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The map label for this gene is uvrB [H]

Identifier: 187933656

GI number: 187933656

Start: 3530307

End: 3532280

Strand: Reverse

Name: uvrB [H]

Synonym: CLL_A3349

Alternate gene names: 187933656

Gene position: 3532280-3530307 (Counterclockwise)

Preceding gene: 187934800

Following gene: 187934209

Centisome position: 92.95

GC content: 30.09

Gene sequence:

>1974_bases
ATGGGAGAATTTAAAATACATTCAAAATTTAAACCTATGGGAGATCAGCCACAAGCTATTGATACTATATTAAAGTCAAT
AAAGCAAGGCAATGAGTTTCAAACTTTATTAGGAGTAACTGGATCTGGAAAGACATTTACTATGGCTAACATAATAGAAA
ATTTACAAAGACCAACTCTAATTTTGGCTCATAACAAAACTCTTGCAGCTCAATTATGCTCTGAATTTAAAGAGTTTTTT
CCAGAAAATATAGTTGAGTACTTTGTATCTTATTATGACTATTATCAACCAGAAGCATATGTACCACAAACTGATACTTT
CATTGAAAAAGATGCATCTATAAATGATGAGATAGATAAGCTTAGGCATTCGGCTACATCAGCACTTTTTGAAAGACGAG
ATGTAATTATAGTGGCATCAGTTTCTTGTATATATGGACTTGGTAATCCTGATGAATATAAAAAATTAACTATAAGTTTA
AGAAAAGGAATGCAAAAAGAGAGAGATGAGATAATAAAAAAACTTATAGAGATTCAATATGAAAGAAATGATATAGATTT
TTCAAGGGGAACATTTAGGGTAAGAGGAGATTTATTAGATATTATTCCATCATCAACTTCTAGTAAAGGAATAAGGATAG
AGTTTTTTGGCGATGAAATTGATAGAATAAGAGAATTTGACGTGTTAACGGGAACAATAATAGGAGAAAGAAATCATGTT
TCGATTTTCCCAGCATCTCACTTTGCAACTTCAAAAGAGACTGTAGAGAGATCTTTAGGTGAAATAGAGAATGAATTAGA
AAATAGACTTAGAGAATTGAATTCACAAGAAAAATTATTAGAAGCTCAAAGATTAAGACAAAGAACAAACTTTGATATAG
AGATGATAAGAGAAATGGGTTATTGTAGTGGAATAGAAAATTATTCTAGAATTTTAGATGGAAGAGCACCAGGTACACCT
CCAAAGACATTAATAGATTATTTTCCAGAAGATTTTTTATTATTTATAGATGAAAGTCATGTTACATTACCTCAAGTAAG
AGCGATGTATGCTGGAGATAGATCAAGAAAAAATACTCTAGTTGATTATGGATTTAGATTGCCATGTGCTTATGATAACA
GGCCACTAAAGTTTGAAGAGTTTGAAAAAAAGATAAATCAAGTTATGTTTGTTAGTGCAACACCAGCTCAATATGAGTTG
GAACATTCACAGTCTATAGCAGAGCAAGTTATAAGACCAACAGGATTATTAGATCCAGAAATTATTATAAAACCAGTAAA
AGGTCAAATTGATGATTTATATACAGAAATTCAGGAAACAATATCAAGAGGATATAGAATATTAATTACAACATTAACTA
AAAGAATGGCAGAAGATTTAACCAAATATATGATTGAATTAGGTGTAAAAGCTACGTATATGCATTCAGATATTGACACT
ATTGAAAGAATGAAAATTATTAGAGACTTAAGACTTGGTGAATATGATGTTTTAGTTGGAATAAATCTTTTAAGAGAAGG
ATTAGACATACCAGAAGTTGCTTTAGTTGCTATATTAGATGCAGATAAAGAAGGTTTTTTAAGATCGGAAACTTCCTTAA
TTCAAACAATAGGAAGAGCCGCTAGAAACTCAGAAAGTAAAGTAATAATGTATGCAGATAATATTACAAAATCAATGAAA
AAGGCTATTAGTGAAACTGAAAGAAGAAGAAAAATACAAACAGAATATAATGAAGAGCACGGAATAATACCACAAACAAT
TAATAAAGAAGTTAGAGAGTTAATAGAGGCTACTAAAGTGGCTGAAGAATCAACAGAGTACGGTATGGAAGTAACAAAAT
CTTTAACTAAGAAAGAAGCAAAAAAACTTATAAAAGAATATACAGACGAAATGAAGCTTGCAGCTAAAAATCTTCAATTT
GAAAGAGCAGCACAGTTAAGAGATAAGATAGAAGAATTGAAAGGAAAAGAGTGA

Upstream 100 bases:

>100_bases
ATGAATTATTGAATGAGTTTATGTTGACTTAGGTTATAATGAAAAGTAAAATATAATAAAATGCATACGAATGTTTGTTC
GCAAAAAAGAGGTGTTAATT

Downstream 100 bases:

>100_bases
TTAGATGAATGATAAGATAGTAATTAAAGGCGCAAAAGTTAATAATTTAAAAAATGTAAGTTTAGAAATACCAAGAGATA
AATTAATAGTATTTACAGGA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MGEFKIHSKFKPMGDQPQAIDTILKSIKQGNEFQTLLGVTGSGKTFTMANIIENLQRPTLILAHNKTLAAQLCSEFKEFF
PENIVEYFVSYYDYYQPEAYVPQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIVASVSCIYGLGNPDEYKKLTISL
RKGMQKERDEIIKKLIEIQYERNDIDFSRGTFRVRGDLLDIIPSSTSSKGIRIEFFGDEIDRIREFDVLTGTIIGERNHV
SIFPASHFATSKETVERSLGEIENELENRLRELNSQEKLLEAQRLRQRTNFDIEMIREMGYCSGIENYSRILDGRAPGTP
PKTLIDYFPEDFLLFIDESHVTLPQVRAMYAGDRSRKNTLVDYGFRLPCAYDNRPLKFEEFEKKINQVMFVSATPAQYEL
EHSQSIAEQVIRPTGLLDPEIIIKPVKGQIDDLYTEIQETISRGYRILITTLTKRMAEDLTKYMIELGVKATYMHSDIDT
IERMKIIRDLRLGEYDVLVGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRAARNSESKVIMYADNITKSMK
KAISETERRRKIQTEYNEEHGIIPQTINKEVRELIEATKVAEESTEYGMEVTKSLTKKEAKKLIKEYTDEMKLAAKNLQF
ERAAQLRDKIEELKGKE

Sequences:

>Translated_657_residues
MGEFKIHSKFKPMGDQPQAIDTILKSIKQGNEFQTLLGVTGSGKTFTMANIIENLQRPTLILAHNKTLAAQLCSEFKEFF
PENIVEYFVSYYDYYQPEAYVPQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIVASVSCIYGLGNPDEYKKLTISL
RKGMQKERDEIIKKLIEIQYERNDIDFSRGTFRVRGDLLDIIPSSTSSKGIRIEFFGDEIDRIREFDVLTGTIIGERNHV
SIFPASHFATSKETVERSLGEIENELENRLRELNSQEKLLEAQRLRQRTNFDIEMIREMGYCSGIENYSRILDGRAPGTP
PKTLIDYFPEDFLLFIDESHVTLPQVRAMYAGDRSRKNTLVDYGFRLPCAYDNRPLKFEEFEKKINQVMFVSATPAQYEL
EHSQSIAEQVIRPTGLLDPEIIIKPVKGQIDDLYTEIQETISRGYRILITTLTKRMAEDLTKYMIELGVKATYMHSDIDT
IERMKIIRDLRLGEYDVLVGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRAARNSESKVIMYADNITKSMK
KAISETERRRKIQTEYNEEHGIIPQTINKEVRELIEATKVAEESTEYGMEVTKSLTKKEAKKLIKEYTDEMKLAAKNLQF
ERAAQLRDKIEELKGKE
>Mature_656_residues
GEFKIHSKFKPMGDQPQAIDTILKSIKQGNEFQTLLGVTGSGKTFTMANIIENLQRPTLILAHNKTLAAQLCSEFKEFFP
ENIVEYFVSYYDYYQPEAYVPQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIVASVSCIYGLGNPDEYKKLTISLR
KGMQKERDEIIKKLIEIQYERNDIDFSRGTFRVRGDLLDIIPSSTSSKGIRIEFFGDEIDRIREFDVLTGTIIGERNHVS
IFPASHFATSKETVERSLGEIENELENRLRELNSQEKLLEAQRLRQRTNFDIEMIREMGYCSGIENYSRILDGRAPGTPP
KTLIDYFPEDFLLFIDESHVTLPQVRAMYAGDRSRKNTLVDYGFRLPCAYDNRPLKFEEFEKKINQVMFVSATPAQYELE
HSQSIAEQVIRPTGLLDPEIIIKPVKGQIDDLYTEIQETISRGYRILITTLTKRMAEDLTKYMIELGVKATYMHSDIDTI
ERMKIIRDLRLGEYDVLVGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRAARNSESKVIMYADNITKSMKK
AISETERRRKIQTEYNEEHGIIPQTINKEVRELIEATKVAEESTEYGMEVTKSLTKKEAKKLIKEYTDEMKLAAKNLQFE
RAAQLRDKIEELKGKE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=662, Percent_Identity=58.3081570996979, Blast_Score=773, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=227, Percent_Identity=25.9911894273128, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75610; Mature: 75479

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEFKIHSKFKPMGDQPQAIDTILKSIKQGNEFQTLLGVTGSGKTFTMANIIENLQRPTL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHEECCCCCEEEHHHHHHHCCCCEE
ILAHNKTLAAQLCSEFKEFFPENIVEYFVSYYDYYQPEAYVPQTDTFIEKDASINDEIDK
EEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHH
LRHSATSALFERRDVIIVASVSCIYGLGNPDEYKKLTISLRKGMQKERDEIIKKLIEIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
ERNDIDFSRGTFRVRGDLLDIIPSSTSSKGIRIEFFGDEIDRIREFDVLTGTIIGERNHV
CCCCCCCCCCEEEEECHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHEEEEECCCCEE
SIFPASHFATSKETVERSLGEIENELENRLRELNSQEKLLEAQRLRQRTNFDIEMIREMG
EEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHH
YCSGIENYSRILDGRAPGTPPKTLIDYFPEDFLLFIDESHVTLPQVRAMYAGDRSRKNTL
HHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCH
VDYGFRLPCAYDNRPLKFEEFEKKINQVMFVSATPAQYELEHSQSIAEQVIRPTGLLDPE
HCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCH
IIIKPVKGQIDDLYTEIQETISRGYRILITTLTKRMAEDLTKYMIELGVKATYMHSDIDT
HEEECCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHH
IERMKIIRDLRLGEYDVLVGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHHH
ARNSESKVIMYADNITKSMKKAISETERRRKIQTEYNEEHGIIPQTINKEVRELIEATKV
HCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AEESTEYGMEVTKSLTKKEAKKLIKEYTDEMKLAAKNLQFERAAQLRDKIEELKGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GEFKIHSKFKPMGDQPQAIDTILKSIKQGNEFQTLLGVTGSGKTFTMANIIENLQRPTL
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHEECCCCCEEEHHHHHHHCCCCEE
ILAHNKTLAAQLCSEFKEFFPENIVEYFVSYYDYYQPEAYVPQTDTFIEKDASINDEIDK
EEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHHHHH
LRHSATSALFERRDVIIVASVSCIYGLGNPDEYKKLTISLRKGMQKERDEIIKKLIEIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
ERNDIDFSRGTFRVRGDLLDIIPSSTSSKGIRIEFFGDEIDRIREFDVLTGTIIGERNHV
CCCCCCCCCCEEEEECHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHEEEEECCCCEE
SIFPASHFATSKETVERSLGEIENELENRLRELNSQEKLLEAQRLRQRTNFDIEMIREMG
EEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHH
YCSGIENYSRILDGRAPGTPPKTLIDYFPEDFLLFIDESHVTLPQVRAMYAGDRSRKNTL
HHCCHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCH
VDYGFRLPCAYDNRPLKFEEFEKKINQVMFVSATPAQYELEHSQSIAEQVIRPTGLLDPE
HCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCH
IIIKPVKGQIDDLYTEIQETISRGYRILITTLTKRMAEDLTKYMIELGVKATYMHSDIDT
HEEECCCCHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHH
IERMKIIRDLRLGEYDVLVGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRA
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHHH
ARNSESKVIMYADNITKSMKKAISETERRRKIQTEYNEEHGIIPQTINKEVRELIEATKV
HCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AEESTEYGMEVTKSLTKKEAKKLIKEYTDEMKLAAKNLQFERAAQLRDKIEELKGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA