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The map label for this gene is zraR [H]

Identifier: 189352392

GI number: 189352392

Start: 450096

End: 451577

Strand: Direct

Name: zraR [H]

Synonym: BMULJ_03611

Alternate gene names: 189352392

Gene position: 450096-451577 (Clockwise)

Preceding gene: 189352391

Following gene: 189352393

Centisome position: 18.2

GC content: 68.89

Gene sequence:

>1482_bases
ATGGTTGCAAGGTCACCCGATGCAAACCGGAACGCGGCGCCCGAGATGCCGCCGGTCTCCGTTACCGCCCCGGAGGCCGG
ACGCAGGCTGTTCGCGATCATGCGCACGCCCGACGAGCCGTTGCTCGCGCAACTGCGCGGGCTCGGCTGGGAGGTGTCGG
TCGCGAAGACGGCCGGCGCCGCGCAGAACATGACGTCCGGCGTCGGCGTCGCCGCCGGGCTGATCGATTTCTCGGGGTTC
ACGTCGCGCGACTATCCGGCACTGAAAGCGTGCCTGAGCCAGCCCGCGATCGGCTGGATCTCGATCGCGCAGGCCGGCGT
GACGATCGGGCCGGCCGTGCGCGAACTGATCCGCAGCTACTGTTTCGATTACGTGACGCTGCCGCTGCCGTACGAATGGA
TTTCGCACGTGCTCGGCCATGCGCGCGGGATGGCCGCGCTCGATCGCGTCGACGGCGCCGCTTATGCGGCGTCGATCGGC
GAGCACGGGATGATCGGCAACTGCGAGGCGATGCAGCAGCTGTTCAGCACGATCCGCAAGGTCGCGAAGACCGACGCGAG
CGTGTTCATCTCCGGCGAATCGGGCACCGGCAAGGAGCTGACCGCGCTTGCGATCCATGAGCGCTCCGGCCGCGGCAAGG
GCCCGTTCGTCGCGATCAACTGCGGCGCGATTCCGCATCATCTGCTGCAGTCCGAGCTGTTCGGCTACGAGCGCGGCGCG
TTTACGGGCGCGACGCAGCGACGCGCGGGCCGTATCGAATCCGCGAACGGCGGCACGCTGTTTCTCGACGAAATCGGCGA
CATGCCGGTCGAAAGCCAGGCGAGCCTGCTGCGCTTCCTGCAGGAGGGCAGAATCGAGCGGCTCGGCGGCCACGAGTCGA
TCGCGGTCGACGTGCGGATCATCTCGGCGACGCACGTCGATCTCGACGGCGCAGTCGAGGCCGGCCGCTTCCGCGCCGAC
CTCTATCACCGGCTGTGCGTGCTGCGCATCCACGAGCCGCCGCTGCGCGCGCGCGGCAAGGACATCGACATCCTCGCGCA
CTACGTGCTGCAGAAGTACAAGGCCGACAGCGGCCGCAAGATCAGCGGCTTCACGTCGGCCGCGCTCGACGCGATGCGGC
GCTACGAATGGCCGGGCAACGTGCGCGAGCGGATCAACCGCGTGCGGCGCGCGATCGTGATGGCGGAGAGCCGGCTGCTG
ACGCCGCACGACCTCGGGCTCGACACGCCGGGCGAAACCGAACCGGTGACGCTCGAGCAGGCGCGCGCGCTCGCCGAGCG
CGTCGCGATCGAGAATGCGCTGCTGCGCAACGATCACCGCATCAACAAGGCCGCGGCCGAGCTCGGCATCTCGCGCGTGA
CGCTGTACCGGATGATGATCGAACACGGGCTCAACGAGCACGACAACGCCGTCGATCACGGCGAGAACGGCGGAAAGGAC
GCGACGCCGCCGGACGACGCCGGTCATTGCCGCGTCGGCTGA

Upstream 100 bases:

>100_bases
CTATTCGGACTGAAATGCGGCCATTATGTCGGTTCGATCGAGGTCCGCCGTGCGCGGCGACGAGCCGGCGCGCGATACCA
ACGCCAAGCGGGGAACAACG

Downstream 100 bases:

>100_bases
ACGGTGCGGGTGCCGACGCGGGGCGCCGCAGCGGCCGGCCGCCCGTCGCATGTAAAGCCGATGAAACATTTCGTGCAGGC
GCAGGCGCGCGTTCGCTTCG

Product: sigma54-dependent DNA-binding transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MVARSPDANRNAAPEMPPVSVTAPEAGRRLFAIMRTPDEPLLAQLRGLGWEVSVAKTAGAAQNMTSGVGVAAGLIDFSGF
TSRDYPALKACLSQPAIGWISIAQAGVTIGPAVRELIRSYCFDYVTLPLPYEWISHVLGHARGMAALDRVDGAAYAASIG
EHGMIGNCEAMQQLFSTIRKVAKTDASVFISGESGTGKELTALAIHERSGRGKGPFVAINCGAIPHHLLQSELFGYERGA
FTGATQRRAGRIESANGGTLFLDEIGDMPVESQASLLRFLQEGRIERLGGHESIAVDVRIISATHVDLDGAVEAGRFRAD
LYHRLCVLRIHEPPLRARGKDIDILAHYVLQKYKADSGRKISGFTSAALDAMRRYEWPGNVRERINRVRRAIVMAESRLL
TPHDLGLDTPGETEPVTLEQARALAERVAIENALLRNDHRINKAAAELGISRVTLYRMMIEHGLNEHDNAVDHGENGGKD
ATPPDDAGHCRVG

Sequences:

>Translated_493_residues
MVARSPDANRNAAPEMPPVSVTAPEAGRRLFAIMRTPDEPLLAQLRGLGWEVSVAKTAGAAQNMTSGVGVAAGLIDFSGF
TSRDYPALKACLSQPAIGWISIAQAGVTIGPAVRELIRSYCFDYVTLPLPYEWISHVLGHARGMAALDRVDGAAYAASIG
EHGMIGNCEAMQQLFSTIRKVAKTDASVFISGESGTGKELTALAIHERSGRGKGPFVAINCGAIPHHLLQSELFGYERGA
FTGATQRRAGRIESANGGTLFLDEIGDMPVESQASLLRFLQEGRIERLGGHESIAVDVRIISATHVDLDGAVEAGRFRAD
LYHRLCVLRIHEPPLRARGKDIDILAHYVLQKYKADSGRKISGFTSAALDAMRRYEWPGNVRERINRVRRAIVMAESRLL
TPHDLGLDTPGETEPVTLEQARALAERVAIENALLRNDHRINKAAAELGISRVTLYRMMIEHGLNEHDNAVDHGENGGKD
ATPPDDAGHCRVG
>Mature_493_residues
MVARSPDANRNAAPEMPPVSVTAPEAGRRLFAIMRTPDEPLLAQLRGLGWEVSVAKTAGAAQNMTSGVGVAAGLIDFSGF
TSRDYPALKACLSQPAIGWISIAQAGVTIGPAVRELIRSYCFDYVTLPLPYEWISHVLGHARGMAALDRVDGAAYAASIG
EHGMIGNCEAMQQLFSTIRKVAKTDASVFISGESGTGKELTALAIHERSGRGKGPFVAINCGAIPHHLLQSELFGYERGA
FTGATQRRAGRIESANGGTLFLDEIGDMPVESQASLLRFLQEGRIERLGGHESIAVDVRIISATHVDLDGAVEAGRFRAD
LYHRLCVLRIHEPPLRARGKDIDILAHYVLQKYKADSGRKISGFTSAALDAMRRYEWPGNVRERINRVRRAIVMAESRLL
TPHDLGLDTPGETEPVTLEQARALAERVAIENALLRNDHRINKAAAELGISRVTLYRMMIEHGLNEHDNAVDHGENGGKD
ATPPDDAGHCRVG

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=421, Percent_Identity=40.1425178147268, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1788550, Length=434, Percent_Identity=38.2488479262673, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI1790299, Length=334, Percent_Identity=42.2155688622754, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082117, Length=247, Percent_Identity=48.582995951417, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=42.0062695924765, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1788905, Length=308, Percent_Identity=40.2597402597403, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1789087, Length=309, Percent_Identity=43.042071197411, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI87082152, Length=324, Percent_Identity=41.0493827160494, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1786524, Length=313, Percent_Identity=43.4504792332268, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=35.7366771159875, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=307, Percent_Identity=35.8306188925081, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87081858, Length=294, Percent_Identity=34.0136054421769, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789828, Length=240, Percent_Identity=33.75, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53338; Mature: 53338

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVARSPDANRNAAPEMPPVSVTAPEAGRRLFAIMRTPDEPLLAQLRGLGWEVSVAKTAGA
CCCCCCCCCCCCCCCCCCCEEECCHHCCEEEEEECCCCHHHHHHHHCCCCEEEEHHHCCC
AQNMTSGVGVAAGLIDFSGFTSRDYPALKACLSQPAIGWISIAQAGVTIGPAVRELIRSY
HHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCCEECHHHHHHHHHH
CFDYVTLPLPYEWISHVLGHARGMAALDRVDGAAYAASIGEHGMIGNCEAMQQLFSTIRK
HHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VAKTDASVFISGESGTGKELTALAIHERSGRGKGPFVAINCGAIPHHLLQSELFGYERGA
HHCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCC
FTGATQRRAGRIESANGGTLFLDEIGDMPVESQASLLRFLQEGRIERLGGHESIAVDVRI
CCCHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEEEEE
ISATHVDLDGAVEAGRFRADLYHRLCVLRIHEPPLRARGKDIDILAHYVLQKYKADSGRK
EEEEEECCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCE
ISGFTSAALDAMRRYEWPGNVRERINRVRRAIVMAESRLLTPHDLGLDTPGETEPVTLEQ
ECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEHHH
ARALAERVAIENALLRNDHRINKAAAELGISRVTLYRMMIEHGLNEHDNAVDHGENGGKD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ATPPDDAGHCRVG
CCCCCCCCCCCCC
>Mature Secondary Structure
MVARSPDANRNAAPEMPPVSVTAPEAGRRLFAIMRTPDEPLLAQLRGLGWEVSVAKTAGA
CCCCCCCCCCCCCCCCCCCEEECCHHCCEEEEEECCCCHHHHHHHHCCCCEEEEHHHCCC
AQNMTSGVGVAAGLIDFSGFTSRDYPALKACLSQPAIGWISIAQAGVTIGPAVRELIRSY
HHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHCCCEECHHHHHHHHHH
CFDYVTLPLPYEWISHVLGHARGMAALDRVDGAAYAASIGEHGMIGNCEAMQQLFSTIRK
HHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHH
VAKTDASVFISGESGTGKELTALAIHERSGRGKGPFVAINCGAIPHHLLQSELFGYERGA
HHCCCCEEEEECCCCCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCC
FTGATQRRAGRIESANGGTLFLDEIGDMPVESQASLLRFLQEGRIERLGGHESIAVDVRI
CCCHHHHHCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEEEEE
ISATHVDLDGAVEAGRFRADLYHRLCVLRIHEPPLRARGKDIDILAHYVLQKYKADSGRK
EEEEEECCCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCE
ISGFTSAALDAMRRYEWPGNVRERINRVRRAIVMAESRLLTPHDLGLDTPGETEPVTLEQ
ECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEHHH
ARALAERVAIENALLRNDHRINKAAAELGISRVTLYRMMIEHGLNEHDNAVDHGENGGKD
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
ATPPDDAGHCRVG
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]