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The map label for this gene is mutL

Identifier: 187932933

GI number: 187932933

Start: 1900776

End: 1902794

Strand: Reverse

Name: mutL

Synonym: CLL_A1818

Alternate gene names: 187932933

Gene position: 1902794-1900776 (Counterclockwise)

Preceding gene: 187933880

Following gene: 187935269

Centisome position: 50.07

GC content: 27.19

Gene sequence:

>2019_bases
ATGAAAAGAATTAATATATTAAATGAAGATACAGCTAATAAAATTGCAGCAGGTGAAGTAGTAGAAAGACCAGCATCAGT
AGTAAAGGAATTAGTTGAAAATGCTATAGATGCAAATTCTAAAAATATATTAATAGAAATAGAAGAGGGTGGAAGTTCTT
TAATAAGAATTATTGATGATGGAGATGGGATTTACAAAGAAGATATAGAGAAAGCCTTTTTACCTCATGCCACAAGTAAG
ATAAAAGAGTCTGAAGATATATATAGTATTAACACATTAGGTTTTAGGGGAGAAGCTCTTCCATCTATTGCATCAGTAGC
TAGAGTTAATTTGAAAACAAAACAAGAAACTGAAGAATGTGGATATGAAATTACAATAGAAGGTGGAAAATTTTCAGAAG
TTACAGAATGTGGGGTTAATAAAGGAACTATAATGGAAGTAAGAGATTTATTTTTCAATGTTCCAGCAAGAAAAAAGTTC
CTTAAAACAACTTCTAAAGAATCTTCTTTAATTAATGATATCATAACTAGAATAGCTTTATCTAACCCTAATATTAGTTT
TAAACTATTTAATAATGGGAAAAAAATTATTCATACGTATGGCAATGGCAATATGAAAGATGTTATAAGAACTATCTATG
GTAAAAGTATAGTTGAAAATGTGTTATATTTTGAAGATACATCTGATATCGCTACTATTTATGGGTATGTAGGGAAAGAG
GCAATTGCTAGAGGTTCTAGAAATAATCAAAGTATTTTTGTAAATAGCAGATATATAAAGAATAGAAGTTTAGGAATTGC
AGTAGAGCAAGCATTTAAATCATTTTCTACTGTAAGTAAGTTTCCTTTCTTTATATTATTTATAGAAATATATCCTGAAT
ATATAGATGTGAATATTCACCCAACTAAATCAGAAGTAAAATTCAATGATGAACGTTTCATTTTTAAAAAGATATTTGGT
GCTGTTCATACATCTTTAAAGGAAGAAGTTTTTAGTACATTTTCAATACCTGAAGAAGTAAATGAAGCTATTAGTAAGAA
TACTAACTTAAATATTGAAGAAATAACTTTTAAAATTGAAGAAGAACAAGAAAAAGTTAAGTTTAATACTAATCATTTGT
CACAAAAGAACATATGTTCTACACAAGGGAATAATAGCATAAATAAGCATATTTATGATGAAAAACACAAAACAGACACT
AATATTCCTTTAAATGTTAATATTCCAGTTGATTTAAAAAGTGATCACATTAAATTAGAAGATGATAATAATAGTATTCC
TAATAAAGAAGTAATTTGTGACAATAATGAAGTTAAGTATGAAAGTTCTTATACATCTGACTCTAATCAGTATGAAAATA
GCTGTAAAAGTGATGTGGATAAGGAAAGTAAATCAAAAACAACAGGAACATCAGAATTAGTAAAAGAAAAAATTCCAAAG
TTCCCTGCTATAAAAATTATTGGTCAATATAATAAAACTTATATATTAGGAGAATATGCAGGAACTCTTTATATGATAGA
TCAACACGCAGCTCATGAAAAAATAATGTTTGAAAAGTATTTAAATGATATAATTTGTGGAGATATAATAATACAGCCAC
TTATGATACCAACAGTAATTGATTTAAGCATGGATGATTACTCGTATTTTGAAGAAAACAAAGATGTATTTAAAGAAGCC
GGGTTTACTATTGAAGATTTCGGTGGCACATCTATAGCATTAAAAGAAGTTCCATACTTTTTAGGTAAACTAAAACCTAA
AAATCTATTTTTAGAAATATTAGATAATCTTAAAAATTTAGGATCAGGTAAAACTACTGAAGTTAAATATAATGCTATAG
CAACTAAAGCATGCAAATCAGCAGTAAAAGGAAACGATTCTTTAGATGAATTAGAAATGGTTAAGTTAATAGAAGAGTTA
AGATATATAGACGATCCATTCCATTGTCCTCATGGAAGACCAACCATTATTCAATTTACTAGTACAGATATAGATAAAAA
ATTTAGGAGGATTGTTTAA

Upstream 100 bases:

>100_bases
TGAAGAAACTTATAAACAGAAATTAAATATCTAAATATACATACAATATGTTATGTTAGATTTACTTATAAAGTAGAGAC
TTACAAAGGGGGTGCACAAT

Downstream 100 bases:

>100_bases
TAATGAAACAAAAGATTTTAGTTCTTGGAGGTCCTACAGCTGTTGGGAAAACAGAACTTTCAATAAAACTTGCTGAAAAA
TTAAACGGGGAGATACTATC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MKRINILNEDTANKIAAGEVVERPASVVKELVENAIDANSKNILIEIEEGGSSLIRIIDDGDGIYKEDIEKAFLPHATSK
IKESEDIYSINTLGFRGEALPSIASVARVNLKTKQETEECGYEITIEGGKFSEVTECGVNKGTIMEVRDLFFNVPARKKF
LKTTSKESSLINDIITRIALSNPNISFKLFNNGKKIIHTYGNGNMKDVIRTIYGKSIVENVLYFEDTSDIATIYGYVGKE
AIARGSRNNQSIFVNSRYIKNRSLGIAVEQAFKSFSTVSKFPFFILFIEIYPEYIDVNIHPTKSEVKFNDERFIFKKIFG
AVHTSLKEEVFSTFSIPEEVNEAISKNTNLNIEEITFKIEEEQEKVKFNTNHLSQKNICSTQGNNSINKHIYDEKHKTDT
NIPLNVNIPVDLKSDHIKLEDDNNSIPNKEVICDNNEVKYESSYTSDSNQYENSCKSDVDKESKSKTTGTSELVKEKIPK
FPAIKIIGQYNKTYILGEYAGTLYMIDQHAAHEKIMFEKYLNDIICGDIIIQPLMIPTVIDLSMDDYSYFEENKDVFKEA
GFTIEDFGGTSIALKEVPYFLGKLKPKNLFLEILDNLKNLGSGKTTEVKYNAIATKACKSAVKGNDSLDELEMVKLIEEL
RYIDDPFHCPHGRPTIIQFTSTDIDKKFRRIV

Sequences:

>Translated_672_residues
MKRINILNEDTANKIAAGEVVERPASVVKELVENAIDANSKNILIEIEEGGSSLIRIIDDGDGIYKEDIEKAFLPHATSK
IKESEDIYSINTLGFRGEALPSIASVARVNLKTKQETEECGYEITIEGGKFSEVTECGVNKGTIMEVRDLFFNVPARKKF
LKTTSKESSLINDIITRIALSNPNISFKLFNNGKKIIHTYGNGNMKDVIRTIYGKSIVENVLYFEDTSDIATIYGYVGKE
AIARGSRNNQSIFVNSRYIKNRSLGIAVEQAFKSFSTVSKFPFFILFIEIYPEYIDVNIHPTKSEVKFNDERFIFKKIFG
AVHTSLKEEVFSTFSIPEEVNEAISKNTNLNIEEITFKIEEEQEKVKFNTNHLSQKNICSTQGNNSINKHIYDEKHKTDT
NIPLNVNIPVDLKSDHIKLEDDNNSIPNKEVICDNNEVKYESSYTSDSNQYENSCKSDVDKESKSKTTGTSELVKEKIPK
FPAIKIIGQYNKTYILGEYAGTLYMIDQHAAHEKIMFEKYLNDIICGDIIIQPLMIPTVIDLSMDDYSYFEENKDVFKEA
GFTIEDFGGTSIALKEVPYFLGKLKPKNLFLEILDNLKNLGSGKTTEVKYNAIATKACKSAVKGNDSLDELEMVKLIEEL
RYIDDPFHCPHGRPTIIQFTSTDIDKKFRRIV
>Mature_672_residues
MKRINILNEDTANKIAAGEVVERPASVVKELVENAIDANSKNILIEIEEGGSSLIRIIDDGDGIYKEDIEKAFLPHATSK
IKESEDIYSINTLGFRGEALPSIASVARVNLKTKQETEECGYEITIEGGKFSEVTECGVNKGTIMEVRDLFFNVPARKKF
LKTTSKESSLINDIITRIALSNPNISFKLFNNGKKIIHTYGNGNMKDVIRTIYGKSIVENVLYFEDTSDIATIYGYVGKE
AIARGSRNNQSIFVNSRYIKNRSLGIAVEQAFKSFSTVSKFPFFILFIEIYPEYIDVNIHPTKSEVKFNDERFIFKKIFG
AVHTSLKEEVFSTFSIPEEVNEAISKNTNLNIEEITFKIEEEQEKVKFNTNHLSQKNICSTQGNNSINKHIYDEKHKTDT
NIPLNVNIPVDLKSDHIKLEDDNNSIPNKEVICDNNEVKYESSYTSDSNQYENSCKSDVDKESKSKTTGTSELVKEKIPK
FPAIKIIGQYNKTYILGEYAGTLYMIDQHAAHEKIMFEKYLNDIICGDIIIQPLMIPTVIDLSMDDYSYFEENKDVFKEA
GFTIEDFGGTSIALKEVPYFLGKLKPKNLFLEILDNLKNLGSGKTTEVKYNAIATKACKSAVKGNDSLDELEMVKLIEEL
RYIDDPFHCPHGRPTIIQFTSTDIDKKFRRIV

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=335, Percent_Identity=36.4179104477612, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI310128478, Length=341, Percent_Identity=26.099706744868, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4505913, Length=341, Percent_Identity=26.099706744868, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=31.5352697095436, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI4505911, Length=319, Percent_Identity=26.6457680250784, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI189458898, Length=319, Percent_Identity=26.6457680250784, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI310128480, Length=292, Percent_Identity=24.6575342465753, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=26.1829652996845, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI91992162, Length=355, Percent_Identity=24.2253521126761, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI91992160, Length=355, Percent_Identity=24.2253521126761, Blast_Score=87, Evalue=6e-17,
Organism=Escherichia coli, GI1790612, Length=357, Percent_Identity=38.0952380952381, Blast_Score=238, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=341, Percent_Identity=33.4310850439883, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17562796, Length=467, Percent_Identity=24.1970021413276, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=331, Percent_Identity=34.7432024169184, Blast_Score=190, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=348, Percent_Identity=31.0344827586207, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6325093, Length=744, Percent_Identity=21.9086021505376, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323063, Length=365, Percent_Identity=24.6575342465753, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17136968, Length=312, Percent_Identity=34.2948717948718, Blast_Score=209, Evalue=7e-54,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=24.6498599439776, Blast_Score=123, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CLOBB (B2TIB8)

Other databases:

- EMBL:   CP001056
- RefSeq:   YP_001886011.1
- GeneID:   6294544
- GenomeReviews:   CP001056_GR
- KEGG:   cbk:CLL_A1818
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 76092; Mature: 76092

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRINILNEDTANKIAAGEVVERPASVVKELVENAIDANSKNILIEIEEGGSSLIRIIDD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GDGIYKEDIEKAFLPHATSKIKESEDIYSINTLGFRGEALPSIASVARVNLKTKQETEEC
CCCCCHHHHHHHHCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHC
GYEITIEGGKFSEVTECGVNKGTIMEVRDLFFNVPARKKFLKTTSKESSLINDIITRIAL
CEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHEE
SNPNISFKLFNNGKKIIHTYGNGNMKDVIRTIYGKSIVENVLYFEDTSDIATIYGYVGKE
CCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHH
AIARGSRNNQSIFVNSRYIKNRSLGIAVEQAFKSFSTVSKFPFFILFIEIYPEYIDVNIH
HHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCHHEEEEEEECCCCEEEEEC
PTKSEVKFNDERFIFKKIFGAVHTSLKEEVFSTFSIPEEVNEAISKNTNLNIEEITFKIE
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEEE
EEQEKVKFNTNHLSQKNICSTQGNNSINKHIYDEKHKTDTNIPLNVNIPVDLKSDHIKLE
CCCHHEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCEEEEECEEECCCEEEEE
DDNNSIPNKEVICDNNEVKYESSYTSDSNQYENSCKSDVDKESKSKTTGTSELVKEKIPK
CCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHCCC
FPAIKIIGQYNKTYILGEYAGTLYMIDQHAAHEKIMFEKYLNDIICGDIIIQPLMIPTVI
CCEEEEEECCCCEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
DLSMDDYSYFEENKDVFKEAGFTIEDFGGTSIALKEVPYFLGKLKPKNLFLEILDNLKNL
ECCCCCHHHHHCCHHHHHHCCCEEEECCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHC
GSGKTTEVKYNAIATKACKSAVKGNDSLDELEMVKLIEELRYIDDPFHCPHGRPTIIQFT
CCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
STDIDKKFRRIV
CCCHHHHHHHCC
>Mature Secondary Structure
MKRINILNEDTANKIAAGEVVERPASVVKELVENAIDANSKNILIEIEEGGSSLIRIIDD
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GDGIYKEDIEKAFLPHATSKIKESEDIYSINTLGFRGEALPSIASVARVNLKTKQETEEC
CCCCCHHHHHHHHCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHC
GYEITIEGGKFSEVTECGVNKGTIMEVRDLFFNVPARKKFLKTTSKESSLINDIITRIAL
CEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHEE
SNPNISFKLFNNGKKIIHTYGNGNMKDVIRTIYGKSIVENVLYFEDTSDIATIYGYVGKE
CCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHH
AIARGSRNNQSIFVNSRYIKNRSLGIAVEQAFKSFSTVSKFPFFILFIEIYPEYIDVNIH
HHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCHHEEEEEEECCCCEEEEEC
PTKSEVKFNDERFIFKKIFGAVHTSLKEEVFSTFSIPEEVNEAISKNTNLNIEEITFKIE
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEEE
EEQEKVKFNTNHLSQKNICSTQGNNSINKHIYDEKHKTDTNIPLNVNIPVDLKSDHIKLE
CCCHHEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCEEEEECEEECCCEEEEE
DDNNSIPNKEVICDNNEVKYESSYTSDSNQYENSCKSDVDKESKSKTTGTSELVKEKIPK
CCCCCCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHCCHHHCCCCCCHHHHHHHHCCC
FPAIKIIGQYNKTYILGEYAGTLYMIDQHAAHEKIMFEKYLNDIICGDIIIQPLMIPTVI
CCEEEEEECCCCEEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
DLSMDDYSYFEENKDVFKEAGFTIEDFGGTSIALKEVPYFLGKLKPKNLFLEILDNLKNL
ECCCCCHHHHHCCHHHHHHCCCEEEECCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHC
GSGKTTEVKYNAIATKACKSAVKGNDSLDELEMVKLIEELRYIDDPFHCPHGRPTIIQFT
CCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
STDIDKKFRRIV
CCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA