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The map label for this gene is lpxB

Identifier: 188527288

GI number: 188527288

Start: 478144

End: 479226

Strand: Direct

Name: lpxB

Synonym: HPSH_02475

Alternate gene names: 188527288

Gene position: 478144-479226 (Clockwise)

Preceding gene: 188527287

Following gene: 188527289

Centisome position: 29.73

GC content: 38.69

Gene sequence:

>1083_bases
ATGCCCACGATTTTAGTGAGCGCTTTAGAAGCGAGCTCTAATGTGCATTTAGAGGAATTACGCCGCAATTTGCCTAAAGA
TTATCGTTTTATTGGCGTGTTTGAAGGCAAAGAGGCGCTCTATAGCCCTAGGGAATTTTCTATCATGGGTTTTAGAGATG
TGATAGGCCGTTTAGGGTTTTTACTCAAAGCCCATAAGGAAATGGTCCAATTAGCCAAACAAGCGGATATGGTGCTTTTA
ATGGATTCTTCTTCTTTCAATATCCCCCTAGCCAAAAAAATCAAAAAACAAGATCCGCATAAAAAAATCATGTATTATAT
TTTACCGCAAGTTTGGGCATGGAAAAAATGGCGCGCTAAAAGCCTTGAAAAATACTGCGATTTTTTGGGAGCGATTTTGC
CTTTTGAAGTGGGCTATTACCAAAAAAAAGCCCAATATGTAGGACACCCTTTATTAGATGAAATTAAATACTATAAAAAA
GATATTAAGGGCGAAACTCTAGTGTTCATGCCAGGAAGCCGAAAAAGTGAAATCGCTAAAATATTCCCTTTGTTTGTCAA
AGTGGCTCAAATTTTAGAACAAAACGAAGGGTTTAAAAGGCGTGTGTTGGTGGTGCCGAGTTTCTTTAAGGGGTTGGATT
TGAAAGCTCTTTATGGGGAAGACATTAAATTATTTGAAATTTCTTATGATGCGCATAAGAGTTTGTTTGAAGCGGAATTT
GCGTTCATTTGCAGCGGCACAGCGACTTTAGAGGCCGCTTTGATTGGCACGCCTTTTGTGTTGGCGTATAGGGCTAAAAC
GATGGATTTTTTGATCGCTAGAATGTTTGTCAATTTGCATTATATAGGTTTAGCGAATATCTTTTATAACGCCTTAAACA
ATGAGACTCCAGGGCTTGGGGAGAGCCAATTACACCCGGAATTGATCCAGCATTTTTTGAGCGTAGAGGGTTTGTTAAAA
GCGTATGAAGAAATGGATAGAGAGCGCTATTTTAAAGAAAGTTTGAGATTAAGGGAATATTTGGCTAGTGGGAGCGCGAG
AAAAATCGCTAATGGAATGGCTTTTTTGCTGAATTTAACTTAA

Upstream 100 bases:

>100_bases
CTAAAAAAGACTTTGAAAATTCGTTACTCAAAATTGAATTAAGGGATTTGCATAAAGAAATCAAGCTTTATCAAGTCCAA
AACCTTTTGAAAGACAAATA

Downstream 100 bases:

>100_bases
TTTTTACTATAATCTCTACTGAATAAGCTTAGGAGATTAAATGAACAAAGAACCTATGAGTATGCATGGATACAATAAAA
TTTGCGCGGAATTGAAGCAA

Product: ipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MPTILVSALEASSNVHLEELRRNLPKDYRFIGVFEGKEALYSPREFSIMGFRDVIGRLGFLLKAHKEMVQLAKQADMVLL
MDSSSFNIPLAKKIKKQDPHKKIMYYILPQVWAWKKWRAKSLEKYCDFLGAILPFEVGYYQKKAQYVGHPLLDEIKYYKK
DIKGETLVFMPGSRKSEIAKIFPLFVKVAQILEQNEGFKRRVLVVPSFFKGLDLKALYGEDIKLFEISYDAHKSLFEAEF
AFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNNETPGLGESQLHPELIQHFLSVEGLLK
AYEEMDRERYFKESLRLREYLASGSARKIANGMAFLLNLT

Sequences:

>Translated_360_residues
MPTILVSALEASSNVHLEELRRNLPKDYRFIGVFEGKEALYSPREFSIMGFRDVIGRLGFLLKAHKEMVQLAKQADMVLL
MDSSSFNIPLAKKIKKQDPHKKIMYYILPQVWAWKKWRAKSLEKYCDFLGAILPFEVGYYQKKAQYVGHPLLDEIKYYKK
DIKGETLVFMPGSRKSEIAKIFPLFVKVAQILEQNEGFKRRVLVVPSFFKGLDLKALYGEDIKLFEISYDAHKSLFEAEF
AFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNNETPGLGESQLHPELIQHFLSVEGLLK
AYEEMDRERYFKESLRLREYLASGSARKIANGMAFLLNLT
>Mature_359_residues
PTILVSALEASSNVHLEELRRNLPKDYRFIGVFEGKEALYSPREFSIMGFRDVIGRLGFLLKAHKEMVQLAKQADMVLLM
DSSSFNIPLAKKIKKQDPHKKIMYYILPQVWAWKKWRAKSLEKYCDFLGAILPFEVGYYQKKAQYVGHPLLDEIKYYKKD
IKGETLVFMPGSRKSEIAKIFPLFVKVAQILEQNEGFKRRVLVVPSFFKGLDLKALYGEDIKLFEISYDAHKSLFEAEFA
FICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNNETPGLGESQLHPELIQHFLSVEGLLKA
YEEMDRERYFKESLRLREYLASGSARKIANGMAFLLNLT

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=319, Percent_Identity=29.7805642633229, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41419; Mature: 41288

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTILVSALEASSNVHLEELRRNLPKDYRFIGVFEGKEALYSPREFSIMGFRDVIGRLGF
CCCCEEEHHHCCCCCCHHHHHHHCCCCCEEEEEECCHHHHCCCCCEEEECHHHHHHHHHH
LLKAHKEMVQLAKQADMVLLMDSSSFNIPLAKKIKKQDPHKKIMYYILPQVWAWKKWRAK
HHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SLEKYCDFLGAILPFEVGYYQKKAQYVGHPLLDEIKYYKKDIKGETLVFMPGSRKSEIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
IFPLFVKVAQILEQNEGFKRRVLVVPSFFKGLDLKALYGEDIKLFEISYDAHKSLFEAEF
HHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCEEEECCCCEEEEEECCHHHHHHHHHHH
AFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNNETPGLG
HHEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ESQLHPELIQHFLSVEGLLKAYEEMDRERYFKESLRLREYLASGSARKIANGMAFLLNLT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCEEEEEECC
>Mature Secondary Structure 
PTILVSALEASSNVHLEELRRNLPKDYRFIGVFEGKEALYSPREFSIMGFRDVIGRLGF
CCCEEEHHHCCCCCCHHHHHHHCCCCCEEEEEECCHHHHCCCCCEEEECHHHHHHHHHH
LLKAHKEMVQLAKQADMVLLMDSSSFNIPLAKKIKKQDPHKKIMYYILPQVWAWKKWRAK
HHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SLEKYCDFLGAILPFEVGYYQKKAQYVGHPLLDEIKYYKKDIKGETLVFMPGSRKSEIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
IFPLFVKVAQILEQNEGFKRRVLVVPSFFKGLDLKALYGEDIKLFEISYDAHKSLFEAEF
HHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCEEEECCCCEEEEEECCHHHHHHHHHHH
AFICSGTATLEAALIGTPFVLAYRAKTMDFLIARMFVNLHYIGLANIFYNALNNETPGLG
HHEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ESQLHPELIQHFLSVEGLLKAYEEMDRERYFKESLRLREYLASGSARKIANGMAFLLNLT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA