Click here to switch to the map view.

The map label for this gene is rmlA1 [H]

Identifier: 187927735

GI number: 187927735

Start: 678433

End: 679317

Strand: Reverse

Name: rmlA1 [H]

Synonym: Rpic_0639

Alternate gene names: 187927735

Gene position: 679317-678433 (Counterclockwise)

Preceding gene: 187927736

Following gene: 187927734

Centisome position: 17.23

GC content: 59.89

Gene sequence:

>885_bases
ATGGCACGCAAAGGCATTATTCTAGCAGGTGGCTCCGGGACACGGCTGTATCCCATCACGCACTCTGTGTCGAAGCAATT
GCTTCCGGTGTACGACAAGCCGATGATCTATTACCCGCTCAGCACGCTGATGCTCGCGGGTATTCGCGACATTCTGATCA
TCTCCACCCCGCAGGACACCCCGCGGTTCTCTGAGATGCTGGGTGACGGCAGTCAATGGGGGCTGAATCTGCAGTACGCG
GTTCAGCCCTCGCCGGATGGACTCGCACAGGCGTTCATCATAGGCAAGGATTTCGTCGGCGGTGACCCGTCTACGCTCAT
CCTCGGGGACAACATCTTCTACGGCCACGATCTGGTAAAGCAGTTGAATCGGGCCAGCGCACAGACCAGCGGCGCCAGCG
TATTTGCCTACCATGTTCACGACCCGGAGCGCTATGGCGTGGTCGAGTTTGATAGCTGCATGCGCGCGGTCTCCCTTGAA
GAAAAGCCTGCCAAACCGCGCTCGAATTACGCGGTCACCGGCCTGTACTTCTATGACGCGGACGTCTGCCAGATCGCCGC
AGGCGTCAAGCCGTCGGCGCGCGGCGAACTCGAGATCACCGAAGTCAATCAACGCTATCTCGAGCGCGGCACTCTGGAAG
TGGAAATCATGGGGCGCGGCTATGCATGGCTCGACACTGGCACGCACGACTCCCTCATCGAAGCCGCCACGTTCATCGCC
ACGCTGCAGCGCCGCCAAGGCCTGATGGTTGCCTGCCCCGAAGAGATTGCATTCCGCCAGCGCTGGATTGATCTGGAACA
AGTCCAGAAACTGGCTGCTCCGCTCGCCAAGAGTGGCTATGGCGCGTATCTCCGCCAGCTTATCGCCGAGGATGTCCCTC
GATGA

Upstream 100 bases:

>100_bases
ACCTCGAGAATCAGGAATGGGTCGCGGATGTGATGTCTGGCGCCTATCGGGATTGGGTTGATGTGAACTACGGTAGCCGC
CGCTAACAACCGGACTTTTC

Downstream 100 bases:

>100_bases
ACCTCAGCGTCACAGAAACCACCCTGCCGGGCGTGCTTATCCTCGAACCTAAGGTCTACGGTGACAGCCGCGGTTTCTTT
TTCGAGAGCTTCAACGGCCG

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MARKGIILAGGSGTRLYPITHSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFSEMLGDGSQWGLNLQYA
VQPSPDGLAQAFIIGKDFVGGDPSTLILGDNIFYGHDLVKQLNRASAQTSGASVFAYHVHDPERYGVVEFDSCMRAVSLE
EKPAKPRSNYAVTGLYFYDADVCQIAAGVKPSARGELEITEVNQRYLERGTLEVEIMGRGYAWLDTGTHDSLIEAATFIA
TLQRRQGLMVACPEEIAFRQRWIDLEQVQKLAAPLAKSGYGAYLRQLIAEDVPR

Sequences:

>Translated_294_residues
MARKGIILAGGSGTRLYPITHSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFSEMLGDGSQWGLNLQYA
VQPSPDGLAQAFIIGKDFVGGDPSTLILGDNIFYGHDLVKQLNRASAQTSGASVFAYHVHDPERYGVVEFDSCMRAVSLE
EKPAKPRSNYAVTGLYFYDADVCQIAAGVKPSARGELEITEVNQRYLERGTLEVEIMGRGYAWLDTGTHDSLIEAATFIA
TLQRRQGLMVACPEEIAFRQRWIDLEQVQKLAAPLAKSGYGAYLRQLIAEDVPR
>Mature_293_residues
ARKGIILAGGSGTRLYPITHSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQDTPRFSEMLGDGSQWGLNLQYAV
QPSPDGLAQAFIIGKDFVGGDPSTLILGDNIFYGHDLVKQLNRASAQTSGASVFAYHVHDPERYGVVEFDSCMRAVSLEE
KPAKPRSNYAVTGLYFYDADVCQIAAGVKPSARGELEITEVNQRYLERGTLEVEIMGRGYAWLDTGTHDSLIEAATFIAT
LQRRQGLMVACPEEIAFRQRWIDLEQVQKLAAPLAKSGYGAYLRQLIAEDVPR

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=254, Percent_Identity=25.9842519685039, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI11761621, Length=254, Percent_Identity=25.1968503937008, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=74.6527777777778, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=66.3157894736842, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1787488, Length=247, Percent_Identity=27.5303643724696, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=180, Percent_Identity=23.8888888888889, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=247, Percent_Identity=25.9109311740891, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355443, Length=245, Percent_Identity=23.265306122449, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644084, Length=245, Percent_Identity=23.265306122449, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32451; Mature: 32320

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKGIILAGGSGTRLYPITHSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQDT
CCCCCEEEECCCCCEEEEEHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFSEMLGDGSQWGLNLQYAVQPSPDGLAQAFIIGKDFVGGDPSTLILGDNIFYGHDLVK
HHHHHHHCCCCCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCEEEEECCEEEHHHHHH
QLNRASAQTSGASVFAYHVHDPERYGVVEFDSCMRAVSLEEKPAKPRSNYAVTGLYFYDA
HHHHHCCCCCCCEEEEEEECCCCCCCEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEEECC
DVCQIAAGVKPSARGELEITEVNQRYLERGTLEVEIMGRGYAWLDTGTHDSLIEAATFIA
HHHHHHCCCCCCCCCCEEEEHHHHHHHHCCCEEEEEEECCEEEEECCCCHHHHHHHHHHH
TLQRRQGLMVACPEEIAFRQRWIDLEQVQKLAAPLAKSGYGAYLRQLIAEDVPR
HHHHHCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARKGIILAGGSGTRLYPITHSVSKQLLPVYDKPMIYYPLSTLMLAGIRDILIISTPQDT
CCCCEEEECCCCCEEEEEHHHHHHHHCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCC
PRFSEMLGDGSQWGLNLQYAVQPSPDGLAQAFIIGKDFVGGDPSTLILGDNIFYGHDLVK
HHHHHHHCCCCCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCEEEEECCEEEHHHHHH
QLNRASAQTSGASVFAYHVHDPERYGVVEFDSCMRAVSLEEKPAKPRSNYAVTGLYFYDA
HHHHHCCCCCCCEEEEEEECCCCCCCEEEHHHHHHHHCCCCCCCCCCCCEEEEEEEEECC
DVCQIAAGVKPSARGELEITEVNQRYLERGTLEVEIMGRGYAWLDTGTHDSLIEAATFIA
HHHHHHCCCCCCCCCCEEEEHHHHHHHHCCCEEEEEEECCEEEEECCCCHHHHHHHHHHH
TLQRRQGLMVACPEEIAFRQRWIDLEQVQKLAAPLAKSGYGAYLRQLIAEDVPR
HHHHHCCCEEECCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]