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The map label for this gene is ald [H]

Identifier: 188586287

GI number: 188586287

Start: 1746383

End: 1747498

Strand: Reverse

Name: ald [H]

Synonym: Nther_1670

Alternate gene names: 188586287

Gene position: 1747498-1746383 (Counterclockwise)

Preceding gene: 188586288

Following gene: 188586286

Centisome position: 55.2

GC content: 39.43

Gene sequence:

>1116_bases
ATGTTAATAGGTGTGCCAAAGGAGATCAAACCAAATGAAAACAGGGTGGCTTTAACCCCTGCTGGGGCCCAGTCTCTTAT
TCAAGAAGGTCATGAAGTTATGATTGAAACTGAAGCAGGAACTGGTAGTGGTTTTTATGATGAGGCTTACAAGGAAGCAG
GAGCCGAAATTGTTTCAAGTGCTAATGATATTTACGATAGAGCAGAAATGGTTATGAAGGTAAAAGAACCTTTACCTCCA
GAGTACGATCTAATGAAAGAAGACCAAATTATGTTCACATTCTTGCACTTGGCTGCAGAACCTGAATTAACTAAAAAACT
AGTTGAGAGAAATGTAGTTGGTATTGCTTATGAAACCATCGAAGCTCATGATGGCTCCCTACCTCTATTAACTCCTATGA
GTGAAGTAGCAGGCAGAATGTCAACTCAAATGGGTTCAAGATTTTTAGAAAAGACTAATGGTGGTAAAGGCGTATTAATG
GGTGGTGTACCAGGAACCAAACCTGCAAAAGTCACCGTTATTGGTGGAGGTATAGTTGGTACTAATGCTGCTAAAATAGC
TCTTGGCATGGGAGCTGAAGTAACAATTCTTGATATCGATCCTGCAAGACTTCGTTATCTAGACGACCTCTATTATAACC
GCCTTGGAACATTAATGAGTAATAGCCTAAACATAGAAGAATGTGTTAAAGAAAGTGACTTGGTAATAGGTGCTGTTCTA
GTTCCAGGAGCAAAGGCTCCTAAGTTAGTTACAGAAGACATGATTAAGAAAATGCCTGAAGGCTCTGTAGTTGTTGATGT
TGCCATCGATCAGGGTGGATCCATCGAGACTATTGATAGAGTTACAACCCATGATGATCCAGTTTACGAAAAACATGGAG
TACTTCACTATGCAGTAGCTAATATGCCAGGTGCAGTTCCCAGAACTTCAACCATTGCATTGACCAACGTAACCCTACCT
TATGCTATTAAAATTGCAAATAAAGGTTGGAAAAAGGCTGTTGAAGAAGACGAAATGTTGGTACCAGGAGTTAATACTGC
CAATGGTAAGTTAACTTATAAACCTGTAGCTAACTCTTTAGATTTAGAATATACCCCACTTGATGAAATTCTGTAA

Upstream 100 bases:

>100_bases
TCAATTTTAGTTGGCAAAGTTGTACAGATGTGTTATTCTTTTACTAAGGGATAAATATAGTGAATAATTTAACATTAATA
TATAAAGGAGGAATAATGAC

Downstream 100 bases:

>100_bases
ATACAATTTGAACTTACACTTAACCGGGGAAAAAATTCCCCGGTTTTTTAATTTATTGTAATATAATCTTTATTATAAAT
ACATATGTTAATATAGGAAG

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MLIGVPKEIKPNENRVALTPAGAQSLIQEGHEVMIETEAGTGSGFYDEAYKEAGAEIVSSANDIYDRAEMVMKVKEPLPP
EYDLMKEDQIMFTFLHLAAEPELTKKLVERNVVGIAYETIEAHDGSLPLLTPMSEVAGRMSTQMGSRFLEKTNGGKGVLM
GGVPGTKPAKVTVIGGGIVGTNAAKIALGMGAEVTILDIDPARLRYLDDLYYNRLGTLMSNSLNIEECVKESDLVIGAVL
VPGAKAPKLVTEDMIKKMPEGSVVVDVAIDQGGSIETIDRVTTHDDPVYEKHGVLHYAVANMPGAVPRTSTIALTNVTLP
YAIKIANKGWKKAVEEDEMLVPGVNTANGKLTYKPVANSLDLEYTPLDEIL

Sequences:

>Translated_371_residues
MLIGVPKEIKPNENRVALTPAGAQSLIQEGHEVMIETEAGTGSGFYDEAYKEAGAEIVSSANDIYDRAEMVMKVKEPLPP
EYDLMKEDQIMFTFLHLAAEPELTKKLVERNVVGIAYETIEAHDGSLPLLTPMSEVAGRMSTQMGSRFLEKTNGGKGVLM
GGVPGTKPAKVTVIGGGIVGTNAAKIALGMGAEVTILDIDPARLRYLDDLYYNRLGTLMSNSLNIEECVKESDLVIGAVL
VPGAKAPKLVTEDMIKKMPEGSVVVDVAIDQGGSIETIDRVTTHDDPVYEKHGVLHYAVANMPGAVPRTSTIALTNVTLP
YAIKIANKGWKKAVEEDEMLVPGVNTANGKLTYKPVANSLDLEYTPLDEIL
>Mature_371_residues
MLIGVPKEIKPNENRVALTPAGAQSLIQEGHEVMIETEAGTGSGFYDEAYKEAGAEIVSSANDIYDRAEMVMKVKEPLPP
EYDLMKEDQIMFTFLHLAAEPELTKKLVERNVVGIAYETIEAHDGSLPLLTPMSEVAGRMSTQMGSRFLEKTNGGKGVLM
GGVPGTKPAKVTVIGGGIVGTNAAKIALGMGAEVTILDIDPARLRYLDDLYYNRLGTLMSNSLNIEECVKESDLVIGAVL
VPGAKAPKLVTEDMIKKMPEGSVVVDVAIDQGGSIETIDRVTTHDDPVYEKHGVLHYAVANMPGAVPRTSTIALTNVTLP
YAIKIANKGWKKAVEEDEMLVPGVNTANGKLTYKPVANSLDLEYTPLDEIL

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=352, Percent_Identity=32.1022727272727, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI122939153, Length=352, Percent_Identity=32.1022727272727, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1787887, Length=377, Percent_Identity=30.7692307692308, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17550456, Length=374, Percent_Identity=29.4117647058824, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39909; Mature: 39909

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIGVPKEIKPNENRVALTPAGAQSLIQEGHEVMIETEAGTGSGFYDEAYKEAGAEIVSS
CCCCCCCCCCCCCCEEEEECCCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
ANDIYDRAEMVMKVKEPLPPEYDLMKEDQIMFTFLHLAAEPELTKKLVERNVVGIAYETI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEHHHHHCCHHHHHHHHHCCEEEEEEEEE
EAHDGSLPLLTPMSEVAGRMSTQMGSRFLEKTNGGKGVLMGGVPGTKPAKVTVIGGGIVG
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
TNAAKIALGMGAEVTILDIDPARLRYLDDLYYNRLGTLMSNSLNIEECVKESDLVIGAVL
CCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEE
VPGAKAPKLVTEDMIKKMPEGSVVVDVAIDQGGSIETIDRVTTHDDPVYEKHGVLHYAVA
ECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEHHHHCCCCCCCCHHHCCEEEEEEC
NMPGAVPRTSTIALTNVTLPYAIKIANKGWKKAVEEDEMLVPGVNTANGKLTYKPVANSL
CCCCCCCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCEEECCCCCCCCEEEEEECCCCC
DLEYTPLDEIL
CCCCCCHHHCC
>Mature Secondary Structure
MLIGVPKEIKPNENRVALTPAGAQSLIQEGHEVMIETEAGTGSGFYDEAYKEAGAEIVSS
CCCCCCCCCCCCCCEEEEECCCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
ANDIYDRAEMVMKVKEPLPPEYDLMKEDQIMFTFLHLAAEPELTKKLVERNVVGIAYETI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEHHHHHCCHHHHHHHHHCCEEEEEEEEE
EAHDGSLPLLTPMSEVAGRMSTQMGSRFLEKTNGGKGVLMGGVPGTKPAKVTVIGGGIVG
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCEEC
TNAAKIALGMGAEVTILDIDPARLRYLDDLYYNRLGTLMSNSLNIEECVKESDLVIGAVL
CCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEE
VPGAKAPKLVTEDMIKKMPEGSVVVDVAIDQGGSIETIDRVTTHDDPVYEKHGVLHYAVA
ECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEHHHHCCCCCCCCHHHCCEEEEEEC
NMPGAVPRTSTIALTNVTLPYAIKIANKGWKKAVEEDEMLVPGVNTANGKLTYKPVANSL
CCCCCCCCCCEEEEEEECCCEEEEECCCHHHHHCCCCCEEECCCCCCCCEEEEEECCCCC
DLEYTPLDEIL
CCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA