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The map label for this gene is hbpA [H]

Identifier: 188527104

GI number: 188527104

Start: 300438

End: 302087

Strand: Direct

Name: hbpA [H]

Synonym: HPSH_01545

Alternate gene names: 188527104

Gene position: 300438-302087 (Clockwise)

Preceding gene: 188527103

Following gene: 188527105

Centisome position: 18.68

GC content: 41.15

Gene sequence:

>1650_bases
ATGAATAATGTTTTTGTTAAGGGTTTGTTTTTTTTTCTTTTGTTGTTTGGGTTCTTTTTGAAAGCTTTAGAAAACCCAAA
CGCTACTCTTAATCCCTCTAAAGAAAATGTTTCCGTTGAAGAGCAAAAGCGTTTTGGAGGCGTTTTAGTTTTTGCTAGAG
GCGCTGATGGATCAAGCATGGATCCTGCCTTAGTAACTGATGGCGAAAGCTATGTGGCAACGGGCAATATTTATGACACG
CTCGTGCAATTCAAATACGGCACCACAGAAATTGAACCCGCCTTAGCGACAAGCTGGGAAATATCCCCGGATGGTCTTGT
ATATACCTTTCATTTACGCAAAGGGGTTTATTTCCACCAGACGAAGTATTGGAATAAAAAAGTAGAGTTTAGCGCTAAAG
ATGTGCTGTTTTCGTTTGAGCGCCAGATGGATAAGGCTAAACGATACTATAACCCGGGGGCTAAAAGCTATAAATACTGG
GAAGGCATGGGCATGTCTCATATTATTAAGAGCATTGAAGCTTTAGATGATTACACGATTAGATTCACGCTTAATGGGCC
AGAAGCCCCGTTTTTAGCCAATTTAGGCATGGACTTTTTGAGCATTTTGAGTAAGGATTATGCTGATTATTTGGCTCAAA
ATAATAAAAAAGACGAGTTGGCTAAAAAACCTATTGGGACAGGGCCTTTCAAATTCTTTTTGTGGAATAAAGATGAAAAA
ATCATTCTTCTAAAAAATCAGGATTATTGGGGGTCTAAAGCTTATTTGGATAAGGTGGTGGTGCGCACCATTCCTAATCC
TTCCACTCGCGCTTTGGCGTTGCGCACCGGTGAAATCATGCTCATGACTGGGCCTAACCTTAGTGAAGTGGAGCAATTAG
AAAAAGTCCCTAATATCGTGGTGGATAAGAGCGCTGGGTTGTTGGCGAGTTGGCTTTCATTAAACACGCAAAAAAAGTAT
TTTAACAACCCTTTAGTGCGTTTAGCCATCAACCATGCGATTAATGTTGATGATTACATCAAAGTGCTTTATGAAGGCTT
TGCCCAAAAAATGGTCAATCCTTTCCCGCCCACCATATGGGGTTATAACTACAACATCAAACCCTATGAATACGATTTGA
AAAAGGCTAAAGAGTTATTGAAACAAGCGGGGTATCCTAACGGCTTTAAAACCACCATTTTTACCACTGCCACCCGTAAC
CCAAAAGGAGCGGTGTTCATACAAGCGAGCCTGGCTAAAATTGGCATTGATGTGAAAATTGAAGTGTATGAGTGGGGGGC
TTATTTGAAAAGAACGGGTCTGGGCGAGCATGAAATGGCGTTTGCAGGCTGGATGGCAGACATTGCGGATCCGGATAATT
TCTTATACACCTTATGGAGCAAGCAAGCAGCCTCAGCTATACCCACTCAAAATGGTTCCTTTTATAAGAGCGACGCCTTT
TCAGATCTTCTTTTAAAGGCTAAACGGGTTTCTGATCAAAAGGAGAGGGAAGCTCTTTATTTAAAGGCTCAAGAAATTAT
CCATAAAGATGCACCCTATGTGCCTTTAGCTTATCCTTATTCGGTGGTGCCGCACTTGTCTAAAGTTAAGGGTTATAAGA
CGACCGGAGTGAGCGTGAATCGGTTTTTTAAGGTGTATTTAGAAAAGTAA

Upstream 100 bases:

>100_bases
CAATTAAACCTTTGGGTGTTTGTTAAACGCCCATAAACGCAATAAAATATTTATAATTTAGATCTCTATCCTTTATAGAA
TTTGTTGTGGAGTTTAGCTT

Downstream 100 bases:

>100_bases
AAGGGGTTGTATGCTGAGTTTTATCATCAAGCGTATTTTGTGGGCGATCCCCACGCTGTTTGGGGTGAGTATCATTGTGT
TTATGATGGTGCATTTAGTG

Product: periplasmic dipeptide-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MNNVFVKGLFFFLLLFGFFLKALENPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSMDPALVTDGESYVATGNIYDT
LVQFKYGTTEIEPALATSWEISPDGLVYTFHLRKGVYFHQTKYWNKKVEFSAKDVLFSFERQMDKAKRYYNPGAKSYKYW
EGMGMSHIIKSIEALDDYTIRFTLNGPEAPFLANLGMDFLSILSKDYADYLAQNNKKDELAKKPIGTGPFKFFLWNKDEK
IILLKNQDYWGSKAYLDKVVVRTIPNPSTRALALRTGEIMLMTGPNLSEVEQLEKVPNIVVDKSAGLLASWLSLNTQKKY
FNNPLVRLAINHAINVDDYIKVLYEGFAQKMVNPFPPTIWGYNYNIKPYEYDLKKAKELLKQAGYPNGFKTTIFTTATRN
PKGAVFIQASLAKIGIDVKIEVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
SDLLLKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVNRFFKVYLEK

Sequences:

>Translated_549_residues
MNNVFVKGLFFFLLLFGFFLKALENPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSMDPALVTDGESYVATGNIYDT
LVQFKYGTTEIEPALATSWEISPDGLVYTFHLRKGVYFHQTKYWNKKVEFSAKDVLFSFERQMDKAKRYYNPGAKSYKYW
EGMGMSHIIKSIEALDDYTIRFTLNGPEAPFLANLGMDFLSILSKDYADYLAQNNKKDELAKKPIGTGPFKFFLWNKDEK
IILLKNQDYWGSKAYLDKVVVRTIPNPSTRALALRTGEIMLMTGPNLSEVEQLEKVPNIVVDKSAGLLASWLSLNTQKKY
FNNPLVRLAINHAINVDDYIKVLYEGFAQKMVNPFPPTIWGYNYNIKPYEYDLKKAKELLKQAGYPNGFKTTIFTTATRN
PKGAVFIQASLAKIGIDVKIEVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
SDLLLKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVNRFFKVYLEK
>Mature_549_residues
MNNVFVKGLFFFLLLFGFFLKALENPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSMDPALVTDGESYVATGNIYDT
LVQFKYGTTEIEPALATSWEISPDGLVYTFHLRKGVYFHQTKYWNKKVEFSAKDVLFSFERQMDKAKRYYNPGAKSYKYW
EGMGMSHIIKSIEALDDYTIRFTLNGPEAPFLANLGMDFLSILSKDYADYLAQNNKKDELAKKPIGTGPFKFFLWNKDEK
IILLKNQDYWGSKAYLDKVVVRTIPNPSTRALALRTGEIMLMTGPNLSEVEQLEKVPNIVVDKSAGLLASWLSLNTQKKY
FNNPLVRLAINHAINVDDYIKVLYEGFAQKMVNPFPPTIWGYNYNIKPYEYDLKKAKELLKQAGYPNGFKTTIFTTATRN
PKGAVFIQASLAKIGIDVKIEVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
SDLLLKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVNRFFKVYLEK

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=508, Percent_Identity=39.3700787401575, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1787551, Length=481, Percent_Identity=30.1455301455301, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1787052, Length=493, Percent_Identity=30.2231237322515, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1787762, Length=493, Percent_Identity=29.4117647058824, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789887, Length=485, Percent_Identity=27.0103092783505, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1787495, Length=495, Percent_Identity=26.0606060606061, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1789397, Length=496, Percent_Identity=25.4032258064516, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081878, Length=490, Percent_Identity=25.9183673469388, Blast_Score=96, Evalue=9e-21,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 62354; Mature: 62354

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS00501 SPASE_I_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVFVKGLFFFLLLFGFFLKALENPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSM
CCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCC
DPALVTDGESYVATGNIYDTLVQFKYGTTEIEPALATSWEISPDGLVYTFHLRKGVYFHQ
CCCEEECCCCEEEECCHHHHHHHEECCCCCCCCCCCCCEECCCCCEEEEEEECCCEEEEE
TKYWNKKVEFSAKDVLFSFERQMDKAKRYYNPGAKSYKYWEGMGMSHIIKSIEALDDYTI
HHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCEEE
RFTLNGPEAPFLANLGMDFLSILSKDYADYLAQNNKKDELAKKPIGTGPFKFFLWNKDEK
EEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCCE
IILLKNQDYWGSKAYLDKVVVRTIPNPSTRALALRTGEIMLMTGPNLSEVEQLEKVPNIV
EEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCCHHHHHHHHHCCCEE
VDKSAGLLASWLSLNTQKKYFNNPLVRLAINHAINVDDYIKVLYEGFAQKMVNPFPPTIW
EECCCCHHHHHHHCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
GYNYNIKPYEYDLKKAKELLKQAGYPNGFKTTIFTTATRNPKGAVFIQASLAKIGIDVKI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEEEHHHCCCEEEE
EVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
EEEECCHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCCEECHHHH
SDLLLKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCEECCCCHH
RFFKVYLEK
HEEEEEECC
>Mature Secondary Structure
MNNVFVKGLFFFLLLFGFFLKALENPNATLNPSKENVSVEEQKRFGGVLVFARGADGSSM
CCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCC
DPALVTDGESYVATGNIYDTLVQFKYGTTEIEPALATSWEISPDGLVYTFHLRKGVYFHQ
CCCEEECCCCEEEECCHHHHHHHEECCCCCCCCCCCCCEECCCCCEEEEEEECCCEEEEE
TKYWNKKVEFSAKDVLFSFERQMDKAKRYYNPGAKSYKYWEGMGMSHIIKSIEALDDYTI
HHHCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCEEE
RFTLNGPEAPFLANLGMDFLSILSKDYADYLAQNNKKDELAKKPIGTGPFKFFLWNKDEK
EEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCCE
IILLKNQDYWGSKAYLDKVVVRTIPNPSTRALALRTGEIMLMTGPNLSEVEQLEKVPNIV
EEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCEEEEECCCHHHHHHHHHCCCEE
VDKSAGLLASWLSLNTQKKYFNNPLVRLAINHAINVDDYIKVLYEGFAQKMVNPFPPTIW
EECCCCHHHHHHHCCCCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
GYNYNIKPYEYDLKKAKELLKQAGYPNGFKTTIFTTATRNPKGAVFIQASLAKIGIDVKI
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEEEHHHCCCEEEE
EVYEWGAYLKRTGLGEHEMAFAGWMADIADPDNFLYTLWSKQAASAIPTQNGSFYKSDAF
EEEECCHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCCCCCEECHHHH
SDLLLKAKRVSDQKEREALYLKAQEIIHKDAPYVPLAYPYSVVPHLSKVKGYKTTGVSVN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCEECCCCHH
RFFKVYLEK
HEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]