRFIANNEITNSDVNNLLIKFEEHNFDVVRMDKLYLYDGKEGFFS
CCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA