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The map label for this gene is dppA [H]

Identifier: 18977780

GI number: 18977780

Start: 1322707

End: 1324824

Strand: Direct

Name: dppA [H]

Synonym: PF1408

Alternate gene names: 18977780

Gene position: 1322707-1324824 (Clockwise)

Preceding gene: 18977779

Following gene: 18977781

Centisome position: 69.31

GC content: 44.33

Gene sequence:

>2118_bases
ATGAAGAAAGGACTGTTAGCAATTTTGCTTGTTGGAGTCATGGTATTGGGAACTTTTGGAAGTGGATGTATTGGAGGAGG
AACCCAAACTCAGACCCAAACACCCACAGAAACTGGAAGCCCAACCCAAACAACCACTCCTAGCGGAGTAACCCAAGCAA
TTTTGGAGCTCGGAAAAGTTACAGTTGTCGATACTGGAACAGCTATCGTTGTAGTTGGTCCCAAAGGTGAAAAACCAAGC
GTTTCAATTCCATCTGGAAAGAAGGTAATTACCGTAACTTATGTGGTGGATGAGCAAAACACTCCAAGCGTTAAAGAGTT
AATGGAGCAAGGTCAGGGATTTGGTGCAATAAACCCAGCATTCTTTAGGGATACAAACGTTGATGCTCTTGTAATAGCTG
CCAGAAGAGAGACTAATCCGGAAGTAAGAACTGAAATATTCAAGGCTCTCTATATCCTGGGCAACTATTATGTCCCAGAA
GTCATACTTGGACAGAACAGGCAACTCCGTGTCTACTGGGACTGGGTTAAGGGAAGATATTACCACCCGACACTCCCAGA
GAGATATGATCTTCTCTGGGAAGACCCCAACGCTCCGGTAGTTGATACAGGAATTGGAAGCTATAAGAACGACCCAGAAA
CCTATGTAATAGCTACCATTGGATGGCCCGAAAGCTTTGACCCAGCTTGGACATATGAAACATTTGGATGGGAGATCTGG
CACGAGATTGGAGACACCTTAGTCACTTACTGGAAAGAAGAGACTGAGCAAGTTACCCCCGACTTGGCAGTTGCATGGGC
CCACAACAAAGAGGGCACCGAGTGGTACTTCGTTATAAGGGGAGGAGTTAAGGCTTATGATCCATGGAATGACAAGACTT
ATCCAATAGATGCAACTGATGTTGTATTCACCTTCTGGCGTGTTGCTAGGTTAGGGCACTCAGTTAGTTGGATGGTTACA
GAATTCATGAATGTCTCAGCTTCCCAGGCACTCACTGAGGAAGAATTCAACAACTACGTTAAGAACAACCCACTTATAGC
AGAGTACAATGGAAAGACTGCAGAAATTAAGTCTCTACAAGACTTACTCAACTTCTTCGGATACAACGGTGAAACTGCCG
GAGTATTCAAGCTTGTCCTTCCACACCCATACGCTGCAGTATTAAACATAGTGGCAGATCCATTCCTAAGCGTAGTTCCA
ATGGAGTACTTGTTAGGAGACAAGTATGAAGAAGCACTCAAGGCAAGCAACTATGGTAAGAACCCAGACGCTTGGGAGGC
TTATGTGCAAGAAGGAGTCGACGATCCAACTCACCAGTTAATGCACAAGTACCCAGTTGGTACTGGACCATTCTATGTTA
AGGAGTACCAAGAGAACTCCTACATAGTCCTTGAATACAATCCATACTATTGGAATGCAACAAGCAACCCAGGACACAAG
AGAGTTATCTACATCATAAACAACGATGCTGTTGCCAGAGTACAACTCTTAACCACTGGAACAGCTGACGTAGCAGCAAT
ACCAACGGACAAAATTGAAGACGTCCAAGGAGTAACGAAGGATGGATATAAAGTGGTAGTGCAGACCGACATACTCTTGC
CAGTTCTAACGTTCATAGTATTCAACACCCAGAAAGAACCCTTCAACGACGTAAAAGTCAGACAGGCCCTAGCATATGCA
ATTCCATATGATCAAATAGCAAAAGTAGTTTACAACAACCTCCTCGAGAGGAACTGGGGACCAATTCCAAAGCCATGGCC
TGGATATACCGAGTACGGAATCATCAAGTACGAATACAACATTGCTAAAGCCAAGCAAATGTTACAAGAAGCAGGAGTTG
ATCCAAGTAAGTATTCAATAACCCTCATCTACAACGCTGGTAACACCCAGCGTGAGAAGGTGATGACTCTAATCCAAAAC
GTGTGGAGCCAGCTTGGATTTAGAGTGACAGTTGAATCTTATGAATGGCCAGTTTACCTCTCCAAGACAGAACATGGAGA
CTACGACGTTTACATAGTAGGTTGGGTACCAGACTACCTTGACTCCGACAATTGGGTAGGCCCATTCCTCTATGGAGCTA
CAGAGTTCTCTGAAATAAACATTGAAGTTTCTGGATGA

