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The map label for this gene is argE [H]

Identifier: 188586469

GI number: 188586469

Start: 1935717

End: 1936907

Strand: Reverse

Name: argE [H]

Synonym: Nther_1854

Alternate gene names: 188586469

Gene position: 1936907-1935717 (Counterclockwise)

Preceding gene: 188586470

Following gene: 188586468

Centisome position: 61.19

GC content: 39.13

Gene sequence:

>1191_bases
TTGCATTCTAATATACCAATTGATAGAGAGGAAATTTTGAATCTTGCATTTGAATTGATCAAAATAGAAAGTCACAAAGA
AGTGGATTATCAAGAGAATAAGATTGCAGAATGGATTAAATCTAAATTTCAAAAAGAAGGTATTGAAAGTGAAACTGTAG
CGGTAGATAATGCCGATGGTCGCCTAAATGTCATGGCTTATTTACCAAAGAAATCGGATCAGATAAGCCTGATGTTTAAC
GGTCATACTGATACTGTACCCCCCTATGGAATGAGCATTGATCCTTTTAAACCAGAAATAAAAGAGGGCAAATTATATGG
TCGGGGAGCTGTGGATATGAAAGGTGGAATAGCAGCTTTTATGGCTACCATGTTTGCCTTAAAAAGGGCGAATATTGAAT
TACCGGGTGGATTAGCCTTTGCTGGAGTCATTGATGAAGAACAAAGCTGCAGAGGAACTGAGTACATTGTCAAAAATGGT
CCAGTACCAGATATGGTCGTAGTAGCAGAACCTACTGACATGAAAGTCTGTCCTGCTCATAAGGGGATGGAGTGGATTGA
AGTTACTTTCAAGGGACAAGCTTCTCATGGAAGCAGGCCCAGAGAGGGGATTAACGCAGTCCTATTAGCTTCAGAGTTTT
CTCTCAAGGTACAAAATGAACTCTTGCCCAAATTAGAACAGAGACATCATGAAATTGCTGGTCAAGCTTCAATTAATGTC
GGTAAGATTCAAGGAGGTGATGATCCTAATATTGTGCCTGATACTTGTGTGGTTCAACTAGATAGAAGATGGCTTCCCGA
TGAAACTATTGAAAGTATTACAGAAGAAGTAACAGAACTGGCTAACAAAGTGACAAAAAATAATAGTAAAGGCAAATATT
CAGTAAGAGGGATGAGAGAAGCAACGGCTGCTTTGTTAAACACTCCTCATTCCACTGATGTAAATAGTTCGCTAGTGCAA
GAAGCGTTACACATTGTTAGCCATGTTTTCCCAGACAGAGAGCCAGGTCCTGTGGCATTTAAAGGATGGAGTGATGCTGC
ACAGCTAAGCAATAATTTAGGTACTAAGGGGATAGTTGTTGGTCCAGGTAATATAGCTCAAGCACACGCAACTTTAGAGT
ACATTGATGTGGAAGAAATAGTAAAATCCGTGCATGTTTATTATGAGTTAGCTAAAAAATTCTGCACTTAA

Upstream 100 bases:

>100_bases
TTAATTGTGCTAATTTTCAAAATAAACAATGCAAATAAGAAAATTTAATAATAGTCCATGCAATAATTTCTACAAAATTA
AATAGAAAGGAGGTATACTA

Downstream 100 bases:

>100_bases
CGAGGTGAAAAAATGTGAAGATAAAAGTACCACACACTTATGTGCTGCTTTTTGTAATAATCTGTATTACTGCTGCATTA
ACTTATGTTATTCCGGCGGG

Product: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MHSNIPIDREEILNLAFELIKIESHKEVDYQENKIAEWIKSKFQKEGIESETVAVDNADGRLNVMAYLPKKSDQISLMFN
GHTDTVPPYGMSIDPFKPEIKEGKLYGRGAVDMKGGIAAFMATMFALKRANIELPGGLAFAGVIDEEQSCRGTEYIVKNG
PVPDMVVVAEPTDMKVCPAHKGMEWIEVTFKGQASHGSRPREGINAVLLASEFSLKVQNELLPKLEQRHHEIAGQASINV
GKIQGGDDPNIVPDTCVVQLDRRWLPDETIESITEEVTELANKVTKNNSKGKYSVRGMREATAALLNTPHSTDVNSSLVQ
EALHIVSHVFPDREPGPVAFKGWSDAAQLSNNLGTKGIVVGPGNIAQAHATLEYIDVEEIVKSVHVYYELAKKFCT

Sequences:

>Translated_396_residues
MHSNIPIDREEILNLAFELIKIESHKEVDYQENKIAEWIKSKFQKEGIESETVAVDNADGRLNVMAYLPKKSDQISLMFN
GHTDTVPPYGMSIDPFKPEIKEGKLYGRGAVDMKGGIAAFMATMFALKRANIELPGGLAFAGVIDEEQSCRGTEYIVKNG
PVPDMVVVAEPTDMKVCPAHKGMEWIEVTFKGQASHGSRPREGINAVLLASEFSLKVQNELLPKLEQRHHEIAGQASINV
GKIQGGDDPNIVPDTCVVQLDRRWLPDETIESITEEVTELANKVTKNNSKGKYSVRGMREATAALLNTPHSTDVNSSLVQ
EALHIVSHVFPDREPGPVAFKGWSDAAQLSNNLGTKGIVVGPGNIAQAHATLEYIDVEEIVKSVHVYYELAKKFCT
>Mature_396_residues
MHSNIPIDREEILNLAFELIKIESHKEVDYQENKIAEWIKSKFQKEGIESETVAVDNADGRLNVMAYLPKKSDQISLMFN
GHTDTVPPYGMSIDPFKPEIKEGKLYGRGAVDMKGGIAAFMATMFALKRANIELPGGLAFAGVIDEEQSCRGTEYIVKNG
PVPDMVVVAEPTDMKVCPAHKGMEWIEVTFKGQASHGSRPREGINAVLLASEFSLKVQNELLPKLEQRHHEIAGQASINV
GKIQGGDDPNIVPDTCVVQLDRRWLPDETIESITEEVTELANKVTKNNSKGKYSVRGMREATAALLNTPHSTDVNSSLVQ
EALHIVSHVFPDREPGPVAFKGWSDAAQLSNNLGTKGIVVGPGNIAQAHATLEYIDVEEIVKSVHVYYELAKKFCT

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=222, Percent_Identity=29.2792792792793, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790395, Length=367, Percent_Identity=26.4305177111717, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1789236, Length=373, Percent_Identity=26.0053619302949, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788816, Length=333, Percent_Identity=27.027027027027, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17551016, Length=266, Percent_Identity=26.6917293233083, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24649206, Length=296, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 43587; Mature: 43587

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSNIPIDREEILNLAFELIKIESHKEVDYQENKIAEWIKSKFQKEGIESETVAVDNADG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
RLNVMAYLPKKSDQISLMFNGHTDTVPPYGMSIDPFKPEIKEGKLYGRGAVDMKGGIAAF
EEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
MATMFALKRANIELPGGLAFAGVIDEEQSCRGTEYIVKNGPVPDMVVVAEPTDMKVCPAH
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCEEEEECCCCCEECCCC
KGMEWIEVTFKGQASHGSRPREGINAVLLASEFSLKVQNELLPKLEQRHHEIAGQASINV
CCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
GKIQGGDDPNIVPDTCVVQLDRRWLPDETIESITEEVTELANKVTKNNSKGKYSVRGMRE
EEECCCCCCCCCCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHH
ATAALLNTPHSTDVNSSLVQEALHIVSHVFPDREPGPVAFKGWSDAAQLSNNLGTKGIVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHCCCCCEEEE
GPGNIAQAHATLEYIDVEEIVKSVHVYYELAKKFCT
CCCCHHHHHHHHEEECHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHSNIPIDREEILNLAFELIKIESHKEVDYQENKIAEWIKSKFQKEGIESETVAVDNADG
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
RLNVMAYLPKKSDQISLMFNGHTDTVPPYGMSIDPFKPEIKEGKLYGRGAVDMKGGIAAF
EEEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
MATMFALKRANIELPGGLAFAGVIDEEQSCRGTEYIVKNGPVPDMVVVAEPTDMKVCPAH
HHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCEEEEECCCCCEECCCC
KGMEWIEVTFKGQASHGSRPREGINAVLLASEFSLKVQNELLPKLEQRHHEIAGQASINV
CCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEE
GKIQGGDDPNIVPDTCVVQLDRRWLPDETIESITEEVTELANKVTKNNSKGKYSVRGMRE
EEECCCCCCCCCCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHH
ATAALLNTPHSTDVNSSLVQEALHIVSHVFPDREPGPVAFKGWSDAAQLSNNLGTKGIVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHCCCCCEEEE
GPGNIAQAHATLEYIDVEEIVKSVHVYYELAKKFCT
CCCCHHHHHHHHEEECHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA