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The map label for this gene is thlA [H]

Identifier: 188527463

GI number: 188527463

Start: 649388

End: 650563

Strand: Reverse

Name: thlA [H]

Synonym: HPSH_03405

Alternate gene names: 188527463

Gene position: 650563-649388 (Counterclockwise)

Preceding gene: 188527464

Following gene: 188527462

Centisome position: 40.44

GC content: 46.26

Gene sequence:

>1176_bases
ATGAATGAAGTGGTTGTAGTGGCGGCAAAACGAAGTGCTGTGGGAAGTTTTTTAGGCTCTCTAAAGAGCGTGGGCGCTAG
AGAAATGGGCGCTGTCGTGCTTAAAGACGCTTTGAAGGCGAGCGGTCTTAAGCCTAGCGATGTGGATTCTGTCATTTTAG
GCAATGTTTTATCCGCCGGTTTGGGTCAAAATATCGCCAGACAGATCCAACTGGACGCTGGCATACCGAATGACAGGAAC
GCTTTTAGCGTCAATATGGTTTGTGGATCGTCTATGAAAGCCATTCAATTAGCGCATGACAGCATCATGCTTGGGCGCGA
TGAGGTGGTGGTGTGCGGTGGCGTGGAAAACATGAGTGCAGCCCCCTATTTGTCGTTTGACATGCGAGATGGGAAAAGAA
TGGGGAATGCGAACATGATAGACTCCATGATTCATGACGGATTGTGGGATGCGTTCAATGATTACCACATGGGGATCACC
GCTGATAATGTCGCTCAAGCATACCACATCAGCCGAGAAGAGCAAGATGCTTTCGCGCTCCAATCGCAACTCAAAGCAAG
AGCCGCCATTAATGCAGGGAAATTCCAAGAAGAAATCACGCCTATTGAAATAGCGAATAAAAAAGGCGTGGTTGTTTTTA
AAGAAGACGAATACCCTAGAGAAACGACGCTAGAATCCCTTGCAAAGCTCAAACCCGCTTTCAAAAAAGACGGATCGGTA
ACGGCAGGAAATTCATCAGGGATCAATGATGGCGCGAGTATTATCATTTTATGCAGCGCTCAAAAAGTGCAAAAATTGGG
GTTAAAAACAATGGCAACTATCAAGGGGTTTGGTTTGGGTGGTTGCAGTCCGGATATAATGGGGATATGCCCTAGTATCG
CTATTAAAAACAATCTTAAAAATGTCAAAATGAATCTCAACGACATCGATCTTTTTGAACTCAATGAAGCCTTCGCCGCG
CAAAGCATAGCCGTGTTAAAAGAGCTTGAATTAAACCCCAATATCGTGAATGTGAATGGAGGCGCGATAGCCATTGGCCA
CCCTATTGGTGCAAGCGGCGCTAGGATTTTGGTAACTTTATTGCATGAAATGAAAAGAAGCGGTCATGGCGTGGGCTGCG
CGTCATTGTGTGTGGGCGGCGGACAAGGGCTATCAGTGGTAGTGGAACAAAAATAA

Upstream 100 bases:

>100_bases
CTCAATCTAAAACAAAACCTAAAACAAAATCAAACCTGTTAGGGTGTCAATCACCTAAAAGTGATACTATGGATTAATAA
ATCAACTTAAAGGTAAAGAC

Downstream 100 bases:

>100_bases
GGAGAATGAGATGAACAAGGTTATAACCGATTTAGACAAAGCATTGAGCGCTTTAAAAGACGGGGATACTATTTTAGTGG
GCGGTTTTGGGCTGTGCGGG

Product: acetyl coenzyme A acetyltransferase (thiolase) (fadA)

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNEVVVVAAKRSAVGSFLGSLKSVGAREMGAVVLKDALKASGLKPSDVDSVILGNVLSAGLGQNIARQIQLDAGIPNDRN
AFSVNMVCGSSMKAIQLAHDSIMLGRDEVVVCGGVENMSAAPYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGIT
ADNVAQAYHISREEQDAFALQSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRETTLESLAKLKPAFKKDGSV
TAGNSSGINDGASIIILCSAQKVQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLKNVKMNLNDIDLFELNEAFAA
QSIAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTLLHEMKRSGHGVGCASLCVGGGQGLSVVVEQK

Sequences:

>Translated_391_residues
MNEVVVVAAKRSAVGSFLGSLKSVGAREMGAVVLKDALKASGLKPSDVDSVILGNVLSAGLGQNIARQIQLDAGIPNDRN
AFSVNMVCGSSMKAIQLAHDSIMLGRDEVVVCGGVENMSAAPYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGIT
ADNVAQAYHISREEQDAFALQSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRETTLESLAKLKPAFKKDGSV
TAGNSSGINDGASIIILCSAQKVQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLKNVKMNLNDIDLFELNEAFAA
QSIAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTLLHEMKRSGHGVGCASLCVGGGQGLSVVVEQK
>Mature_391_residues
MNEVVVVAAKRSAVGSFLGSLKSVGAREMGAVVLKDALKASGLKPSDVDSVILGNVLSAGLGQNIARQIQLDAGIPNDRN
AFSVNMVCGSSMKAIQLAHDSIMLGRDEVVVCGGVENMSAAPYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGIT
ADNVAQAYHISREEQDAFALQSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRETTLESLAKLKPAFKKDGSV
TAGNSSGINDGASIIILCSAQKVQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLKNVKMNLNDIDLFELNEAFAA
QSIAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTLLHEMKRSGHGVGCASLCVGGGQGLSVVVEQK

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=47.5826972010178, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=45.4081632653061, Blast_Score=332, Evalue=2e-91,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=40.4580152671756, Blast_Score=286, Evalue=2e-77,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=38.9873417721519, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=30.6603773584906, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=28.5347043701799, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=49.3606138107417, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=49.7448979591837, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=38.3863080684597, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=40.1496259351621, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI1788683, Length=414, Percent_Identity=28.743961352657, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=43.298969072165, Blast_Score=321, Evalue=4e-88,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=37.8516624040921, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=36.3636363636364, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=29.8469387755102, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=28.6384976525822, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=393, Percent_Identity=43.2569974554707, Blast_Score=295, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=35.3535353535354, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=48.5933503836317, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=41.7948717948718, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=43.1876606683805, Blast_Score=301, Evalue=5e-82,
Organism=Drosophila melanogaster, GI17137578, Length=401, Percent_Identity=32.6683291770574, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41151; Mature: 41151

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVVVVAAKRSAVGSFLGSLKSVGAREMGAVVLKDALKASGLKPSDVDSVILGNVLSAG
CCCEEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LGQNIARQIQLDAGIPNDRNAFSVNMVCGSSMKAIQLAHDSIMLGRDEVVVCGGVENMSA
HCHHHHHHEEECCCCCCCCCEEEEEEEECCCCCEEEEECCCEEECCCCEEEECCCCCCCC
APYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGITADNVAQAYHISREEQDAFAL
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHH
QSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRETTLESLAKLKPAFKKDGSV
HHHHHHHHHHCCCHHHHHCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHCHHHHCCCCE
TAGNSSGINDGASIIILCSAQKVQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLK
ECCCCCCCCCCCEEEEEECHHHHHHHCHHHHHHHCCCCCCCCCCHHHHCCCCHHHHCCCC
NVKMNLNDIDLFELNEAFAAQSIAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTL
EEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHHHH
LHEMKRSGHGVGCASLCVGGGQGLSVVVEQK
HHHHHHCCCCCCHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MNEVVVVAAKRSAVGSFLGSLKSVGAREMGAVVLKDALKASGLKPSDVDSVILGNVLSAG
CCCEEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LGQNIARQIQLDAGIPNDRNAFSVNMVCGSSMKAIQLAHDSIMLGRDEVVVCGGVENMSA
HCHHHHHHEEECCCCCCCCCEEEEEEEECCCCCEEEEECCCEEECCCCEEEECCCCCCCC
APYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGITADNVAQAYHISREEQDAFAL
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHH
QSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRETTLESLAKLKPAFKKDGSV
HHHHHHHHHHCCCHHHHHCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHCHHHHCCCCE
TAGNSSGINDGASIIILCSAQKVQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLK
ECCCCCCCCCCCEEEEEECHHHHHHHCHHHHHHHCCCCCCCCCCHHHHCCCCHHHHCCCC
NVKMNLNDIDLFELNEAFAAQSIAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTL
EEEECCCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHHHH
LHEMKRSGHGVGCASLCVGGGQGLSVVVEQK
HHHHHHCCCCCCHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]