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The map label for this gene is thrC [H]

Identifier: 188585794

GI number: 188585794

Start: 1236299

End: 1237720

Strand: Direct

Name: thrC [H]

Synonym: Nther_1168

Alternate gene names: 188585794

Gene position: 1236299-1237720 (Clockwise)

Preceding gene: 188585793

Following gene: 188585795

Centisome position: 39.05

GC content: 39.94

Gene sequence:

>1422_bases
GTGACGAATAAAAGTTATCAAGCAGTAATGGATAGACGTGGAGAAATCATGAAAAAAGCAGTAGGAATAAACTATAACAA
GTTTGAGCGTTCTCGTGTAGCTTTTGATTACGAATCAATGATGCAAGAAGTAGGTTACAGTGTAGATAAAGTACGAGATA
TTCAAGAAGAAACTGGAATTGGCAACACACCGCTTTTGGAGATGAAAAACTTATCTCAACTAGCTAGAGAACTTGCCCCT
GAAGGAAAAGGTGCTCGCATATTTATCAAGGATGAAGCCTGCAATCCTTCAGGCAGTTTTAAAGCAAGAAGAGGAAGTGT
ATCGGTTTATCATGCAAAAAAACATGGATACAAAGGGGTTATTTCAGCCACTAGTGGAAACTACGGTGCTGCAGTAGCTT
CTCAAGCTGCCATGAGAGGGCTGGATTGTATTGTAGTTCAAGAAGTTTTTGACTCAGAATATAAAGGTCAACCAGAGATT
ATGGAAAAAGGTCGTAAGTGTGAATCCTACGGAGCGGAAGTTGTTCAGTTGACAGTAGGTCCAGAGCTATTTTACAAGTT
CTTGATTCTATTGGAAGAGACAGGCTACTTTAATGCTTCTCTGTATACTCCTTTTGGAATAGCAGGAATAGAGACTCTAG
GATATGAAATTGCAGAACAAACTAGAAATCAAGCAGGTAAAGACCCGGATGCAGTGATAGTTACCAATGCGGGCGGTGGA
AACTTAACTGGAACGGCCAGGGGATTATCAAAGGCCGGATGTAATGACACAGAAATAATTGCAGCCAGTGTTGACTTGAG
TGGTCTTCATAGTGCCAGTGATGTAGATTTTAACCGTAAATCCTTTACAACTGGCCATACTGGCTTTGGTATGCCCTTTA
CAACATGGCCAGATAGATCTGATGTACCAAGAAGTGCTGCACGTCCTTTAAGGCATATGGATCGCTATGTTACTGTATCT
CAAGGTGAAGTGTTCTACATCACAGAAGCCTTGGCGCAACTCGATGGTTTAGAAAGAGGACCAGCTGGAAATACCAGTTT
GGCTGCTGCATTCGATATAGCACAAACCATGGATGAGGACCAAGTGATTGTAGTGCAAGAAACTGAATATACAAGTGCTG
GAAAGCATCCTTATGCTCAATTAACCTTTGCTAAGGAGCAAGGAATAGAAGTGAAAAGAGGAGATCCAGCTAAAGAAGAT
AAGCCCGGTGAACGAATCATTATCCCTGAAACTCCAGAACAAATCAGAACACAAAATGTAGAACTAGATAAATTAAGACA
ATCATATCTCAAAAATGTAGTTAAAAATACAGGTGTGAAAGAACTTGATAATGATGATAAAGATTTTGTAGCAGAGGAAT
TAGGAATTTCTAAAGATAGGGTAGATCAGTTATTGGAAAAAGTTCTGAAAGAGGAGGGTTAA

Upstream 100 bases:

>100_bases
AGGGTATCTCCTGGATACAAACATGACTTTGGTGTACCTCCAACTGAACTTTTATCTATTGGTAAAGAGCTACGAGCTCG
TATGAAGGAGGTGGGTTACG

Downstream 100 bases:

>100_bases
GCATGTCTGACTTTGAAAGTAGAAGACAGCATTTGAAAGAAATGTCAGAAAAAGAACTAGAACAACGATTTTGGGAACTA
GCTGATAAAGCAGTAGACCC

Product: Pyridoxal-5'-phosphate-dependent protein beta subunit

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTNKSYQAVMDRRGEIMKKAVGINYNKFERSRVAFDYESMMQEVGYSVDKVRDIQEETGIGNTPLLEMKNLSQLARELAP
EGKGARIFIKDEACNPSGSFKARRGSVSVYHAKKHGYKGVISATSGNYGAAVASQAAMRGLDCIVVQEVFDSEYKGQPEI
MEKGRKCESYGAEVVQLTVGPELFYKFLILLEETGYFNASLYTPFGIAGIETLGYEIAEQTRNQAGKDPDAVIVTNAGGG
NLTGTARGLSKAGCNDTEIIAASVDLSGLHSASDVDFNRKSFTTGHTGFGMPFTTWPDRSDVPRSAARPLRHMDRYVTVS
QGEVFYITEALAQLDGLERGPAGNTSLAAAFDIAQTMDEDQVIVVQETEYTSAGKHPYAQLTFAKEQGIEVKRGDPAKED
KPGERIIIPETPEQIRTQNVELDKLRQSYLKNVVKNTGVKELDNDDKDFVAEELGISKDRVDQLLEKVLKEEG

Sequences:

>Translated_473_residues
MTNKSYQAVMDRRGEIMKKAVGINYNKFERSRVAFDYESMMQEVGYSVDKVRDIQEETGIGNTPLLEMKNLSQLARELAP
EGKGARIFIKDEACNPSGSFKARRGSVSVYHAKKHGYKGVISATSGNYGAAVASQAAMRGLDCIVVQEVFDSEYKGQPEI
MEKGRKCESYGAEVVQLTVGPELFYKFLILLEETGYFNASLYTPFGIAGIETLGYEIAEQTRNQAGKDPDAVIVTNAGGG
NLTGTARGLSKAGCNDTEIIAASVDLSGLHSASDVDFNRKSFTTGHTGFGMPFTTWPDRSDVPRSAARPLRHMDRYVTVS
QGEVFYITEALAQLDGLERGPAGNTSLAAAFDIAQTMDEDQVIVVQETEYTSAGKHPYAQLTFAKEQGIEVKRGDPAKED
KPGERIIIPETPEQIRTQNVELDKLRQSYLKNVVKNTGVKELDNDDKDFVAEELGISKDRVDQLLEKVLKEEG
>Mature_472_residues
TNKSYQAVMDRRGEIMKKAVGINYNKFERSRVAFDYESMMQEVGYSVDKVRDIQEETGIGNTPLLEMKNLSQLARELAPE
GKGARIFIKDEACNPSGSFKARRGSVSVYHAKKHGYKGVISATSGNYGAAVASQAAMRGLDCIVVQEVFDSEYKGQPEIM
EKGRKCESYGAEVVQLTVGPELFYKFLILLEETGYFNASLYTPFGIAGIETLGYEIAEQTRNQAGKDPDAVIVTNAGGGN
LTGTARGLSKAGCNDTEIIAASVDLSGLHSASDVDFNRKSFTTGHTGFGMPFTTWPDRSDVPRSAARPLRHMDRYVTVSQ
GEVFYITEALAQLDGLERGPAGNTSLAAAFDIAQTMDEDQVIVVQETEYTSAGKHPYAQLTFAKEQGIEVKRGDPAKEDK
PGERIIIPETPEQIRTQNVELDKLRQSYLKNVVKNTGVKELDNDDKDFVAEELGISKDRVDQLLEKVLKEEG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321412, Length=328, Percent_Identity=24.6951219512195, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 51985; Mature: 51854

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKSYQAVMDRRGEIMKKAVGINYNKFERSRVAFDYESMMQEVGYSVDKVRDIQEETGI
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEECHHHHHHHHCCCHHHHHHHHHHCCC
GNTPLLEMKNLSQLARELAPEGKGARIFIKDEACNPSGSFKARRGSVSVYHAKKHGYKGV
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEECCCCEEEEEECCCCCCEE
ISATSGNYGAAVASQAAMRGLDCIVVQEVFDSEYKGQPEIMEKGRKCESYGAEVVQLTVG
EEECCCCCCHHHHHHHHHCCCHHEEHHHHHCCCCCCCHHHHHCCCCHHHCCCEEEEEEEC
PELFYKFLILLEETGYFNASLYTPFGIAGIETLGYEIAEQTRNQAGKDPDAVIVTNAGGG
HHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
NLTGTARGLSKAGCNDTEIIAASVDLSGLHSASDVDFNRKSFTTGHTGFGMPFTTWPDRS
CCCCHHCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DVPRSAARPLRHMDRYVTVSQGEVFYITEALAQLDGLERGPAGNTSLAAAFDIAQTMDED
CCCHHHHHHHHHHHHEEEECCCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
QVIVVQETEYTSAGKHPYAQLTFAKEQGIEVKRGDPAKEDKPGERIIIPETPEQIRTQNV
CEEEEEECCCCCCCCCCCEEEEEEHHCCCEEECCCCCCCCCCCCEEECCCCHHHHHHCCC
ELDKLRQSYLKNVVKNTGVKELDNDDKDFVAEELGISKDRVDQLLEKVLKEEG
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNKSYQAVMDRRGEIMKKAVGINYNKFERSRVAFDYESMMQEVGYSVDKVRDIQEETGI
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEECHHHHHHHHCCCHHHHHHHHHHCCC
GNTPLLEMKNLSQLARELAPEGKGARIFIKDEACNPSGSFKARRGSVSVYHAKKHGYKGV
CCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEECCCCEEEEEECCCCCCEE
ISATSGNYGAAVASQAAMRGLDCIVVQEVFDSEYKGQPEIMEKGRKCESYGAEVVQLTVG
EEECCCCCCHHHHHHHHHCCCHHEEHHHHHCCCCCCCHHHHHCCCCHHHCCCEEEEEEEC
PELFYKFLILLEETGYFNASLYTPFGIAGIETLGYEIAEQTRNQAGKDPDAVIVTNAGGG
HHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
NLTGTARGLSKAGCNDTEIIAASVDLSGLHSASDVDFNRKSFTTGHTGFGMPFTTWPDRS
CCCCHHCCHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DVPRSAARPLRHMDRYVTVSQGEVFYITEALAQLDGLERGPAGNTSLAAAFDIAQTMDED
CCCHHHHHHHHHHHHEEEECCCCEEEHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
QVIVVQETEYTSAGKHPYAQLTFAKEQGIEVKRGDPAKEDKPGERIIIPETPEQIRTQNV
CEEEEEECCCCCCCCCCCEEEEEEHHCCCEEECCCCCCCCCCCCEEECCCCHHHHHHCCC
ELDKLRQSYLKNVVKNTGVKELDNDDKDFVAEELGISKDRVDQLLEKVLKEEG
CHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]