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The map label for this gene is rnz

Identifier: 189026043

GI number: 189026043

Start: 888512

End: 889444

Strand: Reverse

Name: rnz

Synonym: TPASS_0819

Alternate gene names: 189026043

Gene position: 889444-888512 (Counterclockwise)

Preceding gene: 189026044

Following gene: 189026042

Centisome position: 78.06

GC content: 51.23

Gene sequence:

>933_bases
GTGCATATGAATCTTGAAGCGTTTATTTTAGGGTGTGGCGGCATGGTGCCATTACCCCATCGGCATCTGACTTCTGTGTT
GTTGCGTCGTGAGGGAGAGTTGTTTCTGTTCGACGCTGGGGAAGGTACCCAAGTGTCGTTGCGGCGTCTGAGCTTACGCT
GGAAGAAAATCAGTGCCATTTTCATCAGTCACACCCATGCAGACCACATCACTGGGCTGCCGGGGCTTTTGATGCTCTCT
TCTCAAGTTGCTCGCAGCGAACCGCTGTACATCATCGGTCCTCCAAGAACTGCAGAGTATGTGGAAACGAGCCGCAGGAT
TTTGGACATGTACATTAATTACGAGATTATTGTCAAAGAGGTGATAGAACCACAAGTGGTATACCGTGGTAAGGATTTTC
AGGTGCGCTGTTTTTGTCTGGATCATACCAAGCCGTGTATGGGCTACACGCTAGAAGAGCAGGATCGTCCCGGATCATTT
GACCCGCGCGCGGCTCAGGATTTGCACGTTCCCTGTGGGGCGCTGTGGTCTCAGTTACAGTCAGGGGTTGCAGTGCAGTC
CGCGCAGGGGGTGACAGTATATCCTGAACAGGTAATGGGACCGGCGCGTCCGGGGCGTAAGGTGAGCTTCGTCACTGATA
CAAAATATTTGCAGTCCATTGCAGCCGAGGTGCGGAATTCGGATTTCTTTGTGTGTGAGGGAATGTTTGAGAAAGGGATG
GAAAAGGATGCAGCAGAGAAAAAGCATATGACGTGCGTGCAGGCAGCCACGATAGCGCGCGATGCGCGTGTGCGACTTAT
GGCACTCATCCACTATAGCCCTCGATATACCGATCACGAGTTGAAACGTTTATTAAAGGAAGCGCAGCGTGTTTTCCCGC
ACACTATTCTGTCTCGTGATCAATTGATGGTTCCCATTGCGTATCGAGAATAG

Upstream 100 bases:

>100_bases
TGCATACCGACGTGCGTTGCATTTGCGTCCTGAGTACAAAGAGGCACAAGAATCCATCAGGCGCCTGAGTTAACCTCCAA
AAGGTTGACGTCGGAATGGT

Downstream 100 bases:

>100_bases
ATATAACGCGCCGTTGCAATACTCCGTTGGAATACCGAGGCGGTTGGTACAGTTACTTTCTCTGTGGTGTTCTCAGTGGG
AAGGGAGCGCGGCGTGCGGG

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MHMNLEAFILGCGGMVPLPHRHLTSVLLRREGELFLFDAGEGTQVSLRRLSLRWKKISAIFISHTHADHITGLPGLLMLS
SQVARSEPLYIIGPPRTAEYVETSRRILDMYINYEIIVKEVIEPQVVYRGKDFQVRCFCLDHTKPCMGYTLEEQDRPGSF
DPRAAQDLHVPCGALWSQLQSGVAVQSAQGVTVYPEQVMGPARPGRKVSFVTDTKYLQSIAAEVRNSDFFVCEGMFEKGM
EKDAAEKKHMTCVQAATIARDARVRLMALIHYSPRYTDHELKRLLKEAQRVFPHTILSRDQLMVPIAYRE

Sequences:

>Translated_310_residues
MHMNLEAFILGCGGMVPLPHRHLTSVLLRREGELFLFDAGEGTQVSLRRLSLRWKKISAIFISHTHADHITGLPGLLMLS
SQVARSEPLYIIGPPRTAEYVETSRRILDMYINYEIIVKEVIEPQVVYRGKDFQVRCFCLDHTKPCMGYTLEEQDRPGSF
DPRAAQDLHVPCGALWSQLQSGVAVQSAQGVTVYPEQVMGPARPGRKVSFVTDTKYLQSIAAEVRNSDFFVCEGMFEKGM
EKDAAEKKHMTCVQAATIARDARVRLMALIHYSPRYTDHELKRLLKEAQRVFPHTILSRDQLMVPIAYRE
>Mature_310_residues
MHMNLEAFILGCGGMVPLPHRHLTSVLLRREGELFLFDAGEGTQVSLRRLSLRWKKISAIFISHTHADHITGLPGLLMLS
SQVARSEPLYIIGPPRTAEYVETSRRILDMYINYEIIVKEVIEPQVVYRGKDFQVRCFCLDHTKPCMGYTLEEQDRPGSF
DPRAAQDLHVPCGALWSQLQSGVAVQSAQGVTVYPEQVMGPARPGRKVSFVTDTKYLQSIAAEVRNSDFFVCEGMFEKGM
EKDAAEKKHMTCVQAATIARDARVRLMALIHYSPRYTDHELKRLLKEAQRVFPHTILSRDQLMVPIAYRE

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=363, Percent_Identity=27.2727272727273, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI87082078, Length=300, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_TREPA (O07896)

Other databases:

- EMBL:   U93844
- EMBL:   AE000520
- PIR:   H71278
- RefSeq:   NP_219255.1
- ProteinModelPortal:   O07896
- SMR:   O07896
- IntAct:   O07896
- GeneID:   2610912
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0819
- NMPDR:   fig|243276.1.peg.814
- TIGR:   TP_0819
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   PRK00055
- BioCyc:   TPAL243276:TP_0819-MONOMER
- BRENDA:   3.1.26.11
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 35203; Mature: 35203

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHMNLEAFILGCGGMVPLPHRHLTSVLLRREGELFLFDAGEGTQVSLRRLSLRWKKISAI
CCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHEEEEE
FISHTHADHITGLPGLLMLSSQVARSEPLYIIGPPRTAEYVETSRRILDMYINYEIIVKE
EEECCCCHHHCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHH
VIEPQVVYRGKDFQVRCFCLDHTKPCMGYTLEEQDRPGSFDPRAAQDLHVPCGALWSQLQ
HCCCEEEEECCCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
SGVAVQSAQGVTVYPEQVMGPARPGRKVSFVTDTKYLQSIAAEVRNSDFFVCEGMFEKGM
CCCEEECCCCCEECHHHHCCCCCCCCEEEEEECHHHHHHHHHHHCCCCEEEECCHHHCCC
EKDAAEKKHMTCVQAATIARDARVRLMALIHYSPRYTDHELKRLLKEAQRVFPHTILSRD
CHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCC
QLMVPIAYRE
CEEEEEEECC
>Mature Secondary Structure
MHMNLEAFILGCGGMVPLPHRHLTSVLLRREGELFLFDAGEGTQVSLRRLSLRWKKISAI
CCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHHEEEEE
FISHTHADHITGLPGLLMLSSQVARSEPLYIIGPPRTAEYVETSRRILDMYINYEIIVKE
EEECCCCHHHCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHH
VIEPQVVYRGKDFQVRCFCLDHTKPCMGYTLEEQDRPGSFDPRAAQDLHVPCGALWSQLQ
HCCCEEEEECCCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
SGVAVQSAQGVTVYPEQVMGPARPGRKVSFVTDTKYLQSIAAEVRNSDFFVCEGMFEKGM
CCCEEECCCCCEECHHHHCCCCCCCCEEEEEECHHHHHHHHHHHCCCCEEEECCHHHCCC
EKDAAEKKHMTCVQAATIARDARVRLMALIHYSPRYTDHELKRLLKEAQRVFPHTILSRD
CHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCC
QLMVPIAYRE
CEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876