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The map label for this gene is hbd [H]

Identifier: 188585645

GI number: 188585645

Start: 1086377

End: 1087372

Strand: Direct

Name: hbd [H]

Synonym: Nther_1018

Alternate gene names: 188585645

Gene position: 1086377-1087372 (Clockwise)

Preceding gene: 188585644

Following gene: 188585646

Centisome position: 34.32

GC content: 41.16

Gene sequence:

>996_bases
ATGTCCGCAAATAAATTAGCAGTAGTTGGAACAGGAGTAATTGGTAACGGATGGATTGCTAGAGGATTAGCAAAAGGATA
TGATGTGATAGCTTATGATCCGGCTGAAGGGGCAAAAGAGCAAACTCATAAAGCTATCGAAAATGCCTGGCCTGCATTGG
AAAAAATTGGACTAGCCCCAGGTGCATCAAAGGAGAGATTGAAATTTGTAGATGATTTGCCTTCTGCAGTGACAGGAGCG
GATTTGATTCAGGAAAATGTTCCTGAGAGAGAGCAGCTTAAAAGACAAGTTTTAGCTGAAATAGATGAACATGCTCATTC
AGAAGCTATTATAGCTTCTAGTACTTCTGGGATTATTCCTAGTACTTTGCAAAAAGATTGTCGGCATAATCCTGAACGTG
TTATTGTAGCCCATCCTTTTAATCCCGTTCATTTATTGCCATTGGTTGAGCTAGTAGGTGGTGAGCAAACTAGTTCAGTC
GTAATTAATCAAGCTTATGAATTTTATCAACGGTTGGAAATGCGTCCATTGGTAGTAAAACAAGAAATTGAAGGTCATAT
AGCTGACCGTCTGATGGAAGCATTATGGCGCGAAGCTCTTCATATCGTCAATGACGGTGTGGCTACAACTAAAGATGTAG
ATGATGCTGTAGTATACGGGCCCGGTTTGCGATGGGCATTGATGGGCACGTTTATGACATTTCACTTGGCAGGAGGAGAA
GGTGGAATGAGACATATGTTGCATCAATTTGGACCTGCCTTAAAAAAACCTTGGACTAAACTTGAAGCTCCGGAATTGAC
AGATGAATTAGCTGATAGAGTTATCAACGGTTGTGAAAGTCAAGCTGGTGATACCTCTATTAAAGAATGGGAACGACAAA
GGGATGAATTTTTAGTAAAACTTCTTGACCTGGTTAAAGAGTATTGGCCAGAGCAAGAGGACAAGCCCTTAGACGGTCAA
AATGAGCCATACGACAGTAACTCTATGTCAGGTTAG

Upstream 100 bases:

>100_bases
GGCCACTTCGGAATGGAACCCATGACACCAGCAGAAGCTAGAGAGCATTATAATTTACTGGATCCAAAATAAATTCAATA
AAGAAAGCAGGTGATTACAA

Downstream 100 bases:

>100_bases
GGGGAGTAAACATGCCAATTTCCAATTACGGTGAGTGTCCCATTGTAACTACTGAAGTTAAACCCAAGTGGGTGGATTAC
AATGGCCATATGAATGATGC

Product: 3-hydroxyacyl-CoA dehydrogenase NAD-binding

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSANKLAVVGTGVIGNGWIARGLAKGYDVIAYDPAEGAKEQTHKAIENAWPALEKIGLAPGASKERLKFVDDLPSAVTGA
DLIQENVPEREQLKRQVLAEIDEHAHSEAIIASSTSGIIPSTLQKDCRHNPERVIVAHPFNPVHLLPLVELVGGEQTSSV
VINQAYEFYQRLEMRPLVVKQEIEGHIADRLMEALWREALHIVNDGVATTKDVDDAVVYGPGLRWALMGTFMTFHLAGGE
GGMRHMLHQFGPALKKPWTKLEAPELTDELADRVINGCESQAGDTSIKEWERQRDEFLVKLLDLVKEYWPEQEDKPLDGQ
NEPYDSNSMSG

Sequences:

>Translated_331_residues
MSANKLAVVGTGVIGNGWIARGLAKGYDVIAYDPAEGAKEQTHKAIENAWPALEKIGLAPGASKERLKFVDDLPSAVTGA
DLIQENVPEREQLKRQVLAEIDEHAHSEAIIASSTSGIIPSTLQKDCRHNPERVIVAHPFNPVHLLPLVELVGGEQTSSV
VINQAYEFYQRLEMRPLVVKQEIEGHIADRLMEALWREALHIVNDGVATTKDVDDAVVYGPGLRWALMGTFMTFHLAGGE
GGMRHMLHQFGPALKKPWTKLEAPELTDELADRVINGCESQAGDTSIKEWERQRDEFLVKLLDLVKEYWPEQEDKPLDGQ
NEPYDSNSMSG
>Mature_330_residues
SANKLAVVGTGVIGNGWIARGLAKGYDVIAYDPAEGAKEQTHKAIENAWPALEKIGLAPGASKERLKFVDDLPSAVTGAD
LIQENVPEREQLKRQVLAEIDEHAHSEAIIASSTSGIIPSTLQKDCRHNPERVIVAHPFNPVHLLPLVELVGGEQTSSVV
INQAYEFYQRLEMRPLVVKQEIEGHIADRLMEALWREALHIVNDGVATTKDVDDAVVYGPGLRWALMGTFMTFHLAGGEG
GMRHMLHQFGPALKKPWTKLEAPELTDELADRVINGCESQAGDTSIKEWERQRDEFLVKLLDLVKEYWPEQEDKPLDGQN
EPYDSNSMSG

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=328, Percent_Identity=30.7926829268293, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI296179429, Length=230, Percent_Identity=28.695652173913, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI296179427, Length=237, Percent_Identity=27.4261603375527, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1787661, Length=329, Percent_Identity=25.2279635258359, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790281, Length=126, Percent_Identity=30.1587301587302, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788682, Length=138, Percent_Identity=30.4347826086957, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193203623, Length=288, Percent_Identity=30.9027777777778, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI115533614, Length=289, Percent_Identity=30.7958477508651, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17553560, Length=227, Percent_Identity=27.3127753303965, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17549919, Length=228, Percent_Identity=25.8771929824561, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17563036, Length=227, Percent_Identity=27.3127753303965, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129993, Length=316, Percent_Identity=30.0632911392405, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45549573, Length=290, Percent_Identity=29.6551724137931, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24583077, Length=213, Percent_Identity=27.2300469483568, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24583079, Length=213, Percent_Identity=27.2300469483568, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19921000, Length=213, Percent_Identity=27.2300469483568, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 36640; Mature: 36509

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANKLAVVGTGVIGNGWIARGLAKGYDVIAYDPAEGAKEQTHKAIENAWPALEKIGLAP
CCCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
GASKERLKFVDDLPSAVTGADLIQENVPEREQLKRQVLAEIDEHAHSEAIIASSTSGIIP
CCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCH
STLQKDCRHNPERVIVAHPFNPVHLLPLVELVGGEQTSSVVINQAYEFYQRLEMRPLVVK
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHH
QEIEGHIADRLMEALWREALHIVNDGVATTKDVDDAVVYGPGLRWALMGTFMTFHLAGGE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHEEECCC
GGMRHMLHQFGPALKKPWTKLEAPELTDELADRVINGCESQAGDTSIKEWERQRDEFLVK
CHHHHHHHHHCHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LLDLVKEYWPEQEDKPLDGQNEPYDSNSMSG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SANKLAVVGTGVIGNGWIARGLAKGYDVIAYDPAEGAKEQTHKAIENAWPALEKIGLAP
CCCCEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
GASKERLKFVDDLPSAVTGADLIQENVPEREQLKRQVLAEIDEHAHSEAIIASSTSGIIP
CCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCH
STLQKDCRHNPERVIVAHPFNPVHLLPLVELVGGEQTSSVVINQAYEFYQRLEMRPLVVK
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHH
QEIEGHIADRLMEALWREALHIVNDGVATTKDVDDAVVYGPGLRWALMGTFMTFHLAGGE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHEEECCC
GGMRHMLHQFGPALKKPWTKLEAPELTDELADRVINGCESQAGDTSIKEWERQRDEFLVK
CHHHHHHHHHCHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LLDLVKEYWPEQEDKPLDGQNEPYDSNSMSG
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA