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The map label for this gene is rfbD [H]

Identifier: 187927733

GI number: 187927733

Start: 676965

End: 677885

Strand: Reverse

Name: rfbD [H]

Synonym: Rpic_0637

Alternate gene names: 187927733

Gene position: 677885-676965 (Counterclockwise)

Preceding gene: 187927734

Following gene: 187927732

Centisome position: 17.19

GC content: 60.59

Gene sequence:

>921_bases
ATGACCATACACTCGCGCCCCCGCATCGTCGTGACTGGCACGACCGGCCAAGTTGGCTGGGAACTGCTGCGCAGCCTGCA
AGGACTGGGGGAAATCATCAGTGTCGATCGCTCGGTGGTGGATCTGTCCCGCCTTGACGCAGTGCGTGCGCTGATCCGCA
GCATCGAGCCTTCGATCATAGTCAATGCCGCCGCCTACACTGCCGTGGACAAGGCAGAACAGGAGCCGGACCCGGCGTTC
CGACTCAATGCCGATCTTCCAGGCGTGCTTGCCGAGGAATGCAAGCGAACACAAGCGGCGTTCATTCATTACTCGACCGA
CTACGTGTTCGACGGCCGCAAGGACGGCCCCTACACGGAAGCCGACGCCACCAACCCGCTGAATGTCTACGGCGCCTCCA
AGCTGGCAGGTGAGCACAACGCATTGGATGCCAATCCAGCCACTCTGGTTTTTCGTACCAGCTGGGTGTACGGCGCGCGT
GGCAAGAACTTTTTGACCACAATTCAACGGCTCGCGAAGGAACGGCAGCAATTGCGGGTCGTCTCTGACCAGATCGGCGC
GCCCACGTGGTCACGCTCCATTGCTGACCTGACGGCCCATGTCATTGCCCGCGGACTCGGCAGCACGCACGCTGAACCCG
CTTGGTGGACCGTCCACGGTGGCGTCTATCACCTGACCAGCAACGGCAGCACAAGTTGGTACGGCTTTGCCGAGGCTATC
CTACAACGCTCGGGCATCACAGGTGTGGCCGTCGAGCCGATTCCTGCCATGGAATACCCAACGCCTGCGGTCCGGCCCGG
TAACTCGCGATTGGCGCTGAACAAGTTGCAGTCCGTTTTCGGACTCGTACCAGAGAGCTGGGAGCAATCGCTGACCAAAT
GTCTGGCCCCGACCTCAGCTGAACGAATTCATGCTTACTAA

Upstream 100 bases:

>100_bases
ATCCGACGATCGCCATCGACTGGCCACTGGCGGGCGCGGAGCCAATCCTAGCCGCCAAAGATGCAGCAGCGGCAGCGTTT
ACCGGCGCAGAGGTCTTCGC

Downstream 100 bases:

>100_bases
CACGCACCTGATCAGCTTTGACGTCAAAGGTGACGAGCGCGGTTCGTTGATCGCGCTGGAGCAGGGATGCAACGTACCCT
TCCCCGTCGCACGTGCGTAC

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTIHSRPRIVVTGTTGQVGWELLRSLQGLGEIISVDRSVVDLSRLDAVRALIRSIEPSIIVNAAAYTAVDKAEQEPDPAF
RLNADLPGVLAEECKRTQAAFIHYSTDYVFDGRKDGPYTEADATNPLNVYGASKLAGEHNALDANPATLVFRTSWVYGAR
GKNFLTTIQRLAKERQQLRVVSDQIGAPTWSRSIADLTAHVIARGLGSTHAEPAWWTVHGGVYHLTSNGSTSWYGFAEAI
LQRSGITGVAVEPIPAMEYPTPAVRPGNSRLALNKLQSVFGLVPESWEQSLTKCLAPTSAERIHAY

Sequences:

>Translated_306_residues
MTIHSRPRIVVTGTTGQVGWELLRSLQGLGEIISVDRSVVDLSRLDAVRALIRSIEPSIIVNAAAYTAVDKAEQEPDPAF
RLNADLPGVLAEECKRTQAAFIHYSTDYVFDGRKDGPYTEADATNPLNVYGASKLAGEHNALDANPATLVFRTSWVYGAR
GKNFLTTIQRLAKERQQLRVVSDQIGAPTWSRSIADLTAHVIARGLGSTHAEPAWWTVHGGVYHLTSNGSTSWYGFAEAI
LQRSGITGVAVEPIPAMEYPTPAVRPGNSRLALNKLQSVFGLVPESWEQSLTKCLAPTSAERIHAY
>Mature_305_residues
TIHSRPRIVVTGTTGQVGWELLRSLQGLGEIISVDRSVVDLSRLDAVRALIRSIEPSIIVNAAAYTAVDKAEQEPDPAFR
LNADLPGVLAEECKRTQAAFIHYSTDYVFDGRKDGPYTEADATNPLNVYGASKLAGEHNALDANPATLVFRTSWVYGARG
KNFLTTIQRLAKERQQLRVVSDQIGAPTWSRSIADLTAHVIARGLGSTHAEPAWWTVHGGVYHLTSNGSTSWYGFAEAIL
QRSGITGVAVEPIPAMEYPTPAVRPGNSRLALNKLQSVFGLVPESWEQSLTKCLAPTSAERIHAY

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI11034825, Length=285, Percent_Identity=29.4736842105263, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI33519455, Length=285, Percent_Identity=29.4736842105263, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788352, Length=297, Percent_Identity=44.7811447811448, Blast_Score=242, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33305; Mature: 33174

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIHSRPRIVVTGTTGQVGWELLRSLQGLGEIISVDRSVVDLSRLDAVRALIRSIEPSII
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VNAAAYTAVDKAEQEPDPAFRLNADLPGVLAEECKRTQAAFIHYSTDYVFDGRKDGPYTE
EEHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHEEEEEEECCEEECCCCCCCCCC
ADATNPLNVYGASKLAGEHNALDANPATLVFRTSWVYGARGKNFLTTIQRLAKERQQLRV
CCCCCCEEECCCHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VSDQIGAPTWSRSIADLTAHVIARGLGSTHAEPAWWTVHGGVYHLTSNGSTSWYGFAEAI
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCCCCHHHHHHHH
LQRSGITGVAVEPIPAMEYPTPAVRPGNSRLALNKLQSVFGLVPESWEQSLTKCLAPTSA
HHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCH
ERIHAY
HHHCCC
>Mature Secondary Structure 
TIHSRPRIVVTGTTGQVGWELLRSLQGLGEIISVDRSVVDLSRLDAVRALIRSIEPSII
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VNAAAYTAVDKAEQEPDPAFRLNADLPGVLAEECKRTQAAFIHYSTDYVFDGRKDGPYTE
EEHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHEEEEEEECCEEECCCCCCCCCC
ADATNPLNVYGASKLAGEHNALDANPATLVFRTSWVYGARGKNFLTTIQRLAKERQQLRV
CCCCCCEEECCCHHHCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VSDQIGAPTWSRSIADLTAHVIARGLGSTHAEPAWWTVHGGVYHLTSNGSTSWYGFAEAI
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCCCCHHHHHHHH
LQRSGITGVAVEPIPAMEYPTPAVRPGNSRLALNKLQSVFGLVPESWEQSLTKCLAPTSA
HHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCH
ERIHAY
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609 [H]