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The map label for this gene is degS [H]

Identifier: 187927250

GI number: 187927250

Start: 160751

End: 162208

Strand: Direct

Name: degS [H]

Synonym: Rpic_0142

Alternate gene names: 187927250

Gene position: 160751-162208 (Clockwise)

Preceding gene: 187927246

Following gene: 187927258

Centisome position: 4.08

GC content: 64.27

Gene sequence:

>1458_bases
ATGGGTCTGCATGCCATGCGGTCATCCTTGCGCTCCACTCTGCTGCTCGCCGGCGGCATTCTGCTGACGCTCGGGGTGCT
GATTGCCTCGGAGACGGGCAACATCCGCCTGAGCCAGGGCTATCGGCAGGTGATTCAGTCGCAGCAGGCTGAAACCGCCA
TCAACGAACTGCTTGCCGAGCTGGTGAACGCCGAGGCGGGGCAACGCGGGTTCCTGCTCACGGGCAAGGACGAATACCTC
GATCCATACAACAAGGCCATCCCGCACATCCACGCGTTGATGGCAGAAATTCGCGATCACTACGCCAACGATCCTGACGC
GCTGAAGCTGTTCTCGGAGACGGCGCTCCAGGTGAGCCGCAAGCTCACCGAGATGGAACTCACGCTCATTTACGGCAAGC
GTGATCTGGAAGTGGCGCTCGATCTCGTGCGCACCGATTTCGGCAAGGCATCGATGGAAGCGGTGCGGCAGGGGCTGGAC
CGCCTGCGTCAGCGTGAGATCGCCACCGTGGCCCGCAGCCTTGAACACGCCGAGCGCGATCTGGCGCTCTCGCGCTACGG
CATTGCGCTCATCACGGCGGTCAACATCATCCTGCTGGTGGTACTGGGCATGCAGCACGCCAAGCGCCTTGCCGTGACGG
AGCGTGAGCGCGACATGGCGGAGGAGGAAAGCCAGAAGCTCGACCGTATGGTGCGTGAGCGCACGCGTCAGTTGTCCGAC
TTGGCTGCGCACTTGCAGCGTGTGACCGAAGATGAGAAGACGCGCCTCGCGCGCGAGCTGCACGACGAGCTGGGCGCCAT
CCTCACCGCCACCAAGATGGACCTCCACTGGCTGCGTTCACGCATTCATGCCAATGAGCCTGCGGTAAGCGAAAAGATCA
CGCGCGTGATGGCCCACGTGGATCAGGGCATCCAGATCAAGCGCCGCCTGATCGAAGACCTGCGCCCGACGATCCTGCTC
AACCTGGGTTTGGTGGAAGCGCTCTCGCAATTGACGGAGGACGTGGGCACGCGCAATGGCTGGCATACGGAAGTGAGCCT
GCCCGACGATATGCCCAAGCTGACCGACGATGCGGCCATCGCGCTGTATCGGATCGTGCAGGAATCGCTGACCAACGCAT
CGAAATACGCGCATGCGACCACGGTGTCGGTGGCGCTCGATGTGGGTGAAGAGGGCGTGCGCTTGCGCGTGCGCGACAAC
GGCCGTGGGTTCCCCGCCGATATCGAGCGGCGCCGCATGGTCGGCCACCACGGCCTGCTGGGGATGGAGCAGCGCGCCAT
TGCGCTGGGCGGCACGCTCGTCATCGACTCAATGCCAGGCGGCGGTGTGACGATCATCGTCGAGCTGCCTCCCAGCGATG
CCGTATTCGACCGAGGCGCGGCTAACGAACCGTCGGGCATGCAGGCGCTGACTGGCGGTATTGCGCCTGCCCCGGGCCGC
GGCGGCGCGACGGTGTAA

Upstream 100 bases:

>100_bases
CGCCCCAAGTGTCGCCCGGGGCGCCCACGCGGTATCATCCGAATTGCCAAAAAAACACAAACGCAACGCGCGCCGCGTCG
GGCGGTTTGACGCGTTTCCT

Downstream 100 bases:

>100_bases
GTCGCTCGCCGTAACGCATCGCCCAAACAAAAAGCCCCATCGCGGGGCTTTTTGTTTTTGATGCCGGCGTCGCTGGCGCT
GACGTTACATCTTCTGCTTG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MGLHAMRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAELVNAEAGQRGFLLTGKDEYL
DPYNKAIPHIHALMAEIRDHYANDPDALKLFSETALQVSRKLTEMELTLIYGKRDLEVALDLVRTDFGKASMEAVRQGLD
RLRQREIATVARSLEHAERDLALSRYGIALITAVNIILLVVLGMQHAKRLAVTERERDMAEEESQKLDRMVRERTRQLSD
LAAHLQRVTEDEKTRLARELHDELGAILTATKMDLHWLRSRIHANEPAVSEKITRVMAHVDQGIQIKRRLIEDLRPTILL
NLGLVEALSQLTEDVGTRNGWHTEVSLPDDMPKLTDDAAIALYRIVQESLTNASKYAHATTVSVALDVGEEGVRLRVRDN
GRGFPADIERRRMVGHHGLLGMEQRAIALGGTLVIDSMPGGGVTIIVELPPSDAVFDRGAANEPSGMQALTGGIAPAPGR
GGATV

Sequences:

>Translated_485_residues
MGLHAMRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAELVNAEAGQRGFLLTGKDEYL
DPYNKAIPHIHALMAEIRDHYANDPDALKLFSETALQVSRKLTEMELTLIYGKRDLEVALDLVRTDFGKASMEAVRQGLD
RLRQREIATVARSLEHAERDLALSRYGIALITAVNIILLVVLGMQHAKRLAVTERERDMAEEESQKLDRMVRERTRQLSD
LAAHLQRVTEDEKTRLARELHDELGAILTATKMDLHWLRSRIHANEPAVSEKITRVMAHVDQGIQIKRRLIEDLRPTILL
NLGLVEALSQLTEDVGTRNGWHTEVSLPDDMPKLTDDAAIALYRIVQESLTNASKYAHATTVSVALDVGEEGVRLRVRDN
GRGFPADIERRRMVGHHGLLGMEQRAIALGGTLVIDSMPGGGVTIIVELPPSDAVFDRGAANEPSGMQALTGGIAPAPGR
GGATV
>Mature_484_residues
GLHAMRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAELVNAEAGQRGFLLTGKDEYLD
PYNKAIPHIHALMAEIRDHYANDPDALKLFSETALQVSRKLTEMELTLIYGKRDLEVALDLVRTDFGKASMEAVRQGLDR
LRQREIATVARSLEHAERDLALSRYGIALITAVNIILLVVLGMQHAKRLAVTERERDMAEEESQKLDRMVRERTRQLSDL
AAHLQRVTEDEKTRLARELHDELGAILTATKMDLHWLRSRIHANEPAVSEKITRVMAHVDQGIQIKRRLIEDLRPTILLN
LGLVEALSQLTEDVGTRNGWHTEVSLPDDMPKLTDDAAIALYRIVQESLTNASKYAHATTVSVALDVGEEGVRLRVRDNG
RGFPADIERRRMVGHHGLLGMEQRAIALGGTLVIDSMPGGGVTIIVELPPSDAVFDRGAANEPSGMQALTGGIAPAPGRG
GATV

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=260, Percent_Identity=27.6923076923077, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1788812, Length=210, Percent_Identity=31.9047619047619, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53354; Mature: 53223

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLHAMRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
LVNAEAGQRGFLLTGKDEYLDPYNKAIPHIHALMAEIRDHYANDPDALKLFSETALQVSR
HHCCCCCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KLTEMELTLIYGKRDLEVALDLVRTDFGKASMEAVRQGLDRLRQREIATVARSLEHAERD
HHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALSRYGIALITAVNIILLVVLGMQHAKRLAVTERERDMAEEESQKLDRMVRERTRQLSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAHLQRVTEDEKTRLARELHDELGAILTATKMDLHWLRSRIHANEPAVSEKITRVMAHV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DQGIQIKRRLIEDLRPTILLNLGLVEALSQLTEDVGTRNGWHTEVSLPDDMPKLTDDAAI
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHH
ALYRIVQESLTNASKYAHATTVSVALDVGEEGVRLRVRDNGRGFPADIERRRMVGHHGLL
HHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCC
GMEQRAIALGGTLVIDSMPGGGVTIIVELPPSDAVFDRGAANEPSGMQALTGGIAPAPGR
CCCHHHHEECCEEEEECCCCCCEEEEEEECCCCHHHCCCCCCCCCCHHHHHCCCCCCCCC
GGATV
CCCCC
>Mature Secondary Structure 
GLHAMRSSLRSTLLLAGGILLTLGVLIASETGNIRLSQGYRQVIQSQQAETAINELLAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
LVNAEAGQRGFLLTGKDEYLDPYNKAIPHIHALMAEIRDHYANDPDALKLFSETALQVSR
HHCCCCCCCCEEECCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
KLTEMELTLIYGKRDLEVALDLVRTDFGKASMEAVRQGLDRLRQREIATVARSLEHAERD
HHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALSRYGIALITAVNIILLVVLGMQHAKRLAVTERERDMAEEESQKLDRMVRERTRQLSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAHLQRVTEDEKTRLARELHDELGAILTATKMDLHWLRSRIHANEPAVSEKITRVMAHV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DQGIQIKRRLIEDLRPTILLNLGLVEALSQLTEDVGTRNGWHTEVSLPDDMPKLTDDAAI
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHH
ALYRIVQESLTNASKYAHATTVSVALDVGEEGVRLRVRDNGRGFPADIERRRMVGHHGLL
HHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCC
GMEQRAIALGGTLVIDSMPGGGVTIIVELPPSDAVFDRGAANEPSGMQALTGGIAPAPGR
CCCHHHHEECCEEEEECCCCCCEEEEEEECCCCHHHCCCCCCCCCCHHHHHCCCCCCCCC
GGATV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]