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The map label for this gene is dacC [H]

Identifier: 187927291

GI number: 187927291

Start: 201236

End: 202438

Strand: Reverse

Name: dacC [H]

Synonym: Rpic_0183

Alternate gene names: 187927291

Gene position: 202438-201236 (Counterclockwise)

Preceding gene: 187927292

Following gene: 187927290

Centisome position: 5.13

GC content: 64.09

Gene sequence:

>1203_bases
ATGCAGACCCGCTTCGCCCATTTCACGCCCTTCGCCTTCCATTCCGCCGCCGCGACCGCCGTGGCGGCCGCCGTGCTGGT
CACTGCGCTACCCGCTATGGCGCAGCCGGTGCCCGCACCGCAGGTCGCGGCCCGCTCATGGATGCTGACCGACGTGACCA
GCGGCCAGGTGCTCGGCGGTGCCAACATGGATGAACGCATCGAGCCCGCCTCGCTCACCAAGCTGATGACGGCCTATCTG
GTCTTCGAAGCCGTGCGCGACGGCAAGCTCAAGTACGACCAGATGATCACGCCCACCGAGACCGTGCGCACCGTCAAGAC
CGACGAATCGCGCATGTTCCTGGAAGCCGGCAAACCGGCCTCAGTGCGGGAGATGACGCAAGGCCTGATCATCCAGTCCG
GCAACGATGCAGCCCTCGTGCTGGCAGAGGCCGTAGGCGGCACTGAGACGAACTTCGTGATGCTGATGAACCGCGAAGCC
GAGCGTCTGGGCATGAAGAACACGCATTTCGCGAACGCCGCGGGCCTGCCCGATCCGAACCACTACTCCACGGCACGTGA
TCTTTCGATCCTGACCGCGGCGCTGATCAAGGATTTCCCGCAGGACTACAAGTTCTACTCGCAGAAGGAATTCACCTATA
ACAACATCAAGCAGTCCAACCGCAACCGCCTGCTGTGGCTCGACCCGACCGTCGACGGGGGCAAGACAGGCCACACCAAG
TCGGCCGGCTACTGCCTCGTCACCTCTGCCAACCGTCCGCTGCCGGACGTGCCGGGCGCGAACCGCCGCCTGCTGTCGGT
CATCATCGGCACCAAGAGCGACGCGATCCGCACACAGGAGAGCTTGAAGGTCCTGAACTACGGCTATCAGTTCTTCGATA
CGGTGCGTCTCTACAAGGCCAAGGAAGCGCTGCAGACGCCCGACGTGTACAAGGGCCAGGCCAAGAGCGTGAAGCTGGGC
GTGGCGGAGGACAAGTGGATCACCGTGCCCAAGGGCGCAGGTGCGCGCCTGAAGCCTGTGCTCGAGCGCAAGGACCCGCT
GATCGCCCCGATCGCCCAAGGCCAGCAGCTGGGCACTGTGAAGGTGATGGACGGTTCGACCGTGGTGTCGGAGTTCCCGG
TGGTGGCGCTCGAAGCGGTGCCGGAAGCCGGCTTCGTCGGCCGCACGATCGACGCGGTCAAGCTGTGGTTTAAAAAGAAG
TAG

Upstream 100 bases:

>100_bases
CCGTAACACCCACCCGTTGATTTTCCGGACGCCGCGCCTCCCCCCCCCTTTTTTCTGGCAGGCGGCGCCATTGAACTCCA
AGCAGACCGCAGGACCCGAC

Downstream 100 bases:

>100_bases
TCGTCCCCACTTACTTCGACATGACCTCCTCTCACACGCCCCCGCCGGGCCATATTCCGCCCGAACAGTCGCTCATCGAG
TACCCGAGCGATTTCCCCAT

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MQTRFAHFTPFAFHSAAATAVAAAVLVTALPAMAQPVPAPQVAARSWMLTDVTSGQVLGGANMDERIEPASLTKLMTAYL
VFEAVRDGKLKYDQMITPTETVRTVKTDESRMFLEAGKPASVREMTQGLIIQSGNDAALVLAEAVGGTETNFVMLMNREA
ERLGMKNTHFANAAGLPDPNHYSTARDLSILTAALIKDFPQDYKFYSQKEFTYNNIKQSNRNRLLWLDPTVDGGKTGHTK
SAGYCLVTSANRPLPDVPGANRRLLSVIIGTKSDAIRTQESLKVLNYGYQFFDTVRLYKAKEALQTPDVYKGQAKSVKLG
VAEDKWITVPKGAGARLKPVLERKDPLIAPIAQGQQLGTVKVMDGSTVVSEFPVVALEAVPEAGFVGRTIDAVKLWFKKK

Sequences:

>Translated_400_residues
MQTRFAHFTPFAFHSAAATAVAAAVLVTALPAMAQPVPAPQVAARSWMLTDVTSGQVLGGANMDERIEPASLTKLMTAYL
VFEAVRDGKLKYDQMITPTETVRTVKTDESRMFLEAGKPASVREMTQGLIIQSGNDAALVLAEAVGGTETNFVMLMNREA
ERLGMKNTHFANAAGLPDPNHYSTARDLSILTAALIKDFPQDYKFYSQKEFTYNNIKQSNRNRLLWLDPTVDGGKTGHTK
SAGYCLVTSANRPLPDVPGANRRLLSVIIGTKSDAIRTQESLKVLNYGYQFFDTVRLYKAKEALQTPDVYKGQAKSVKLG
VAEDKWITVPKGAGARLKPVLERKDPLIAPIAQGQQLGTVKVMDGSTVVSEFPVVALEAVPEAGFVGRTIDAVKLWFKKK
>Mature_400_residues
MQTRFAHFTPFAFHSAAATAVAAAVLVTALPAMAQPVPAPQVAARSWMLTDVTSGQVLGGANMDERIEPASLTKLMTAYL
VFEAVRDGKLKYDQMITPTETVRTVKTDESRMFLEAGKPASVREMTQGLIIQSGNDAALVLAEAVGGTETNFVMLMNREA
ERLGMKNTHFANAAGLPDPNHYSTARDLSILTAALIKDFPQDYKFYSQKEFTYNNIKQSNRNRLLWLDPTVDGGKTGHTK
SAGYCLVTSANRPLPDVPGANRRLLSVIIGTKSDAIRTQESLKVLNYGYQFFDTVRLYKAKEALQTPDVYKGQAKSVKLG
VAEDKWITVPKGAGARLKPVLERKDPLIAPIAQGQQLGTVKVMDGSTVVSEFPVVALEAVPEAGFVGRTIDAVKLWFKKK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=374, Percent_Identity=41.9786096256684, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1786851, Length=395, Percent_Identity=38.7341772151899, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI87082022, Length=385, Percent_Identity=37.6623376623377, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI87082054, Length=221, Percent_Identity=34.3891402714932, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43626; Mature: 43626

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTRFAHFTPFAFHSAAATAVAAAVLVTALPAMAQPVPAPQVAARSWMLTDVTSGQVLGG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCCCEECC
ANMDERIEPASLTKLMTAYLVFEAVRDGKLKYDQMITPTETVRTVKTDESRMFLEAGKPA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEEECCCCEEEEECCCCC
SVREMTQGLIIQSGNDAALVLAEAVGGTETNFVMLMNREAERLGMKNTHFANAAGLPDPN
HHHHHHCCEEEECCCCEEEEEEECCCCCCCCEEEEEECCHHHCCCCCCCCCCCCCCCCCC
HYSTARDLSILTAALIKDFPQDYKFYSQKEFTYNNIKQSNRNRLLWLDPTVDGGKTGHTK
CCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCC
SAGYCLVTSANRPLPDVPGANRRLLSVIIGTKSDAIRTQESLKVLNYGYQFFDTVRLYKA
CCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
KEALQTPDVYKGQAKSVKLGVAEDKWITVPKGAGARLKPVLERKDPLIAPIAQGQQLGTV
HHHHCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHCCCCCEEECCCCCCCCEE
KVMDGSTVVSEFPVVALEAVPEAGFVGRTIDAVKLWFKKK
EEECCCEEHHHCCEEEEEECCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MQTRFAHFTPFAFHSAAATAVAAAVLVTALPAMAQPVPAPQVAARSWMLTDVTSGQVLGG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCCCEECC
ANMDERIEPASLTKLMTAYLVFEAVRDGKLKYDQMITPTETVRTVKTDESRMFLEAGKPA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEEECCCCEEEEECCCCC
SVREMTQGLIIQSGNDAALVLAEAVGGTETNFVMLMNREAERLGMKNTHFANAAGLPDPN
HHHHHHCCEEEECCCCEEEEEEECCCCCCCCEEEEEECCHHHCCCCCCCCCCCCCCCCCC
HYSTARDLSILTAALIKDFPQDYKFYSQKEFTYNNIKQSNRNRLLWLDPTVDGGKTGHTK
CCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCC
SAGYCLVTSANRPLPDVPGANRRLLSVIIGTKSDAIRTQESLKVLNYGYQFFDTVRLYKA
CCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
KEALQTPDVYKGQAKSVKLGVAEDKWITVPKGAGARLKPVLERKDPLIAPIAQGQQLGTV
HHHHCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCHHHHCCCCCEEECCCCCCCCEE
KVMDGSTVVSEFPVVALEAVPEAGFVGRTIDAVKLWFKKK
EEECCCEEHHHCCEEEEEECCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]