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The map label for this gene is aspC [H]

Identifier: 187933734

GI number: 187933734

Start: 2601578

End: 2602867

Strand: Reverse

Name: aspC [H]

Synonym: CLL_A2506

Alternate gene names: 187933734

Gene position: 2602867-2601578 (Counterclockwise)

Preceding gene: 187935153

Following gene: 187933633

Centisome position: 68.49

GC content: 25.81

Gene sequence:

>1290_bases
ATGAATAGAGTAATGATAAGCAATTTAAATAAATATCAAAATAAAAATGTAGTAATAAAAGGATTTATTCATCGTATAAG
GAGACTTAAAAAAATAAGTTTTATTATATTAAGAGATAGAACAGGACTTATGCAATGTGTTGTAGATAATGAAAAATTAT
ATATAGATAAAATAAAATTAGAATCAGTTGTATCAATAGAAGGATGCGTAAAGGAAAGTAAAAATACTTTAAGCCATTTT
GAAGTGCAAGTAGAAAATTTAATTATAATAAATGAACCAGTAGAAGATCTTCCTATTGAAATAAATAAGGAAAATTTAGA
GATTAATTTAGATACAAAACTTAATAATAGAATGCTTAGTTTAAGACATGAAAAAGTAAGTTCAATTTTTAAAATAGAGA
ATATTATAGCTAATGGATTTAGAAAATTTCTAAATAATAATGGATTCACTGAAATATCAACACCTAAAATTGTAAATGAA
GGTGCAGAAGGGGGAAGTGAAGTTTTTAAATTAAAATATTTTGAAAAAAATGCGTATTTAGCTCAAAGTCCACAATTTTA
TAAACAAATGATGGTTGGAGCAGGTTTTGAAAGAGTATTTGAAATTAGTCATGTGTATAGAGCAGAGGAGCATAATACCA
CTAGACATTTAAATGAGTATGTAAGTATGGATTTAGAAATGGGATTTATTGAAGATGAAAAAGATATAATGGATTTAGAA
GAAGAATTATTGAAATTTATACTAGATAAGGTAAAGATAGAAGGCAAAAAATATTTAGAATTATTAAATGCAGAGATCCC
TATAATTGAAAATACAATACCAAGAATGAAGTTTAGTGAAGCAATTGAGATTTTAAAAAATGAATATAATAAAGTAGAAG
AGAGTGATGATATGGATACAGAAGGCGAAAAATTAATCTGCCAATATATAAAAGAAAAATATAATAGCGATTTTGTATTT
TTAACTCATTATCCAAGAAAAAAAAGACCTATGTATACAATGCCATGTGGCGAAGATGAAACTCATAGTTTTGATTTATT
ATTTAGAGGACTTGAAATTACAACAGGAGGTCAAAGAATTCATGAGTATAATATGCTCATAGAAAATATGAAATATAAAG
GGTTTAATCCACAAAATTATGAAAGTTATATATCAAACTTTAAGTATGGGATGATGCCCCATGGAGGATTAGCAATAGGA
CTTGAAAGAATAACTTGTAGAATGTTAGGAATTGAAAATGTGAGAGAAGGAAGTTTAATTCCTAGAGATAGAACAAGATT
ATTACCTTAA

Upstream 100 bases:

>100_bases
ATTCGCCCCTTATGTTAAAAAGCATAGGGGCGAATTTTTTTTTCTTATATTATTTCTAGGATTTTATAAGATTAAAATAT
TATTAGGAGATGAAAATTAA

Downstream 100 bases:

>100_bases
TTTTAAGAGTACTAGATTAATAAGCTTAACTGGTTCATAGTGGGAAAATATAACTGGTTAAGCTTTTTAAGTTTTAGAGT
AGAGTATGGAATGTAAAATA

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNRVMISNLNKYQNKNVVIKGFIHRIRRLKKISFIILRDRTGLMQCVVDNEKLYIDKIKLESVVSIEGCVKESKNTLSHF
EVQVENLIIINEPVEDLPIEINKENLEINLDTKLNNRMLSLRHEKVSSIFKIENIIANGFRKFLNNNGFTEISTPKIVNE
GAEGGSEVFKLKYFEKNAYLAQSPQFYKQMMVGAGFERVFEISHVYRAEEHNTTRHLNEYVSMDLEMGFIEDEKDIMDLE
EELLKFILDKVKIEGKKYLELLNAEIPIIENTIPRMKFSEAIEILKNEYNKVEESDDMDTEGEKLICQYIKEKYNSDFVF
LTHYPRKKRPMYTMPCGEDETHSFDLLFRGLEITTGGQRIHEYNMLIENMKYKGFNPQNYESYISNFKYGMMPHGGLAIG
LERITCRMLGIENVREGSLIPRDRTRLLP

Sequences:

>Translated_429_residues
MNRVMISNLNKYQNKNVVIKGFIHRIRRLKKISFIILRDRTGLMQCVVDNEKLYIDKIKLESVVSIEGCVKESKNTLSHF
EVQVENLIIINEPVEDLPIEINKENLEINLDTKLNNRMLSLRHEKVSSIFKIENIIANGFRKFLNNNGFTEISTPKIVNE
GAEGGSEVFKLKYFEKNAYLAQSPQFYKQMMVGAGFERVFEISHVYRAEEHNTTRHLNEYVSMDLEMGFIEDEKDIMDLE
EELLKFILDKVKIEGKKYLELLNAEIPIIENTIPRMKFSEAIEILKNEYNKVEESDDMDTEGEKLICQYIKEKYNSDFVF
LTHYPRKKRPMYTMPCGEDETHSFDLLFRGLEITTGGQRIHEYNMLIENMKYKGFNPQNYESYISNFKYGMMPHGGLAIG
LERITCRMLGIENVREGSLIPRDRTRLLP
>Mature_429_residues
MNRVMISNLNKYQNKNVVIKGFIHRIRRLKKISFIILRDRTGLMQCVVDNEKLYIDKIKLESVVSIEGCVKESKNTLSHF
EVQVENLIIINEPVEDLPIEINKENLEINLDTKLNNRMLSLRHEKVSSIFKIENIIANGFRKFLNNNGFTEISTPKIVNE
GAEGGSEVFKLKYFEKNAYLAQSPQFYKQMMVGAGFERVFEISHVYRAEEHNTTRHLNEYVSMDLEMGFIEDEKDIMDLE
EELLKFILDKVKIEGKKYLELLNAEIPIIENTIPRMKFSEAIEILKNEYNKVEESDDMDTEGEKLICQYIKEKYNSDFVF
LTHYPRKKRPMYTMPCGEDETHSFDLLFRGLEITTGGQRIHEYNMLIENMKYKGFNPQNYESYISNFKYGMMPHGGLAIG
LERITCRMLGIENVREGSLIPRDRTRLLP

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI45439306, Length=443, Percent_Identity=35.4401805869075, Blast_Score=284, Evalue=9e-77,
Organism=Homo sapiens, GI4758762, Length=444, Percent_Identity=30.8558558558559, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI226491502, Length=440, Percent_Identity=26.8181818181818, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI40789249, Length=253, Percent_Identity=28.0632411067194, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1787161, Length=458, Percent_Identity=25.3275109170306, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788173, Length=287, Percent_Identity=27.5261324041812, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1789256, Length=449, Percent_Identity=24.0534521158129, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790571, Length=455, Percent_Identity=23.2967032967033, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17551876, Length=457, Percent_Identity=35.6673960612691, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71984122, Length=439, Percent_Identity=31.6628701594533, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17556372, Length=418, Percent_Identity=23.9234449760766, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32566633, Length=306, Percent_Identity=26.4705882352941, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323011, Length=465, Percent_Identity=35.0537634408602, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6321807, Length=431, Percent_Identity=29.2343387470998, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319872, Length=470, Percent_Identity=27.2340425531915, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6325153, Length=303, Percent_Identity=26.4026402640264, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17136276, Length=467, Percent_Identity=34.475374732334, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI19921528, Length=436, Percent_Identity=33.0275229357798, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI19922416, Length=451, Percent_Identity=21.5077605321508, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24584738, Length=290, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020780
- InterPro:   IPR004523
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 50253; Mature: 50253

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVMISNLNKYQNKNVVIKGFIHRIRRLKKISFIILRDRTGLMQCVVDNEKLYIDKIKL
CCCEEECCCHHHCCCCEEEHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCEEEEEEEEH
ESVVSIEGCVKESKNTLSHFEVQVENLIIINEPVEDLPIEINKENLEINLDTKLNNRMLS
HHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCEEEECCEEEEEECCCCCCHHHH
LRHEKVSSIFKIENIIANGFRKFLNNNGFTEISTPKIVNEGAEGGSEVFKLKYFEKNAYL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHCCCCCCCCCEEEEEEEECCCCC
AQSPQFYKQMMVGAGFERVFEISHVYRAEEHNTTRHLNEYVSMDLEMGFIEDEKDIMDLE
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEECCCCCCHHHHHHH
EELLKFILDKVKIEGKKYLELLNAEIPIIENTIPRMKFSEAIEILKNEYNKVEESDDMDT
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
EGEKLICQYIKEKYNSDFVFLTHYPRKKRPMYTMPCGEDETHSFDLLFRGLEITTGGQRI
CHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCCCCCCEEHEEECEEEECCCHHH
HEYNMLIENMKYKGFNPQNYESYISNFKYGMMPHGGLAIGLERITCRMLGIENVREGSLI
HHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCC
PRDRTRLLP
CCCHHCCCC
>Mature Secondary Structure
MNRVMISNLNKYQNKNVVIKGFIHRIRRLKKISFIILRDRTGLMQCVVDNEKLYIDKIKL
CCCEEECCCHHHCCCCEEEHHHHHHHHHHHHEEEEEEECCCCEEEEEECCCEEEEEEEEH
ESVVSIEGCVKESKNTLSHFEVQVENLIIINEPVEDLPIEINKENLEINLDTKLNNRMLS
HHHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCEEEECCEEEEEECCCCCCHHHH
LRHEKVSSIFKIENIIANGFRKFLNNNGFTEISTPKIVNEGAEGGSEVFKLKYFEKNAYL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHCCCCCCCCCEEEEEEEECCCCC
AQSPQFYKQMMVGAGFERVFEISHVYRAEEHNTTRHLNEYVSMDLEMGFIEDEKDIMDLE
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEECCCCCCHHHHHHH
EELLKFILDKVKIEGKKYLELLNAEIPIIENTIPRMKFSEAIEILKNEYNKVEESDDMDT
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
EGEKLICQYIKEKYNSDFVFLTHYPRKKRPMYTMPCGEDETHSFDLLFRGLEITTGGQRI
CHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCCCCCCEEHEEECEEEECCCHHH
HEYNMLIENMKYKGFNPQNYESYISNFKYGMMPHGGLAIGLERITCRMLGIENVREGSLI
HHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCC
PRDRTRLLP
CCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]