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The map label for this gene is adc

Identifier: 187933144

GI number: 187933144

Start: 2234859

End: 2235599

Strand: Reverse

Name: adc

Synonym: CLL_A2135

Alternate gene names: 187933144

Gene position: 2235599-2234859 (Counterclockwise)

Preceding gene: 187934878

Following gene: 187934965

Centisome position: 58.83

GC content: 33.33

Gene sequence:

>741_bases
ATGTTAAAAAGTGAAGTATCTAAACAAATTACAACACCACTAACAGCTCCAGCATTTCCAAGGGGACCTTATAGGTTCCA
TAACCGTGAATATTTTAATATTATATACCGTACTGATGCTGATGCTTTACGTAAAATTGTACCAGAACCTTTAGAATTAG
GAGAAGATCCTTTAGTTAGATTTGAAATGATGGCTATGCCTGACACAAGTGGATTAGGATCTTATACAGAATGTGGACAG
GCTATACCAGTAAGCTATAATGGTAAAAAGGGTGACTATTTGCATATGATGTATTTAGATAATCAGCCAGCTATTGCCGT
TGGAAGAGAACTTAGTGCATATCCTAAAAAACTTGGTTATCCTAAGTTATTTGTTGATTCAGACACACTAGTTGGTACAT
TAGATTATGGAAAATTAAGAGTAGCAATAGCAACTATGGGGTATAAGCATAAACAATTAGATTTAAATGAAGCAAAGGAA
CAAATTTGTCGTCCTAATTTTATGTTAAAAATTATACCTAACTATGATGGAACTCCAAGAATATGTGAGTTAATATCTGC
ACAAATTAAAGACATTACTGTACATGAGGCATGGACTGGTCCTGCAAGATTACAATTATTTGATCATGCTATGGCACCAT
TTAATGACTTACCTGTAAAAGAAATAGTTTCAAGTTCTCATATTCTCACAGACTTAACACTTCCATCTCCTGAGGTTATA
TATGATTATCTTAAAAAGTAG

Upstream 100 bases:

>100_bases
TCTATCTATAGCATTTATACTATAAATGACATTATAATTTAAAAATACAATTAAGTTAAAATGAGAATGTCAAATATTTA
ATGTAAGAAGATGAATAGTT

Downstream 100 bases:

>100_bases
TTTAATATATTAATAAATAAAATAAATTGCAAACTGTTTTAAATAATTAAAAAATCTAAGTTAAGAATATGATTTCTATT
TAGTATAGAGATCATATTCT

Product: acetoacetate decarboxylase

Products: NA

Alternate protein names: AAD; ADC

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLKSEVSKQITTPLTAPAFPRGPYRFHNREYFNIIYRTDADALRKIVPEPLELGEDPLVRFEMMAMPDTSGLGSYTECGQ
AIPVSYNGKKGDYLHMMYLDNQPAIAVGRELSAYPKKLGYPKLFVDSDTLVGTLDYGKLRVAIATMGYKHKQLDLNEAKE
QICRPNFMLKIIPNYDGTPRICELISAQIKDITVHEAWTGPARLQLFDHAMAPFNDLPVKEIVSSSHILTDLTLPSPEVI
YDYLKK

Sequences:

>Translated_246_residues
MLKSEVSKQITTPLTAPAFPRGPYRFHNREYFNIIYRTDADALRKIVPEPLELGEDPLVRFEMMAMPDTSGLGSYTECGQ
AIPVSYNGKKGDYLHMMYLDNQPAIAVGRELSAYPKKLGYPKLFVDSDTLVGTLDYGKLRVAIATMGYKHKQLDLNEAKE
QICRPNFMLKIIPNYDGTPRICELISAQIKDITVHEAWTGPARLQLFDHAMAPFNDLPVKEIVSSSHILTDLTLPSPEVI
YDYLKK
>Mature_246_residues
MLKSEVSKQITTPLTAPAFPRGPYRFHNREYFNIIYRTDADALRKIVPEPLELGEDPLVRFEMMAMPDTSGLGSYTECGQ
AIPVSYNGKKGDYLHMMYLDNQPAIAVGRELSAYPKKLGYPKLFVDSDTLVGTLDYGKLRVAIATMGYKHKQLDLNEAKE
QICRPNFMLKIIPNYDGTPRICELISAQIKDITVHEAWTGPARLQLFDHAMAPFNDLPVKEIVSSSHILTDLTLPSPEVI
YDYLKK

Specific function: Catalyzes the conversion of acetoacetate to acetone and carbon dioxide

COG id: COG4689

COG function: function code Q; Acetoacetate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ADC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADC_CLOBB (B2TLN8)

Other databases:

- EMBL:   CP001056
- RefSeq:   YP_001886324.1
- GeneID:   6294216
- GenomeReviews:   CP001056_GR
- KEGG:   cbk:CLL_A2135
- HOGENOM:   HBG294597
- OMA:   MGYKHRP
- ProtClustDB:   PRK02265
- HAMAP:   MF_00597
- InterPro:   IPR010451

Pfam domain/function: PF06314 ADC

EC number: =4.1.1.4

Molecular weight: Translated: 27800; Mature: 27800

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSEVSKQITTPLTAPAFPRGPYRFHNREYFNIIYRTDADALRKIVPEPLELGEDPLVR
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHCCCHHHCCCCCCEE
FEMMAMPDTSGLGSYTECGQAIPVSYNGKKGDYLHMMYLDNQPAIAVGRELSAYPKKLGY
EEEEECCCCCCCCCHHHCCCCCCEEECCCCCCEEEEEEECCCCCEEECCHHHHHHHHCCC
PKLFVDSDTLVGTLDYGKLRVAIATMGYKHKQLDLNEAKEQICRPNFMLKIIPNYDGTPR
CEEEEECCCEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCHH
ICELISAQIKDITVHEAWTGPARLQLFDHAMAPFNDLPVKEIVSSSHILTDLTLPSPEVI
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCHHHH
YDYLKK
HHHHCC
>Mature Secondary Structure
MLKSEVSKQITTPLTAPAFPRGPYRFHNREYFNIIYRTDADALRKIVPEPLELGEDPLVR
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHCCCHHHCCCCCCEE
FEMMAMPDTSGLGSYTECGQAIPVSYNGKKGDYLHMMYLDNQPAIAVGRELSAYPKKLGY
EEEEECCCCCCCCCHHHCCCCCCEEECCCCCCEEEEEEECCCCCEEECCHHHHHHHHCCC
PKLFVDSDTLVGTLDYGKLRVAIATMGYKHKQLDLNEAKEQICRPNFMLKIIPNYDGTPR
CEEEEECCCEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCHH
ICELISAQIKDITVHEAWTGPARLQLFDHAMAPFNDLPVKEIVSSSHILTDLTLPSPEVI
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCHHHH
YDYLKK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA