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The map label for this gene is yhdN [H]

Identifier: 188585690

GI number: 188585690

Start: 1120199

End: 1121362

Strand: Direct

Name: yhdN [H]

Synonym: Nther_1063

Alternate gene names: 188585690

Gene position: 1120199-1121362 (Clockwise)

Preceding gene: 188585689

Following gene: 188585691

Centisome position: 35.39

GC content: 30.33

Gene sequence:

>1164_bases
ATGAATTATCGAAAACATAGAGATTTTGAACTTTCGGAAATAGGTATTGGTACTTATTCATTAAGTGGTGTTTATGGAAA
TGTAGATATTAATATGTTCAAGGAAATGCTTAAGAGGGCTTATGATTTAGGGATAAATTTTTTTGATACGGCAGAAGCAT
ATGATGAAGCCGAAGAAATTTTAGGAGATGCTGTTAAAGATTTTCGAAAGGATATTTATATTTCAAGTAAGGTGGGGGTC
AAAGGGGGGAATAAACCAAACCTCTCTAAAGAGTATATAAAGTCAGCTTGCGAAGAAAGCTTGAGAAAATTACAAACTGA
TTATATAGATATTTACCATGTACACTTTAATGATCCTTATACTCCTGTTGAAGAAACTATTAGTGCATTAGAACAGTTAG
TGAAAGAAGGTAAAATAAGAAAATATGGTCTGGGACATCTAAGTAAAGATGTATTCAAAAAATATTTTAGTGAAGGAAAT
GTTTTTTCCGTTATTATGGAAATGAATCCACTTTATTATGACAAAGAGGTACTCACACTATGCCGAAAGTATAATGTAGC
TATAATCCCTTTTAGCGTAACAGGGAGAGGACTTTTAACAGATGAGTTTTGGAACAAAGATGATTATGAGTTTGAGTCGG
GAGATATAAGGAATATAGACCCTCAATTCTTTAAAGATAATTTTGAATTTGCTAAAAAAGTGAGTGGTAAGTTTAAAAAA
ATTGCAGATAAGTATAATAAAACATTGGTTCAAGTGACAATTTCTTGGATATTAAATCAAAATGGAGTAGTTAGTGCGTT
AACAGGACCATCAAAGATTACCCATTTGGAAGAAAATATTGGTGGTAGTGGTTGGCAATTAAAATCAGAAGATTTAGCTG
AACTTGATGATTTTCTTAGAGCAGAACAAAAAAATTTAGAGGTTAAACAAAAAGAAACTATAAATAATATACTAGGGAAA
TCTTTGCCAAAAGATGTTGAACAGTCTTTTGTAGATTTAATATATGTAATTGAAACTTCAATAAAGCTGAAATTAATAAC
TGAGAAGGACATACTGCCCATTTTTTACGATTTGTTTGCCCTAAAGTCAAACCTTGCCAAAGATGATATTTCAGAGTTGG
AACAGATAAAATTTAAATTACAAAATTTAATAGAAACAAAATAA

Upstream 100 bases:

>100_bases
AGGAAAGAAATTGAATAAAGTGAGATATATAAAAAAATTGATATGAAACAACGGAAACGTTAGGATCAAAGCTTCTGAAT
TCCAAGGAGGTTTGTTGGTC

Downstream 100 bases:

>100_bases
AGAAAAAATAACAGGTATGTAGCAAATAAGTGTTATATGCCAGATTAGTTAGTATAGAAAGGGAAAGGTGACTTGAAAAT
GAGAATTTTGACTTTATTAT

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MNYRKHRDFELSEIGIGTYSLSGVYGNVDINMFKEMLKRAYDLGINFFDTAEAYDEAEEILGDAVKDFRKDIYISSKVGV
KGGNKPNLSKEYIKSACEESLRKLQTDYIDIYHVHFNDPYTPVEETISALEQLVKEGKIRKYGLGHLSKDVFKKYFSEGN
VFSVIMEMNPLYYDKEVLTLCRKYNVAIIPFSVTGRGLLTDEFWNKDDYEFESGDIRNIDPQFFKDNFEFAKKVSGKFKK
IADKYNKTLVQVTISWILNQNGVVSALTGPSKITHLEENIGGSGWQLKSEDLAELDDFLRAEQKNLEVKQKETINNILGK
SLPKDVEQSFVDLIYVIETSIKLKLITEKDILPIFYDLFALKSNLAKDDISELEQIKFKLQNLIETK

Sequences:

>Translated_387_residues
MNYRKHRDFELSEIGIGTYSLSGVYGNVDINMFKEMLKRAYDLGINFFDTAEAYDEAEEILGDAVKDFRKDIYISSKVGV
KGGNKPNLSKEYIKSACEESLRKLQTDYIDIYHVHFNDPYTPVEETISALEQLVKEGKIRKYGLGHLSKDVFKKYFSEGN
VFSVIMEMNPLYYDKEVLTLCRKYNVAIIPFSVTGRGLLTDEFWNKDDYEFESGDIRNIDPQFFKDNFEFAKKVSGKFKK
IADKYNKTLVQVTISWILNQNGVVSALTGPSKITHLEENIGGSGWQLKSEDLAELDDFLRAEQKNLEVKQKETINNILGK
SLPKDVEQSFVDLIYVIETSIKLKLITEKDILPIFYDLFALKSNLAKDDISELEQIKFKLQNLIETK
>Mature_387_residues
MNYRKHRDFELSEIGIGTYSLSGVYGNVDINMFKEMLKRAYDLGINFFDTAEAYDEAEEILGDAVKDFRKDIYISSKVGV
KGGNKPNLSKEYIKSACEESLRKLQTDYIDIYHVHFNDPYTPVEETISALEQLVKEGKIRKYGLGHLSKDVFKKYFSEGN
VFSVIMEMNPLYYDKEVLTLCRKYNVAIIPFSVTGRGLLTDEFWNKDDYEFESGDIRNIDPQFFKDNFEFAKKVSGKFKK
IADKYNKTLVQVTISWILNQNGVVSALTGPSKITHLEENIGGSGWQLKSEDLAELDDFLRAEQKNLEVKQKETINNILGK
SLPKDVEQSFVDLIYVIETSIKLKLITEKDILPIFYDLFALKSNLAKDDISELEQIKFKLQNLIETK

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI27436969, Length=297, Percent_Identity=29.96632996633, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4504825, Length=297, Percent_Identity=29.96632996633, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI27436964, Length=328, Percent_Identity=27.7439024390244, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI27436962, Length=328, Percent_Identity=27.7439024390244, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI27436966, Length=326, Percent_Identity=27.6073619631902, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI27436971, Length=333, Percent_Identity=25.8258258258258, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI87081735, Length=276, Percent_Identity=32.2463768115942, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788070, Length=321, Percent_Identity=27.1028037383178, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1788081, Length=299, Percent_Identity=26.0869565217391, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789375, Length=297, Percent_Identity=25.5892255892256, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786400, Length=268, Percent_Identity=25.3731343283582, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789199, Length=341, Percent_Identity=24.9266862170088, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212645785, Length=158, Percent_Identity=36.7088607594937, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17564128, Length=322, Percent_Identity=23.9130434782609, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17550248, Length=309, Percent_Identity=22.9773462783171, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323998, Length=309, Percent_Identity=25.5663430420712, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319958, Length=298, Percent_Identity=25.1677852348993, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6325169, Length=307, Percent_Identity=21.1726384364821, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322615, Length=260, Percent_Identity=23.8461538461538, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319951, Length=189, Percent_Identity=27.5132275132275, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24657054, Length=332, Percent_Identity=25, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640980, Length=307, Percent_Identity=23.4527687296417, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45549126, Length=307, Percent_Identity=23.4527687296417, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646155, Length=218, Percent_Identity=29.8165137614679, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24663317, Length=327, Percent_Identity=22.6299694189602, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 44545; Mature: 44545

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYRKHRDFELSEIGIGTYSLSGVYGNVDINMFKEMLKRAYDLGINFFDTAEAYDEAEEI
CCCCCCCCCCHHHCCCCEEEECCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGDAVKDFRKDIYISSKVGVKGGNKPNLSKEYIKSACEESLRKLQTDYIDIYHVHFNDPY
HHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCC
TPVEETISALEQLVKEGKIRKYGLGHLSKDVFKKYFSEGNVFSVIMEMNPLYYDKEVLTL
CCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCEECHHHHHH
CRKYNVAIIPFSVTGRGLLTDEFWNKDDYEFESGDIRNIDPQFFKDNFEFAKKVSGKFKK
HHHCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IADKYNKTLVQVTISWILNQNGVVSALTGPSKITHLEENIGGSGWQLKSEDLAELDDFLR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHH
AEQKNLEVKQKETINNILGKSLPKDVEQSFVDLIYVIETSIKLKLITEKDILPIFYDLFA
HHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHH
LKSNLAKDDISELEQIKFKLQNLIETK
HHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYRKHRDFELSEIGIGTYSLSGVYGNVDINMFKEMLKRAYDLGINFFDTAEAYDEAEEI
CCCCCCCCCCHHHCCCCEEEECCEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LGDAVKDFRKDIYISSKVGVKGGNKPNLSKEYIKSACEESLRKLQTDYIDIYHVHFNDPY
HHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCC
TPVEETISALEQLVKEGKIRKYGLGHLSKDVFKKYFSEGNVFSVIMEMNPLYYDKEVLTL
CCHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHCCCCEEEEEEECCCCEECHHHHHH
CRKYNVAIIPFSVTGRGLLTDEFWNKDDYEFESGDIRNIDPQFFKDNFEFAKKVSGKFKK
HHHCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IADKYNKTLVQVTISWILNQNGVVSALTGPSKITHLEENIGGSGWQLKSEDLAELDDFLR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHH
AEQKNLEVKQKETINNILGKSLPKDVEQSFVDLIYVIETSIKLKLITEKDILPIFYDLFA
HHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHH
LKSNLAKDDISELEQIKFKLQNLIETK
HHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]