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The map label for this gene is cdd [H]

Identifier: 188585829

GI number: 188585829

Start: 1272572

End: 1272988

Strand: Direct

Name: cdd [H]

Synonym: Nther_1203

Alternate gene names: 188585829

Gene position: 1272572-1272988 (Clockwise)

Preceding gene: 188585828

Following gene: 188585830

Centisome position: 40.2

GC content: 38.85

Gene sequence:

>417_bases
ATGAAGAAAAAAGAAATTAAAGAAGAATTAATTCGTAATTTGTTAAGCCAAGCAGAACAAGCACTACAAAATGCCTATGT
GCCTTATTCAAATTACCCAGTTGGAGCTGCAATGAAAACTAAAGATGGAGAAACTTTTACTGGCTGCAATGTAGAAAATG
CCTCATATGGATTGACGAATTGTGCAGAAAGGACAGCTATATTTAAAGCTGTTAGCCACGGTTATAGAGATATCCAAGTG
ATGGCGGTGGTCTCAAACTCCGAAAGACATGCTTCACCCTGTGGTGCTTGTCGACAAGTGATCTCAGAGTTTAGTGATGA
TGCTATATTAATTCTTGCCAATAAAGATGGTGATTATCAGATTGTGAAAGCAAGTGAACTGTTGCCGGGGGCTTTTACGG
CACAGGAATTAGAGTAA

Upstream 100 bases:

>100_bases
ATCGAAGAGGGATTAAAATTTGTGATTTCAGGTGGGGTAGTAGCACCTCCTGTCGCGGACATGCATGATAAAACTTACAT
AAAGGAGGGACAAGGGGAAT

Downstream 100 bases:

>100_bases
GAGGTAAAATCTATGAAACATCTATTTGTAATAAGAGGAATCTAAAAATCTTTAAATGAGTGAAAAAATATTAAAAGAGA
GGAGAATGCTATATGGAAAT

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MKKKEIKEELIRNLLSQAEQALQNAYVPYSNYPVGAAMKTKDGETFTGCNVENASYGLTNCAERTAIFKAVSHGYRDIQV
MAVVSNSERHASPCGACRQVISEFSDDAILILANKDGDYQIVKASELLPGAFTAQELE

Sequences:

>Translated_138_residues
MKKKEIKEELIRNLLSQAEQALQNAYVPYSNYPVGAAMKTKDGETFTGCNVENASYGLTNCAERTAIFKAVSHGYRDIQV
MAVVSNSERHASPCGACRQVISEFSDDAILILANKDGDYQIVKASELLPGAFTAQELE
>Mature_138_residues
MKKKEIKEELIRNLLSQAEQALQNAYVPYSNYPVGAAMKTKDGETFTGCNVENASYGLTNCAERTAIFKAVSHGYRDIQV
MAVVSNSERHASPCGACRQVISEFSDDAILILANKDGDYQIVKASELLPGAFTAQELE

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=134, Percent_Identity=46.2686567164179, Blast_Score=135, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17540514, Length=125, Percent_Identity=47.2, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17551074, Length=132, Percent_Identity=46.2121212121212, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323274, Length=141, Percent_Identity=37.5886524822695, Blast_Score=91, Evalue=8e-20,
Organism=Drosophila melanogaster, GI19920920, Length=120, Percent_Identity=47.5, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24582741, Length=129, Percent_Identity=41.0852713178295, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24582744, Length=141, Percent_Identity=36.1702127659575, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 15110; Mature: 15110

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKEIKEELIRNLLSQAEQALQNAYVPYSNYPVGAAMKTKDGETFTGCNVENASYGLTN
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEECCCCCCCCCCCHHH
CAERTAIFKAVSHGYRDIQVMAVVSNSERHASPCGACRQVISEFSDDAILILANKDGDYQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEE
IVKASELLPGAFTAQELE
EEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKKEIKEELIRNLLSQAEQALQNAYVPYSNYPVGAAMKTKDGETFTGCNVENASYGLTN
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCEECCCCCCCCCCCHHH
CAERTAIFKAVSHGYRDIQVMAVVSNSERHASPCGACRQVISEFSDDAILILANKDGDYQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCEE
IVKASELLPGAFTAQELE
EEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]