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The map label for this gene is adk

Identifier: 189025822

GI number: 189025822

Start: 648383

End: 649018

Strand: Reverse

Name: adk

Synonym: TPASS_0595

Alternate gene names: 189025822

Gene position: 649018-648383 (Counterclockwise)

Preceding gene: 189025823

Following gene: 189025821

Centisome position: 56.96

GC content: 52.04

Gene sequence:

>636_bases
ATGAGGTTTGTTTTTCTTGGTCCTCCTGGTGCCGGTAAGGGTACGCTTGCAGGTGAAATTTCTGGGCGTTGTGGCGTTGT
GCACATCTCCACAGGGGGTATTCTTCGGGCAGCAATTCAGAAACAGACGGCATTAGGTAAAAAAGTTCAAAAAGTAGTTG
AAGTGGGCGGCTTGGTAGATGACCAGACCGTTACGGAGCTAGTGCGGGAGCGTGTCAGTCACGAAGATGTGGTTAGCGGT
TTTATTCTAGATGGGTTTCCTCGCACTGTCACGCAGGCTAGGTGCTTAGAGGACATTGTGCCGATAGACTACGCGGTGAG
TATTGTAGTACCGGACGATGTCCTTGTTGCGCGTCTTACTGGCCGCAGGGTGTGTTCGGCCTGTGGGAGCAGTTATCATG
TGCTCTTTGCGCAGCCTAAGAGAGAGGGTGTGTGCGATCGGTGTAGAGGAGTACTGGTCGTGCGGGAGGATGACAAGATG
TCGGCAATTCTTCAGAGGCTTACCGCCTATCGAGCGCAGGCGGAGCCCATTGTCCACTTTTACAGTGAGCGGGGGAAATT
AGTTTCTCTTAATGGTGCTCCGCCGATATCGGATGTAGTGTTGGAGTTTCAAGAGCGTTTTGCACAATCACGGTGA

Upstream 100 bases:

>100_bases
CGCGCGCGGCGTGTACGCCTTCGGGTCGGTTGTGTGCGCGAGAGAACGGGGTGAGGTGTGTTTTTTCTTCCCCGTAGGAA
GATAAGGTGGAGTTTGTTTC

Downstream 100 bases:

>100_bases
GCTCGATGTATGTGGGGGGTGCGTCGTATGGTACCTGCTTTTTTGCAGGTCGTATTTCCCCTTGTTGGTTGTGCGCATTA
TATTTTGTGGGGGCGGGCTA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRFVFLGPPGAGKGTLAGEISGRCGVVHISTGGILRAAIQKQTALGKKVQKVVEVGGLVDDQTVTELVRERVSHEDVVSG
FILDGFPRTVTQARCLEDIVPIDYAVSIVVPDDVLVARLTGRRVCSACGSSYHVLFAQPKREGVCDRCRGVLVVREDDKM
SAILQRLTAYRAQAEPIVHFYSERGKLVSLNGAPPISDVVLEFQERFAQSR

Sequences:

>Translated_211_residues
MRFVFLGPPGAGKGTLAGEISGRCGVVHISTGGILRAAIQKQTALGKKVQKVVEVGGLVDDQTVTELVRERVSHEDVVSG
FILDGFPRTVTQARCLEDIVPIDYAVSIVVPDDVLVARLTGRRVCSACGSSYHVLFAQPKREGVCDRCRGVLVVREDDKM
SAILQRLTAYRAQAEPIVHFYSERGKLVSLNGAPPISDVVLEFQERFAQSR
>Mature_211_residues
MRFVFLGPPGAGKGTLAGEISGRCGVVHISTGGILRAAIQKQTALGKKVQKVVEVGGLVDDQTVTELVRERVSHEDVVSG
FILDGFPRTVTQARCLEDIVPIDYAVSIVVPDDVLVARLTGRRVCSACGSSYHVLFAQPKREGVCDRCRGVLVVREDDKM
SAILQRLTAYRAQAEPIVHFYSERGKLVSLNGAPPISDVVLEFQERFAQSR

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=190, Percent_Identity=39.4736842105263, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI4502013, Length=190, Percent_Identity=39.4736842105263, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI19923437, Length=211, Percent_Identity=32.2274881516588, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI310110345, Length=193, Percent_Identity=35.2331606217617, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI53832003, Length=193, Percent_Identity=35.2331606217617, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI8051579, Length=193, Percent_Identity=35.2331606217617, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI53832001, Length=193, Percent_Identity=35.2331606217617, Blast_Score=127, Evalue=8e-30,
Organism=Homo sapiens, GI4502011, Length=202, Percent_Identity=29.7029702970297, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22749187, Length=193, Percent_Identity=26.9430051813472, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI28144899, Length=189, Percent_Identity=26.4550264550265, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI28144897, Length=189, Percent_Identity=26.4550264550265, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786680, Length=211, Percent_Identity=38.8625592417062, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=35.981308411215, Blast_Score=146, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17567503, Length=200, Percent_Identity=28.5, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=196, Percent_Identity=27.0408163265306, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=216, Percent_Identity=38.4259259259259, Blast_Score=165, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6321018, Length=204, Percent_Identity=28.921568627451, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=37.5586854460094, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17737899, Length=192, Percent_Identity=37.5, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24645822, Length=192, Percent_Identity=37.5, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24663208, Length=200, Percent_Identity=28.5, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=200, Percent_Identity=28.5, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_TREPA (O83604)

Other databases:

- EMBL:   AE000520
- PIR:   D71306
- RefSeq:   NP_219033.1
- ProteinModelPortal:   O83604
- SMR:   O83604
- GeneID:   2611182
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0595
- NMPDR:   fig|243276.1.peg.592
- TIGR:   TP_0595
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   CLSK2300256
- BioCyc:   TPAL243276:TP_0595-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 22934; Mature: 22934

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVFLGPPGAGKGTLAGEISGRCGVVHISTGGILRAAIQKQTALGKKVQKVVEVGGLVD
CEEEEECCCCCCCCCEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DQTVTELVRERVSHEDVVSGFILDGFPRTVTQARCLEDIVPIDYAVSIVVPDDVLVARLT
HHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHH
GRRVCSACGSSYHVLFAQPKREGVCDRCRGVLVVREDDKMSAILQRLTAYRAQAEPIVHF
HHHHHHHCCCCEEEEEECCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHH
YSERGKLVSLNGAPPISDVVLEFQERFAQSR
HHCCCCEEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFVFLGPPGAGKGTLAGEISGRCGVVHISTGGILRAAIQKQTALGKKVQKVVEVGGLVD
CEEEEECCCCCCCCCEEEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DQTVTELVRERVSHEDVVSGFILDGFPRTVTQARCLEDIVPIDYAVSIVVPDDVLVARLT
HHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHH
GRRVCSACGSSYHVLFAQPKREGVCDRCRGVLVVREDDKMSAILQRLTAYRAQAEPIVHF
HHHHHHHCCCCEEEEEECCCCCCHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHH
YSERGKLVSLNGAPPISDVVLEFQERFAQSR
HHCCCCEEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876