Click here to switch to the map view.

The map label for this gene is yicM [H]

Identifier: 189352185

GI number: 189352185

Start: 220889

End: 222088

Strand: Direct

Name: yicM [H]

Synonym: BMULJ_03403

Alternate gene names: 189352185

Gene position: 220889-222088 (Clockwise)

Preceding gene: 189352183

Following gene: 189352188

Centisome position: 8.93

GC content: 72.17

Gene sequence:

>1200_bases
ATGAATCCCGGAATCTCCTCCACCGCCGCGCAGGCGGCTCCCCGCGAACCGGCCTGGGGCGCGGTGTTCGCGATGGCGCT
CGGCGTGTTCGGGCTCGTCACGGCCGAATTCCTGCCTGCGAGCCTGCTCACGCCGATGGCCGACAGTCTCGGCGTCACCG
AAGGCGTCGCCGGTCAGGCGGTCACCGCGACCGCGACGGTCGCGCTCGTGACGAGCCTGCTGATCGCCGCCGCGACGCGC
ACGATCGACCGTCGGCGCGTGCTGCTCGCGTTCTCGCTGCTGCTGGTCGCCTCGAATCTCGCGGTCGCGTTCGCGACGAA
CCTGACGACGGTGCTGATCGGCCGCGTTGTGCTCGGCATCGCGCTCGGCGGCTTCTGGACGATGGCGACCGCGACCGCGA
TGCGGCTCGTGCCGGCCGCGATGGTGCCGCGCGCGCTGTCGATCATCTTCAGCGGCGTCGCCGTCGCGACGATCGCGGCC
GCGCCGCTCGGCAGCTACTTCGGTCACCTGATCGGCTGGCGCAACGTCTTCCTGATCGCGGCCGCGCTCGGCGGCATCGC
GTTCCTGTCGCAGGTCGCGACGCTGCCGTCGATGCCGCCGAGCGGCACGACGCGGCTGCGCACGCTGATCGACGTACTGC
GCCGGCCGGGCGTCGGCCTCGGGATGTTCGCGACGACGCTCGTCTTCACCGGTCACTTCGCCTTCTTCACGTATCTGCGG
CCGTTCCTCGAGCAGGTCGCGGGCGTCGGCGTCAACGGGCTGTCGGCGATCCTGCTCGGCTACGGCGTCGCGAACTTCGT
CGGCACGTCGCTCGCGGGCCGCGTGCTCGAACACCGGCTGCGGCCGATGCTGATCGCGATGCCCGCGCTGATGGTCGTGC
TCGGCGTGCTGCTGGTCGTGCTCGGCCGCGCACCGGCGATCGATGCGATCCTCGTCGCGTTGTGGGGGATGGCGTTCGGC
GGCGTGCCGGTCGCATGGTCGACGTGGGTCACGCGCACGGTGCCGGACGAAGCGGAGAGCGCGGGCGGCCTCATCGTCGC
GGCCGTGCAGCTCGCGATCGCGACGGGCGCGGCGGCGGGCGGCGTCGTGTTCGATGCGACCGGCGCAGGCGGCGTGTTCG
TCGGGGCGGCAGTGGTGCTGGCCGTCGCGGTCGCGACGATCGTCACCGCGGTGCCGAAGCGCGTCGAAGCCGTGTCGTAA

Upstream 100 bases:

>100_bases
CGGACGTTTGATCAATAAAGACGGATTGTATGTCATAGACCGTCCTGCCGTCGCTCCTTACGATACGCCGTCATCGACCT
TTTACGATACGGAACGACGG

Downstream 100 bases:

>100_bases
CGAGTGCAGTGTGCGGTGCCCGGTCGGGCACCGCTTCGATTCGTCGACGGGAATGTCGCGTTGCGCGGGCGCCGGCCGGT
GCAACGGCGGCGGCGCGCAG

Product: drug:H+ antiporter-1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNPGISSTAAQAAPREPAWGAVFAMALGVFGLVTAEFLPASLLTPMADSLGVTEGVAGQAVTATATVALVTSLLIAAATR
TIDRRRVLLAFSLLLVASNLAVAFATNLTTVLIGRVVLGIALGGFWTMATATAMRLVPAAMVPRALSIIFSGVAVATIAA
APLGSYFGHLIGWRNVFLIAAALGGIAFLSQVATLPSMPPSGTTRLRTLIDVLRRPGVGLGMFATTLVFTGHFAFFTYLR
PFLEQVAGVGVNGLSAILLGYGVANFVGTSLAGRVLEHRLRPMLIAMPALMVVLGVLLVVLGRAPAIDAILVALWGMAFG
GVPVAWSTWVTRTVPDEAESAGGLIVAAVQLAIATGAAAGGVVFDATGAGGVFVGAAVVLAVAVATIVTAVPKRVEAVS

Sequences:

>Translated_399_residues
MNPGISSTAAQAAPREPAWGAVFAMALGVFGLVTAEFLPASLLTPMADSLGVTEGVAGQAVTATATVALVTSLLIAAATR
TIDRRRVLLAFSLLLVASNLAVAFATNLTTVLIGRVVLGIALGGFWTMATATAMRLVPAAMVPRALSIIFSGVAVATIAA
APLGSYFGHLIGWRNVFLIAAALGGIAFLSQVATLPSMPPSGTTRLRTLIDVLRRPGVGLGMFATTLVFTGHFAFFTYLR
PFLEQVAGVGVNGLSAILLGYGVANFVGTSLAGRVLEHRLRPMLIAMPALMVVLGVLLVVLGRAPAIDAILVALWGMAFG
GVPVAWSTWVTRTVPDEAESAGGLIVAAVQLAIATGAAAGGVVFDATGAGGVFVGAAVVLAVAVATIVTAVPKRVEAVS
>Mature_399_residues
MNPGISSTAAQAAPREPAWGAVFAMALGVFGLVTAEFLPASLLTPMADSLGVTEGVAGQAVTATATVALVTSLLIAAATR
TIDRRRVLLAFSLLLVASNLAVAFATNLTTVLIGRVVLGIALGGFWTMATATAMRLVPAAMVPRALSIIFSGVAVATIAA
APLGSYFGHLIGWRNVFLIAAALGGIAFLSQVATLPSMPPSGTTRLRTLIDVLRRPGVGLGMFATTLVFTGHFAFFTYLR
PFLEQVAGVGVNGLSAILLGYGVANFVGTSLAGRVLEHRLRPMLIAMPALMVVLGVLLVVLGRAPAIDAILVALWGMAFG
GVPVAWSTWVTRTVPDEAESAGGLIVAAVQLAIATGAAAGGVVFDATGAGGVFVGAAVVLAVAVATIVTAVPKRVEAVS

Specific function: Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine [H]

COG id: COG2814

COG function: function code G; Arabinose efflux permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily [H]

Homologues:

Organism=Escherichia coli, GI145693198, Length=368, Percent_Identity=45.6521739130435, Blast_Score=321, Evalue=5e-89,
Organism=Escherichia coli, GI1787808, Length=239, Percent_Identity=30.5439330543933, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787947, Length=307, Percent_Identity=28.0130293159609, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786595, Length=279, Percent_Identity=27.2401433691756, Blast_Score=95, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40422; Mature: 40422

Theoretical pI: Translated: 11.60; Mature: 11.60

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA