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The map label for this gene is xseA

Identifier: 188527066

GI number: 188527066

Start: 252807

End: 254069

Strand: Direct

Name: xseA

Synonym: HPSH_01345

Alternate gene names: 188527066

Gene position: 252807-254069 (Clockwise)

Preceding gene: 188527065

Following gene: 188527068

Centisome position: 15.72

GC content: 41.01

Gene sequence:

>1263_bases
GTGGATGTATTGAGCGTGAGCGAAATCAATGCGCAAATCAAAGCCCTTTTAGAAGCGACTTTTTTGCAAGTTAGGGTTCA
AGGGGAAGTGAGTAATTTGACGATCCATAAGGTGAGCGGTCATGCGTATTTTTCGCTCAAAGACAGCCAGTCAGTCATCA
GATGCGTGCTGTTTAAAGGGAACGCTAACAGGCTCAAATTCGCTTTAAAAGAAGGGCAGGAAGTGGTTGTTTTTGGGGGC
ATTAGCGCGTATGTTCCAAGGGGGGATTATCAAATCAATTGCTTTGAAATAGAGCCTAAAAACATAGGTTCATTAACCCT
AGCTTTAGAGCAATTGAAAGAAAAATTACGCCTTAAGGGCTATTTTGACAAAGCCAACAAATTACCCAAACCGCATTTTC
CTAAACGAGTGGCAGTCATCACTTCTCAAAATTCAGCCGCTTGGGCGGACATGAAAAAGATCGCTTCCAAACGATGGCCG
ATGTGTGAATTGGTTTGCATCAATGCGTTAATGCAAGGGGAGGGCTGCGTTCAAAGCGTGGTGGAGAGCATCGCTTATGC
GGATAGCTTTCATGGCACAAAAAACGCTTTTGATGCGATTGTGGTGGCTAGGGGTGGGGGGAGCATGGAGGATTTGTATC
CTTTCAATGATGAGAAAATCGCTGATGCATTGCATTTGGCTAAAACTTTCAGCATGTCAGCTATTGGGCATGAGAGCGAT
TTTTTATTGAGCGATTTGGTAGCGGATTTAAGGGCTTCTACGCCTTCAAACGCGATGGAGATTTTACTCCCTAGCAGCGA
TGAATGGTTGCAAAGACTTGATGGGTTTAATTTGAAATTGCACCGCTCTTTTAAAATTTTGCTCCATCAAAAAAAGGCGC
ATTTAGAGCATTTAGAGGCTTCTTTAAAACGATTGAGTTTTGAAAACAAGCACCATTTAAACGCTTTAAAGCTAGAGAAA
TTAAAAATCGCTTTAGAAAATAAAACCCTAGAATTTTTACGCTTCAAAAAAACGCTTTTGGAAAAAATCTCTACTCAAAC
ATTAACAAGCCCTTTTTTACAAACTAAAACAGAGAGATTAAACAGGCTAGAAAACGCCCTTAAACTCGCTCATGCAAATT
TGAAATTACCCCAATTTGGGGCGTTTGTGAGCAAAAATAACCAAGCGATAGAATTAGAGGCATTAAAAAGGGGCGATAAA
ATTGAATTGAGCAATGAAAAAGCTAGAGCGAGCGCTGAAATTTTAAGCGTGGATAGGGTGTAG

Upstream 100 bases:

>100_bases
GCAAAATGCGTTGTGGCTAGCGGGTGTGGGGTTTTTGGTTTTTATCATGTTTTTAGGGCTTTTCAATGACCTCACTCGTT
TGCTATAAAAGGGGGAATTG

Downstream 100 bases:

>100_bases
GGGTTTGAAAAATAATATTTAAAATAAAATAGATTTTGTTTTTAAAATTTCGTATTCACTTCTTTTAACAATCTTTTCTA
AACGCAATAGCATGATGTTT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MDVLSVSEINAQIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCVLFKGNANRLKFALKEGQEVVVFGG
ISAYVPRGDYQINCFEIEPKNIGSLTLALEQLKEKLRLKGYFDKANKLPKPHFPKRVAVITSQNSAAWADMKKIASKRWP
MCELVCINALMQGEGCVQSVVESIAYADSFHGTKNAFDAIVVARGGGSMEDLYPFNDEKIADALHLAKTFSMSAIGHESD
FLLSDLVADLRASTPSNAMEILLPSSDEWLQRLDGFNLKLHRSFKILLHQKKAHLEHLEASLKRLSFENKHHLNALKLEK
LKIALENKTLEFLRFKKTLLEKISTQTLTSPFLQTKTERLNRLENALKLAHANLKLPQFGAFVSKNNQAIELEALKRGDK
IELSNEKARASAEILSVDRV

Sequences:

>Translated_420_residues
MDVLSVSEINAQIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCVLFKGNANRLKFALKEGQEVVVFGG
ISAYVPRGDYQINCFEIEPKNIGSLTLALEQLKEKLRLKGYFDKANKLPKPHFPKRVAVITSQNSAAWADMKKIASKRWP
MCELVCINALMQGEGCVQSVVESIAYADSFHGTKNAFDAIVVARGGGSMEDLYPFNDEKIADALHLAKTFSMSAIGHESD
FLLSDLVADLRASTPSNAMEILLPSSDEWLQRLDGFNLKLHRSFKILLHQKKAHLEHLEASLKRLSFENKHHLNALKLEK
LKIALENKTLEFLRFKKTLLEKISTQTLTSPFLQTKTERLNRLENALKLAHANLKLPQFGAFVSKNNQAIELEALKRGDK
IELSNEKARASAEILSVDRV
>Mature_420_residues
MDVLSVSEINAQIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCVLFKGNANRLKFALKEGQEVVVFGG
ISAYVPRGDYQINCFEIEPKNIGSLTLALEQLKEKLRLKGYFDKANKLPKPHFPKRVAVITSQNSAAWADMKKIASKRWP
MCELVCINALMQGEGCVQSVVESIAYADSFHGTKNAFDAIVVARGGGSMEDLYPFNDEKIADALHLAKTFSMSAIGHESD
FLLSDLVADLRASTPSNAMEILLPSSDEWLQRLDGFNLKLHRSFKILLHQKKAHLEHLEASLKRLSFENKHHLNALKLEK
LKIALENKTLEFLRFKKTLLEKISTQTLTSPFLQTKTERLNRLENALKLAHANLKLPQFGAFVSKNNQAIELEALKRGDK
IELSNEKARASAEILSVDRV

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=330, Percent_Identity=35.4545454545455, Blast_Score=211, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 47038; Mature: 47038

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVLSVSEINAQIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCVLFKG
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEECCEEEEEECCCCCEEEEEEEEC
NANRLKFALKEGQEVVVFGGISAYVPRGDYQINCFEIEPKNIGSLTLALEQLKEKLRLKG
CCCCEEEEECCCCEEEEECCCEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
YFDKANKLPKPHFPKRVAVITSQNSAAWADMKKIASKRWPMCELVCINALMQGEGCVQSV
CHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHH
VESIAYADSFHGTKNAFDAIVVARGGGSMEDLYPFNDEKIADALHLAKTFSMSAIGHESD
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
FLLSDLVADLRASTPSNAMEILLPSSDEWLQRLDGFNLKLHRSFKILLHQKKAHLEHLEA
HHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCEEEECHHEEEHHHHHHHHHHHHH
SLKRLSFENKHHLNALKLEKLKIALENKTLEFLRFKKTLLEKISTQTLTSPFLQTKTERL
HHHHHCCCCCCCCCCEEEEHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRLENALKLAHANLKLPQFGAFVSKNNQAIELEALKRGDKIELSNEKARASAEILSVDRV
HHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEHHHCCCCEEEECCCHHHHHHHHEEECCC
>Mature Secondary Structure
MDVLSVSEINAQIKALLEATFLQVRVQGEVSNLTIHKVSGHAYFSLKDSQSVIRCVLFKG
CCCCCHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEECCEEEEEECCCCCEEEEEEEEC
NANRLKFALKEGQEVVVFGGISAYVPRGDYQINCFEIEPKNIGSLTLALEQLKEKLRLKG
CCCCEEEEECCCCEEEEECCCEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
YFDKANKLPKPHFPKRVAVITSQNSAAWADMKKIASKRWPMCELVCINALMQGEGCVQSV
CHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHH
VESIAYADSFHGTKNAFDAIVVARGGGSMEDLYPFNDEKIADALHLAKTFSMSAIGHESD
HHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCH
FLLSDLVADLRASTPSNAMEILLPSSDEWLQRLDGFNLKLHRSFKILLHQKKAHLEHLEA
HHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCEEEECHHEEEHHHHHHHHHHHHH
SLKRLSFENKHHLNALKLEKLKIALENKTLEFLRFKKTLLEKISTQTLTSPFLQTKTERL
HHHHHCCCCCCCCCCEEEEHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRLENALKLAHANLKLPQFGAFVSKNNQAIELEALKRGDKIELSNEKARASAEILSVDRV
HHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEHHHCCCCEEEECCCHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA