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The map label for this gene is guaA [H]

Identifier: 190570912

GI number: 190570912

Start: 528270

End: 529832

Strand: Direct

Name: guaA [H]

Synonym: WPa_0492

Alternate gene names: 190570912

Gene position: 528270-529832 (Clockwise)

Preceding gene: 190570911

Following gene: 190570914

Centisome position: 35.63

GC content: 35.7

Gene sequence:

>1563_bases
TTGTCAGCAATTGCCGTTATTGATTTTGGTTCACAGTTTACACAGCTTATTGCAAGACAAATCAGGGAAATGGGCGTTTA
CTGTGAAATATTTCCAAGCAATATCGATTTCGAAACAGTATCAAAATTCAATGGATTTATTTTTTCTGGAGGACCGCAAT
CTGTAAATGACAATTGCTCTGAAGTAAGTGAAGTAGCACATAAAATTATAAAACTTAACGAAACAATAAACACTCCTATA
CTTGGAATATGTTATGGACAGCAACTCATTTGTCATTATTTCGGGGCAAAGGTAAGAAAAGAATTCAATCAGGAATTTGG
CAAAACTAAAATCAAGATACTAAAAGAATCCCCAATTATAAAGGATACTTGGGACGTTAATTCCGAAGTCGATGTGCTAA
TGAACCATGCAGACAGTGTCGAAACTATACCGCAAGGATTTACTGCTATTGCCTCAGGTATAATAAATCAAACAATCGCA
ATAATTGCCAACGAACAGCGGAAGATTTACTGCACTCAGTTCCATCCTGAAGTTAAGCCTACGACAAATGGTAGTAAACT
TCTCTCTAATTTCTTAGATATTGCAAATTGTGAGAGAGATTGGACAATGAAGTCATTCATTGAAAAACAGAAGGAAAAAA
TTCAAAACTTAGTAGGGGAGAAAAAAGTAATTGCTGCAGTAAGTGGGGGGGTTGATTCAAGTGTTGCAGCAGTTCTTACA
CACAAAGCTATAGGAAAACAATTAAACTGTATTTTTATCGATACTGGGTTATTGCGTAAGAGCCAGACCACTGCTATGTT
AAAAGAAATTCCAATAAATTACGTTGATAAATCAAACTTGTTTTTAAGTAGGTTAAAGGGAATAACTGATCCGGAAGAAA
AGCGAAAAATTATCGGCAATACTTTTATCGAAGTATTTGAAGAAGAGGCAAAAAAAATAGGTGATGTGGATTTTTTAATG
CAAGGCACCATTTACTCTGATGTAGTTGAATCAGGGCACGCTTCAGGAAACACTAGTACAATTAAATCTCATCACAATGT
TGGTGGGTTGCCAGAAAAAATGAATCTGAAATTAGTAGAACCTTTACGCTATCTCTTTAAAGATGAAGTAAGGCTGCTTG
GCAAAGAAATTGGGCTTTCAGATGAGATAATATTTCAACATCCATTTCCTGGGCCTGGACTTGCAGTGAGGATCATATGT
GAGGTTGATGAAGAAAAGGTACGAATATTGCAAGAAGTAGATGAAATATATATCAACACAATGAAAAATTATGATCTGTA
TGATAAAATATGGCAGGCTTTTGCTGTACTGTTACCAGTAAAAACTGTGGGAGTTATGGGAGATAATCGTACATACGGAT
ATGTTTGCGCTTTAAGGGCTGTGACTTCATCTGATGGCATGACAGCTGATGCATTTCCATTTGAAAATAAAGATCAACAT
TCGTTAGTATTTTGGAGGTTTTTGCAAGACATCAGTAGTATAATTGTTAACAAAGTTTCCAGAGTAAATCGAGTTGTGTA
TGATTTAACTTCCAAGCCACCAGCAACTATTGAGTGGGAGTAG

Upstream 100 bases:

