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The map label for this gene is cusR [H]

Identifier: 188527213

GI number: 188527213

Start: 399227

End: 399898

Strand: Direct

Name: cusR [H]

Synonym: HPSH_02100

Alternate gene names: 188527213

Gene position: 399227-399898 (Clockwise)

Preceding gene: 188527212

Following gene: 188527216

Centisome position: 24.82

GC content: 41.07

Gene sequence:

>672_bases
ATGCGCGTTCTACTGATTGAAAAAAATTCTGTTTTGGGTGGAGAAATTGAAAAGGGCTTAAATGCTAAAGGCTTTATGGC
TGATGTAACAGAGAGTTTAGAGGATGGGGAATATCTTATGGATATTAGGAATTATGACTTGGTTATGGTTAGCGATAAAA
ATGCTTTAAGTTTTGTTTCTAGAATCAAAGAAAAGCATTCTTCTATTGTTGTTTTAGTTTCTTCGGATAACCCTACAAGC
GAGGAGGAAGTCCATGCGTTTGAGCAAGGTGCGGACGATTATATCGCTAAGCCTTATCGCAGCATTAAGGCTTTAGTCGC
AAGGATTGAGGCTCGTTTGAGGTTTTGGGGCTCTAATGTGATTGAAATTGGGGATTTGATCATTAGCCCTGATGAAGAAA
AGATTATTTACAAGGGGCGTGAAGTTGAGGTTAAAGGGAAGCCTTTTGAAGTGCTTACCCATCTTGCCAGACATAGGGAT
CAAATCGTCTCCAAAGAACAGCTTTTAGACGCTATTTGGGAAGAGCCTGAAATGGTTACCCCTAATGTCATTGAAGTGGC
TATCAATCAAATCCGCCAAAAAATGGATAAACCCTTGGGGATTTCCACGGTTGAAACCGTAAGGCGCAGAGGCTATCGTT
TTTGCTACCCAAAACCGGCGTGTGAAGAATGA

Upstream 100 bases:

>100_bases
TTGATCAAGCGATAACTTTTATTAATATTTTCTTAAACTAATTTAAAATTATGATATAATCAGCACCTGAATTACTCTTA
AATGCAGGAGCCAACAAACC

Downstream 100 bases:

>100_bases
ATTCCGTGGTTTTTGGCTAAAAATAGATTAAAATGAGGGTGTGGCTCTATCAAATATTGACCATAAAACTTAAAACATGC
TAAAAGCATTCTTTACAATC

Product: putative transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRVLLIEKNSVLGGEIEKGLNAKGFMADVTESLEDGEYLMDIRNYDLVMVSDKNALSFVSRIKEKHSSIVVLVSSDNPTS
EEEVHAFEQGADDYIAKPYRSIKALVARIEARLRFWGSNVIEIGDLIISPDEEKIIYKGREVEVKGKPFEVLTHLARHRD
QIVSKEQLLDAIWEEPEMVTPNVIEVAINQIRQKMDKPLGISTVETVRRRGYRFCYPKPACEE

Sequences:

>Translated_223_residues
MRVLLIEKNSVLGGEIEKGLNAKGFMADVTESLEDGEYLMDIRNYDLVMVSDKNALSFVSRIKEKHSSIVVLVSSDNPTS
EEEVHAFEQGADDYIAKPYRSIKALVARIEARLRFWGSNVIEIGDLIISPDEEKIIYKGREVEVKGKPFEVLTHLARHRD
QIVSKEQLLDAIWEEPEMVTPNVIEVAINQIRQKMDKPLGISTVETVRRRGYRFCYPKPACEE
>Mature_223_residues
MRVLLIEKNSVLGGEIEKGLNAKGFMADVTESLEDGEYLMDIRNYDLVMVSDKNALSFVSRIKEKHSSIVVLVSSDNPTS
EEEVHAFEQGADDYIAKPYRSIKALVARIEARLRFWGSNVIEIGDLIISPDEEKIIYKGREVEVKGKPFEVLTHLARHRD
QIVSKEQLLDAIWEEPEMVTPNVIEVAINQIRQKMDKPLGISTVETVRRRGYRFCYPKPACEE

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=27.1111111111111, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI2367329, Length=177, Percent_Identity=29.9435028248588, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=28.310502283105, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=23.9819004524887, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=26.2222222222222, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=26.027397260274, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786599, Length=173, Percent_Identity=30.0578034682081, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=24, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25422; Mature: 25422

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLIEKNSVLGGEIEKGLNAKGFMADVTESLEDGEYLMDIRNYDLVMVSDKNALSFVS
CEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHH
RIKEKHSSIVVLVSSDNPTSEEEVHAFEQGADDYIAKPYRSIKALVARIEARLRFWGSNV
HHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IEIGDLIISPDEEKIIYKGREVEVKGKPFEVLTHLARHRDQIVSKEQLLDAIWEEPEMVT
EEECCEEECCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PNVIEVAINQIRQKMDKPLGISTVETVRRRGYRFCYPKPACEE
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCCCCCC
>Mature Secondary Structure
MRVLLIEKNSVLGGEIEKGLNAKGFMADVTESLEDGEYLMDIRNYDLVMVSDKNALSFVS
CEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCHHHHHHH
RIKEKHSSIVVLVSSDNPTSEEEVHAFEQGADDYIAKPYRSIKALVARIEARLRFWGSNV
HHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IEIGDLIISPDEEKIIYKGREVEVKGKPFEVLTHLARHRDQIVSKEQLLDAIWEEPEMVT
EEECCEEECCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PNVIEVAINQIRQKMDKPLGISTVETVRRRGYRFCYPKPACEE
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]