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The map label for this gene is hlyIII [C]

Identifier: 189026260

GI number: 189026260

Start: 1135380

End: 1136096

Strand: Reverse

Name: hlyIII [C]

Synonym: TPASS_1037

Alternate gene names: 189026260

Gene position: 1136096-1135380 (Counterclockwise)

Preceding gene: 189026261

Following gene: 189026258

Centisome position: 99.71

GC content: 49.51

Gene sequence:

>717_bases
GTGGAAAAAATTGTTAACGCAGACGGATCGGATGCTATCTGTCCTGCGTCTGCGGCCTGTGCTAAGTCCATACGATCTTA
CCAGGAGAGCTATTCTCTTGGTGAGGAAATCGCAAATGCAGTCACCCACGGTATCGGTGTCGGACTATCCATCGTTGCAC
TGGTGCTCCTGGTGGTGCGTGCAGTGCACTATACGCCGGCTGACTTGACGGCTCGCTATGTTGTTGGTTTTAGTGTCTTT
GGCTCCTCACTCATTGTGCTGTACCTGTGCTCTACGCTGTACCATGCTCTGCCTCGTGGAGCGAAGTATGTGTTCGGTGT
TATTGATCACTGTTGTATTTACGTGCTCATTGCAGGTACGTATACTGCGAGTTGCCTGACTACACTGTACGGCGCGATCG
GATGGACTGTTTTTGGGGTTATTTGGGGATTAGCGTGTAGTGGGAGCGTAATATACTCCGTGTTTGGGCATCGGGTACGG
TGGCTGTCTCTCGTGATGTATATAGCGATGGGGTGGCTGGTAGTGTTTGTAGCAAAGCCGTTGCGGGAACGGCTCCCTGA
GATTAGCTTTCTGTTTTTGGTATTAGGAGGCGTGCTCTACACGGTTGGTTGTGTATTCTACGCACTCAAGAGAATAAAGT
GGACGCATACTATCTGGCATATGTTCGTCATCGGCGGTAGCGTCATGCATTTTTTTTCGCTGTATTTAAGCTTTTAA

Upstream 100 bases:

>100_bases
GCACATAAGGCCTCTCTCCCGTTACAGCATGAGGGGAGGGAGGTGTTGGTTGAAGTGCTTGGGGAAGTGTGCATAATCGT
CCTACGGAAGGGGGCGTTTT

Downstream 100 bases:

>100_bases
ATCCATAAGCCTCCTATGATAGATAGGAGGTTCGTTTCTTTGCGCAGACCGCATCCTGTCTGACGGAGCGAGCGAGTTCG
CGCAGTCCTTTATGGTGATG

Product: hemolysin III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MEKIVNADGSDAICPASAACAKSIRSYQESYSLGEEIANAVTHGIGVGLSIVALVLLVVRAVHYTPADLTARYVVGFSVF
GSSLIVLYLCSTLYHALPRGAKYVFGVIDHCCIYVLIAGTYTASCLTTLYGAIGWTVFGVIWGLACSGSVIYSVFGHRVR
WLSLVMYIAMGWLVVFVAKPLRERLPEISFLFLVLGGVLYTVGCVFYALKRIKWTHTIWHMFVIGGSVMHFFSLYLSF

Sequences:

>Translated_238_residues
MEKIVNADGSDAICPASAACAKSIRSYQESYSLGEEIANAVTHGIGVGLSIVALVLLVVRAVHYTPADLTARYVVGFSVF
GSSLIVLYLCSTLYHALPRGAKYVFGVIDHCCIYVLIAGTYTASCLTTLYGAIGWTVFGVIWGLACSGSVIYSVFGHRVR
WLSLVMYIAMGWLVVFVAKPLRERLPEISFLFLVLGGVLYTVGCVFYALKRIKWTHTIWHMFVIGGSVMHFFSLYLSF
>Mature_238_residues
MEKIVNADGSDAICPASAACAKSIRSYQESYSLGEEIANAVTHGIGVGLSIVALVLLVVRAVHYTPADLTARYVVGFSVF
GSSLIVLYLCSTLYHALPRGAKYVFGVIDHCCIYVLIAGTYTASCLTTLYGAIGWTVFGVIWGLACSGSVIYSVFGHRVR
WLSLVMYIAMGWLVVFVAKPLRERLPEISFLFLVLGGVLYTVGCVFYALKRIKWTHTIWHMFVIGGSVMHFFSLYLSF

Specific function: Unknown

COG id: COG1272

COG function: function code R; Predicted membrane protein, hemolysin III homolog

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0073 (Hly-III) family

Homologues:

Organism=Escherichia coli, GI1789266, Length=210, Percent_Identity=46.6666666666667, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71996356, Length=236, Percent_Identity=27.5423728813559, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640324, Length=232, Percent_Identity=28.448275862069, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1037_TREPA (O84000)

Other databases:

- EMBL:   AE000520
- PIR:   D71250
- RefSeq:   NP_219474.1
- ProteinModelPortal:   O84000
- IntAct:   O84000
- GeneID:   2610936
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP1037
- NMPDR:   fig|243276.1.peg.1032
- TIGR:   TP_1037
- HOGENOM:   HBG717325
- OMA:   IDHSSIY
- ProtClustDB:   CLSK218978
- BioCyc:   TPAL243276:TP_1037-MONOMER
- GO:   GO:0019835
- InterPro:   IPR004254
- InterPro:   IPR005744
- PANTHER:   PTHR20855
- PANTHER:   PTHR20855:SF3
- TIGRFAMs:   TIGR01065

Pfam domain/function: PF03006 HlyIII

EC number: NA

Molecular weight: Translated: 26095; Mature: 26095

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2204d860)-; HASH(0x1f238f08)-; HASH(0x21aae054)-; HASH(0x220d576c)-; HASH(0x21bb3da8)-; HASH(0x21927b64)-; HASH(0x21970cb4)-;

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIVNADGSDAICPASAACAKSIRSYQESYSLGEEIANAVTHGIGVGLSIVALVLLVVR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVHYTPADLTARYVVGFSVFGSSLIVLYLCSTLYHALPRGAKYVFGVIDHCCIYVLIAGT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YTASCLTTLYGAIGWTVFGVIWGLACSGSVIYSVFGHRVRWLSLVMYIAMGWLVVFVAKP
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRERLPEISFLFLVLGGVLYTVGCVFYALKRIKWTHTIWHMFVIGGSVMHFFSLYLSF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MEKIVNADGSDAICPASAACAKSIRSYQESYSLGEEIANAVTHGIGVGLSIVALVLLVVR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVHYTPADLTARYVVGFSVFGSSLIVLYLCSTLYHALPRGAKYVFGVIDHCCIYVLIAGT
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
YTASCLTTLYGAIGWTVFGVIWGLACSGSVIYSVFGHRVRWLSLVMYIAMGWLVVFVAKP
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRERLPEISFLFLVLGGVLYTVGCVFYALKRIKWTHTIWHMFVIGGSVMHFFSLYLSF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9665876