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The map label for this gene is lysP [H]

Identifier: 189352283

GI number: 189352283

Start: 332276

End: 333820

Strand: Direct

Name: lysP [H]

Synonym: BMULJ_03502

Alternate gene names: 189352283

Gene position: 332276-333820 (Clockwise)

Preceding gene: 189352279

Following gene: 189352284

Centisome position: 13.44

GC content: 65.89

Gene sequence:

>1545_bases
ATGTCCGCACTTCCGAATTCCGACCGACCCGGTTCGTCCGAGAACCCACCCAAGCTTCACCGCGCGCTGAAGGCGCGCCA
CCTGACGATGATCGCGATCGGCGGCTCGATCGGCACGGGCCTGTTCGTCGCGTCCGGCGCGTCGATCTCGCAGGCCGGCC
CCGGCGGCGCGATGATCGCCTACATGCTGATCGGGCTGATGGTGTACTTCCTGATGACGAGCCTCGGCGAAATGGCCGCG
TTCATGCCGGTGTCGGGCTCGTTCGCGACGTACGGCGCGAAATACGTGGACGAAGGCTTCGGCTTCGCGCTCGGCTGGAA
CTACTGGTACAACTGGGCCGTGACGATCGCGGTCGAGCTGGTCGCCGCGCAGCTCGTGATGCACTACTGGTTCCCGGACG
TACCGGGCGTCTGGTGGAGCGCCGCGTTCCTCGGCGTGATGTTCCTGCTGAACGCACTGACCGTGCGCGGCTTCGGCGAG
GCCGAATACTGGTTCGCGCTGATCAAGGTCGTCACCGTGGTCGCCTTCATCGGCGTCGGCCTGCTGATGATCTTCGGCAT
TCTGAAGGGCGCGCCGCACGGCGGCTGGAGCAACCTGACGATCGGCGACGCGCCGTTCGCGGGCGGCCTGCCGGCGATGA
TGGGCGTCGCGATGATCGCCGGCTTCTCGTTCCAGGGCACCGAGCTGATCGGTGTCGCGGCCGGCGAATCGGAAAACCCG
CGCACGACGATTCCGCGCGCGGTGCGTCAGGTGTTCTGGCGGATCCTGCTGTTCTACGTGCTCGCGATCTTCGTGATCGG
CGTGCTGATTCCGTACACCGACCCGAACCTGCTGAAGACCGACGTGACCGACATCGGCGTGAGCCCGTTCACGCTCGTGT
TCCGTCACGCGGGTCTCGCGTTCGCCGCGGGCGTGATGAACGCCGTGATCCTGACGGCAGTGCTGTCGGCCGGCAACTCG
GGCATGTATGCGTCGACGCGCATGCTGTACAACCTCGCCACCGAAGGCCGCGCGCCGAAGCTGTTCGCGAAGCTGTCGGC
AGGCGGCGTGCCGCGCAATGCGCTCTACGCGACGACGGCCGTCGGCGCGCTGTGCTTCTTCACGTCGCTCTACGGCGACA
AGACCGTCTACATGTGGCTGCTCAACACGTCGGGAATGACGGGCTTCATCGCATGGCTCGGCATCGCGGTCAGCCACTAC
CGGTTCCGCAAGGGCTACGTGAAGCAGGGTTACCGCGTCGATCAACTGCCGTACGAGTCGAAGTGGTTCCCGTTCGGCCC
GCTGTTCGCGTTCGTGCTCTGCATCGTGATCGCGCTCGGTCAGGACTATCAGGCGTTTCTCGCGAACCGGATCGACTGGG
CGGGCGTCGTCGCGACCTATGTCGGCATCCCGCTGTTCCTCGCGGTATGGCTCGGCTATCGGCTCGTGAAGAAAAGCCGT
TTCGTCCGCTACGAGGACATGGAAATCGCGCCGTGGGTCGCCGCGAACCGCGACGGGCAGCGCGGCGCACAGGCGCAGCC
GGTCTCGCAGCGCGAAACCGCATAA

Upstream 100 bases:

>100_bases
CAACGCGCACCGGGGCCGCATCGCAGGCCGCGCATCGCACCTCCCGGTTCCGTATGCGCCGCTCCGGCTCCCGCCGGTCC
GCTCAACGTTCGTCTCGTTT

Downstream 100 bases:

>100_bases
CGACGCGCGCGGCGCGCGGCGGCGGACGCCGTGCCGGACGACGAAACGGGAAGCGCCAGGCTTCCCGTTTTTTTTGCTCG
GATTTTCTCTATGCAGGGTC

Product: AAT family amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MSALPNSDRPGSSENPPKLHRALKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMIAYMLIGLMVYFLMTSLGEMAA
FMPVSGSFATYGAKYVDEGFGFALGWNYWYNWAVTIAVELVAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNALTVRGFGE
AEYWFALIKVVTVVAFIGVGLLMIFGILKGAPHGGWSNLTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENP
RTTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKTDVTDIGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNS
GMYASTRMLYNLATEGRAPKLFAKLSAGGVPRNALYATTAVGALCFFTSLYGDKTVYMWLLNTSGMTGFIAWLGIAVSHY
RFRKGYVKQGYRVDQLPYESKWFPFGPLFAFVLCIVIALGQDYQAFLANRIDWAGVVATYVGIPLFLAVWLGYRLVKKSR
FVRYEDMEIAPWVAANRDGQRGAQAQPVSQRETA

Sequences:

>Translated_514_residues
MSALPNSDRPGSSENPPKLHRALKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMIAYMLIGLMVYFLMTSLGEMAA
FMPVSGSFATYGAKYVDEGFGFALGWNYWYNWAVTIAVELVAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNALTVRGFGE
AEYWFALIKVVTVVAFIGVGLLMIFGILKGAPHGGWSNLTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENP
RTTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKTDVTDIGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNS
GMYASTRMLYNLATEGRAPKLFAKLSAGGVPRNALYATTAVGALCFFTSLYGDKTVYMWLLNTSGMTGFIAWLGIAVSHY
RFRKGYVKQGYRVDQLPYESKWFPFGPLFAFVLCIVIALGQDYQAFLANRIDWAGVVATYVGIPLFLAVWLGYRLVKKSR
FVRYEDMEIAPWVAANRDGQRGAQAQPVSQRETA
>Mature_513_residues
SALPNSDRPGSSENPPKLHRALKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMIAYMLIGLMVYFLMTSLGEMAAF
MPVSGSFATYGAKYVDEGFGFALGWNYWYNWAVTIAVELVAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNALTVRGFGEA
EYWFALIKVVTVVAFIGVGLLMIFGILKGAPHGGWSNLTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENPR
TTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKTDVTDIGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSG
MYASTRMLYNLATEGRAPKLFAKLSAGGVPRNALYATTAVGALCFFTSLYGDKTVYMWLLNTSGMTGFIAWLGIAVSHYR
FRKGYVKQGYRVDQLPYESKWFPFGPLFAFVLCIVIALGQDYQAFLANRIDWAGVVATYVGIPLFLAVWLGYRLVKKSRF
VRYEDMEIAPWVAANRDGQRGAQAQPVSQRETA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=362, Percent_Identity=22.9281767955801, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788480, Length=477, Percent_Identity=75.2620545073375, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=483, Percent_Identity=39.9585921325052, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI48994972, Length=485, Percent_Identity=35.8762886597938, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1786789, Length=424, Percent_Identity=37.9716981132075, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1786302, Length=399, Percent_Identity=37.844611528822, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789017, Length=403, Percent_Identity=35.4838709677419, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI87081915, Length=402, Percent_Identity=36.318407960199, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1790653, Length=500, Percent_Identity=33.4, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786602, Length=396, Percent_Identity=33.8383838383838, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87081869, Length=247, Percent_Identity=24.6963562753036, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=492, Percent_Identity=36.3821138211382, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6324061, Length=493, Percent_Identity=36.9168356997972, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6324990, Length=521, Percent_Identity=32.4376199616123, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6324059, Length=502, Percent_Identity=35.8565737051793, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6322892, Length=491, Percent_Identity=35.4378818737271, Blast_Score=296, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6324924, Length=494, Percent_Identity=32.9959514170041, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=500, Percent_Identity=31.2, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6324553, Length=433, Percent_Identity=36.0277136258661, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6322967, Length=474, Percent_Identity=32.9113924050633, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6321053, Length=518, Percent_Identity=30.6949806949807, Blast_Score=242, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6319824, Length=499, Percent_Identity=28.8577154308617, Blast_Score=240, Evalue=5e-64,
Organism=Saccharomyces cerevisiae, GI6320717, Length=481, Percent_Identity=29.3139293139293, Blast_Score=236, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6319542, Length=485, Percent_Identity=28.4536082474227, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6320251, Length=485, Percent_Identity=28.659793814433, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324981, Length=529, Percent_Identity=30.4347826086957, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6319543, Length=484, Percent_Identity=28.7190082644628, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6319608, Length=499, Percent_Identity=26.6533066132265, Blast_Score=213, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6320364, Length=552, Percent_Identity=25.5434782608696, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI221512776, Length=368, Percent_Identity=23.9130434782609, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666159, Length=368, Percent_Identity=23.9130434782609, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 55714; Mature: 55583

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALPNSDRPGSSENPPKLHRALKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMIA
CCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHH
YMLIGLMVYFLMTSLGEMAAFMPVSGSFATYGAKYVDEGFGFALGWNYWYNWAVTIAVEL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHCCCCEEEEHHHHHHHHHHHHHHH
VAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNALTVRGFGEAEYWFALIKVVTVVAFIGVG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LLMIFGILKGAPHGGWSNLTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENP
HHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
RTTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKTDVTDIGVSPFTLVFRHAGLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHCCCCHHHHHHHHHHHH
FAAGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPKLFAKLSAGGVPRNALYATTA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHH
VGALCFFTSLYGDKTVYMWLLNTSGMTGFIAWLGIAVSHYRFRKGYVKQGYRVDQLPYES
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
KWFPFGPLFAFVLCIVIALGQDYQAFLANRIDWAGVVATYVGIPLFLAVWLGYRLVKKSR
CCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVRYEDMEIAPWVAANRDGQRGAQAQPVSQRETA
CEEECCCEECCCEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SALPNSDRPGSSENPPKLHRALKARHLTMIAIGGSIGTGLFVASGASISQAGPGGAMIA
CCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCEEECCCCCCCCCCCHHHHH
YMLIGLMVYFLMTSLGEMAAFMPVSGSFATYGAKYVDEGFGFALGWNYWYNWAVTIAVEL
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHCCCCEEEEHHHHHHHHHHHHHHH
VAAQLVMHYWFPDVPGVWWSAAFLGVMFLLNALTVRGFGEAEYWFALIKVVTVVAFIGVG
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LLMIFGILKGAPHGGWSNLTIGDAPFAGGLPAMMGVAMIAGFSFQGTELIGVAAGESENP
HHHHHHHHHCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCC
RTTIPRAVRQVFWRILLFYVLAIFVIGVLIPYTDPNLLKTDVTDIGVSPFTLVFRHAGLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHCCCCHHHHHHHHHHHH
FAAGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPKLFAKLSAGGVPRNALYATTA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHH
VGALCFFTSLYGDKTVYMWLLNTSGMTGFIAWLGIAVSHYRFRKGYVKQGYRVDQLPYES
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
KWFPFGPLFAFVLCIVIALGQDYQAFLANRIDWAGVVATYVGIPLFLAVWLGYRLVKKSR
CCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVRYEDMEIAPWVAANRDGQRGAQAQPVSQRETA
CEEECCCEECCCEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]