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The map label for this gene is ethA [H]

Identifier: 187927533

GI number: 187927533

Start: 462283

End: 463833

Strand: Direct

Name: ethA [H]

Synonym: Rpic_0433

Alternate gene names: 187927533

Gene position: 462283-463833 (Clockwise)

Preceding gene: 187927531

Following gene: 187927534

Centisome position: 11.73

GC content: 65.25

Gene sequence:

>1551_bases
ATGAATACGACGATGGAGCGAAGCGCCAGCCCCGGCGTGCCCCGCAACCGGGCAGCCGCGCCGGATACCGACCTCGACGT
GCTCATCGTCGGCGCGGGCCTCTCGGGCATTGGCGCGGCGTATCACCTGCGCGAGCGCTGCCCGTCGGCGCGTTTCACCA
TCCTCGAAGGGCGCGAATCCATCGGCGGCACGTGGGACTTGTTCCGCTATCCGGGCATCCGATCGGACTCCGACATGTTC
ACGCTCGGCTACAGCTTCCGGCCGTGGCACAGCAACAAGGCCATCTCCGACGGTCAGACGATTCTCGATTACATCCGCGA
CACCGCAGGCGTGTTCGGCATCGACAAATCCATCCGCTTCCGCCATAAGGTGACGGGTGCGAGCTGGGATTCCGCCGCCG
CGCGCTGGACCGTGCAGGCGCTACGCTGCGATGGCTCGCGCGAGGAACCGGTGCTGTTCACCTGCAAGTTCCTCTACATG
TGCAGCGGCTACTACGACTACGAAGAGGGCCACGCCCCGACGTGGCCCGCGATGGACACTTTCCAAGGCCGCATCGTCCA
TCCGCAGCATTGGCCGAACGATCTGTCGTACGGCGGCAAGCGCGTGGTGGTGATCGGCAGTGGCGCCACGGCGGTCACGC
TGGTGCCCGCGATGGCCGGCACCGCGCAGCACGTGACGATGCTGCAGCGCTCGCCCACGTACATCGTTTCGCGGCCCGAG
CAGGATGCCGTGGCCAACACGTTGCGCCGCTGGTTGCCGTCCGGCCTGGCTCACCGGCTGGTGCGCACGAAGAACGTGCT
GCTGACGATGTACTTCTACAGCCTCGCCCGTCGCAAGCCCAAGGCATTCAAAGAGTTCATCATCCGCATGGCCGGCAAGC
AAATCGGCCCCGGCTTCGACGTGCGCAAACACCTCACGCCGCGCTACAACCCGTGGGACCAGCGCCTGTGCCTCGTGCCC
GATGGCGACCTGTTCAAGACCATCCGTGCAGGCAAGGCGTCGATTGCGACCGACGAAATCGCGCGCTTCACGCCGACCGG
CCTGCAGCTCAAGAGCGGTGAACATCTTGACGCTGACGTGATCGTCACGGCCACTGGGCTCAAGCTGAAGGTGCTGGGCG
GCGCGGCCATCACTGTCGACGGGCGTGCCGTGAATCTGGCCGAGACGGTGTCGTACAAGGGCATGATGTACAGCGGCGTG
CCGAACCTCGCGTCGTCGTTCGGCTATACGAATGCGTCGTGGACGCTCAAGGCTGAGTTGATCGCGCAGTACGTCTGCCG
GCTGCTCAACCACATGCAGTCCAACGGCTTCGATACCTGCGTGCCGCGTCTCGGTGACGAAGCCATGAGCCGCGAACCCG
CCGTCGATCTGACGTCCGGCTACATCCAGCGTGCGGCGGCCATCCTGCCCAAGCAGGGCGACAAGCAGCCGTGGAAGTCA
TATCAGAACTACGCGCGCGATCTGATGATGCTCAAGTTCGGCACACTGGCCGACAGTGCCATGCAGTTCGAACGCCGTGC
CCAGCCGACCGGCGCGGCGCAGCCCGCCTAA

Upstream 100 bases:

>100_bases
TTGACGTCAGGACGCCTGAAAATTAAAGTGGTGACGAATCACACCACATTTAGAGCGAAATTTGCCACGCCTGCCCGCAA
GGCTGCAAACAGGAGACCGC

Downstream 100 bases:

>100_bases
CCGCCTCCCGCTTTGGGGACACTATGACCTACACCATTCTTGGCGTCATCGCGCTTGCCATCCTCGCGCCTGTTGCGTTC
ACGTTTTTCATCGCTCGCCG

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MNTTMERSASPGVPRNRAAAPDTDLDVLIVGAGLSGIGAAYHLRERCPSARFTILEGRESIGGTWDLFRYPGIRSDSDMF
TLGYSFRPWHSNKAISDGQTILDYIRDTAGVFGIDKSIRFRHKVTGASWDSAAARWTVQALRCDGSREEPVLFTCKFLYM
CSGYYDYEEGHAPTWPAMDTFQGRIVHPQHWPNDLSYGGKRVVVIGSGATAVTLVPAMAGTAQHVTMLQRSPTYIVSRPE
QDAVANTLRRWLPSGLAHRLVRTKNVLLTMYFYSLARRKPKAFKEFIIRMAGKQIGPGFDVRKHLTPRYNPWDQRLCLVP
DGDLFKTIRAGKASIATDEIARFTPTGLQLKSGEHLDADVIVTATGLKLKVLGGAAITVDGRAVNLAETVSYKGMMYSGV
PNLASSFGYTNASWTLKAELIAQYVCRLLNHMQSNGFDTCVPRLGDEAMSREPAVDLTSGYIQRAAAILPKQGDKQPWKS
YQNYARDLMMLKFGTLADSAMQFERRAQPTGAAQPA

Sequences:

>Translated_516_residues
MNTTMERSASPGVPRNRAAAPDTDLDVLIVGAGLSGIGAAYHLRERCPSARFTILEGRESIGGTWDLFRYPGIRSDSDMF
TLGYSFRPWHSNKAISDGQTILDYIRDTAGVFGIDKSIRFRHKVTGASWDSAAARWTVQALRCDGSREEPVLFTCKFLYM
CSGYYDYEEGHAPTWPAMDTFQGRIVHPQHWPNDLSYGGKRVVVIGSGATAVTLVPAMAGTAQHVTMLQRSPTYIVSRPE
QDAVANTLRRWLPSGLAHRLVRTKNVLLTMYFYSLARRKPKAFKEFIIRMAGKQIGPGFDVRKHLTPRYNPWDQRLCLVP
DGDLFKTIRAGKASIATDEIARFTPTGLQLKSGEHLDADVIVTATGLKLKVLGGAAITVDGRAVNLAETVSYKGMMYSGV
PNLASSFGYTNASWTLKAELIAQYVCRLLNHMQSNGFDTCVPRLGDEAMSREPAVDLTSGYIQRAAAILPKQGDKQPWKS
YQNYARDLMMLKFGTLADSAMQFERRAQPTGAAQPA
>Mature_516_residues
MNTTMERSASPGVPRNRAAAPDTDLDVLIVGAGLSGIGAAYHLRERCPSARFTILEGRESIGGTWDLFRYPGIRSDSDMF
TLGYSFRPWHSNKAISDGQTILDYIRDTAGVFGIDKSIRFRHKVTGASWDSAAARWTVQALRCDGSREEPVLFTCKFLYM
CSGYYDYEEGHAPTWPAMDTFQGRIVHPQHWPNDLSYGGKRVVVIGSGATAVTLVPAMAGTAQHVTMLQRSPTYIVSRPE
QDAVANTLRRWLPSGLAHRLVRTKNVLLTMYFYSLARRKPKAFKEFIIRMAGKQIGPGFDVRKHLTPRYNPWDQRLCLVP
DGDLFKTIRAGKASIATDEIARFTPTGLQLKSGEHLDADVIVTATGLKLKVLGGAAITVDGRAVNLAETVSYKGMMYSGV
PNLASSFGYTNASWTLKAELIAQYVCRLLNHMQSNGFDTCVPRLGDEAMSREPAVDLTSGYIQRAAAILPKQGDKQPWKS
YQNYARDLMMLKFGTLADSAMQFERRAQPTGAAQPA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17561948, Length=383, Percent_Identity=22.7154046997389, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57040; Mature: 57040

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTMERSASPGVPRNRAAAPDTDLDVLIVGAGLSGIGAAYHLRERCPSARFTILEGRES
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCHH
IGGTWDLFRYPGIRSDSDMFTLGYSFRPWHSNKAISDGQTILDYIRDTAGVFGIDKSIRF
CCCCEEHHCCCCCCCCCCEEEECCEECCCCCCCCCCCHHHHHHHHHHHCCEEECCCCEEE
RHKVTGASWDSAAARWTVQALRCDGSREEPVLFTCKFLYMCSGYYDYEEGHAPTWPAMDT
EEEECCCCCCCHHHHEEEEEEECCCCCCCCEEEEEEHHHHHCCCCCCCCCCCCCCCCCCC
FQGRIVHPQHWPNDLSYGGKRVVVIGSGATAVTLVPAMAGTAQHVTMLQRSPTYIVSRPE
CCCEEECCCCCCCCCCCCCEEEEEEECCCCEEEEHHHHCCCHHHHHHHHCCCCEEEECCC
QDAVANTLRRWLPSGLAHRLVRTKNVLLTMYFYSLARRKPKAFKEFIIRMAGKQIGPGFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
VRKHLTPRYNPWDQRLCLVPDGDLFKTIRAGKASIATDEIARFTPTGLQLKSGEHLDADV
HHHCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCCCHHHHHHCCCCCEEECCCCCCCCEE
IVTATGLKLKVLGGAAITVDGRAVNLAETVSYKGMMYSGVPNLASSFGYTNASWTLKAEL
EEEECCEEEEEECCEEEEECCCEEEHHHHHHHCCEEECCCCHHHHHCCCCCCCEEEHHHH
IAQYVCRLLNHMQSNGFDTCVPRLGDEAMSREPAVDLTSGYIQRAAAILPKQGDKQPWKS
HHHHHHHHHHHHHCCCCCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
YQNYARDLMMLKFGTLADSAMQFERRAQPTGAAQPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNTTMERSASPGVPRNRAAAPDTDLDVLIVGAGLSGIGAAYHLRERCPSARFTILEGRES
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCHH
IGGTWDLFRYPGIRSDSDMFTLGYSFRPWHSNKAISDGQTILDYIRDTAGVFGIDKSIRF
CCCCEEHHCCCCCCCCCCEEEECCEECCCCCCCCCCCHHHHHHHHHHHCCEEECCCCEEE
RHKVTGASWDSAAARWTVQALRCDGSREEPVLFTCKFLYMCSGYYDYEEGHAPTWPAMDT
EEEECCCCCCCHHHHEEEEEEECCCCCCCCEEEEEEHHHHHCCCCCCCCCCCCCCCCCCC
FQGRIVHPQHWPNDLSYGGKRVVVIGSGATAVTLVPAMAGTAQHVTMLQRSPTYIVSRPE
CCCEEECCCCCCCCCCCCCEEEEEEECCCCEEEEHHHHCCCHHHHHHHHCCCCEEEECCC
QDAVANTLRRWLPSGLAHRLVRTKNVLLTMYFYSLARRKPKAFKEFIIRMAGKQIGPGFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
VRKHLTPRYNPWDQRLCLVPDGDLFKTIRAGKASIATDEIARFTPTGLQLKSGEHLDADV
HHHCCCCCCCCCCCEEEECCCCHHHHHHHCCCCCCCHHHHHHCCCCCEEECCCCCCCCEE
IVTATGLKLKVLGGAAITVDGRAVNLAETVSYKGMMYSGVPNLASSFGYTNASWTLKAEL
EEEECCEEEEEECCEEEEECCCEEEHHHHHHHCCEEECCCCHHHHHCCCCCCCEEEHHHH
IAQYVCRLLNHMQSNGFDTCVPRLGDEAMSREPAVDLTSGYIQRAAAILPKQGDKQPWKS
HHHHHHHHHHHHHCCCCCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHH
YQNYARDLMMLKFGTLADSAMQFERRAQPTGAAQPA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]