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The map label for this gene is atoC [H]

Identifier: 188527450

GI number: 188527450

Start: 634532

End: 635677

Strand: Reverse

Name: atoC [H]

Synonym: HPSH_03340

Alternate gene names: 188527450

Gene position: 635677-634532 (Counterclockwise)

Preceding gene: 188527451

Following gene: 188527449

Centisome position: 39.52

GC content: 40.14

Gene sequence:

>1146_bases
ATGAAAATCGCCATTGTAGAAGACGATATTAACATGCGTAAAAGCCTGGAGCTTTTTTTTGAGCTTCAAGACGATTTAGA
GATTGTGAGTTTTAAAAACCCTAAAGACGCTTTAGCCAAGTTAGATGAAAGCTTTGATTTAGTCATCACGGATATTAACA
TGCCCCATATGGACGGCTTGGAATTTTTACGCCTTTTAGAAGGCAAGTATGAATCCATTGTGATTACCGGTAATGCGACC
TTAAATAAAGCCATTGATTCCATTCGTTTAGGCGTGAAAGACTTTTTCCAAAAGCCTTTTAAACCAGAATTGCTTTTAGA
ATCCATCTATCGCACCAAAAAAGTTTTAGAATTTCAAAAAAAACACCCTTTAGAAAAACCTTTAAAAAAACCACACAAAC
ACAGCTTTTTAGCCGCTTCAAAAGCGTTAGAAGAGAGCAAACGGCAAGCCTTAAAAGTCGCAAGCACGGACGCTAATGTC
ATGCTATTAGGCGAAAGCGGGGTGGGTAAGGAGGTTTTTGCTCATTTCATCCACCAGCATTCGCAACGCTCCAAACACCC
TTTTATAGCAATCAACATGTCCGCTATCCCAGAGCATTTATTAGAAAGCGAGCTTTTTGGGTATCAAAAAGGGGCGTTCA
CGGACGCCACAGCTCCTAAAATGGGGCTTTTTGAAAGCGCTCATAAAGGCACGATCTTTTTAGATGAAATCGCTGAAATG
CCCATTCAATTGCAAAGCAAACTTTTAAGAGTGGTTCAAGAAAAAGAAATCACGCGCCTTGGGGATAATAAGAGCGTTAA
AATTGATGTTCGTTTCATTTCTGCTACCAACGCTAACATGAAAGAAAAAATCGCTGCGAAAGAATTTAGAGAGGATCTGT
TCTTCCGCTTGCAAATTGTGCCTATAGTTATTGCGCCTTTAAGAGAGAGGGTAGAAGAGATTTTACCCATTGCTGAAATC
AAGCTTAAAGAAGTGTGCGATGCGTATCATTTGGGGCCAAAATCCTTTTCAAAAAACGCCGCAAAACGCCTTTTAGAATA
TTCTTGGCATGGGAATGTGCGAGAGCTTTTAGGCGTGGTGGAGAGAGCGGCGATTTTAAGCGAAGGAGCAGAAATCCAAG
AAAAAGATTTGTTTTTAGAAAGGTAG

Upstream 100 bases:

>100_bases
GCACCACTACCACAAGCATTCTTAACCTCAAAGCCTTAAGCGTTAGAGCGAGTTTGGTGGGAGATGCGCTATTTTTAGAT
ATTTTTAGAAAGGAAGAAGA

Downstream 100 bases:

>100_bases
TATCATTTCATGGAGTTATTAAAAATCATTTATTAGAAACGCTTAATTTGGGATTTTTGCTTAAAGGGATTTAAAGATGA
GGGTTCAATTAATGGGGAGT

Product: transcriptional activator of flagella proteins

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MKIAIVEDDINMRKSLELFFELQDDLEIVSFKNPKDALAKLDESFDLVITDINMPHMDGLEFLRLLEGKYESIVITGNAT
LNKAIDSIRLGVKDFFQKPFKPELLLESIYRTKKVLEFQKKHPLEKPLKKPHKHSFLAASKALEESKRQALKVASTDANV
MLLGESGVGKEVFAHFIHQHSQRSKHPFIAINMSAIPEHLLESELFGYQKGAFTDATAPKMGLFESAHKGTIFLDEIAEM
PIQLQSKLLRVVQEKEITRLGDNKSVKIDVRFISATNANMKEKIAAKEFREDLFFRLQIVPIVIAPLRERVEEILPIAEI
KLKEVCDAYHLGPKSFSKNAAKRLLEYSWHGNVRELLGVVERAAILSEGAEIQEKDLFLER

Sequences:

>Translated_381_residues
MKIAIVEDDINMRKSLELFFELQDDLEIVSFKNPKDALAKLDESFDLVITDINMPHMDGLEFLRLLEGKYESIVITGNAT
LNKAIDSIRLGVKDFFQKPFKPELLLESIYRTKKVLEFQKKHPLEKPLKKPHKHSFLAASKALEESKRQALKVASTDANV
MLLGESGVGKEVFAHFIHQHSQRSKHPFIAINMSAIPEHLLESELFGYQKGAFTDATAPKMGLFESAHKGTIFLDEIAEM
PIQLQSKLLRVVQEKEITRLGDNKSVKIDVRFISATNANMKEKIAAKEFREDLFFRLQIVPIVIAPLRERVEEILPIAEI
KLKEVCDAYHLGPKSFSKNAAKRLLEYSWHGNVRELLGVVERAAILSEGAEIQEKDLFLER
>Mature_381_residues
MKIAIVEDDINMRKSLELFFELQDDLEIVSFKNPKDALAKLDESFDLVITDINMPHMDGLEFLRLLEGKYESIVITGNAT
LNKAIDSIRLGVKDFFQKPFKPELLLESIYRTKKVLEFQKKHPLEKPLKKPHKHSFLAASKALEESKRQALKVASTDANV
MLLGESGVGKEVFAHFIHQHSQRSKHPFIAINMSAIPEHLLESELFGYQKGAFTDATAPKMGLFESAHKGTIFLDEIAEM
PIQLQSKLLRVVQEKEITRLGDNKSVKIDVRFISATNANMKEKIAAKEFREDLFFRLQIVPIVIAPLRERVEEILPIAEI
KLKEVCDAYHLGPKSFSKNAAKRLLEYSWHGNVRELLGVVERAAILSEGAEIQEKDLFLER

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=383, Percent_Identity=38.6422976501305, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1788905, Length=351, Percent_Identity=38.1766381766382, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1790299, Length=380, Percent_Identity=34.7368421052632, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790437, Length=383, Percent_Identity=33.9425587467363, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI87082117, Length=230, Percent_Identity=44.7826086956522, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1789087, Length=238, Percent_Identity=43.2773109243698, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1789233, Length=254, Percent_Identity=41.7322834645669, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1786524, Length=243, Percent_Identity=44.4444444444444, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87082152, Length=253, Percent_Identity=39.9209486166008, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI87081872, Length=234, Percent_Identity=40.1709401709402, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1787583, Length=244, Percent_Identity=35.2459016393443, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI87081858, Length=218, Percent_Identity=33.9449541284404, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1789828, Length=244, Percent_Identity=30.327868852459, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 43387; Mature: 43387

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIVEDDINMRKSLELFFELQDDLEIVSFKNPKDALAKLDESFDLVITDINMPHMDGL
CEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEECCCCCCCHH
EFLRLLEGKYESIVITGNATLNKAIDSIRLGVKDFFQKPFKPELLLESIYRTKKVLEFQK
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KHPLEKPLKKPHKHSFLAASKALEESKRQALKVASTDANVMLLGESGVGKEVFAHFIHQH
HCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
SQRSKHPFIAINMSAIPEHLLESELFGYQKGAFTDATAPKMGLFESAHKGTIFLDEIAEM
HCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCEEHHHHHHC
PIQLQSKLLRVVQEKEITRLGDNKSVKIDVRFISATNANMKEKIAAKEFREDLFFRLQIV
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
PIVIAPLRERVEEILPIAEIKLKEVCDAYHLGPKSFSKNAAKRLLEYSWHGNVRELLGVV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ERAAILSEGAEIQEKDLFLER
HHHHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure
MKIAIVEDDINMRKSLELFFELQDDLEIVSFKNPKDALAKLDESFDLVITDINMPHMDGL
CEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEECCCCCCCHH
EFLRLLEGKYESIVITGNATLNKAIDSIRLGVKDFFQKPFKPELLLESIYRTKKVLEFQK
HHHHHHCCCCCEEEEECCCHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KHPLEKPLKKPHKHSFLAASKALEESKRQALKVASTDANVMLLGESGVGKEVFAHFIHQH
HCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
SQRSKHPFIAINMSAIPEHLLESELFGYQKGAFTDATAPKMGLFESAHKGTIFLDEIAEM
HCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCEEHHHHHHC
PIQLQSKLLRVVQEKEITRLGDNKSVKIDVRFISATNANMKEKIAAKEFREDLFFRLQIV
CHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
PIVIAPLRERVEEILPIAEIKLKEVCDAYHLGPKSFSKNAAKRLLEYSWHGNVRELLGVV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ERAAILSEGAEIQEKDLFLER
HHHHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]