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The map label for this gene is vanR [H]

Identifier: 187933165

GI number: 187933165

Start: 2796307

End: 2796993

Strand: Reverse

Name: vanR [H]

Synonym: CLL_A2681

Alternate gene names: 187933165

Gene position: 2796993-2796307 (Counterclockwise)

Preceding gene: 187935687

Following gene: 187933272

Centisome position: 73.6

GC content: 26.64

Gene sequence:

>687_bases
ATGAAGGGATATATTCTTATAGTTGATGATGATGAAAATATAAGAAATTTATTGAGTATCTATTTAGAAAATGAAAATTT
TAAAACTATAAAAGCAGAGAATGCTAAAGAAGCAATTAAAATCATAGATGAGAAAGAAATAGAACTAGTTCTTTTAGATA
TAATGATGCCACAAATAGATGGAATTGAGGCATGTATGAGAATAAGAAAAGATAAAAATATGCCAATAATTATGATATCT
GCAAAATCAGAAGATATGGATAAAATTCATGGATTAACTGCTGGCGCAGATGATTATATAACAAAACCATTTAATCCATT
AGAACTTATAGCTAGGGTAAAATCTCAGCTTAGAAGGTATCAAAAATATAATACAGGTTCAAATAATCAAAAAGTTATAA
TTGAAATTGGAGATTTGACTATTAATACTGATACTAGACAAATTTGGGTTGGTGAGAATGAAATAAGATTAACTCCAAAG
GAATTTGATATTTTAGAATTACTAGCAAGAAATAAAGGGATTGTTTTAAGCATAAGAAAAATATATGAAGAGGTTTGGAA
AGAAGAATTTTTCAAATCAGATAATACTGTTACAGTTCATATAACGAATTTAAGAGAAAAAATTGAAGCTGATCCTAAAG
CTCCTGTATATATAAAAACAATATGGGGAGTAGGTTATAAGATATGA

Upstream 100 bases:

>100_bases
AATAATTATTTTAAAAATATTAAGGCTAAGAAGGAGTTTTTAAATATTCCACCAGCATATGTTCTTAGCTGCACAAATAA
ATTATAAGGAGAAGATAAGG

Downstream 100 bases:

>100_bases
TTGACTTTAAAAAAGTTAGAATAAATTTAATCTGGGGAATTATTATTGGATTTTTTTTATCTCAAGTTATTGTTGCAGAA
GGGTATGCAATATTAGTGTT

Product: regulatory protein VanR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKGYILIVDDDENIRNLLSIYLENENFKTIKAENAKEAIKIIDEKEIELVLLDIMMPQIDGIEACMRIRKDKNMPIIMIS
AKSEDMDKIHGLTAGADDYITKPFNPLELIARVKSQLRRYQKYNTGSNNQKVIIEIGDLTINTDTRQIWVGENEIRLTPK
EFDILELLARNKGIVLSIRKIYEEVWKEEFFKSDNTVTVHITNLREKIEADPKAPVYIKTIWGVGYKI

Sequences:

>Translated_228_residues
MKGYILIVDDDENIRNLLSIYLENENFKTIKAENAKEAIKIIDEKEIELVLLDIMMPQIDGIEACMRIRKDKNMPIIMIS
AKSEDMDKIHGLTAGADDYITKPFNPLELIARVKSQLRRYQKYNTGSNNQKVIIEIGDLTINTDTRQIWVGENEIRLTPK
EFDILELLARNKGIVLSIRKIYEEVWKEEFFKSDNTVTVHITNLREKIEADPKAPVYIKTIWGVGYKI
>Mature_228_residues
MKGYILIVDDDENIRNLLSIYLENENFKTIKAENAKEAIKIIDEKEIELVLLDIMMPQIDGIEACMRIRKDKNMPIIMIS
AKSEDMDKIHGLTAGADDYITKPFNPLELIARVKSQLRRYQKYNTGSNNQKVIIEIGDLTINTDTRQIWVGENEIRLTPK
EFDILELLARNKGIVLSIRKIYEEVWKEEFFKSDNTVTVHITNLREKIEADPKAPVYIKTIWGVGYKI

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=38.8392857142857, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=34.8214285714286, Blast_Score=154, Evalue=5e-39,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=31.6017316017316, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=33.1858407079646, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=34.2222222222222, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=33.9285714285714, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=32, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=31.25, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=33.6244541484716, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.390134529148, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=31.140350877193, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=28.9473684210526, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.0701754385965, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=36.3636363636364, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790299, Length=130, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26444; Mature: 26444

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGYILIVDDDENIRNLLSIYLENENFKTIKAENAKEAIKIIDEKEIELVLLDIMMPQID
CCEEEEEEECCHHHHHHHHHEECCCCEEEEECCCHHHHHHHHCCCCEEEEEEEHHCCCCC
GIEACMRIRKDKNMPIIMISAKSEDMDKIHGLTAGADDYITKPFNPLELIARVKSQLRRY
HHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QKYNTGSNNQKVIIEIGDLTINTDTRQIWVGENEIRLTPKEFDILELLARNKGIVLSIRK
HHCCCCCCCCEEEEEECCEEEECCCCEEEECCCEEEECCCHHHHHHHHHCCCCEEEEHHH
IYEEVWKEEFFKSDNTVTVHITNLREKIEADPKAPVYIKTIWGVGYKI
HHHHHHHHHHHCCCCEEEEEEECCHHHHCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MKGYILIVDDDENIRNLLSIYLENENFKTIKAENAKEAIKIIDEKEIELVLLDIMMPQID
CCEEEEEEECCHHHHHHHHHEECCCCEEEEECCCHHHHHHHHCCCCEEEEEEEHHCCCCC
GIEACMRIRKDKNMPIIMISAKSEDMDKIHGLTAGADDYITKPFNPLELIARVKSQLRRY
HHHHHHHHHCCCCCCEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QKYNTGSNNQKVIIEIGDLTINTDTRQIWVGENEIRLTPKEFDILELLARNKGIVLSIRK
HHCCCCCCCCEEEEEECCEEEECCCCEEEECCCEEEECCCHHHHHHHHHCCCCEEEEHHH
IYEEVWKEEFFKSDNTVTVHITNLREKIEADPKAPVYIKTIWGVGYKI
HHHHHHHHHHHCCCCEEEEEEECCHHHHCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]