Click here to switch to the map view.

The map label for this gene is mmlH [H]

Identifier: 189352174

GI number: 189352174

Start: 206813

End: 208111

Strand: Direct

Name: mmlH [H]

Synonym: BMULJ_03392

Alternate gene names: 189352174

Gene position: 206813-208111 (Clockwise)

Preceding gene: 189352173

Following gene: 189352175

Centisome position: 8.36

GC content: 68.9

Gene sequence:

>1299_bases
ATGGAAAGCAAGACCCTCGCGGCGGGAACCGCCGAGCCCGAGCGCCCCGCGCGCAGCGGCCTGTTCTCGTGGTACGCCGA
CGCGCAGCCGCGCGAGCGCCGTGCCTTCTGGAGCTGCAAGGTCGGCTACATGCTCGACGGGATGGACACGCAGATGCTGT
CGTTCGTGATCCCGACGATCGTCGCGACCTGGGGCATCTCGCTCGCCGATGCCGGCTTCATCGGCACCATCACGCTGCTC
GCCTCGGCGGCCGGCGGCTGGCTCGCCGGGCTGCTGTCCGACCGGATCGGCCGCGTGCGCACGCTGCAGCTGACGGTGCT
CTGGTTCGCGGTGTTCACCGCGCTGTGCGGGCTCGCGCAGAACTATCATCAGCTGGTCGCCGCGCGCGCGCTGATGGGCT
TCGGCTTCGGCGGCGAATGGACGGCCGGCGCCGTGCTGATCGGCGAAGTGATCCGCGCGCGCGATCGCGGCAAGGCGGTC
GGCCTCGTGCAGTCGGGCTGGGCAATCGGCTGGGGGCTCTGCGCGCTGCTGTATGCGCTGCTGTTCTCGGTGCTGCCCGC
CGAGCTCGCATGGCGCGCGCTGTTTCTCGTCGGGCTCGCGCCGGCGCTGCTCGTCGTCGTGATTCGCCGCTACGTGAAGG
AGCCGGACGTCTACCAGAAGGAGAAGGCCGCGCAGGCACGCGAAGCCGATGCGCCGCGCTTCACCGAGATCTTCGCGCCG
AAGCTGATCACGACGACGCTGCGCGCGGCGCTGCTGACGACGGGCGCGCAAGGCGGCTACTACGCGATCACGACCTGGCT
GCCGACGTTTCTGAAGACCGAGCGCCATCTGACCGTGATGGGCACGGGCGGCTATCTCGCGATGATCATCCTCGGCTCGT
GGGTCGGCTATCTGACGAGCGCGTACCTGACCGACCGGCTCGGCCGCAAGCCGAACTTCATCCTGTTCGCGCTCGGCTCG
ATGGCGATCGCGTTCGCCTATACGTCGCTGCATCTGACCGATACGTCGATGCTGTTCCTCGGTTTCCCGCTCGGCTTCTT
CGCATCGGGCATCTTCTCCGGCATGGGCGCATTCCTGACCGAGCTGTTTCCGACGCGCGTGCGCGGCTCGGGGCAGGGCT
TCTGCTACAACGTCGGCCGCGCGATCGGCGCCTTGTTTCCGTTCCTGATCGGCGCGCTCGCGAAACACTACGGGCTCGGC
GCGAGCATCGGCATCTTCGCGGTCGCCGCGTACGGCGTGATGATCGTCGCCGCGCTGACGCTGCCCGAGACGCGCGGCCG
CGAACTCGACGCCGCGTAA

Upstream 100 bases:

>100_bases
GACGATCCGCCCCGGCCGGAGGGCGGCGCGCATCCGCGCAGCGTGCCGCGCGGTTCGGCGCGGCACGACTTTGACGGCGC
TTAACGACAGGAGCCACACC

Downstream 100 bases:

>100_bases
GCGGCGCACCGCCCGCCCGTTCGTTCTTTCCCGTTTTCACCGCTTCGTCACGCGGCGCGCGATGCGCGCCGTGCGGCGGC
GCTCGTCCTCCGATTCAACG

Product: permease of the major facilitator superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MESKTLAAGTAEPERPARSGLFSWYADAQPRERRAFWSCKVGYMLDGMDTQMLSFVIPTIVATWGISLADAGFIGTITLL
ASAAGGWLAGLLSDRIGRVRTLQLTVLWFAVFTALCGLAQNYHQLVAARALMGFGFGGEWTAGAVLIGEVIRARDRGKAV
GLVQSGWAIGWGLCALLYALLFSVLPAELAWRALFLVGLAPALLVVVIRRYVKEPDVYQKEKAAQAREADAPRFTEIFAP
KLITTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIILGSWVGYLTSAYLTDRLGRKPNFILFALGS
MAIAFAYTSLHLTDTSMLFLGFPLGFFASGIFSGMGAFLTELFPTRVRGSGQGFCYNVGRAIGALFPFLIGALAKHYGLG
ASIGIFAVAAYGVMIVAALTLPETRGRELDAA

Sequences:

>Translated_432_residues
MESKTLAAGTAEPERPARSGLFSWYADAQPRERRAFWSCKVGYMLDGMDTQMLSFVIPTIVATWGISLADAGFIGTITLL
ASAAGGWLAGLLSDRIGRVRTLQLTVLWFAVFTALCGLAQNYHQLVAARALMGFGFGGEWTAGAVLIGEVIRARDRGKAV
GLVQSGWAIGWGLCALLYALLFSVLPAELAWRALFLVGLAPALLVVVIRRYVKEPDVYQKEKAAQAREADAPRFTEIFAP
KLITTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIILGSWVGYLTSAYLTDRLGRKPNFILFALGS
MAIAFAYTSLHLTDTSMLFLGFPLGFFASGIFSGMGAFLTELFPTRVRGSGQGFCYNVGRAIGALFPFLIGALAKHYGLG
ASIGIFAVAAYGVMIVAALTLPETRGRELDAA
>Mature_432_residues
MESKTLAAGTAEPERPARSGLFSWYADAQPRERRAFWSCKVGYMLDGMDTQMLSFVIPTIVATWGISLADAGFIGTITLL
ASAAGGWLAGLLSDRIGRVRTLQLTVLWFAVFTALCGLAQNYHQLVAARALMGFGFGGEWTAGAVLIGEVIRARDRGKAV
GLVQSGWAIGWGLCALLYALLFSVLPAELAWRALFLVGLAPALLVVVIRRYVKEPDVYQKEKAAQAREADAPRFTEIFAP
KLITTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIILGSWVGYLTSAYLTDRLGRKPNFILFALGS
MAIAFAYTSLHLTDTSMLFLGFPLGFFASGIFSGMGAFLTELFPTRVRGSGQGFCYNVGRAIGALFPFLIGALAKHYGLG
ASIGIFAVAAYGVMIVAALTLPETRGRELDAA

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=445, Percent_Identity=24.4943820224719, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI213021148, Length=444, Percent_Identity=24.7747747747748, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082404, Length=395, Percent_Identity=27.3417721518987, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081723, Length=394, Percent_Identity=29.1878172588832, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082231, Length=203, Percent_Identity=28.0788177339901, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790550, Length=391, Percent_Identity=25.8312020460358, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788068, Length=452, Percent_Identity=24.5575221238938, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788292, Length=368, Percent_Identity=27.1739130434783, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789941, Length=383, Percent_Identity=28.4595300261097, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786229, Length=414, Percent_Identity=22.463768115942, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082320, Length=401, Percent_Identity=24.6882793017456, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=439, Percent_Identity=24.373576309795, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19922874, Length=386, Percent_Identity=23.5751295336788, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46425; Mature: 46425

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKTLAAGTAEPERPARSGLFSWYADAQPRERRAFWSCKVGYMLDGMDTQMLSFVIPTI
CCCCCCCCCCCCCCCHHHHCCHHHHCCCCCHHHHHHHEEEECEEECCCHHHHHHHHHHHH
VATWGISLADAGFIGTITLLASAAGGWLAGLLSDRIGRVRTLQLTVLWFAVFTALCGLAQ
HHHHCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NYHQLVAARALMGFGFGGEWTAGAVLIGEVIRARDRGKAVGLVQSGWAIGWGLCALLYAL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHHHHH
LFSVLPAELAWRALFLVGLAPALLVVVIRRYVKEPDVYQKEKAAQAREADAPRFTEIFAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHH
KLITTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIILGSWVGYLTS
HHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
AYLTDRLGRKPNFILFALGSMAIAFAYTSLHLTDTSMLFLGFPLGFFASGIFSGMGAFLT
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHEEECCHHHHHHHCCHHHHHHHHHHHHHHHHH
ELFPTRVRGSGQGFCYNVGRAIGALFPFLIGALAKHYGLGASIGIFAVAAYGVMIVAALT
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LPETRGRELDAA
CCCCCCCCCCCC
>Mature Secondary Structure
MESKTLAAGTAEPERPARSGLFSWYADAQPRERRAFWSCKVGYMLDGMDTQMLSFVIPTI
CCCCCCCCCCCCCCCHHHHCCHHHHCCCCCHHHHHHHEEEECEEECCCHHHHHHHHHHHH
VATWGISLADAGFIGTITLLASAAGGWLAGLLSDRIGRVRTLQLTVLWFAVFTALCGLAQ
HHHHCCHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NYHQLVAARALMGFGFGGEWTAGAVLIGEVIRARDRGKAVGLVQSGWAIGWGLCALLYAL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHCCCHHHHHHHHHHHHH
LFSVLPAELAWRALFLVGLAPALLVVVIRRYVKEPDVYQKEKAAQAREADAPRFTEIFAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHH
KLITTTLRAALLTTGAQGGYYAITTWLPTFLKTERHLTVMGTGGYLAMIILGSWVGYLTS
HHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
AYLTDRLGRKPNFILFALGSMAIAFAYTSLHLTDTSMLFLGFPLGFFASGIFSGMGAFLT
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHEEECCHHHHHHHCCHHHHHHHHHHHHHHHHH
ELFPTRVRGSGQGFCYNVGRAIGALFPFLIGALAKHYGLGASIGIFAVAAYGVMIVAALT
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
LPETRGRELDAA
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]