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The map label for this gene is fabF [H]

Identifier: 187927407

GI number: 187927407

Start: 319563

End: 320780

Strand: Reverse

Name: fabF [H]

Synonym: Rpic_0303

Alternate gene names: 187927407

Gene position: 320780-319563 (Counterclockwise)

Preceding gene: 187927408

Following gene: 187927406

Centisome position: 8.14

GC content: 67.65

Gene sequence:

>1218_bases
GTGAAGCCCGTCCTGCTCACGCATTTCACCGCCACGAGCTGCCTCGGACGTGGCCTTGACGCCACGCTCGACGCGTTGCG
CGGGCAACGGGGCGGCCTCGCGCCGTGCACCTTCCCGCGCGCCGATCTCGACACGTGGATCGGCGAAGTGCCTGGCGCCG
ATGCCGCGCCCGTGCGCGCAGACCTGGCCGATTTCGATTGCCGCAACAACAGGCTCGCCCAGATCGGCCTCACACAGGAC
GGTTTTGCCGAAAGCGTTGAAGCCGCCAAGGCACGCCACGGCGCCGGACGCGTCGGCGTATTCATCGGCACCAGCACGTC
GGGCATTCTCGAAACCGAACGCGCCTACCAGCAGCGCGATCCGCAAACGGGCGCGCTGCCGGCCAGCTTTCACTACGCGC
AGACGCACAATATCTATTCTCCAGCCGCATTTGTGCGCGCGTACTTCGGATTGAGCGGGCCGGCCACGGCGATCTCGTCG
GCGTGCTCGTCGGGGGCCAAGGTGTTTGCCTCGGCGCGGCGCATGTTGGCTGCGGGCCTGATCGATGCGGCGGTGGTTGG
TGGTGTCGATTCGCTGTGCCTGACGGCGCTGTACGGGTTCAACTCGCTGGAGCTGCTGTCGCGGCAACCGTGCCGGCCGT
ACGACGTGGCGCGTGACGGCATCTCCATCGGCGAGGCCGCCGCCTTTGCGCTGCTGGAGCGTGCCCCCGAGGCAAACGAC
GCGCTGGACGACGATGCCATCCTGCTGCTCGGCATTGGCGAATCGAGCGATGCGCATCACATGTCGTCGCCGCACCCCGA
AGGGCTGGGGGCACGCGCTGCCATGGCGCAAGCGCTCGCTACCAGCGGCCTGAGCACGGCGGACATCGACTACATCAACC
TGCACGGCACCGGCACACCCAGCAATGACGCAGCGGAGTCCCGCGCCATCCAGGCGCTGTTCCACGGCACGGCGTGCAGT
TCGACCAAGGGCGCGACCGGCCACACGCTGGGCGCGGCCGGAGCTTTGGAAGCCGTGATCACAGCACTGGCGCTGCGCCA
TCAATTTCTGCCTGCCGGCATCAACACCACGCAGCCGGACCCGGCGCTCATCGCCAACTATCTGACGGAGAGCGGCCACG
CCCGCGTTCGCACGGCACTCAGCAACGCCTTCGGATTTGGCGGCACGAATTGCAGCCTGGTCTTCGGCCGCGCAGATCAC
CTGGGCCTGTCGTCATGA

Upstream 100 bases:

>100_bases
CCACGCGCTCGCAAATGACCATTTGATAAAATTTGTTGACGATCGGCGCAGCAGCCTGCCGAATCCACCCCACCCCACAA
TTGCCGCGACATCGCCCCCA

Downstream 100 bases:

>100_bases
CCCGACTCAGCGCCTTCATCGAGAGCGCCGGCATCCTCGGGCCCGGTCTGCCGGATTGGCCGCATACGGCCGACGTGCTT
GCCGGCCGTGCGCGCTACGC

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MKPVLLTHFTATSCLGRGLDATLDALRGQRGGLAPCTFPRADLDTWIGEVPGADAAPVRADLADFDCRNNRLAQIGLTQD
GFAESVEAAKARHGAGRVGVFIGTSTSGILETERAYQQRDPQTGALPASFHYAQTHNIYSPAAFVRAYFGLSGPATAISS
ACSSGAKVFASARRMLAAGLIDAAVVGGVDSLCLTALYGFNSLELLSRQPCRPYDVARDGISIGEAAAFALLERAPEAND
ALDDDAILLLGIGESSDAHHMSSPHPEGLGARAAMAQALATSGLSTADIDYINLHGTGTPSNDAAESRAIQALFHGTACS
STKGATGHTLGAAGALEAVITALALRHQFLPAGINTTQPDPALIANYLTESGHARVRTALSNAFGFGGTNCSLVFGRADH
LGLSS

Sequences:

>Translated_405_residues
MKPVLLTHFTATSCLGRGLDATLDALRGQRGGLAPCTFPRADLDTWIGEVPGADAAPVRADLADFDCRNNRLAQIGLTQD
GFAESVEAAKARHGAGRVGVFIGTSTSGILETERAYQQRDPQTGALPASFHYAQTHNIYSPAAFVRAYFGLSGPATAISS
ACSSGAKVFASARRMLAAGLIDAAVVGGVDSLCLTALYGFNSLELLSRQPCRPYDVARDGISIGEAAAFALLERAPEAND
ALDDDAILLLGIGESSDAHHMSSPHPEGLGARAAMAQALATSGLSTADIDYINLHGTGTPSNDAAESRAIQALFHGTACS
STKGATGHTLGAAGALEAVITALALRHQFLPAGINTTQPDPALIANYLTESGHARVRTALSNAFGFGGTNCSLVFGRADH
LGLSS
>Mature_405_residues
MKPVLLTHFTATSCLGRGLDATLDALRGQRGGLAPCTFPRADLDTWIGEVPGADAAPVRADLADFDCRNNRLAQIGLTQD
GFAESVEAAKARHGAGRVGVFIGTSTSGILETERAYQQRDPQTGALPASFHYAQTHNIYSPAAFVRAYFGLSGPATAISS
ACSSGAKVFASARRMLAAGLIDAAVVGGVDSLCLTALYGFNSLELLSRQPCRPYDVARDGISIGEAAAFALLERAPEAND
ALDDDAILLLGIGESSDAHHMSSPHPEGLGARAAMAQALATSGLSTADIDYINLHGTGTPSNDAAESRAIQALFHGTACS
STKGATGHTLGAAGALEAVITALALRHQFLPAGINTTQPDPALIANYLTESGHARVRTALSNAFGFGGTNCSLVFGRADH
LGLSS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=264, Percent_Identity=42.0454545454545, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=47.5862068965517, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI41872631, Length=311, Percent_Identity=26.0450160771704, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787337, Length=262, Percent_Identity=38.9312977099237, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=30.7692307692308, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983541, Length=409, Percent_Identity=29.0953545232274, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=34.1085271317829, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI212642053, Length=333, Percent_Identity=27.027027027027, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=315, Percent_Identity=26.031746031746, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=440, Percent_Identity=28.4090909090909, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24644341, Length=316, Percent_Identity=35.4430379746835, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24581345, Length=324, Percent_Identity=26.2345679012346, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI221330659, Length=321, Percent_Identity=25.2336448598131, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920632, Length=321, Percent_Identity=25.2336448598131, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 41718; Mature: 41718

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVLLTHFTATSCLGRGLDATLDALRGQRGGLAPCTFPRADLDTWIGEVPGADAAPVRA
CCCEEEEHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHH
DLADFDCRNNRLAQIGLTQDGFAESVEAAKARHGAGRVGVFIGTSTSGILETERAYQQRD
HHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCC
PQTGALPASFHYAQTHNIYSPAAFVRAYFGLSGPATAISSACSSGAKVFASARRMLAAGL
CCCCCCCCCEEHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDAAVVGGVDSLCLTALYGFNSLELLSRQPCRPYDVARDGISIGEAAAFALLERAPEAND
HHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCC
ALDDDAILLLGIGESSDAHHMSSPHPEGLGARAAMAQALATSGLSTADIDYINLHGTGTP
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
SNDAAESRAIQALFHGTACSSTKGATGHTLGAAGALEAVITALALRHQFLPAGINTTQPD
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PALIANYLTESGHARVRTALSNAFGFGGTNCSLVFGRADHLGLSS
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKPVLLTHFTATSCLGRGLDATLDALRGQRGGLAPCTFPRADLDTWIGEVPGADAAPVRA
CCCEEEEHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHH
DLADFDCRNNRLAQIGLTQDGFAESVEAAKARHGAGRVGVFIGTSTSGILETERAYQQRD
HHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCC
PQTGALPASFHYAQTHNIYSPAAFVRAYFGLSGPATAISSACSSGAKVFASARRMLAAGL
CCCCCCCCCEEHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDAAVVGGVDSLCLTALYGFNSLELLSRQPCRPYDVARDGISIGEAAAFALLERAPEAND
HHHHHHCCHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCC
ALDDDAILLLGIGESSDAHHMSSPHPEGLGARAAMAQALATSGLSTADIDYINLHGTGTP
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
SNDAAESRAIQALFHGTACSSTKGATGHTLGAAGALEAVITALALRHQFLPAGINTTQPD
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PALIANYLTESGHARVRTALSNAFGFGGTNCSLVFGRADHLGLSS
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]