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The map label for this gene is mtaD [H]

Identifier: 188585774

GI number: 188585774

Start: 1213863

End: 1215200

Strand: Direct

Name: mtaD [H]

Synonym: Nther_1148

Alternate gene names: 188585774

Gene position: 1213863-1215200 (Clockwise)

Preceding gene: 188585772

Following gene: 188585775

Centisome position: 38.35

GC content: 36.02

Gene sequence:

>1338_bases
ATGACCACAACTTTAATACAAAATGGCTTGTTAGTTACGATGAATAAAGATAGAGAGATATATACAGGAGATATTCTAAT
AAAAGACAATAAAATATCAAAAATAAGCAGTGAAAGCATTTCAACCAATGTGGACCAAGTGATTGATGCTACAGACAAAG
TTATTATTCCTGGTATGATACAACCCCATGTACATCTTACTCAAACACTTTTTAGAGGCCAAGCCGATGATTTAGAACTT
CTTGATTGGTTAAAAAATAGAATATGGCCTTTAGAGGGGGCTCATACGGATCAATCTAATTATATTTCCGCATATCTGGG
AATTGCAGAACTGATAAAAGGTGGAACAACTTCAATTATCGATATGGAAACAGTCCATCATACTGAAGCTGCCTTAAAAG
CCATTTATGACACAGGTTATCGAGCTGTTACCGGTAAATGTATAATGGACGATGGTGGGGATATCCCTGAAACATTAAGA
GAAACAACTAAAGAATCTATACAAGAAAGTGTTAGATTATTGGAAAAGTGGCACAATCAGGGTAATGGAAGAATTAAGTA
CGGATTCGCACCTAGATTTGCCATATCAAGTAGCCAAAAAGCCCTTTCCCAAGTGAGGGATTTAGCTCGGGAATACGGAG
TATTAATTCATACTCATGCTTCTGAAAATCAATATGAAACCAGCTTAGTTGAAGAAAAAACAGGTTTACGAAATGTTAAA
TTATTTGAAAAACTAGGTTTAACTGGTGAAGATTTAATACTGGCTCATTGTATCTGGCTGAATGAAGAAGAAATGGAGAT
CTTAACAAGTACTGGTACTAAAATTGTACACTGTCCTAGTTCTAATTTAAAACTTGCTTCAGGAATTGCTAAAATACCTG
ATTTGTTAAAAATGGGGGCGAATGTCTCTTTAGCTTCAGATGGTGCACCTTGTAACAATAATATGGATATGTTTGTTGAA
ATGCGAAATGCCGCATTGATACATAAAGCATTTAACTTAGATCCAACAGTTATAAATGCAGAAAAAGTTTTTGAAATGGC
TACTCTAGGTGGTGCCAAGGCCATGGGTATGGAGGAACAGTTAGGTAGTATTGAAGAAGGAAAATTAGCTGATTTGGCAA
TTGTAGATTTGAATGGGGTACATGTGGCTCCACGAACAGGTGAGGACGTGATTGCCAAGTTAGTATATTGTGCTAGGGCA
ACGGATGTAACTACTACGATTATTGACGGAAAAATTGTAATGGAGGAACAACAACTTACCACTATAGATGAAGAAGCGGT
AAAAAAAGAGGCCAATAAACTTTTAGATAATCAAATCAAAAGAGCAGGCTTGGATTAG

Upstream 100 bases:

>100_bases
CCTATCTTTGTAAAGAGATATCATCATTTAGGACTGAGTTGAATAAAATAGTATTATTTGGTATGTTGATTACATATATA
AAGCAAGGGAGCGTGTATTT

Downstream 100 bases:

>100_bases
ATTTATTAATGTAGTTTTAGATGAAGGAAGTTTGAAATAATATTTTTTAAAACCCAGGGCCAAAATAAAACTACACTTTT
AATGGGGGTAAATTATGAGG

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTTTLIQNGLLVTMNKDREIYTGDILIKDNKISKISSESISTNVDQVIDATDKVIIPGMIQPHVHLTQTLFRGQADDLEL
LDWLKNRIWPLEGAHTDQSNYISAYLGIAELIKGGTTSIIDMETVHHTEAALKAIYDTGYRAVTGKCIMDDGGDIPETLR
ETTKESIQESVRLLEKWHNQGNGRIKYGFAPRFAISSSQKALSQVRDLAREYGVLIHTHASENQYETSLVEEKTGLRNVK
LFEKLGLTGEDLILAHCIWLNEEEMEILTSTGTKIVHCPSSNLKLASGIAKIPDLLKMGANVSLASDGAPCNNNMDMFVE
MRNAALIHKAFNLDPTVINAEKVFEMATLGGAKAMGMEEQLGSIEEGKLADLAIVDLNGVHVAPRTGEDVIAKLVYCARA
TDVTTTIIDGKIVMEEQQLTTIDEEAVKKEANKLLDNQIKRAGLD

Sequences:

>Translated_445_residues
MTTTLIQNGLLVTMNKDREIYTGDILIKDNKISKISSESISTNVDQVIDATDKVIIPGMIQPHVHLTQTLFRGQADDLEL
LDWLKNRIWPLEGAHTDQSNYISAYLGIAELIKGGTTSIIDMETVHHTEAALKAIYDTGYRAVTGKCIMDDGGDIPETLR
ETTKESIQESVRLLEKWHNQGNGRIKYGFAPRFAISSSQKALSQVRDLAREYGVLIHTHASENQYETSLVEEKTGLRNVK
LFEKLGLTGEDLILAHCIWLNEEEMEILTSTGTKIVHCPSSNLKLASGIAKIPDLLKMGANVSLASDGAPCNNNMDMFVE
MRNAALIHKAFNLDPTVINAEKVFEMATLGGAKAMGMEEQLGSIEEGKLADLAIVDLNGVHVAPRTGEDVIAKLVYCARA
TDVTTTIIDGKIVMEEQQLTTIDEEAVKKEANKLLDNQIKRAGLD
>Mature_444_residues
TTTLIQNGLLVTMNKDREIYTGDILIKDNKISKISSESISTNVDQVIDATDKVIIPGMIQPHVHLTQTLFRGQADDLELL
DWLKNRIWPLEGAHTDQSNYISAYLGIAELIKGGTTSIIDMETVHHTEAALKAIYDTGYRAVTGKCIMDDGGDIPETLRE
TTKESIQESVRLLEKWHNQGNGRIKYGFAPRFAISSSQKALSQVRDLAREYGVLIHTHASENQYETSLVEEKTGLRNVKL
FEKLGLTGEDLILAHCIWLNEEEMEILTSTGTKIVHCPSSNLKLASGIAKIPDLLKMGANVSLASDGAPCNNNMDMFVEM
RNAALIHKAFNLDPTVINAEKVFEMATLGGAKAMGMEEQLGSIEEGKLADLAIVDLNGVHVAPRTGEDVIAKLVYCARAT
DVTTTIIDGKIVMEEQQLTTIDEEAVKKEANKLLDNQIKRAGLD

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=379, Percent_Identity=28.7598944591029, Blast_Score=158, Evalue=9e-39,
Organism=Escherichia coli, GI1789249, Length=419, Percent_Identity=30.5489260143198, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI87082177, Length=407, Percent_Identity=24.0786240786241, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17540282, Length=389, Percent_Identity=23.1362467866324, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319963, Length=405, Percent_Identity=28.1481481481481, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24643849, Length=387, Percent_Identity=25.3229974160207, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48974; Mature: 48842

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTLIQNGLLVTMNKDREIYTGDILIKDNKISKISSESISTNVDQVIDATDKVIIPGMI
CCCEEEECCEEEEECCCCEEEEEEEEEECCCCCCCCCHHHHCCHHHHHCCCCCEEECCCC
QPHVHLTQTLFRGQADDLELLDWLKNRIWPLEGAHTDQSNYISAYLGIAELIKGGTTSII
CCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
DMETVHHTEAALKAIYDTGYRAVTGKCIMDDGGDIPETLRETTKESIQESVRLLEKWHNQ
EEHHHHHHHHHHHHHHHCCCEEEECEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GNGRIKYGFAPRFAISSSQKALSQVRDLAREYGVLIHTHASENQYETSLVEEKTGLRNVK
CCCEEEECCCCCEECCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCHHH
LFEKLGLTGEDLILAHCIWLNEEEMEILTSTGTKIVHCPSSNLKLASGIAKIPDLLKMGA
HHHHHCCCCCCEEEEEEEECCCHHHHHEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCC
NVSLASDGAPCNNNMDMFVEMRNAALIHKAFNLDPTVINAEKVFEMATLGGAKAMGMEEQ
CEEECCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCEECHHHHHHHHHCCCCHHCCCHHH
LGSIEEGKLADLAIVDLNGVHVAPRTGEDVIAKLVYCARATDVTTTIIDGKIVMEEQQLT
HCCCCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCEEEEECCHHH
TIDEEAVKKEANKLLDNQIKRAGLD
HHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTTLIQNGLLVTMNKDREIYTGDILIKDNKISKISSESISTNVDQVIDATDKVIIPGMI
CCEEEECCEEEEECCCCEEEEEEEEEECCCCCCCCCHHHHCCHHHHHCCCCCEEECCCC
QPHVHLTQTLFRGQADDLELLDWLKNRIWPLEGAHTDQSNYISAYLGIAELIKGGTTSII
CCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
DMETVHHTEAALKAIYDTGYRAVTGKCIMDDGGDIPETLRETTKESIQESVRLLEKWHNQ
EEHHHHHHHHHHHHHHHCCCEEEECEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GNGRIKYGFAPRFAISSSQKALSQVRDLAREYGVLIHTHASENQYETSLVEEKTGLRNVK
CCCEEEECCCCCEECCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCHHH
LFEKLGLTGEDLILAHCIWLNEEEMEILTSTGTKIVHCPSSNLKLASGIAKIPDLLKMGA
HHHHHCCCCCCEEEEEEEECCCHHHHHEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCC
NVSLASDGAPCNNNMDMFVEMRNAALIHKAFNLDPTVINAEKVFEMATLGGAKAMGMEEQ
CEEECCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCEECHHHHHHHHHCCCCHHCCCHHH
LGSIEEGKLADLAIVDLNGVHVAPRTGEDVIAKLVYCARATDVTTTIIDGKIVMEEQQLT
HCCCCCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCEEEEECCHHH
TIDEEAVKKEANKLLDNQIKRAGLD
HHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA