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The map label for this gene is pqqL [C]

Identifier: 187927349

GI number: 187927349

Start: 257275

End: 258708

Strand: Direct

Name: pqqL [C]

Synonym: Rpic_0242

Alternate gene names: 187927349

Gene position: 257275-258708 (Clockwise)

Preceding gene: 187927347

Following gene: 187927350

Centisome position: 6.53

GC content: 64.09

Gene sequence:

>1434_bases
ATGGCCTTGGCGGCGGGCCTGCTGGCCGGCCATGTTGGCGCGCAGGAGCTGGCCGCTGCACCGGGCCGTCCGGTGGCCGC
AGCCAGCAGTGCCAAAGTAGGTGCCAGCCAGTCCGACACGCACGAATACAAGCTGCCTAACGGGCTGCAGTTGATCGTCA
AGGAAGACCACCGCGCCCCCACCGTGGCGCACATGGTCTGGTATCACGCCGGCAGCATCGACGAGCACAACGGCACCACG
GGTGTCGCCCACATGCTTGAGCACATGATGTTCAAGGGCACCAAGGCAGTTGGCCCGGGCGAGTTCTCCCGCCGCGTGGC
TGCCCTGGGTGGCCGTGAAAACGCCATGACAACGCGCGACTTCACGATGTACTTCCAGCAGATCGAGAAATCGCACTTGG
CCGATGTGATGGGGCTCGAAGCCGATCGCATGGCCAATCTCCAGCTGACCGACAAGGAGTTCAAGCCGGAGATGAACGTG
GTGAAGGAAGAGCGCCGCATGCGCATCGACGACTCCGCCCGTTCCACTGTCTATGAGCAGATGCTCGCCACGCTGTTCAA
TGCCGCGCCGTACCGCAACCCGACCATCGGCTGGCCGGGAGACCTCGACACGATGACGGTGCAGGACGCCCAGAACTGGT
ACCACGCCTGGTACACGCCCAACAACGTCACCGTGATCGTCGCGGGCGATGTGAAACCCGACGAAGTCTTCCGCCTCGCG
CAGCGCACCTACGGCAAGCTCAAGCCGCATGCACTGCCGCGCCGCTATGCGCAGGAGGAGCCCAAGCAGATCGGCGTGAA
GCGCATCTGGGTGAAGGCGCCGGCCGAGAATCCGTACGTTGTGCTGGCCTACAAGGTGCCGCGCCTGAGCGATGTGGAAA
AAGACGTCGATCCGTATGCGCTGGAAGTCCTGTCGGCCGTGCTCGATGGCTATGACAACGCGCGCCTGCCGAGCCAGCTC
GTCAAGGGCGAAAAGCGCATCGCCGACGATGTCAACGCCGGCTACGACGGTCTGAACCGCGGTCCGTCGATTTTCCTGAT
GGACGGTACGCCCGCCGACGGCCACACCACCGCCGAGATCGAACAGGCGCTGCGCGGGCAGATCGAGCGCATCGCCAAGG
AAGGCGTGACCGATGCCGAACTGAAGCGCGTGAAGGCACAGGTTGTGGCCGCGCAGATCTACAAGCGCGACTCGGTTTTC
GGGCAGGGCATGGAGATCGGCATGAACGAGATGAGCGGCCTGTCGTGGCGCTCCATCGATCGCCAGCTTGAGAAGATCAA
GGGCGTGACGTCGGCGCAGATCCAGCACGTGGCGCAGACGTACTTCAGCGAAGACAACCTCGTCGTCGCCACGCTGCTGC
CGCAACCGATCGATCCCAACAAACCGGCGCGCAAGCCCGTTCCCGGCATGCGCGATGAAGGAGGGCTGCGTTGA

Upstream 100 bases:

>100_bases
GTTAGAATCAAGCGTCGAATTTTATCAGACAGCCCTTATGCGCTCTTCCATGCGAATCGTTTCAAACCGGGCCCGGTCGC
GCGTCTGGCAATTGGCCGCG

Downstream 100 bases:

>100_bases
TGCGCGCCATGTCTCTGACCCTCAAGACGGCGCTGGTCGCCATTGTTGCAGCGGCGGCCCAGAGTGCCCTGGCCGCGCTG
CCCATCGAACACTGGACGGC

Product: peptidase M16 domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MALAAGLLAGHVGAQELAAAPGRPVAAASSAKVGASQSDTHEYKLPNGLQLIVKEDHRAPTVAHMVWYHAGSIDEHNGTT
GVAHMLEHMMFKGTKAVGPGEFSRRVAALGGRENAMTTRDFTMYFQQIEKSHLADVMGLEADRMANLQLTDKEFKPEMNV
VKEERRMRIDDSARSTVYEQMLATLFNAAPYRNPTIGWPGDLDTMTVQDAQNWYHAWYTPNNVTVIVAGDVKPDEVFRLA
QRTYGKLKPHALPRRYAQEEPKQIGVKRIWVKAPAENPYVVLAYKVPRLSDVEKDVDPYALEVLSAVLDGYDNARLPSQL
VKGEKRIADDVNAGYDGLNRGPSIFLMDGTPADGHTTAEIEQALRGQIERIAKEGVTDAELKRVKAQVVAAQIYKRDSVF
GQGMEIGMNEMSGLSWRSIDRQLEKIKGVTSAQIQHVAQTYFSEDNLVVATLLPQPIDPNKPARKPVPGMRDEGGLR

Sequences:

>Translated_477_residues
MALAAGLLAGHVGAQELAAAPGRPVAAASSAKVGASQSDTHEYKLPNGLQLIVKEDHRAPTVAHMVWYHAGSIDEHNGTT
GVAHMLEHMMFKGTKAVGPGEFSRRVAALGGRENAMTTRDFTMYFQQIEKSHLADVMGLEADRMANLQLTDKEFKPEMNV
VKEERRMRIDDSARSTVYEQMLATLFNAAPYRNPTIGWPGDLDTMTVQDAQNWYHAWYTPNNVTVIVAGDVKPDEVFRLA
QRTYGKLKPHALPRRYAQEEPKQIGVKRIWVKAPAENPYVVLAYKVPRLSDVEKDVDPYALEVLSAVLDGYDNARLPSQL
VKGEKRIADDVNAGYDGLNRGPSIFLMDGTPADGHTTAEIEQALRGQIERIAKEGVTDAELKRVKAQVVAAQIYKRDSVF
GQGMEIGMNEMSGLSWRSIDRQLEKIKGVTSAQIQHVAQTYFSEDNLVVATLLPQPIDPNKPARKPVPGMRDEGGLR
>Mature_476_residues
ALAAGLLAGHVGAQELAAAPGRPVAAASSAKVGASQSDTHEYKLPNGLQLIVKEDHRAPTVAHMVWYHAGSIDEHNGTTG
VAHMLEHMMFKGTKAVGPGEFSRRVAALGGRENAMTTRDFTMYFQQIEKSHLADVMGLEADRMANLQLTDKEFKPEMNVV
KEERRMRIDDSARSTVYEQMLATLFNAAPYRNPTIGWPGDLDTMTVQDAQNWYHAWYTPNNVTVIVAGDVKPDEVFRLAQ
RTYGKLKPHALPRRYAQEEPKQIGVKRIWVKAPAENPYVVLAYKVPRLSDVEKDVDPYALEVLSAVLDGYDNARLPSQLV
KGEKRIADDVNAGYDGLNRGPSIFLMDGTPADGHTTAEIEQALRGQIERIAKEGVTDAELKRVKAQVVAAQIYKRDSVFG
QGMEIGMNEMSGLSWRSIDRQLEKIKGVTSAQIQHVAQTYFSEDNLVVATLLPQPIDPNKPARKPVPGMRDEGGLR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=267, Percent_Identity=26.5917602996255, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI94538354, Length=243, Percent_Identity=24.2798353909465, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1787770, Length=240, Percent_Identity=31.6666666666667, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71999683, Length=204, Percent_Identity=26.9607843137255, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17553678, Length=239, Percent_Identity=28.4518828451883, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323192, Length=414, Percent_Identity=21.256038647343, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357875, Length=231, Percent_Identity=28.1385281385281, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24646943, Length=231, Percent_Identity=28.1385281385281, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 52693; Mature: 52561

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALAAGLLAGHVGAQELAAAPGRPVAAASSAKVGASQSDTHEYKLPNGLQLIVKEDHRAP
CCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCC
TVAHMVWYHAGSIDEHNGTTGVAHMLEHMMFKGTKAVGPGEFSRRVAALGGRENAMTTRD
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHH
FTMYFQQIEKSHLADVMGLEADRMANLQLTDKEFKPEMNVVKEERRMRIDDSARSTVYEQ
HHHHHHHHHHHHHHHHHCCCHHHHCCCEECCHHCCCHHHHHHHHHHCCCCCHHHHHHHHH
MLATLFNAAPYRNPTIGWPGDLDTMTVQDAQNWYHAWYTPNNVTVIVAGDVKPDEVFRLA
HHHHHHHCCCCCCCCCCCCCCCCCEEHHHCCCCEEEEECCCCEEEEEECCCCHHHHHHHH
QRTYGKLKPHALPRRYAQEEPKQIGVKRIWVKAPAENPYVVLAYKVPRLSDVEKDVDPYA
HHHHHCCCCCHHHHHHHHCCHHHCCCEEEEEECCCCCCEEEEEEECCCCCCHHHCCCHHH
LEVLSAVLDGYDNARLPSQLVKGEKRIADDVNAGYDGLNRGPSIFLMDGTPADGHTTAEI
HHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHH
EQALRGQIERIAKEGVTDAELKRVKAQVVAAQIYKRDSVFGQGMEIGMNEMSGLSWRSID
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHCCCHHHHHH
RQLEKIKGVTSAQIQHVAQTYFSEDNLVVATLLPQPIDPNKPARKPVPGMRDEGGLR
HHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ALAAGLLAGHVGAQELAAAPGRPVAAASSAKVGASQSDTHEYKLPNGLQLIVKEDHRAP
CHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCC
TVAHMVWYHAGSIDEHNGTTGVAHMLEHMMFKGTKAVGPGEFSRRVAALGGRENAMTTRD
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHH
FTMYFQQIEKSHLADVMGLEADRMANLQLTDKEFKPEMNVVKEERRMRIDDSARSTVYEQ
HHHHHHHHHHHHHHHHHCCCHHHHCCCEECCHHCCCHHHHHHHHHHCCCCCHHHHHHHHH
MLATLFNAAPYRNPTIGWPGDLDTMTVQDAQNWYHAWYTPNNVTVIVAGDVKPDEVFRLA
HHHHHHHCCCCCCCCCCCCCCCCCEEHHHCCCCEEEEECCCCEEEEEECCCCHHHHHHHH
QRTYGKLKPHALPRRYAQEEPKQIGVKRIWVKAPAENPYVVLAYKVPRLSDVEKDVDPYA
HHHHHCCCCCHHHHHHHHCCHHHCCCEEEEEECCCCCCEEEEEEECCCCCCHHHCCCHHH
LEVLSAVLDGYDNARLPSQLVKGEKRIADDVNAGYDGLNRGPSIFLMDGTPADGHTTAEI
HHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCHHHH
EQALRGQIERIAKEGVTDAELKRVKAQVVAAQIYKRDSVFGQGMEIGMNEMSGLSWRSID
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCHHHHCCCHHHHHH
RQLEKIKGVTSAQIQHVAQTYFSEDNLVVATLLPQPIDPNKPARKPVPGMRDEGGLR
HHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]