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The map label for this gene is adiC [H]

Identifier: 189183626

GI number: 189183626

Start: 740780

End: 742063

Strand: Direct

Name: adiC [H]

Synonym: OTT_0719

Alternate gene names: 189183626

Gene position: 740780-742063 (Clockwise)

Preceding gene: 189183625

Following gene: 189183628

Centisome position: 36.87

GC content: 31.15

Gene sequence:

>1284_bases
ATGTCAACAGTAAAAAAAATAGGTTTTTGGTCAGTTTTATCAATTGTAATAAGCAGCCAAGTTGGCTCTGGTGTATTTCT
TTTACCAAGCACTTTAGCACCATTTGGTTATATTGGAATTCTAAGCTTGTTGTTAACTGGCTTATGTGCAACACTTTTAG
CGCTGATTTTTGCAAACTTATGCAGACAATTCCCTAAGACAGGAGGACCACATGCTTTTGTTTATAAAGCTTTTGGAATA
AAAGCAGCATTTTTTACTGCTTGGACTTACTGGATAATATCTTGGATTAGTTCTGTAGCACTTGTATTGACTGCAGTTAG
CTATATCAGTTACATATTTGATTGCTACAACATATATATTACCATAACATTAAAAGTCGCAATAACAATTATATCAATGC
TATTAAACCTTAATGGATTATATGCTTCTAGATGGTTAGATTTTGCGCTTACCTTACTTAAAATACCTTCCTTAGTAATT
TTACCGCTTATTTGTATACCTTCAATTAATTATAGCTATTTTTTCATTAACGAAAATTATACCATACACTCCTATCTACA
AGCTTTACAAGCAGCGGCTTTTATAACATTTTGGGGATTTATTGGAGTTGAAACAGCTACAGCACCAGCTGAAGCTGTTA
TAAATCCAACTAAAACTATTCCGCGAGCAATTATTATTGGTACTAGTTGTGTCATAGCAATGTATTTACTATCGAACATA
GCAATATTAGGAACAGTTCCAAATAATATTTTGAAAGTATCTACAGCCCCATTTGCTGAAGCTGCAAATATCATTCTTGG
AGGTCATTGGAATAAAATTATTGCATTTACAGCAATAATAATCTGCCTAAGTACTCTAAATGCTTGGATTTTAACTAGTG
GCCAAATAGCATTAGGAGCTGCTAAGGATCAATTATTTCCTCAACTTTTTTTAAAAACAAATCAACAAGGAGCTCCAATA
TGGGGAATCATTATCTCATCATTAGGAATGGTAGTATTAATACTTTGTACTATAAATTCAAATTTAGCTGAACAAATAAA
TTTCGTGATTAACATATCTGTTGTTGCATTCTTATGGATTTATGCTATTTGCACTATTAGCTATTTAAAAATTCTATCTA
TTTCAAATCATAAACAAATTAACTATAGCAGCATTATTATTAGTGTTATTGCTTTAACATTTTGTATATGGATTATGCTA
GGATCAGGCTGGTATATGTTATTATCATCTTTATTTTTTATTACTACTGGTATACCAGTTTACCTATATATAACCCGAGT
TTGA

Upstream 100 bases:

>100_bases
TTATATCTAAATTCTTAGTTACACTATTTAAAAAAGTTACTATTATTAATATTCAATAAAAATATTTTTATCCTATAAAT
TTAATATAACTTTAATTTTT

Downstream 100 bases:

>100_bases
TACGAGTAGAATTTCAAACTATAAACAGAGCAAGTATTACAACTGTTAGTTAAACACTAAAAAATAGAAAAAATAAAAAT
GTACATAAAAAAACAAGTAA

Product: amino acid transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSTVKKIGFWSVLSIVISSQVGSGVFLLPSTLAPFGYIGILSLLLTGLCATLLALIFANLCRQFPKTGGPHAFVYKAFGI
KAAFFTAWTYWIISWISSVALVLTAVSYISYIFDCYNIYITITLKVAITIISMLLNLNGLYASRWLDFALTLLKIPSLVI
LPLICIPSINYSYFFINENYTIHSYLQALQAAAFITFWGFIGVETATAPAEAVINPTKTIPRAIIIGTSCVIAMYLLSNI
AILGTVPNNILKVSTAPFAEAANIILGGHWNKIIAFTAIIICLSTLNAWILTSGQIALGAAKDQLFPQLFLKTNQQGAPI
WGIIISSLGMVVLILCTINSNLAEQINFVINISVVAFLWIYAICTISYLKILSISNHKQINYSSIIISVIALTFCIWIML
GSGWYMLLSSLFFITTGIPVYLYITRV

Sequences:

>Translated_427_residues
MSTVKKIGFWSVLSIVISSQVGSGVFLLPSTLAPFGYIGILSLLLTGLCATLLALIFANLCRQFPKTGGPHAFVYKAFGI
KAAFFTAWTYWIISWISSVALVLTAVSYISYIFDCYNIYITITLKVAITIISMLLNLNGLYASRWLDFALTLLKIPSLVI
LPLICIPSINYSYFFINENYTIHSYLQALQAAAFITFWGFIGVETATAPAEAVINPTKTIPRAIIIGTSCVIAMYLLSNI
AILGTVPNNILKVSTAPFAEAANIILGGHWNKIIAFTAIIICLSTLNAWILTSGQIALGAAKDQLFPQLFLKTNQQGAPI
WGIIISSLGMVVLILCTINSNLAEQINFVINISVVAFLWIYAICTISYLKILSISNHKQINYSSIIISVIALTFCIWIML
GSGWYMLLSSLFFITTGIPVYLYITRV
>Mature_426_residues
STVKKIGFWSVLSIVISSQVGSGVFLLPSTLAPFGYIGILSLLLTGLCATLLALIFANLCRQFPKTGGPHAFVYKAFGIK
AAFFTAWTYWIISWISSVALVLTAVSYISYIFDCYNIYITITLKVAITIISMLLNLNGLYASRWLDFALTLLKIPSLVIL
PLICIPSINYSYFFINENYTIHSYLQALQAAAFITFWGFIGVETATAPAEAVINPTKTIPRAIIIGTSCVIAMYLLSNIA
ILGTVPNNILKVSTAPFAEAANIILGGHWNKIIAFTAIIICLSTLNAWILTSGQIALGAAKDQLFPQLFLKTNQQGAPIW
GIIISSLGMVVLILCTINSNLAEQINFVINISVVAFLWIYAICTISYLKILSISNHKQINYSSIIISVIALTFCIWIMLG
SGWYMLLSSLFFITTGIPVYLYITRV

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI2367353, Length=409, Percent_Identity=32.0293398533007, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1790575, Length=416, Percent_Identity=29.0865384615385, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786908, Length=385, Percent_Identity=27.5324675324675, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1787890, Length=441, Percent_Identity=25.8503401360544, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87082250, Length=326, Percent_Identity=24.8466257668712, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790653, Length=319, Percent_Identity=21.9435736677116, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786302, Length=382, Percent_Identity=21.2041884816754, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71995382, Length=416, Percent_Identity=23.3173076923077, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71995388, Length=416, Percent_Identity=23.3173076923077, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71993915, Length=385, Percent_Identity=24.6753246753247, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566699, Length=402, Percent_Identity=23.6318407960199, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221331183, Length=321, Percent_Identity=23.6760124610592, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647653, Length=321, Percent_Identity=23.6760124610592, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664379, Length=321, Percent_Identity=23.6760124610592, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357367, Length=321, Percent_Identity=26.1682242990654, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46836; Mature: 46704

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVKKIGFWSVLSIVISSQVGSGVFLLPSTLAPFGYIGILSLLLTGLCATLLALIFANL
CCCHHHHHHHHHHHHHHHHCCCCCEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CRQFPKTGGPHAFVYKAFGIKAAFFTAWTYWIISWISSVALVLTAVSYISYIFDCYNIYI
HHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
TITLKVAITIISMLLNLNGLYASRWLDFALTLLKIPSLVILPLICIPSINYSYFFINENY
EEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCC
TIHSYLQALQAAAFITFWGFIGVETATAPAEAVINPTKTIPRAIIIGTSCVIAMYLLSNI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHCCHHHEEHHHHHHHHHHHHCC
AILGTVPNNILKVSTAPFAEAANIILGGHWNKIIAFTAIIICLSTLNAWILTSGQIALGA
EEEECCCCCEEEECCCCCHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEEC
AKDQLFPQLFLKTNQQGAPIWGIIISSLGMVVLILCTINSNLAEQINFVINISVVAFLWI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAICTISYLKILSISNHKQINYSSIIISVIALTFCIWIMLGSGWYMLLSSLFFITTGIPV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEE
YLYITRV
EEEEEEC
>Mature Secondary Structure 
STVKKIGFWSVLSIVISSQVGSGVFLLPSTLAPFGYIGILSLLLTGLCATLLALIFANL
CCHHHHHHHHHHHHHHHHCCCCCEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
CRQFPKTGGPHAFVYKAFGIKAAFFTAWTYWIISWISSVALVLTAVSYISYIFDCYNIYI
HHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
TITLKVAITIISMLLNLNGLYASRWLDFALTLLKIPSLVILPLICIPSINYSYFFINENY
EEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCC
TIHSYLQALQAAAFITFWGFIGVETATAPAEAVINPTKTIPRAIIIGTSCVIAMYLLSNI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHCCHHHEEHHHHHHHHHHHHCC
AILGTVPNNILKVSTAPFAEAANIILGGHWNKIIAFTAIIICLSTLNAWILTSGQIALGA
EEEECCCCCEEEECCCCCHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHEEECCCEEEEC
AKDQLFPQLFLKTNQQGAPIWGIIISSLGMVVLILCTINSNLAEQINFVINISVVAFLWI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAICTISYLKILSISNHKQINYSSIIISVIALTFCIWIMLGSGWYMLLSSLFFITTGIPV
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEE
YLYITRV
EEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]