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The map label for this gene is spaR [H]

Identifier: 187934010

GI number: 187934010

Start: 2292974

End: 2293636

Strand: Reverse

Name: spaR [H]

Synonym: CLL_A2207

Alternate gene names: 187934010

Gene position: 2293636-2292974 (Counterclockwise)

Preceding gene: 187935009

Following gene: 187934808

Centisome position: 60.35

GC content: 27.0

Gene sequence:

>663_bases
GTGGCTACTATTTTAGCTATAGATGATGAGATTGGAATATTAAATATTATAAAAGTTGCATTAGAAAAAGAAGGTCATAT
AGTAACTACTGTTTCTAATGCTAATGAAATATCATATAATCAATACACTAAATATGATTTAATACTTCTGGATATAATGA
TGCCAGAAATTGATGGATTTACTTTGTGCAATAAAATAAGAAGTTTAGTAGACTGTCCTATTTTATTTTTAACAGCAAAG
ACTATGGAGGAAGATATAGTTAAGGGACTTAGTTTTGGTGGAGATGATTATATAACAAAACCTTTTGGAATAAGTGAACT
AAGAGCTAGAGTAAATGCACATTTAAGAAGAGAACGTAGAGAAAAACAAAATGCTTTTTATATTTCTGAACTTAAATTTT
ATATAAATTCAAAAGAAGTATATCATGATGAAGAGTTAATTTCATTTACCAAAAGTGAATATAATATATGTGAATATTTA
GCATTAAATCATGGGCAAGTATTTTCAAAGGAGCAAATTTATGAAAGCGTCTTTGGATTTGATGGTCATAGTGATACAAC
TGCTATTGTAGAACATATTAAAAATATAAGAAGTAAACTAAAAGTAAGAGGTATAAATACAATAGAAACTGTTTGGGGGA
TTGGTTATAAGTGGAAAGAATAA

Upstream 100 bases:

>100_bases
TTGATTCAAATACTTTAGATGATCTTTTAGGAGACAATGAATATACTGTTTTAATCAAATTATCATATGAAGAAATATAA
ACGTGTTTGGAGGAATAAAT

Downstream 100 bases:

>100_bases
AGAAACAAAAAAGCATAGCTAAAATATTTGCTACGTATATAGCTACATTTTGTATAATTACAGTTCTTCAAATTATAATA
ATCTCATTTTTATTTATTAT

Product: regulatory protein VanR

Products: NA

Alternate protein names: Subtilin biosynthesis regulatory protein spaR [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MATILAIDDEIGILNIIKVALEKEGHIVTTVSNANEISYNQYTKYDLILLDIMMPEIDGFTLCNKIRSLVDCPILFLTAK
TMEEDIVKGLSFGGDDYITKPFGISELRARVNAHLRRERREKQNAFYISELKFYINSKEVYHDEELISFTKSEYNICEYL
ALNHGQVFSKEQIYESVFGFDGHSDTTAIVEHIKNIRSKLKVRGINTIETVWGIGYKWKE

Sequences:

>Translated_220_residues
MATILAIDDEIGILNIIKVALEKEGHIVTTVSNANEISYNQYTKYDLILLDIMMPEIDGFTLCNKIRSLVDCPILFLTAK
TMEEDIVKGLSFGGDDYITKPFGISELRARVNAHLRRERREKQNAFYISELKFYINSKEVYHDEELISFTKSEYNICEYL
ALNHGQVFSKEQIYESVFGFDGHSDTTAIVEHIKNIRSKLKVRGINTIETVWGIGYKWKE
>Mature_219_residues
ATILAIDDEIGILNIIKVALEKEGHIVTTVSNANEISYNQYTKYDLILLDIMMPEIDGFTLCNKIRSLVDCPILFLTAKT
MEEDIVKGLSFGGDDYITKPFGISELRARVNAHLRRERREKQNAFYISELKFYINSKEVYHDEELISFTKSEYNICEYLA
LNHGQVFSKEQIYESVFGFDGHSDTTAIVEHIKNIRSKLKVRGINTIETVWGIGYKWKE

Specific function: Member of the two-component regulatory system spaK/spaR involved in the regulation of the biosynthesis of lantibiotic subtilin. SpaR may function as a regulatory protein [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=33.4801762114537, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790552, Length=215, Percent_Identity=30.6976744186047, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=30.3571428571429, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI87082012, Length=215, Percent_Identity=31.6279069767442, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786784, Length=217, Percent_Identity=33.1797235023041, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=30, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787375, Length=217, Percent_Identity=31.3364055299539, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=30.6306306306306, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=29.0178571428571, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=33.1858407079646, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=30.5936073059361, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=27.1929824561404, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=26.5765765765766, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25345; Mature: 25214

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATILAIDDEIGILNIIKVALEKEGHIVTTVSNANEISYNQYTKYDLILLDIMMPEIDGF
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHEEEEEEHHCCCCCH
TLCNKIRSLVDCPILFLTAKTMEEDIVKGLSFGGDDYITKPFGISELRARVNAHLRRERR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EKQNAFYISELKFYINSKEVYHDEELISFTKSEYNICEYLALNHGQVFSKEQIYESVFGF
HHHCCEEEEHHHEEECCCHHHCHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCC
DGHSDTTAIVEHIKNIRSKLKVRGINTIETVWGIGYKWKE
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure 
ATILAIDDEIGILNIIKVALEKEGHIVTTVSNANEISYNQYTKYDLILLDIMMPEIDGF
EEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHEEEEEEHHCCCCCH
TLCNKIRSLVDCPILFLTAKTMEEDIVKGLSFGGDDYITKPFGISELRARVNAHLRRERR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EKQNAFYISELKFYINSKEVYHDEELISFTKSEYNICEYLALNHGQVFSKEQIYESVFGF
HHHCCEEEEHHHEEECCCHHHCHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCC
DGHSDTTAIVEHIKNIRSKLKVRGINTIETVWGIGYKWKE
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8439156 [H]