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The map label for this gene is dxs [H]

Identifier: 188527159

GI number: 188527159

Start: 345239

End: 347089

Strand: Direct

Name: dxs [H]

Synonym: HPSH_01830

Alternate gene names: 188527159

Gene position: 345239-347089 (Clockwise)

Preceding gene: 188527158

Following gene: 188527160

Centisome position: 21.46

GC content: 43.06

Gene sequence:

>1851_bases
TTGCAAAATAAAACTTTTGATTTAAACCCTAATGATATTGCAGGCTTGGAGTTGGTGTGCCAAACGCTGCGGAGTCGTAT
TTTAGAAGTGGTGAGCGCTAATGGGGGGCATTTAAGCTCTTCTTTAGGGGCTGTGGAGCTGATTGTAAGCATGCATGCCT
TATTTGATTGCCAAAAAAACCCTTTTATTTTTGACACTTCGCACCAGGCTTACGCTCACAAGCTCTTAACCGGGCGCTTT
GAAAGCTTTAGCACTTTAAGGCAATTTAAAGGTTTGAGCGGCTTTACTAAACCCAGCGAGAGCGCATACGATTATTTCAT
TGCCGGGCATAGTTCCACTTCGGTGTCTATAGGCGTGGGGGTGGCTAAAGCTTTTTGTTTGAAACAAGCGCTGGGCATGC
CCATAGCTTTATTAGGCGATGGGAGCATTAGTGCAGGGATTTTTTATGAAGCCTTAAACGAACTGGGCGATAGGAAATAC
CCCATGATCATGATTTTGAACGATAATGAAATGAGTATCAGCACGCCTATTGGAGCCTTATCCAAAGCCCTTAGCCAGCT
GATGAAAGGCCCGTTTTACCAGTCTTTCCGCTCTAAAGTTAAAAAAATCTTAAACACCTTACCTGAAAGCGTGAATTACT
TAGCGAGCCGTTTTGAAGAATCTTTCAAGCTCATCACCCCAGGCGTGTTTTTTGAAGAATTAGGCATTAACTATATAGGA
CCTATTAATGGGCATGATTTGAGCGCGATTATTGAAACCTTAAAACTCGCCAAAGAGCTTAAAGAGCCGGTGCTAATCCA
TGCGCAAACCTTAAAGGGCAAAGGCTATAAAATCGCTGAAGGGCGGTATGAAAAATGGCATGGGGTGGGGCCTTTTGATT
TGGATACCGGCTTGTCTAAAAAATCCAAAAGCGCGATTTTATCGCCCACTGAAGCGTATTCTAACACCCTTTTAGAATTA
GCCAAGAAAGATGAAAAAATCGTAGGCGTAACCGCTGCTATGCCTAGCGGTACAGGACTAGACAAACTCATTGACGCTTA
CCCTTTGCGCTTTTTTGATGTCGCTATCGCTGAACAACACGCTTTAACTTCTAGCAGTGCTATGGCTAAAGAGGGGTTTA
AACCTTTTGTGAGTATCTATTCTACTTTTTTGCAAAGGGCTTATGATTCCATTGTGCATGACGCTTGCATTTCTAGCTTG
CCGATTAAATTAGCCATTGACAGGGCTGGGATTGTGGGCGAAGATGGCGAGACGCACCAAGGGCTTTTAGATGTGTCGTA
TTTGCGCTCTATCCCCAACATGGTCATTTTTGCCCCACGAGATAATGAGACTTTAAAAAACGCCGTGCGTTTTGCCAATG
AACATCATTCAAGCCCTTGCGCGTTCCGCTACCCTAGGGGGTCGTTTGCGTTAAAAGAGGGGGTTTTTGAGCCTAGCGGT
TTTGTTTTAGGGCAAAGCGAATTGTTGAAAAAAGAGGGCGAAATTTTACTCATTGGCTATGGTAATGGCGTGGGGCGGGC
GCATTTAGTCCAACTGGCTTTAAAAGAAAAAAACATAGAGTGCGCGCTTTTGGATCTCAGGTTTTTAAAGCCCTTAGATC
AAAATTTAAGCGCCATCATTGCCCCTTATCAAAAGCTCTATGTTTTTAGCGATAATTACAAGCTTGGGGGGGTGGCTAGC
GCGATTTTAGAGTTTTTGAGCGAACAAAATATTTTAAAGCCTGTTAAAAGCTTTGAAATCATTGATGAATTTATCATGCA
TGGGAACACCGCTTTAGTGGAAAAATCCTTAGGTTTAGACACAGAGAGTTTGACTGACGCTATTTTAAAAGATTTAGGAC
AAGAGAGATGA

Upstream 100 bases:

>100_bases
GCGTTATGATCACTAGCTCTAACGGGAGCCTTGATGGGAATTTAATGGAGCGCTTTAAAACGCTCAAAGAAAGCGTGTTG
GAAAATTTTAAGGTGTGATT

Downstream 100 bases:

>100_bases
AATCAAAAGTGCCAATGAAAAATATCCGCAATTTTTCCATTATCGCTCACATTGACCATGGTAAAAGCACTTTAGCGGAT
TGTTTGATCGCTGAATGCAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MQNKTFDLNPNDIAGLELVCQTLRSRILEVVSANGGHLSSSLGAVELIVSMHALFDCQKNPFIFDTSHQAYAHKLLTGRF
ESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIGVGVAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDRKY
PMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLASRFEESFKLITPGVFFEELGINYIG
PINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGLSKKSKSAILSPTEAYSNTLLEL
AKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSL
PIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHHSSPCAFRYPRGSFALKEGVFEPSG
FVLGQSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDQNLSAIIAPYQKLYVFSDNYKLGGVAS
AILEFLSEQNILKPVKSFEIIDEFIMHGNTALVEKSLGLDTESLTDAILKDLGQER

Sequences:

>Translated_616_residues
MQNKTFDLNPNDIAGLELVCQTLRSRILEVVSANGGHLSSSLGAVELIVSMHALFDCQKNPFIFDTSHQAYAHKLLTGRF
ESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIGVGVAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDRKY
PMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLASRFEESFKLITPGVFFEELGINYIG
PINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGLSKKSKSAILSPTEAYSNTLLEL
AKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSL
PIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHHSSPCAFRYPRGSFALKEGVFEPSG
FVLGQSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDQNLSAIIAPYQKLYVFSDNYKLGGVAS
AILEFLSEQNILKPVKSFEIIDEFIMHGNTALVEKSLGLDTESLTDAILKDLGQER
>Mature_616_residues
MQNKTFDLNPNDIAGLELVCQTLRSRILEVVSANGGHLSSSLGAVELIVSMHALFDCQKNPFIFDTSHQAYAHKLLTGRF
ESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIGVGVAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDRKY
PMIMILNDNEMSISTPIGALSKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLASRFEESFKLITPGVFFEELGINYIG
PINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGLSKKSKSAILSPTEAYSNTLLEL
AKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQHALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSL
PIKLAIDRAGIVGEDGETHQGLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHHSSPCAFRYPRGSFALKEGVFEPSG
FVLGQSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDQNLSAIIAPYQKLYVFSDNYKLGGVAS
AILEFLSEQNILKPVKSFEIIDEFIMHGNTALVEKSLGLDTESLTDAILKDLGQER

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=411, Percent_Identity=25.0608272506083, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4507521, Length=411, Percent_Identity=25.0608272506083, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI133778974, Length=372, Percent_Identity=23.1182795698925, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637459, Length=382, Percent_Identity=24.869109947644, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI225637461, Length=382, Percent_Identity=24.869109947644, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI225637463, Length=382, Percent_Identity=24.0837696335079, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1786622, Length=596, Percent_Identity=40.9395973154362, Blast_Score=443, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17539652, Length=393, Percent_Identity=24.6819338422392, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24666278, Length=269, Percent_Identity=29.7397769516729, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24645119, Length=391, Percent_Identity=25.8312020460358, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45551847, Length=391, Percent_Identity=25.8312020460358, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45550715, Length=391, Percent_Identity=25.8312020460358, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67505; Mature: 67505

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKTFDLNPNDIAGLELVCQTLRSRILEVVSANGGHLSSSLGAVELIVSMHALFDCQKN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PFIFDTSHQAYAHKLLTGRFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIGVG
CEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEHHH
VAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDRKYPMIMILNDNEMSISTPIGAL
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHHHH
SKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLASRFEESFKLITPGVFFEELGINYIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEC
PINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGLSK
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCHHCCCCCCCCCCCCCCC
KSKSAILSPTEAYSNTLLELAKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQH
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHHH
ALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSLPIKLAIDRAGIVGEDGETHQ
HHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
GLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHHSSPCAFRYPRGSFALKEGVFEPSG
CHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCCCCCC
FVLGQSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDQNLSAII
CEECHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEHHHHHCHHHCCHHHHH
APYQKLYVFSDNYKLGGVASAILEFLSEQNILKPVKSFEIIDEFIMHGNTALVEKSLGLD
CCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
TESLTDAILKDLGQER
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQNKTFDLNPNDIAGLELVCQTLRSRILEVVSANGGHLSSSLGAVELIVSMHALFDCQKN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PFIFDTSHQAYAHKLLTGRFESFSTLRQFKGLSGFTKPSESAYDYFIAGHSSTSVSIGVG
CEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEHHH
VAKAFCLKQALGMPIALLGDGSISAGIFYEALNELGDRKYPMIMILNDNEMSISTPIGAL
HHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHHHH
SKALSQLMKGPFYQSFRSKVKKILNTLPESVNYLASRFEESFKLITPGVFFEELGINYIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEC
PINGHDLSAIIETLKLAKELKEPVLIHAQTLKGKGYKIAEGRYEKWHGVGPFDLDTGLSK
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCHHCCCCCCCCCCCCCCC
KSKSAILSPTEAYSNTLLELAKKDEKIVGVTAAMPSGTGLDKLIDAYPLRFFDVAIAEQH
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHHH
ALTSSSAMAKEGFKPFVSIYSTFLQRAYDSIVHDACISSLPIKLAIDRAGIVGEDGETHQ
HHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
GLLDVSYLRSIPNMVIFAPRDNETLKNAVRFANEHHSSPCAFRYPRGSFALKEGVFEPSG
CHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHCCCCCCC
FVLGQSELLKKEGEILLIGYGNGVGRAHLVQLALKEKNIECALLDLRFLKPLDQNLSAII
CEECHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEHHHHHCHHHCCHHHHH
APYQKLYVFSDNYKLGGVASAILEFLSEQNILKPVKSFEIIDEFIMHGNTALVEKSLGLD
CCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
TESLTDAILKDLGQER
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA