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The map label for this gene is glyQS [H]

Identifier: 189499024

GI number: 189499024

Start: 28826

End: 30292

Strand: Reverse

Name: glyQS [H]

Synonym: Cphamn1_0024

Alternate gene names: 189499024

Gene position: 30292-28826 (Counterclockwise)

Preceding gene: 189499025

Following gene: 189499023

Centisome position: 1.11

GC content: 50.99

Gene sequence:

>1467_bases
ATGGGCAATGCAGATAAACGGGTGCAGAGCGTAGCTCAGTCTCCTGAGAAAGTCATGAACAAACTTGTTTCGCTTGCAAA
GCGAAGAGGGTTCATTTATCCCTCTTCGGAGATCTACGGAGGGCTCTCCTCCTGCTTCGACTACGGTCCGCTCGGCAGCG
AGATGAAAAAAAACATCAAGGACCTCTGGTGGATATCGATGACAAGAAAACACCGGAACATCGTGGGCATAGACGCTTCG
ATCATGATGAACCCGACGGTCTGGGAGGCGTCAGGCCATGTTTCGAGCTTTAACGACCCGATGATCGACGACAAGACAAC
CAAGCGCCGTTACCGTGCCGACCACCTTATAGAAAACCACATCGAGAAGCTTCGCCGCGACGCCAAGGAAGAAGATGCGC
ACAGGGTAAGCTCCTACTATGAAAGCGCTTCTGAAGCAGAAGACCAGAACCGGGCATTCTACGATATTATCATTGCAGAG
GAGATCAAGGCTCCAGACACCGGTTCAGCAGACTGGACAGAAGTACGCCAGTTCAACCTGATGTTCCAATGCAATATGGG
CGCGCTTGCCGAATCATCCGGCAAAGTCTATCTGCGACCGGAAACCGCTCAGGGAATCTTCGTGAACTTCCATAACGTCC
GCGAATCCAGCCGCATGAAAGTACCTTTCGGCATAGCGCAGATAGGCAAGGCATTCCGCAACGAGATCGTGAAAGGCAAC
TTCATCTTCCGCATGGTTGAATTCGAACAGATGGAAATGCAGTATTTCGTCAAGCCCGGCACCCAGGTGGAAAGCTTCGA
GTCCTGGCGTGAAGAACGGTTCAACTGGTATATCGAGAGGCTGGGCATCACTCCTGAAAAGCTGCACTGGTATAAACACG
ACAAGCTGGCCCATTACGCCGATCTGGCTTATGACATCAAGTTCGAGTACCCGTTTGGAATCGAAGAGATCGAGGGCATC
CACTCACGAACCGATTTCGATCTGAAACAGCATCAGGAATTTTCAGGCAAAAACATGGAGTATATCGATCAGACAACCAA
TGAACGGTACATCCCCTATGTGGTCGAAACCTCGGCAGGCAGTGACCGGCTGTTCCTGGCTCTGCTCTGCGACTCCTACA
CAGAAGATGTCATAGACGGCGAACAACGCGTCATGATGAGATTCGCGCCGAAAATCGCCCCGGTAAAGGCCGCGATACTG
CCACTGATGAAGAAAGGGGAAATGGGAGAAAAAGCAGCAAAACTCCGGGATGAGCTTGCCACGGACTTCATGGTACAGTA
CGACGATGCCGGTTCAATCGGAAAACGTTACCGTCGGCAGGACGAGATCGGAACACCTTTCTGCTTCACGGTCGATCACG
ATTCAATGGAAGATCACTCCGTTACCGTCAGGTATCGTGATACCGCAAAGCAGGAGAGAATCGAAATCTCGAAAGTAAAG
GAATTTCTTGGAGCCAAACTTGTTTAA

Upstream 100 bases:

>100_bases
GCTTGCAGCAATAACCAGTACACAAGCGGGCCGCTTCCCTGCAATGGCCCAATGGATTGTCGGGAAATAACGGTTTCAAC
ACTACTACCTGAAAATAATT

Downstream 100 bases:

>100_bases
GTTCAATGGAATTGTTTGCCTGATAGAAAGGGATTTTCAGTTCCGACCTGAGAGTATGCTATGATCTATTCCTTTGACAA
TAACGAACAACCGGTCTAAC

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MGNADKRVQSVAQSPEKVMNKLVSLAKRRGFIYPSSEIYGGLSSCFDYGPLGSEMKKNIKDLWWISMTRKHRNIVGIDAS
IMMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENHIEKLRRDAKEEDAHRVSSYYESASEAEDQNRAFYDIIIAE
EIKAPDTGSADWTEVRQFNLMFQCNMGALAESSGKVYLRPETAQGIFVNFHNVRESSRMKVPFGIAQIGKAFRNEIVKGN
FIFRMVEFEQMEMQYFVKPGTQVESFESWREERFNWYIERLGITPEKLHWYKHDKLAHYADLAYDIKFEYPFGIEEIEGI
HSRTDFDLKQHQEFSGKNMEYIDQTTNERYIPYVVETSAGSDRLFLALLCDSYTEDVIDGEQRVMMRFAPKIAPVKAAIL
PLMKKGEMGEKAAKLRDELATDFMVQYDDAGSIGKRYRRQDEIGTPFCFTVDHDSMEDHSVTVRYRDTAKQERIEISKVK
EFLGAKLV

Sequences:

>Translated_488_residues
MGNADKRVQSVAQSPEKVMNKLVSLAKRRGFIYPSSEIYGGLSSCFDYGPLGSEMKKNIKDLWWISMTRKHRNIVGIDAS
IMMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENHIEKLRRDAKEEDAHRVSSYYESASEAEDQNRAFYDIIIAE
EIKAPDTGSADWTEVRQFNLMFQCNMGALAESSGKVYLRPETAQGIFVNFHNVRESSRMKVPFGIAQIGKAFRNEIVKGN
FIFRMVEFEQMEMQYFVKPGTQVESFESWREERFNWYIERLGITPEKLHWYKHDKLAHYADLAYDIKFEYPFGIEEIEGI
HSRTDFDLKQHQEFSGKNMEYIDQTTNERYIPYVVETSAGSDRLFLALLCDSYTEDVIDGEQRVMMRFAPKIAPVKAAIL
PLMKKGEMGEKAAKLRDELATDFMVQYDDAGSIGKRYRRQDEIGTPFCFTVDHDSMEDHSVTVRYRDTAKQERIEISKVK
EFLGAKLV
>Mature_487_residues
GNADKRVQSVAQSPEKVMNKLVSLAKRRGFIYPSSEIYGGLSSCFDYGPLGSEMKKNIKDLWWISMTRKHRNIVGIDASI
MMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENHIEKLRRDAKEEDAHRVSSYYESASEAEDQNRAFYDIIIAEE
IKAPDTGSADWTEVRQFNLMFQCNMGALAESSGKVYLRPETAQGIFVNFHNVRESSRMKVPFGIAQIGKAFRNEIVKGNF
IFRMVEFEQMEMQYFVKPGTQVESFESWREERFNWYIERLGITPEKLHWYKHDKLAHYADLAYDIKFEYPFGIEEIEGIH
SRTDFDLKQHQEFSGKNMEYIDQTTNERYIPYVVETSAGSDRLFLALLCDSYTEDVIDGEQRVMMRFAPKIAPVKAAILP
LMKKGEMGEKAAKLRDELATDFMVQYDDAGSIGKRYRRQDEIGTPFCFTVDHDSMEDHSVTVRYRDTAKQERIEISKVKE
FLGAKLV

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=361, Percent_Identity=32.6869806094183, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32564541, Length=403, Percent_Identity=31.5136476426799, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17554996, Length=403, Percent_Identity=31.5136476426799, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325338, Length=375, Percent_Identity=30.1333333333333, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319597, Length=395, Percent_Identity=28.6075949367089, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21357965, Length=360, Percent_Identity=33.0555555555556, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24664462, Length=362, Percent_Identity=32.8729281767956, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 56576; Mature: 56445

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNADKRVQSVAQSPEKVMNKLVSLAKRRGFIYPSSEIYGGLSSCFDYGPLGSEMKKNIK
CCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCHHHHHHHH
DLWWISMTRKHRNIVGIDASIMMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENH
HHHHHHHHHCCCCEEECCCEEEECCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IEKLRRDAKEEDAHRVSSYYESASEAEDQNRAFYDIIIAEEIKAPDTGSADWTEVRQFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHCCCCCCCCCCHHHHHHEEE
MFQCNMGALAESSGKVYLRPETAQGIFVNFHNVRESSRMKVPFGIAQIGKAFRNEIVKGN
EEEECCCCEECCCCEEEECCCCCCEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHCCCC
FIFRMVEFEQMEMQYFVKPGTQVESFESWREERFNWYIERLGITPEKLHWYKHDKLAHYA
EEEEEHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHH
DLAYDIKFEYPFGIEEIEGIHSRTDFDLKQHQEFSGKNMEYIDQTTNERYIPYVVETSAG
CEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHCCCCCCCCCEEEECCCC
SDRLFLALLCDSYTEDVIDGEQRVMMRFAPKIAPVKAAILPLMKKGEMGEKAAKLRDELA
CCCEEEEEHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TDFMVQYDDAGSIGKRYRRQDEIGTPFCFTVDHDSMEDHSVTVRYRDTAKQERIEISKVK
HHHEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHH
EFLGAKLV
HHHCCCCC
>Mature Secondary Structure 
GNADKRVQSVAQSPEKVMNKLVSLAKRRGFIYPSSEIYGGLSSCFDYGPLGSEMKKNIK
CCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCHHHHHHHH
DLWWISMTRKHRNIVGIDASIMMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENH
HHHHHHHHHCCCCEEECCCEEEECCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IEKLRRDAKEEDAHRVSSYYESASEAEDQNRAFYDIIIAEEIKAPDTGSADWTEVRQFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHCCCCCCCCCCHHHHHHEEE
MFQCNMGALAESSGKVYLRPETAQGIFVNFHNVRESSRMKVPFGIAQIGKAFRNEIVKGN
EEEECCCCEECCCCEEEECCCCCCEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHHCCCC
FIFRMVEFEQMEMQYFVKPGTQVESFESWREERFNWYIERLGITPEKLHWYKHDKLAHYA
EEEEEHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHH
DLAYDIKFEYPFGIEEIEGIHSRTDFDLKQHQEFSGKNMEYIDQTTNERYIPYVVETSAG
CEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHCCCCCCCCCEEEECCCC
SDRLFLALLCDSYTEDVIDGEQRVMMRFAPKIAPVKAAILPLMKKGEMGEKAAKLRDELA
CCCEEEEEHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TDFMVQYDDAGSIGKRYRRQDEIGTPFCFTVDHDSMEDHSVTVRYRDTAKQERIEISKVK
HHHEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHH
EFLGAKLV
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]