Definition Wolbachia endosymbiont of Culex quinquefasciatus Pel, complete genome.
Accession NC_010981
Length 1,482,455

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The map label for this gene is proP [H]

Identifier: 190570816

GI number: 190570816

Start: 407599

End: 408861

Strand: Reverse

Name: proP [H]

Synonym: WPa_0385

Alternate gene names: 190570816

Gene position: 408861-407599 (Counterclockwise)

Preceding gene: 190570818

Following gene: 190570813

Centisome position: 27.58

GC content: 35.08

Gene sequence:

>1263_bases
ATGAGCGATATTCAAAAAGCAATACTATCAAGTATAATCTGCAATATGATTATATGGTATGAAATAACTCTGTTTGGAGT
TTTGACGCATATAATAAGTGACGTTTTTTTTTCATCAGAAAGCGACTACATAAAAAAAATCAAATTCCTTGGCAGTTTTG
CAATTGGCTTTGGATTTAGACCACTTGGTGCGTTTATTTTTGGTTACATTGGAGATAAGTATGGCAGGAGGAAAATTTTA
CTGACTTCCGTAATATTAGCTTCGATATCGTCTACTGCAATTGCGGTTATACCTAGCTTTAGAGAAATAGGAATATTTTC
TCCTATACTGCTTCTGTTTTGTAGGATAGTACAAGGAATGGCAGCAGGTGGAGAAACAAGTGTTAACTCTGCTTTTTTAA
TAGAGCATTCAAGCGATAAAAAAAATCTAGGATTCTTAGGGAGCATGAAAGCGTTTAGTGGTGCTCTCGGTTCTATCACA
TGCTTTGTAATGATAGCTATTTGCAAAAAGTTTACAGGTGAAAATTATGAAATTTGGGGCTGGAGGTTGCCCTTCTATTT
CTGCTTCATTATGGGCATAATAGGCTTTTTAACAAGATATATAATGGAAGAGAGCTTAGCATATAAAATTCATGATCAAA
ATAGAAGCTTATCTGATTCTCCATTTTTAGAATTAATCAAAACCTACAAAAAAGCATTTATATTAGCAATTGGGCTTGGT
ATCGCTCAAAATGCAATCGTTTATTCGGTAATAATGTTTTATAACATATCTGTAAAAGCGCTTACTCTGTCAGGTATTGA
TATTAAAAATGTAGTAAGGATTATAGTTGAAATTACATTTGGAACGTCCGCAGTGCTATTTGCAATACTGTCTGATAAAG
TTGGAAGAAAAAATGTAATGATTCCTACATTAGTAGCTCTAGCTTGCGCCGGTTTGCCGGTACTTTCGCTATTATCAAAT
GATAACCACTATATTGTCACGCTCTCTTTTCTGTTGATAAGTGTGCCGATAGGTGCATCTTTTGGAATATATAATTCTCT
TGCCTGCGAGTTATTTCCAACAAAAGTTAGGTGCACCGGCTTTAGCCTCGCACATAACATATCTGCAGGTATTTTTGGCG
GCCTTTCTCCATCGATATGCATGTGGCTTATAGAAAAAACCGAAACAAAACTTGCCGCAGGGATTTACCTTACTGTTTGT
GCATTGATTAGCCTAATATCTGTACTTCAAATTAAAGCCAAAGACAAAAAAATTGATTGGTGA

Upstream 100 bases:

>100_bases
GTAAACAATTTTATACTAAAACAGTTACAAAGTTCTAAACTACAATCTATAGACAAAAATACTTGTTATTAGTAAGTTAA
ATTATAGTGAGTTAAAAATT

Downstream 100 bases:

>100_bases
AATCGCTTTAGTCAAAAGATAGCGCTTCAATAGATTTTTCGATATGTTTAGGGACAGGAGCAGTAATAGTGACTTCTTTA
TTATTTGGCAATTTTAAAGA

Product: major facilitator family transporter

Products: betaine [Cytoplasm]; Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: Proline porter II; PPII [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSDIQKAILSSIICNMIIWYEITLFGVLTHIISDVFFSSESDYIKKIKFLGSFAIGFGFRPLGAFIFGYIGDKYGRRKIL
LTSVILASISSTAIAVIPSFREIGIFSPILLLFCRIVQGMAAGGETSVNSAFLIEHSSDKKNLGFLGSMKAFSGALGSIT
CFVMIAICKKFTGENYEIWGWRLPFYFCFIMGIIGFLTRYIMEESLAYKIHDQNRSLSDSPFLELIKTYKKAFILAIGLG
IAQNAIVYSVIMFYNISVKALTLSGIDIKNVVRIIVEITFGTSAVLFAILSDKVGRKNVMIPTLVALACAGLPVLSLLSN
DNHYIVTLSFLLISVPIGASFGIYNSLACELFPTKVRCTGFSLAHNISAGIFGGLSPSICMWLIEKTETKLAAGIYLTVC
ALISLISVLQIKAKDKKIDW

Sequences:

>Translated_420_residues
MSDIQKAILSSIICNMIIWYEITLFGVLTHIISDVFFSSESDYIKKIKFLGSFAIGFGFRPLGAFIFGYIGDKYGRRKIL
LTSVILASISSTAIAVIPSFREIGIFSPILLLFCRIVQGMAAGGETSVNSAFLIEHSSDKKNLGFLGSMKAFSGALGSIT
CFVMIAICKKFTGENYEIWGWRLPFYFCFIMGIIGFLTRYIMEESLAYKIHDQNRSLSDSPFLELIKTYKKAFILAIGLG
IAQNAIVYSVIMFYNISVKALTLSGIDIKNVVRIIVEITFGTSAVLFAILSDKVGRKNVMIPTLVALACAGLPVLSLLSN
DNHYIVTLSFLLISVPIGASFGIYNSLACELFPTKVRCTGFSLAHNISAGIFGGLSPSICMWLIEKTETKLAAGIYLTVC
ALISLISVLQIKAKDKKIDW
>Mature_419_residues
SDIQKAILSSIICNMIIWYEITLFGVLTHIISDVFFSSESDYIKKIKFLGSFAIGFGFRPLGAFIFGYIGDKYGRRKILL
TSVILASISSTAIAVIPSFREIGIFSPILLLFCRIVQGMAAGGETSVNSAFLIEHSSDKKNLGFLGSMKAFSGALGSITC
FVMIAICKKFTGENYEIWGWRLPFYFCFIMGIIGFLTRYIMEESLAYKIHDQNRSLSDSPFLELIKTYKKAFILAIGLGI
AQNAIVYSVIMFYNISVKALTLSGIDIKNVVRIIVEITFGTSAVLFAILSDKVGRKNVMIPTLVALACAGLPVLSLLSND
NHYIVTLSFLLISVPIGASFGIYNSLACELFPTKVRCTGFSLAHNISAGIFGGLSPSICMWLIEKTETKLAAGIYLTVCA
LISLISVLQIKAKDKKIDW

Specific function: Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in th

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790550, Length=430, Percent_Identity=32.3255813953488, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1788292, Length=423, Percent_Identity=27.6595744680851, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1789941, Length=422, Percent_Identity=28.436018957346, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788942, Length=423, Percent_Identity=24.822695035461, Blast_Score=135, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR015041
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF08946 Osmo_CC; PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 46099; Mature: 45968

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIQKAILSSIICNMIIWYEITLFGVLTHIISDVFFSSESDYIKKIKFLGSFAIGFGFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCH
PLGAFIFGYIGDKYGRRKILLTSVILASISSTAIAVIPSFREIGIFSPILLLFCRIVQGM
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
AAGGETSVNSAFLIEHSSDKKNLGFLGSMKAFSGALGSITCFVMIAICKKFTGENYEIWG
CCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEE
WRLPFYFCFIMGIIGFLTRYIMEESLAYKIHDQNRSLSDSPFLELIKTYKKAFILAIGLG
EHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IAQNAIVYSVIMFYNISVKALTLSGIDIKNVVRIIVEITFGTSAVLFAILSDKVGRKNVM
HHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCH
IPTLVALACAGLPVLSLLSNDNHYIVTLSFLLISVPIGASFGIYNSLACELFPTKVRCTG
HHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCHHHHHHEECCCEEEEEC
FSLAHNISAGIFGGLSPSICMWLIEKTETKLAAGIYLTVCALISLISVLQIKAKDKKIDW
HHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SDIQKAILSSIICNMIIWYEITLFGVLTHIISDVFFSSESDYIKKIKFLGSFAIGFGFR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCH
PLGAFIFGYIGDKYGRRKILLTSVILASISSTAIAVIPSFREIGIFSPILLLFCRIVQGM
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
AAGGETSVNSAFLIEHSSDKKNLGFLGSMKAFSGALGSITCFVMIAICKKFTGENYEIWG
CCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEE
WRLPFYFCFIMGIIGFLTRYIMEESLAYKIHDQNRSLSDSPFLELIKTYKKAFILAIGLG
EHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IAQNAIVYSVIMFYNISVKALTLSGIDIKNVVRIIVEITFGTSAVLFAILSDKVGRKNVM
HHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCH
IPTLVALACAGLPVLSLLSNDNHYIVTLSFLLISVPIGASFGIYNSLACELFPTKVRCTG
HHHHHHHHHCCHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCHHHHHHEECCCEEEEEC
FSLAHNISAGIFGGLSPSICMWLIEKTETKLAAGIYLTVCALISLISVLQIKAKDKKIDW
HHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: betaine [Periplasm]; Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + betaine [Periplasm] = Proton [Cytoplasm] + betaine [Cytoplasm] Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]