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The map label for this gene is mrpD [H]

Identifier: 189499071

GI number: 189499071

Start: 73626

End: 75128

Strand: Direct

Name: mrpD [H]

Synonym: Cphamn1_0077

Alternate gene names: 189499071

Gene position: 73626-75128 (Clockwise)

Preceding gene: 189499070

Following gene: 189499072

Centisome position: 2.69

GC content: 51.7

Gene sequence:

>1503_bases
ATGTTGCCCATACTGCTTCCTCTGTGCACTGCGGTGGTCATGATCTTCTTCCGCAGGTTGGTGGTTTTGCACCGCTTCCT
GAATGTGGCAGGGACAGCCCTCATGCTCGGTGTGTCGCTGGTTATGCTCGGCAACGTTCAGTCAGGGGGAATTCTCTCGT
TGCAGATCGGAGGCTGGCAAGCGCCTTTCGGCATTTCCCTGGTAGCCGATATGCTCTCTTCGATTATGGTGGTAGCCACC
GCGCTGATCGGTTTCACCACCGCGCTCTATTCCCTTGGAACCATCGATAAAGACAAGGAGCATTTTTTCTATCATCCTTT
GCTGCAACTGTTGCTGATGGGTATCAACGGCGCGTTCCTGACGGAGGATATCTTTAACCTCTATGTCTGGTTCGAGGTGA
TGCTTATCTCATCCTTTGTTCTGCTTGTTCTCGGGGGAAAGCCTGAGCAGCTTGAAGGCGCGATGAAGTATGTGACGCTG
AATCTGCTTTCCTCATCGATCTTCCTTGCCGCGGTCGGTATTCTCTACGGTATTGCAGGTACGCTCAATATGGCCGATCT
TGCCGTCAGGATTCCCATGCTCGGTCACAAGGATCTGCTTTCAGTGGTCGCGGTGCTCTTCATGATCACTTTCGGGATCA
AGGCTGCGATCTTTCCGCTTTTCTTCTGGCTGCCAGCCTCGTATCACACACCACCTGTTGCTGTTTCTGCCATTTTTGCC
GGTCTCCTGACGAAAGTGGGAGTGTATGCGATCATGCGGATGTTTACTACGGTCCTCATCCATGAGGAAGCCGCCTTGAT
CCATCAGCTCCTGCTTGTCTTGTCAGCGTTTACGATGGTTGTAGGAGTGCTGGGAGCGGTAGCGCAATATGATATGCGCA
AGCTGCTCTCTTTTCATATTATCAGCCAGATAGGCTATATGATTTTCGCTCTGGCGATTCAGTCTCCGCTCGCCATCGCA
GGAGCACTCTTCTACATTGTTCACAATATTGTCGCCAAAACAAATCTTTTCTATATAAGCGGGCTTGTCAACCGCCTGAA
AGGATCCTGGGATCTCAGGAGGATTGGCGGGGTCTACCGTTTTTATCCGATGCTGGGGGTATTGTTTCTCGTTCCTGCTC
TGGGGCTTGCCGGTATTCCTCCCCTGTCGGGGTTCTGGGCAAAGTTCGTTGTGATAAAGGCGGGAATTGATTCGGAGCAC
TATCTGCTGGTCGGTATTGCTCTCTTTGTCAGCATGCTGACCCTGTATTCCATGATCAAGATCTGGAATGAGGCGTTCTG
GAAAGACGATCCACGGGGAGAGGGCAGCGTTGAAGATGAGGGATATCTGCTCATTTCGAGCATGAAGAAAGTGGCGATGG
TAGTGCCGATAGTCATACTCGGATCTGTTACGGTCGTGTTCGGGTTCTGGTTCGAACCGTTTTTCGTGATTGTCCAGAGC
GCGGCTGTCGAACTGCTTGATCAGGGGAACTACATTCAGGCGGTACTGGGGGAACGTCCATGA

Upstream 100 bases:

>100_bases
TACTCTTCAAACGTACCTATCAGACGGTGGGTACGGAGGATCTGGACAAGATGAAAAGCACTGACCAACTTCCCGGAGAA
GAGCTATGAGCAGGATTATC

Downstream 100 bases:

>100_bases
ACCTGTTTCTTTTCAACATACTGCTGGCAATCGCCTGGATGCTGCTCGTTGGAGAGGTCAGCGCCGGAACATTCACCGGG
GGTATGATCGTCGGTTATCT

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MLPILLPLCTAVVMIFFRRLVVLHRFLNVAGTALMLGVSLVMLGNVQSGGILSLQIGGWQAPFGISLVADMLSSIMVVAT
ALIGFTTALYSLGTIDKDKEHFFYHPLLQLLLMGINGAFLTEDIFNLYVWFEVMLISSFVLLVLGGKPEQLEGAMKYVTL
NLLSSSIFLAAVGILYGIAGTLNMADLAVRIPMLGHKDLLSVVAVLFMITFGIKAAIFPLFFWLPASYHTPPVAVSAIFA
GLLTKVGVYAIMRMFTTVLIHEEAALIHQLLLVLSAFTMVVGVLGAVAQYDMRKLLSFHIISQIGYMIFALAIQSPLAIA
GALFYIVHNIVAKTNLFYISGLVNRLKGSWDLRRIGGVYRFYPMLGVLFLVPALGLAGIPPLSGFWAKFVVIKAGIDSEH
YLLVGIALFVSMLTLYSMIKIWNEAFWKDDPRGEGSVEDEGYLLISSMKKVAMVVPIVILGSVTVVFGFWFEPFFVIVQS
AAVELLDQGNYIQAVLGERP

Sequences:

>Translated_500_residues
MLPILLPLCTAVVMIFFRRLVVLHRFLNVAGTALMLGVSLVMLGNVQSGGILSLQIGGWQAPFGISLVADMLSSIMVVAT
ALIGFTTALYSLGTIDKDKEHFFYHPLLQLLLMGINGAFLTEDIFNLYVWFEVMLISSFVLLVLGGKPEQLEGAMKYVTL
NLLSSSIFLAAVGILYGIAGTLNMADLAVRIPMLGHKDLLSVVAVLFMITFGIKAAIFPLFFWLPASYHTPPVAVSAIFA
GLLTKVGVYAIMRMFTTVLIHEEAALIHQLLLVLSAFTMVVGVLGAVAQYDMRKLLSFHIISQIGYMIFALAIQSPLAIA
GALFYIVHNIVAKTNLFYISGLVNRLKGSWDLRRIGGVYRFYPMLGVLFLVPALGLAGIPPLSGFWAKFVVIKAGIDSEH
YLLVGIALFVSMLTLYSMIKIWNEAFWKDDPRGEGSVEDEGYLLISSMKKVAMVVPIVILGSVTVVFGFWFEPFFVIVQS
AAVELLDQGNYIQAVLGERP
>Mature_500_residues
MLPILLPLCTAVVMIFFRRLVVLHRFLNVAGTALMLGVSLVMLGNVQSGGILSLQIGGWQAPFGISLVADMLSSIMVVAT
ALIGFTTALYSLGTIDKDKEHFFYHPLLQLLLMGINGAFLTEDIFNLYVWFEVMLISSFVLLVLGGKPEQLEGAMKYVTL
NLLSSSIFLAAVGILYGIAGTLNMADLAVRIPMLGHKDLLSVVAVLFMITFGIKAAIFPLFFWLPASYHTPPVAVSAIFA
GLLTKVGVYAIMRMFTTVLIHEEAALIHQLLLVLSAFTMVVGVLGAVAQYDMRKLLSFHIISQIGYMIFALAIQSPLAIA
GALFYIVHNIVAKTNLFYISGLVNRLKGSWDLRRIGGVYRFYPMLGVLFLVPALGLAGIPPLSGFWAKFVVIKAGIDSEH
YLLVGIALFVSMLTLYSMIKIWNEAFWKDDPRGEGSVEDEGYLLISSMKKVAMVVPIVILGSVTVVFGFWFEPFFVIVQS
AAVELLDQGNYIQAVLGERP

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=203, Percent_Identity=27.5862068965517, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI251831116, Length=225, Percent_Identity=24, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788831, Length=409, Percent_Identity=27.1393643031785, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1788613, Length=370, Percent_Identity=29.4594594594595, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788829, Length=351, Percent_Identity=27.6353276353276, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788827, Length=345, Percent_Identity=26.6666666666667, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI145693160, Length=499, Percent_Identity=24.8496993987976, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788614, Length=343, Percent_Identity=24.7813411078717, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI2367154, Length=445, Percent_Identity=25.6179775280899, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 54750; Mature: 54750

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]