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The map label for this gene is prsA [H]

Identifier: 187933209

GI number: 187933209

Start: 3562590

End: 3563333

Strand: Reverse

Name: prsA [H]

Synonym: CLL_A3378

Alternate gene names: 187933209

Gene position: 3563333-3562590 (Counterclockwise)

Preceding gene: 187932560

Following gene: 187935163

Centisome position: 93.76

GC content: 30.11

Gene sequence:

>744_bases
ATGGAAAATAAGGTATTGGCAATTGTTGCCGGAAACGAAATCAAAGATAAAGACTTAGATACAGTACTAAATAGATATCC
ACAAGAAAGAAGAGCTATGTTCCAAGGAGAACAAGGAAGAGAAGCATTATTAGAACAAGTGGTAGCTTTTGAATTAATGC
GTAATTTTGGTAAGGAATTAAAAATAGATGAGACTGAAGAATATAAAAATTTAGTTGAAGGATTAGCAAAAGAGGCATTA
ACTCAATTAGCAATCAATAAAGTATTAGCAGATGTTACAGTTACTGATGAAGATGTTAAAAAGTATTATGATGATAATTC
AAGTATGTTTATAAATCCACCAACAGTTTCAGCAAAACATATTTTAGTTAAGACTGAAGAAGAAGCTACTTCTATAAAAG
AAGAAATAGCAAATGGATTAGCATTTGAAGAAGCTGCTAAGAAATATTCAACTTGTCCATCTAAAGAACAAGGTGGAAGT
TTAGGTAACTTTGGAAAAGGTTCTATGGTACCAGAATTTGAAAAAGTTGCTTTCGAATCAGAAGTTGGAAAAGTTAGTGA
ACCAGTTAAGACTCAATTTGGTTATCACTTAATATTAGTAGAAGACAAAACTGAAAGCACAACTGTACCGTTTGATCAAG
TTAAAGATGCTGTGTTAAAACAACTTATAAATGAAAGACAACAAAACAAATATTTAGAAATGATAAAACAATTATCAGAT
AAATATGGTGTTGAAAGAAAATAG

Upstream 100 bases:

>100_bases
ATAAATAATAATAATAAATTTTCTTTTTTTATTGTTAGTAGAGATATATATTGTTAAAATATAGAGGTATATAAAAAAAT
AGCTAAAAAGGAGAATTAAC

Downstream 100 bases:

>100_bases
TAATATTACTTATAATTAGTAACAGAAAAAAAGTGGTTTTATATAAAACCACTTTTTTTTATAAAATTTCTATAATGAAA
ACTTTCGTATATCTACTTTT

Product: foldase protein PrsA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MENKVLAIVAGNEIKDKDLDTVLNRYPQERRAMFQGEQGREALLEQVVAFELMRNFGKELKIDETEEYKNLVEGLAKEAL
TQLAINKVLADVTVTDEDVKKYYDDNSSMFINPPTVSAKHILVKTEEEATSIKEEIANGLAFEEAAKKYSTCPSKEQGGS
LGNFGKGSMVPEFEKVAFESEVGKVSEPVKTQFGYHLILVEDKTESTTVPFDQVKDAVLKQLINERQQNKYLEMIKQLSD
KYGVERK

Sequences:

>Translated_247_residues
MENKVLAIVAGNEIKDKDLDTVLNRYPQERRAMFQGEQGREALLEQVVAFELMRNFGKELKIDETEEYKNLVEGLAKEAL
TQLAINKVLADVTVTDEDVKKYYDDNSSMFINPPTVSAKHILVKTEEEATSIKEEIANGLAFEEAAKKYSTCPSKEQGGS
LGNFGKGSMVPEFEKVAFESEVGKVSEPVKTQFGYHLILVEDKTESTTVPFDQVKDAVLKQLINERQQNKYLEMIKQLSD
KYGVERK
>Mature_247_residues
MENKVLAIVAGNEIKDKDLDTVLNRYPQERRAMFQGEQGREALLEQVVAFELMRNFGKELKIDETEEYKNLVEGLAKEAL
TQLAINKVLADVTVTDEDVKKYYDDNSSMFINPPTVSAKHILVKTEEEATSIKEEIANGLAFEEAAKKYSTCPSKEQGGS
LGNFGKGSMVPEFEKVAFESEVGKVSEPVKTQFGYHLILVEDKTESTTVPFDQVKDAVLKQLINERQQNKYLEMIKQLSD
KYGVERK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1790211, Length=86, Percent_Identity=51.1627906976744, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1786645, Length=148, Percent_Identity=27.027027027027, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27897; Mature: 27897

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKVLAIVAGNEIKDKDLDTVLNRYPQERRAMFQGEQGREALLEQVVAFELMRNFGKEL
CCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
KIDETEEYKNLVEGLAKEALTQLAINKVLADVTVTDEDVKKYYDDNSSMFINPPTVSAKH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCCCCCE
ILVKTEEEATSIKEEIANGLAFEEAAKKYSTCPSKEQGGSLGNFGKGSMVPEFEKVAFES
EEEECCHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHH
EVGKVSEPVKTQFGYHLILVEDKTESTTVPFDQVKDAVLKQLINERQQNKYLEMIKQLSD
HHHHHCCHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYGVERK
HCCCCCC
>Mature Secondary Structure
MENKVLAIVAGNEIKDKDLDTVLNRYPQERRAMFQGEQGREALLEQVVAFELMRNFGKEL
CCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCC
KIDETEEYKNLVEGLAKEALTQLAINKVLADVTVTDEDVKKYYDDNSSMFINPPTVSAKH
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEECCCCCCCCE
ILVKTEEEATSIKEEIANGLAFEEAAKKYSTCPSKEQGGSLGNFGKGSMVPEFEKVAFES
EEEECCHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHH
EVGKVSEPVKTQFGYHLILVEDKTESTTVPFDQVKDAVLKQLINERQQNKYLEMIKQLSD
HHHHHCCHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYGVERK
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]