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The map label for this gene is lysA [H]

Identifier: 188586528

GI number: 188586528

Start: 2009625

End: 2010941

Strand: Reverse

Name: lysA [H]

Synonym: Nther_1914

Alternate gene names: 188586528

Gene position: 2010941-2009625 (Counterclockwise)

Preceding gene: 188586533

Following gene: 188586527

Centisome position: 63.53

GC content: 34.02

Gene sequence:

>1317_bases
ATGTCAGAATCAGTAATAATCAATGAAGATGGAAATTTGGAAATAGGTGGTTGTGATTTAGTAAAATTAGCTCAACAATA
TGATACACCTTTGAATATATTAGATGAAGAACATATTAGGAATAAATGTAGAAAATATCGAAGAATTTTAGAACAATATT
ATCCTACAACTGAATTGGCTTATGCTGGTAAAGCTTTTTTGTCAACAACCATTTGTAAAATAGTTGAAGAAGAAGGCTTG
TTCCTTGATGTAGTCTCGGAAGGGGAATTATTTACAGCGGTTCAGGCTGGTTTTCCTGGGGACAAGCTGTTATTTCATGG
AAATAATAAAACCTCAAGAGAATTAGAATATGCCTTAGATTGTAATGTGGGAAGAATAGTAGTTGATAGCTTCTTGGAAC
TTGAACTGATTGAAAAGTTAGCACAAAAAAAGAGTACTAGGGTCCAAATTTATTTTAGAGTTAAACCCGGGATAGAGGCT
CATACCCACAAATATATATTAACTGGTCAAGAGGACTCCAAATTTGGCTTCAGCTTACGTCAAGACGATATAATGAAAGC
TGTAAACTTTGCAATCAAATCTTCATATATTGATTTACAAGGACTACACTGTCATATTGGTTCACAAATTAATGAAAGTA
AACCTTATAGATTAGCTGCTAAAACCATGATGGAATTATTAATTTCAATTCAAAAAATATATAATTACAGTATTTCGGAA
CTGGATTTAGGTGGGGGTATGGGAATAAAATATCGAAGTGATGATTCGAAATTAGATATTGATTCACTTATGAATGAAAT
ATCCCAACTTATCCTGGATATGGCAAAAGACTCTAAAATAGAATTGCCGAAATTAATTTTTGAACCCGGGCGTTCAATTA
TTGGAGAAGCGGGTGTCATGTTGTATCGTGTTGGAGTCATTAAAGAAATACCAGGTATTAGAAATTATGTTTCAGTAGAC
GGAGGAATGAGCGATAATATTAGACCAGCTCTTTACGGAGCTGAATACTCTGCTGTAGTGGCAAACAAGGCCAATTATCC
TCATAATAATAGTTATACTGTTGTAGGTAAAATCTGTGAATCAGGTGATGTTCTCCTACAAAATATAGATTTAGTAGATA
ATCTAACACCTGGAGATTTACTTACCGTTTTTAGCTGTGGTGCGTATACTTATTCCATGTCAAGTAATTATAATAGACTA
CCAAAACCAGCAGTGGTGTTAGTAAACCAAGGTCAAGCTGATCTCATAGTTCGTCGAGAAAGTTTAGAAGATGTGATCCA
AAATGACCTTATCCCAGAAAGGTTTAGGAGGAACTAA

Upstream 100 bases:

>100_bases
CTATTTACTGTCAAGGATAATTTGTTGTTTTATTGACAAATATTAAAAAACAGTGATAGGATTAGTTTTAAAAATAAAAG
GGTTGTGATTATAAGTGGTC

Downstream 100 bases:

>100_bases
AGTGAAGTTTGAAAAAATGCATGGTTTGGGGAACGATTTTATTTTGATGAAAGATTTTCAGAGAAATTATCCTGATCTGG
CAAAACGGCTATGTGACCGT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSESVIINEDGNLEIGGCDLVKLAQQYDTPLNILDEEHIRNKCRKYRRILEQYYPTTELAYAGKAFLSTTICKIVEEEGL
FLDVVSEGELFTAVQAGFPGDKLLFHGNNKTSRELEYALDCNVGRIVVDSFLELELIEKLAQKKSTRVQIYFRVKPGIEA
HTHKYILTGQEDSKFGFSLRQDDIMKAVNFAIKSSYIDLQGLHCHIGSQINESKPYRLAAKTMMELLISIQKIYNYSISE
LDLGGGMGIKYRSDDSKLDIDSLMNEISQLILDMAKDSKIELPKLIFEPGRSIIGEAGVMLYRVGVIKEIPGIRNYVSVD
GGMSDNIRPALYGAEYSAVVANKANYPHNNSYTVVGKICESGDVLLQNIDLVDNLTPGDLLTVFSCGAYTYSMSSNYNRL
PKPAVVLVNQGQADLIVRRESLEDVIQNDLIPERFRRN

Sequences:

>Translated_438_residues
MSESVIINEDGNLEIGGCDLVKLAQQYDTPLNILDEEHIRNKCRKYRRILEQYYPTTELAYAGKAFLSTTICKIVEEEGL
FLDVVSEGELFTAVQAGFPGDKLLFHGNNKTSRELEYALDCNVGRIVVDSFLELELIEKLAQKKSTRVQIYFRVKPGIEA
HTHKYILTGQEDSKFGFSLRQDDIMKAVNFAIKSSYIDLQGLHCHIGSQINESKPYRLAAKTMMELLISIQKIYNYSISE
LDLGGGMGIKYRSDDSKLDIDSLMNEISQLILDMAKDSKIELPKLIFEPGRSIIGEAGVMLYRVGVIKEIPGIRNYVSVD
GGMSDNIRPALYGAEYSAVVANKANYPHNNSYTVVGKICESGDVLLQNIDLVDNLTPGDLLTVFSCGAYTYSMSSNYNRL
PKPAVVLVNQGQADLIVRRESLEDVIQNDLIPERFRRN
>Mature_437_residues
SESVIINEDGNLEIGGCDLVKLAQQYDTPLNILDEEHIRNKCRKYRRILEQYYPTTELAYAGKAFLSTTICKIVEEEGLF
LDVVSEGELFTAVQAGFPGDKLLFHGNNKTSRELEYALDCNVGRIVVDSFLELELIEKLAQKKSTRVQIYFRVKPGIEAH
THKYILTGQEDSKFGFSLRQDDIMKAVNFAIKSSYIDLQGLHCHIGSQINESKPYRLAAKTMMELLISIQKIYNYSISEL
DLGGGMGIKYRSDDSKLDIDSLMNEISQLILDMAKDSKIELPKLIFEPGRSIIGEAGVMLYRVGVIKEIPGIRNYVSVDG
GMSDNIRPALYGAEYSAVVANKANYPHNNSYTVVGKICESGDVLLQNIDLVDNLTPGDLLTVFSCGAYTYSMSSNYNRLP
KPAVVLVNQGQADLIVRRESLEDVIQNDLIPERFRRN

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=27.8688524590164, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49129; Mature: 48998

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVIINEDGNLEIGGCDLVKLAQQYDTPLNILDEEHIRNKCRKYRRILEQYYPTTELA
CCCCEEEECCCCEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
YAGKAFLSTTICKIVEEEGLFLDVVSEGELFTAVQAGFPGDKLLFHGNNKTSRELEYALD
HCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCEEEEEC
CNVGRIVVDSFLELELIEKLAQKKSTRVQIYFRVKPGIEAHTHKYILTGQEDSKFGFSLR
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCC
QDDIMKAVNFAIKSSYIDLQGLHCHIGSQINESKPYRLAAKTMMELLISIQKIYNYSISE
HHHHHHHHHHHHHHCCEEEECEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCE
LDLGGGMGIKYRSDDSKLDIDSLMNEISQLILDMAKDSKIELPKLIFEPGRSIIGEAGVM
EECCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHCCCHH
LYRVGVIKEIPGIRNYVSVDGGMSDNIRPALYGAEYSAVVANKANYPHNNSYTVVGKICE
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEEEECC
SGDVLLQNIDLVDNLTPGDLLTVFSCGAYTYSMSSNYNRLPKPAVVLVNQGQADLIVRRE
CCCEEEEECCHHCCCCCCHHHHHEECCCEEEECCCCCCCCCCCEEEEEECCCCEEEEEHH
SLEDVIQNDLIPERFRRN
HHHHHHHHCCCCHHHCCC
>Mature Secondary Structure 
SESVIINEDGNLEIGGCDLVKLAQQYDTPLNILDEEHIRNKCRKYRRILEQYYPTTELA
CCCEEEECCCCEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
YAGKAFLSTTICKIVEEEGLFLDVVSEGELFTAVQAGFPGDKLLFHGNNKTSRELEYALD
HCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCEEEEECCCCCCCCEEEEEC
CNVGRIVVDSFLELELIEKLAQKKSTRVQIYFRVKPGIEAHTHKYILTGQEDSKFGFSLR
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCC
QDDIMKAVNFAIKSSYIDLQGLHCHIGSQINESKPYRLAAKTMMELLISIQKIYNYSISE
HHHHHHHHHHHHHHCCEEEECEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCE
LDLGGGMGIKYRSDDSKLDIDSLMNEISQLILDMAKDSKIELPKLIFEPGRSIIGEAGVM
EECCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHCCCHH
LYRVGVIKEIPGIRNYVSVDGGMSDNIRPALYGAEYSAVVANKANYPHNNSYTVVGKICE
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEECCCEEEEEEECCCCCCCCCEEEEEEECC
SGDVLLQNIDLVDNLTPGDLLTVFSCGAYTYSMSSNYNRLPKPAVVLVNQGQADLIVRRE
CCCEEEEECCHHCCCCCCHHHHHEECCCEEEECCCCCCCCCCCEEEEEECCCCEEEEEHH
SLEDVIQNDLIPERFRRN
HHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]