>100_bases
ACTTTAGTCATATATTAAAGTTTTTAAACAGGTCTTAGTTTACTTACTTTATTGTTTTCTTTATTATCAAATATTGCTTT
AAATAATATGGAGGAGCACA

Downstream 100 bases:

>100_bases
CAATAATTTCATTCCAGTTTCAGCTACTCGAATCACACCAAAGAGGCTGCTTGCATAACTCAAATTTTAAGGAAAACTAT
TTAATGTCATTCCAGCGCGT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSAIAVIDFGSQFTQLIARQIREMGVYCEIFPSNIDFETVSKFNGFIFSGGPQSVNDNCSEVSEVAHKIIKLNETINTPI
LGICYGQQLICHYFGAKVRKEFNQEFGKTKIKILKESPIIKDTWDVNSEVDVLMNHADSVETIPQGFTAIASGIINQTIA
IIANEQRKIYCTQFHPEVKPTTNGSKLLSNFLDIANCERDWTMKSFIEKQKEKIQNLVGEKKVIAAVSGGVDSSVAAVLT
HKAIGKQLNCIFIDTGLLRKSQTTAMLKEIPINYVDKSNLFLSRLKGITDPEEKRKIIGNTFIEVFEEEAKKIGDVDFLM
QGTIYSDVVESGHASGNTSTIKSHHNVGGLPEKMNLKLVEPLRYLFKDEVRLLGKEIGLSDEIIFQHPFPGPGLAVRIIC
EVDEEKVRILQEVDEIYINTMKNYDLYDKIWQAFAVLLPVKTVGVMGDNRTYGYVCALRAVTSSDGMTADAFPFENKDQH
SLVFWRFLQDISSIIVNKVSRVNRVVYDLTSKPPATIEWE

Sequences:

>Translated_520_residues
MSAIAVIDFGSQFTQLIARQIREMGVYCEIFPSNIDFETVSKFNGFIFSGGPQSVNDNCSEVSEVAHKIIKLNETINTPI
LGICYGQQLICHYFGAKVRKEFNQEFGKTKIKILKESPIIKDTWDVNSEVDVLMNHADSVETIPQGFTAIASGIINQTIA
IIANEQRKIYCTQFHPEVKPTTNGSKLLSNFLDIANCERDWTMKSFIEKQKEKIQNLVGEKKVIAAVSGGVDSSVAAVLT
HKAIGKQLNCIFIDTGLLRKSQTTAMLKEIPINYVDKSNLFLSRLKGITDPEEKRKIIGNTFIEVFEEEAKKIGDVDFLM
QGTIYSDVVESGHASGNTSTIKSHHNVGGLPEKMNLKLVEPLRYLFKDEVRLLGKEIGLSDEIIFQHPFPGPGLAVRIIC
EVDEEKVRILQEVDEIYINTMKNYDLYDKIWQAFAVLLPVKTVGVMGDNRTYGYVCALRAVTSSDGMTADAFPFENKDQH
SLVFWRFLQDISSIIVNKVSRVNRVVYDLTSKPPATIEWE
>Mature_519_residues
SAIAVIDFGSQFTQLIARQIREMGVYCEIFPSNIDFETVSKFNGFIFSGGPQSVNDNCSEVSEVAHKIIKLNETINTPIL
GICYGQQLICHYFGAKVRKEFNQEFGKTKIKILKESPIIKDTWDVNSEVDVLMNHADSVETIPQGFTAIASGIINQTIAI
IANEQRKIYCTQFHPEVKPTTNGSKLLSNFLDIANCERDWTMKSFIEKQKEKIQNLVGEKKVIAAVSGGVDSSVAAVLTH
KAIGKQLNCIFIDTGLLRKSQTTAMLKEIPINYVDKSNLFLSRLKGITDPEEKRKIIGNTFIEVFEEEAKKIGDVDFLMQ
GTIYSDVVESGHASGNTSTIKSHHNVGGLPEKMNLKLVEPLRYLFKDEVRLLGKEIGLSDEIIFQHPFPGPGLAVRIICE
VDEEKVRILQEVDEIYINTMKNYDLYDKIWQAFAVLLPVKTVGVMGDNRTYGYVCALRAVTSSDGMTADAFPFENKDQHS
LVFWRFLQDISSIIVNKVSRVNRVVYDLTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=570, Percent_Identity=35.0877192982456, Blast_Score=273, Evalue=4e-73,
Organism=Escherichia coli, GI1788854, Length=534, Percent_Identity=44.7565543071161, Blast_Score=458, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71992717, Length=585, Percent_Identity=35.042735042735, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI71992710, Length=585, Percent_Identity=35.042735042735, Blast_Score=285, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=585, Percent_Identity=35.042735042735, Blast_Score=284, Evalue=7e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=534, Percent_Identity=46.8164794007491, Blast_Score=455, Evalue=1e-129,
Organism=Drosophila melanogaster, GI281365319, Length=563, Percent_Identity=33.5701598579041, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58372; Mature: 58241

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIAVIDFGSQFTQLIARQIREMGVYCEIFPSNIDFETVSKFNGFIFSGGPQSVNDNCS
CCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCEEECCCCCCCCCCHH
EVSEVAHKIIKLNETINTPILGICYGQQLICHYFGAKVRKEFNQEFGKTKIKILKESPII
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
KDTWDVNSEVDVLMNHADSVETIPQGFTAIASGIINQTIAIIANEQRKIYCTQFHPEVKP
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCC
TTNGSKLLSNFLDIANCERDWTMKSFIEKQKEKIQNLVGEKKVIAAVSGGVDSSVAAVLT
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHH
HKAIGKQLNCIFIDTGLLRKSQTTAMLKEIPINYVDKSNLFLSRLKGITDPEEKRKIIGN
HHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
TFIEVFEEEAKKIGDVDFLMQGTIYSDVVESGHASGNTSTIKSHHNVGGLPEKMNLKLVE
HHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCHHHH
PLRYLFKDEVRLLGKEIGLSDEIIFQHPFPGPGLAVRIICEVDEEKVRILQEVDEIYINT
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
MKNYDLYDKIWQAFAVLLPVKTVGVMGDNRTYGYVCALRAVTSSDGMTADAFPFENKDQH
HCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEEEEHCCCCCCEECCCCCCCCCCC
SLVFWRFLQDISSIIVNKVSRVNRVVYDLTSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure 
SAIAVIDFGSQFTQLIARQIREMGVYCEIFPSNIDFETVSKFNGFIFSGGPQSVNDNCS
CEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCEEECCCCCCCCCCHH
EVSEVAHKIIKLNETINTPILGICYGQQLICHYFGAKVRKEFNQEFGKTKIKILKESPII
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
KDTWDVNSEVDVLMNHADSVETIPQGFTAIASGIINQTIAIIANEQRKIYCTQFHPEVKP
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCC
TTNGSKLLSNFLDIANCERDWTMKSFIEKQKEKIQNLVGEKKVIAAVSGGVDSSVAAVLT
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHHH
HKAIGKQLNCIFIDTGLLRKSQTTAMLKEIPINYVDKSNLFLSRLKGITDPEEKRKIIGN
HHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHH
TFIEVFEEEAKKIGDVDFLMQGTIYSDVVESGHASGNTSTIKSHHNVGGLPEKMNLKLVE
HHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCHHHH
PLRYLFKDEVRLLGKEIGLSDEIIFQHPFPGPGLAVRIICEVDEEKVRILQEVDEIYINT
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
MKNYDLYDKIWQAFAVLLPVKTVGVMGDNRTYGYVCALRAVTSSDGMTADAFPFENKDQH
HCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEEEEHCCCCCCEECCCCCCCCCCC
SLVFWRFLQDISSIIVNKVSRVNRVVYDLTSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA