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The map label for this gene is fadI [H]

Identifier: 187927517

GI number: 187927517

Start: 441729

End: 443048

Strand: Reverse

Name: fadI [H]

Synonym: Rpic_0414

Alternate gene names: 187927517

Gene position: 443048-441729 (Counterclockwise)

Preceding gene: 187927518

Following gene: 187927516

Centisome position: 11.24

GC content: 66.97

Gene sequence:

>1320_bases
ATGCTCGTCAACGCGCAGTTGCGCCGCGTCGCCATCCTTGGCGGTAACCGCATTCCGTTCGCCCGCTCGAATACGGCCTA
CGCTACCGCATCGAACCAGCAGATGCTGACCGCCGCGCTGCAGGGCCTGATCGACCGCTTCAACCTGCACGGCCAGCGTC
TGGACGAAGTCGTGGCCGGCGCGGTCATCAAGCACGCGCGCGATTTCAACCTGACGCGCGAAACGGTGCTCTCCACCACG
CTCGCCAAGCAGACGCCCGCTTACGACATCCAGCAGGCCTGCGGCACGGGGCTGGAAGCCGCCATTCTCGTTGCCAACAA
GATTGCACTGGGGCAGATCGACGTGGGCATTGCCGGCGGCACGGACACCACCTCCGATGCGCCCGTCGGCCTGAACGAAA
AGATGCGCAAGATCCTGCTGGAGGCCAACCGCGCCAAGTCCACAGGCGCGCGCGTCAAAGCGCTGGCCGGCCTGCGGCCG
TCGATGTTCGTGCGCCCGCTGCTGCCGCGCAACAGCGAGCCGCGCACCGGCCTGTCGATGGGCGAACACTGCGAGCTGAT
GGCCAAGCGCTGGGGCATCCGCCGCGAAGACCAGGACGCGCTGGCCCTGCGCAGCCACCACAACCTCACGGCCGCCTACG
AGCGGGGCTTCTTCACCGACCTGATGACCGCCCACCTGGGGCTCGATCGCGACAACAACCTGCGCAGCAACTTGACCATC
GAGCAACTGGCGAAGCTGCAGCCGGTATTCGACCGCAGCGCCGCCGGCACCATGACGGCCGGCAACTCCACGCCGCTCAC
CGATGGCGCATCGTGCGTACTGCTCGCCAGCGAAGACTGGGCGCGCGCGCACAACCTGCCCGTGCTCGCCTACATGACCT
GCGCGGATACGGCTGCCGTCGATTTCTTCAGCAGCACGCCGGAGCAGAACGAAGGGCTGCTGATGGCGCCGGCCTATGCC
GTCTCGCGCATGCTGCAACGCGCGGGGCTCACCCTGCAGGACTTCGACTACTACGAGATCCACGAAGCCTTTGCCGCACA
GGTGCTCAGCACGCTGGCGGCCTGGGAATCGCCTGAATACTGCCGCGAAAAGCTCGGCCGCAGCGCCCCCATGGGCAGCA
TCGACCGTAGCAAGCTGAACGTGAATGGCAGCTCGCTTGGCACGGGCCATCCGTTTGCCGCCACGGGCGGGCGCATTGTC
GCGACGCTGGCCAAGATGCTGGCGCAGCGCGGCAGCGGGCGTGGGCTGGTGTCGATCTGTGCCGCTGGCGGCCAAGGTGT
CGTTGCCATTCTGGAGCGCCCCGAAACGATGTCGCACTAA

Upstream 100 bases:

>100_bases
CGCGCGTTTGAGGTGCGCAACGCCACGGGCGACAAGCCCTATCTGCGCGGCATGCTGACGCTGCCGCACGCACAACAAGA
CAACACGGGAGACTGAATTC

Downstream 100 bases:

>100_bases
ACCGCTCGGGCCAAAACGGGAACGGCCCGGGTCTACCAAGATTCAAAAACCCGCGCGGCACACAATAAAACCACGCCGCG
TTTTTCATGGACGGAGACAC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLVNAQLRRVAILGGNRIPFARSNTAYATASNQQMLTAALQGLIDRFNLHGQRLDEVVAGAVIKHARDFNLTRETVLSTT
LAKQTPAYDIQQACGTGLEAAILVANKIALGQIDVGIAGGTDTTSDAPVGLNEKMRKILLEANRAKSTGARVKALAGLRP
SMFVRPLLPRNSEPRTGLSMGEHCELMAKRWGIRREDQDALALRSHHNLTAAYERGFFTDLMTAHLGLDRDNNLRSNLTI
EQLAKLQPVFDRSAAGTMTAGNSTPLTDGASCVLLASEDWARAHNLPVLAYMTCADTAAVDFFSSTPEQNEGLLMAPAYA
VSRMLQRAGLTLQDFDYYEIHEAFAAQVLSTLAAWESPEYCREKLGRSAPMGSIDRSKLNVNGSSLGTGHPFAATGGRIV
ATLAKMLAQRGSGRGLVSICAAGGQGVVAILERPETMSH

Sequences:

>Translated_439_residues
MLVNAQLRRVAILGGNRIPFARSNTAYATASNQQMLTAALQGLIDRFNLHGQRLDEVVAGAVIKHARDFNLTRETVLSTT
LAKQTPAYDIQQACGTGLEAAILVANKIALGQIDVGIAGGTDTTSDAPVGLNEKMRKILLEANRAKSTGARVKALAGLRP
SMFVRPLLPRNSEPRTGLSMGEHCELMAKRWGIRREDQDALALRSHHNLTAAYERGFFTDLMTAHLGLDRDNNLRSNLTI
EQLAKLQPVFDRSAAGTMTAGNSTPLTDGASCVLLASEDWARAHNLPVLAYMTCADTAAVDFFSSTPEQNEGLLMAPAYA
VSRMLQRAGLTLQDFDYYEIHEAFAAQVLSTLAAWESPEYCREKLGRSAPMGSIDRSKLNVNGSSLGTGHPFAATGGRIV
ATLAKMLAQRGSGRGLVSICAAGGQGVVAILERPETMSH
>Mature_439_residues
MLVNAQLRRVAILGGNRIPFARSNTAYATASNQQMLTAALQGLIDRFNLHGQRLDEVVAGAVIKHARDFNLTRETVLSTT
LAKQTPAYDIQQACGTGLEAAILVANKIALGQIDVGIAGGTDTTSDAPVGLNEKMRKILLEANRAKSTGARVKALAGLRP
SMFVRPLLPRNSEPRTGLSMGEHCELMAKRWGIRREDQDALALRSHHNLTAAYERGFFTDLMTAHLGLDRDNNLRSNLTI
EQLAKLQPVFDRSAAGTMTAGNSTPLTDGASCVLLASEDWARAHNLPVLAYMTCADTAAVDFFSSTPEQNEGLLMAPAYA
VSRMLQRAGLTLQDFDYYEIHEAFAAQVLSTLAAWESPEYCREKLGRSAPMGSIDRSKLNVNGSSLGTGHPFAATGGRIV
ATLAKMLAQRGSGRGLVSICAAGGQGVVAILERPETMSH

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=435, Percent_Identity=36.7816091954023, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI167614485, Length=437, Percent_Identity=29.2906178489703, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI4501853, Length=440, Percent_Identity=29.5454545454545, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI148539872, Length=446, Percent_Identity=26.457399103139, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4557237, Length=435, Percent_Identity=26.4367816091954, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI194353979, Length=108, Percent_Identity=40.7407407407407, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788683, Length=437, Percent_Identity=39.5881006864989, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI87082165, Length=438, Percent_Identity=32.4200913242009, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788554, Length=435, Percent_Identity=31.7241379310345, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787663, Length=438, Percent_Identity=29.6803652968037, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI48994986, Length=439, Percent_Identity=28.246013667426, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=33.5664335664336, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI133906874, Length=433, Percent_Identity=28.4064665127021, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17535921, Length=436, Percent_Identity=25.4587155963303, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25147385, Length=426, Percent_Identity=24.6478873239437, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322031, Length=437, Percent_Identity=30.6636155606407, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=439, Percent_Identity=25.9681093394077, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=37.122969837587, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24655093, Length=433, Percent_Identity=27.0207852193995, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI17648125, Length=440, Percent_Identity=27.7272727272727, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24640423, Length=442, Percent_Identity=25.1131221719457, Blast_Score=128, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 47130; Mature: 47130

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVNAQLRRVAILGGNRIPFARSNTAYATASNQQMLTAALQGLIDRFNLHGQRLDEVVAG
CCCCCCEEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AVIKHARDFNLTRETVLSTTLAKQTPAYDIQQACGTGLEAAILVANKIALGQIDVGIAGG
HHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHEEECEEEEEEECC
TDTTSDAPVGLNEKMRKILLEANRAKSTGARVKALAGLRPSMFVRPLLPRNSEPRTGLSM
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCC
GEHCELMAKRWGIRREDQDALALRSHHNLTAAYERGFFTDLMTAHLGLDRDNNLRSNLTI
CHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCH
EQLAKLQPVFDRSAAGTMTAGNSTPLTDGASCVLLASEDWARAHNLPVLAYMTCADTAAV
HHHHHHCHHHCCCCCCCEECCCCCCCCCCCCEEEEECCCHHHHCCCCEEEEEEHHHHHHH
DFFSSTPEQNEGLLMAPAYAVSRMLQRAGLTLQDFDYYEIHEAFAAQVLSTLAAWESPEY
HHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHH
CREKLGRSAPMGSIDRSKLNVNGSSLGTGHPFAATGGRIVATLAKMLAQRGSGRGLVSIC
HHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
AAGGQGVVAILERPETMSH
ECCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MLVNAQLRRVAILGGNRIPFARSNTAYATASNQQMLTAALQGLIDRFNLHGQRLDEVVAG
CCCCCCEEEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AVIKHARDFNLTRETVLSTTLAKQTPAYDIQQACGTGLEAAILVANKIALGQIDVGIAGG
HHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHEEECEEEEEEECC
TDTTSDAPVGLNEKMRKILLEANRAKSTGARVKALAGLRPSMFVRPLLPRNSEPRTGLSM
CCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCC
GEHCELMAKRWGIRREDQDALALRSHHNLTAAYERGFFTDLMTAHLGLDRDNNLRSNLTI
CHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCH
EQLAKLQPVFDRSAAGTMTAGNSTPLTDGASCVLLASEDWARAHNLPVLAYMTCADTAAV
HHHHHHCHHHCCCCCCCEECCCCCCCCCCCCEEEEECCCHHHHCCCCEEEEEEHHHHHHH
DFFSSTPEQNEGLLMAPAYAVSRMLQRAGLTLQDFDYYEIHEAFAAQVLSTLAAWESPEY
HHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHCCCHHH
CREKLGRSAPMGSIDRSKLNVNGSSLGTGHPFAATGGRIVATLAKMLAQRGSGRGLVSIC
HHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEE
AAGGQGVVAILERPETMSH
ECCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA