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The map label for this gene is uvrY [H]

Identifier: 187927253

GI number: 187927253

Start: 163047

End: 163679

Strand: Reverse

Name: uvrY [H]

Synonym: Rpic_0145

Alternate gene names: 187927253

Gene position: 163679-163047 (Counterclockwise)

Preceding gene: 187927254

Following gene: 187927252

Centisome position: 4.15

GC content: 60.82

Gene sequence:

>633_bases
ATGATTCGCGTCCTGATTGCGGACGACCACGAGATCGTTCGCGCCGGCCTTCGACAGTTTCTGTCCGAAGAGCGGGACAT
CGAAGTCGCGGGGGAAGCGGCCAGCGGGGAAGAGGTGATGGAGCAACTCCGCACCGGGGCCTTTGACGTCGTGGTGCTCG
ACATTTCCATGCCCGATCGCAACGGCATCGACACCCTCAAGCTGGCTCGCCAGCGCCATCCGGATCTGCCGGTGCTGATC
CTGTCGACCTTCCCGGAAGACCAGTACGCCATCAACCTGATCCGCGCAGGGGCATCGGGCTATCTGACAAAAGAAAGCGC
GCCGGACGAGCTGGTCAAGGCCATCCGTACCGTGTCGCAAGGCCGTCGCTATGTCAGCCCGACCGTGGCCGAGCTGCTCA
TTGGCGGCCTGGAAAAGCCGACCGACCAGCCGCTGCACCAGACGCTGTCCAAGCGTGAGTTTCAGATCTTCTGCAAGCTG
GCGCGCGGGCAATCGGTATCGATCATCGCGGAAGAGCTGTTCCTGAGCGTCAAGACGGTCAGCACTTACCGCACGCGGAT
TCTGGAAAAGATGGGCATGAAATCCAATGCCGATCTGACGTATTACGCCATCAAGAACGGCCTGGTTGAGTAG

Upstream 100 bases:

>100_bases
CGTTTTGGCGCAACAGTCCGATACAATTGCTGTCGTATCGAACCAACAAGCGCAGCGCACGGAGTCGGGCAATCCGCCCA
GCGCGCTCATAAGGAGCAGC

Downstream 100 bases:

>100_bases
CACCTGATGGGGCGCCAAAACCCCTTGGCGCCCCGCAAACCCAACTGGCATGTAGGACAACGCCTGATACCACCTCGGCA
ACCCGCTGGCTAACATCAAC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIRVLIADDHEIVRAGLRQFLSEERDIEVAGEAASGEEVMEQLRTGAFDVVVLDISMPDRNGIDTLKLARQRHPDLPVLI
LSTFPEDQYAINLIRAGASGYLTKESAPDELVKAIRTVSQGRRYVSPTVAELLIGGLEKPTDQPLHQTLSKREFQIFCKL
ARGQSVSIIAEELFLSVKTVSTYRTRILEKMGMKSNADLTYYAIKNGLVE

Sequences:

>Translated_210_residues
MIRVLIADDHEIVRAGLRQFLSEERDIEVAGEAASGEEVMEQLRTGAFDVVVLDISMPDRNGIDTLKLARQRHPDLPVLI
LSTFPEDQYAINLIRAGASGYLTKESAPDELVKAIRTVSQGRRYVSPTVAELLIGGLEKPTDQPLHQTLSKREFQIFCKL
ARGQSVSIIAEELFLSVKTVSTYRTRILEKMGMKSNADLTYYAIKNGLVE
>Mature_210_residues
MIRVLIADDHEIVRAGLRQFLSEERDIEVAGEAASGEEVMEQLRTGAFDVVVLDISMPDRNGIDTLKLARQRHPDLPVLI
LSTFPEDQYAINLIRAGASGYLTKESAPDELVKAIRTVSQGRRYVSPTVAELLIGGLEKPTDQPLHQTLSKREFQIFCKL
ARGQSVSIIAEELFLSVKTVSTYRTRILEKMGMKSNADLTYYAIKNGLVE

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=212, Percent_Identity=41.5094339622642, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=38.5, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1788712, Length=205, Percent_Identity=31.7073170731707, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1788521, Length=198, Percent_Identity=32.8282828282828, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1786747, Length=200, Percent_Identity=30, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=30.0546448087432, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788546, Length=208, Percent_Identity=27.4038461538462, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082052, Length=122, Percent_Identity=34.4262295081967, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23418; Mature: 23418

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVLIADDHEIVRAGLRQFLSEERDIEVAGEAASGEEVMEQLRTGAFDVVVLDISMPDR
CEEEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCEEEEEEEEECCCC
NGIDTLKLARQRHPDLPVLILSTFPEDQYAINLIRAGASGYLTKESAPDELVKAIRTVSQ
CCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GRRYVSPTVAELLIGGLEKPTDQPLHQTLSKREFQIFCKLARGQSVSIIAEELFLSVKTV
CCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
STYRTRILEKMGMKSNADLTYYAIKNGLVE
HHHHHHHHHHHCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MIRVLIADDHEIVRAGLRQFLSEERDIEVAGEAASGEEVMEQLRTGAFDVVVLDISMPDR
CEEEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCEEEEEEEEECCCC
NGIDTLKLARQRHPDLPVLILSTFPEDQYAINLIRAGASGYLTKESAPDELVKAIRTVSQ
CCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GRRYVSPTVAELLIGGLEKPTDQPLHQTLSKREFQIFCKLARGQSVSIIAEELFLSVKTV
CCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
STYRTRILEKMGMKSNADLTYYAIKNGLVE
HHHHHHHHHHHCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]