Upstream 100 bases:

>100_bases
CAAAATTTCTAGCATATTGGGTTAAAAATACCACATCATCGAAAAACTTATAGCTTGAGTACACTTTAGATATTAACTGA
AAACTCGAGGTGATGGCCAA

Downstream 100 bases:

>100_bases
CTTCTTTCCTATTTTTCTTTTGTCTTTCTGTCTTTTCATATACCGAAGGATTTTTATTTTGTTGACAAAAAAGTTTAGAC
GAAAATTTTAATGCGACAAT

Product: putative dipeptide-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MKKGLLAILLVGVMVLGTFGSGCIGGGTQTQTQTPTETGSPTQTTTPSGVTQAILELGKVTVVDTGTAIVVVGPKGEKPS
VSIPSGKKVITVTYVVDEQNTPSVKELMEQGQGFGAINPAFFRDTNVDALVIAARRETNPEVRTEIFKALYILGNYYVPE
VILGQNRQLRVYWDWVKGRYYHPTLPERYDLLWEDPNAPVVDTGIGSYKNDPETYVIATIGWPESFDPAWTYETFGWEIW
HEIGDTLVTYWKEETEQVTPDLAVAWAHNKEGTEWYFVIRGGVKAYDPWNDKTYPIDATDVVFTFWRVARLGHSVSWMVT
EFMNVSASQALTEEEFNNYVKNNPLIAEYNGKTAEIKSLQDLLNFFGYNGETAGVFKLVLPHPYAAVLNIVADPFLSVVP
MEYLLGDKYEEALKASNYGKNPDAWEAYVQEGVDDPTHQLMHKYPVGTGPFYVKEYQENSYIVLEYNPYYWNATSNPGHK
RVIYIINNDAVARVQLLTTGTADVAAIPTDKIEDVQGVTKDGYKVVVQTDILLPVLTFIVFNTQKEPFNDVKVRQALAYA
IPYDQIAKVVYNNLLERNWGPIPKPWPGYTEYGIIKYEYNIAKAKQMLQEAGVDPSKYSITLIYNAGNTQREKVMTLIQN
VWSQLGFRVTVESYEWPVYLSKTEHGDYDVYIVGWVPDYLDSDNWVGPFLYGATEFSEINIEVSG

Sequences:

>Translated_705_residues
MKKGLLAILLVGVMVLGTFGSGCIGGGTQTQTQTPTETGSPTQTTTPSGVTQAILELGKVTVVDTGTAIVVVGPKGEKPS
VSIPSGKKVITVTYVVDEQNTPSVKELMEQGQGFGAINPAFFRDTNVDALVIAARRETNPEVRTEIFKALYILGNYYVPE
VILGQNRQLRVYWDWVKGRYYHPTLPERYDLLWEDPNAPVVDTGIGSYKNDPETYVIATIGWPESFDPAWTYETFGWEIW
HEIGDTLVTYWKEETEQVTPDLAVAWAHNKEGTEWYFVIRGGVKAYDPWNDKTYPIDATDVVFTFWRVARLGHSVSWMVT
EFMNVSASQALTEEEFNNYVKNNPLIAEYNGKTAEIKSLQDLLNFFGYNGETAGVFKLVLPHPYAAVLNIVADPFLSVVP
MEYLLGDKYEEALKASNYGKNPDAWEAYVQEGVDDPTHQLMHKYPVGTGPFYVKEYQENSYIVLEYNPYYWNATSNPGHK
RVIYIINNDAVARVQLLTTGTADVAAIPTDKIEDVQGVTKDGYKVVVQTDILLPVLTFIVFNTQKEPFNDVKVRQALAYA
IPYDQIAKVVYNNLLERNWGPIPKPWPGYTEYGIIKYEYNIAKAKQMLQEAGVDPSKYSITLIYNAGNTQREKVMTLIQN
VWSQLGFRVTVESYEWPVYLSKTEHGDYDVYIVGWVPDYLDSDNWVGPFLYGATEFSEINIEVSG
>Mature_705_residues
MKKGLLAILLVGVMVLGTFGSGCIGGGTQTQTQTPTETGSPTQTTTPSGVTQAILELGKVTVVDTGTAIVVVGPKGEKPS
VSIPSGKKVITVTYVVDEQNTPSVKELMEQGQGFGAINPAFFRDTNVDALVIAARRETNPEVRTEIFKALYILGNYYVPE
VILGQNRQLRVYWDWVKGRYYHPTLPERYDLLWEDPNAPVVDTGIGSYKNDPETYVIATIGWPESFDPAWTYETFGWEIW
HEIGDTLVTYWKEETEQVTPDLAVAWAHNKEGTEWYFVIRGGVKAYDPWNDKTYPIDATDVVFTFWRVARLGHSVSWMVT
EFMNVSASQALTEEEFNNYVKNNPLIAEYNGKTAEIKSLQDLLNFFGYNGETAGVFKLVLPHPYAAVLNIVADPFLSVVP
MEYLLGDKYEEALKASNYGKNPDAWEAYVQEGVDDPTHQLMHKYPVGTGPFYVKEYQENSYIVLEYNPYYWNATSNPGHK
RVIYIINNDAVARVQLLTTGTADVAAIPTDKIEDVQGVTKDGYKVVVQTDILLPVLTFIVFNTQKEPFNDVKVRQALAYA
IPYDQIAKVVYNNLLERNWGPIPKPWPGYTEYGIIKYEYNIAKAKQMLQEAGVDPSKYSITLIYNAGNTQREKVMTLIQN
VWSQLGFRVTVESYEWPVYLSKTEHGDYDVYIVGWVPDYLDSDNWVGPFLYGATEFSEINIEVSG

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=497, Percent_Identity=26.7605633802817, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1787762, Length=474, Percent_Identity=23.4177215189873, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1787551, Length=518, Percent_Identity=23.7451737451737, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87081878, Length=472, Percent_Identity=22.8813559322034, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1787052, Length=295, Percent_Identity=24.7457627118644, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787495, Length=261, Percent_Identity=26.0536398467433, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789397, Length=497, Percent_Identity=21.9315895372233, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 79410; Mature: 79410

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGLLAILLVGVMVLGTFGSGCIGGGTQTQTQTPTETGSPTQTTTPSGVTQAILELGKV
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCE
TVVDTGTAIVVVGPKGEKPSVSIPSGKKVITVTYVVDEQNTPSVKELMEQGQGFGAINPA
EEEECCCEEEEECCCCCCCCEECCCCCEEEEEEEEEECCCCCHHHHHHHCCCCCCCCCCC
FFRDTNVDALVIAARRETNPEVRTEIFKALYILGNYYVPEVILGQNRQLRVYWDWVKGRY
CEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEECCEE
YHPTLPERYDLLWEDPNAPVVDTGIGSYKNDPETYVIATIGWPESFDPAWTYETFGWEIW
ECCCCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEEECCCCCCCCCEEECCCCHHHH
HEIGDTLVTYWKEETEQVTPDLAVAWAHNKEGTEWYFVIRGGVKAYDPWNDKTYPIDATD
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCEECCCCCCCCCCCCHHH
VVFTFWRVARLGHSVSWMVTEFMNVSASQALTEEEFNNYVKNNPLIAEYNGKTAEIKSLQ
HHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHH
DLLNFFGYNGETAGVFKLVLPHPYAAVLNIVADPFLSVVPMEYLLGDKYEEALKASNYGK
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
NPDAWEAYVQEGVDDPTHQLMHKYPVGTGPFYVKEYQENSYIVLEYNPYYWNATSNPGHK
CCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCEEECCCCCCCCE
RVIYIINNDAVARVQLLTTGTADVAAIPTDKIEDVQGVTKDGYKVVVQTDILLPVLTFIV
EEEEEECCCCEEEEEEEECCCCCEEECCCCHHHHHCCCCCCCCEEEEEEHHHHHHHHHHH
FNTQKEPFNDVKVRQALAYAIPYDQIAKVVYNNLLERNWGPIPKPWPGYTEYGIIKYEYN
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
IAKAKQMLQEAGVDPSKYSITLIYNAGNTQREKVMTLIQNVWSQLGFRVTVESYEWPVYL
HHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEE
SKTEHGDYDVYIVGWVPDYLDSDNWVGPFLYGATEFSEINIEVSG
EECCCCCEEEEEEECCCHHCCCCCCCCCCEECCCEEEEEEEEECC
>Mature Secondary Structure
MKKGLLAILLVGVMVLGTFGSGCIGGGTQTQTQTPTETGSPTQTTTPSGVTQAILELGKV
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCE
TVVDTGTAIVVVGPKGEKPSVSIPSGKKVITVTYVVDEQNTPSVKELMEQGQGFGAINPA
EEEECCCEEEEECCCCCCCCEECCCCCEEEEEEEEEECCCCCHHHHHHHCCCCCCCCCCC
FFRDTNVDALVIAARRETNPEVRTEIFKALYILGNYYVPEVILGQNRQLRVYWDWVKGRY
CEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEECCEE
YHPTLPERYDLLWEDPNAPVVDTGIGSYKNDPETYVIATIGWPESFDPAWTYETFGWEIW
ECCCCCCCCCEEEECCCCCEEECCCCCCCCCCCEEEEEEECCCCCCCCCEEECCCCHHHH
HEIGDTLVTYWKEETEQVTPDLAVAWAHNKEGTEWYFVIRGGVKAYDPWNDKTYPIDATD
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCEECCCCCCCCCCCCHHH
VVFTFWRVARLGHSVSWMVTEFMNVSASQALTEEEFNNYVKNNPLIAEYNGKTAEIKSLQ
HHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHH
DLLNFFGYNGETAGVFKLVLPHPYAAVLNIVADPFLSVVPMEYLLGDKYEEALKASNYGK
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
NPDAWEAYVQEGVDDPTHQLMHKYPVGTGPFYVKEYQENSYIVLEYNPYYWNATSNPGHK
CCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCEEECCCCCCCCE
RVIYIINNDAVARVQLLTTGTADVAAIPTDKIEDVQGVTKDGYKVVVQTDILLPVLTFIV
EEEEEECCCCEEEEEEEECCCCCEEECCCCHHHHHCCCCCCCCEEEEEEHHHHHHHHHHH
FNTQKEPFNDVKVRQALAYAIPYDQIAKVVYNNLLERNWGPIPKPWPGYTEYGIIKYEYN
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECC
IAKAKQMLQEAGVDPSKYSITLIYNAGNTQREKVMTLIQNVWSQLGFRVTVESYEWPVYL
HHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEE
SKTEHGDYDVYIVGWVPDYLDSDNWVGPFLYGATEFSEINIEVSG
EECCCCCEEEEEEECCCHHCCCCCCCCCCEECCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]