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The map label for this gene is bcd [H]

Identifier: 187927237

GI number: 187927237

Start: 149838

End: 151019

Strand: Reverse

Name: bcd [H]

Synonym: Rpic_0129

Alternate gene names: 187927237

Gene position: 151019-149838 (Counterclockwise)

Preceding gene: 187927238

Following gene: 187927236

Centisome position: 3.83

GC content: 63.96

Gene sequence:

>1182_bases
ATGATTGATCTGCCCGGCCTGAAATTCGACTTGGGCGAAGACATCGAGATGCTGCGTTCGGCCGTGCGCGATTGGGCGCA
GGGCGAGCTGGCACCGCGTGCCGGCGAAATCGACCGCACCGACCAGTTCCCGATGGACGCGTGGCGCAAGATGGGCGAGC
TGGGCGTGCTCGGCATCACGGTGGCCGAGGAGTACGGCGGCGCCAACATGGGCTACCTGGCGCACATGATCGCCATGGAA
GAAATCAGCCGTGCATCGGCGTCAGTGGGCCTGTCGTATGGCGCGCACTCGAATCTGTGCGTGAACCAGATCCATCGCAA
CGGCACGGCGGCCCAGAAGGCCAAGTACCTGCCCAAGCTGGTTTCCGGCGAATGGGTGGGGGCGCTGGCGATGAGCGAGC
CGAATGCCGGGTCGGACGTCGTCAGCATGAAGCTGCGCGCGGAACTGAAAGGCGACCGCTACGTGCTCAACGGCACCAAG
ATGTGGATCACCAACGGCCCCGACTGCGACGTGCTGGTCGTCTACGCCAAGACCGAGCCCGAACTGGGCGCGCGCGGCAT
GACGGCGTTCATCGTCGAAAAAGGCATGAAGGGTTTCTCGGTGGCGCAGAAGCTGGACAAGCTTGGCATGCGCGGCTCGC
ACACGGGCGAACTGGTGTTCGAGAATGTAGAAGTGCCGGTGGAAAACATCCTCGGTCAGGAAAACGGCGGCACCAAGGTG
CTGATGAGCGGCCTGGATTACGAGCGCGCGGTGCTCTCCGGCGGCCCGATCGGCATCATGCAGGCCTGCATGGACGTGGT
CACGCCGTACATCCACGACCGCAAGCAGTTCGGCCAGAGCATTGGCGAATTCCAGCTCATCCAGGGCAAGATGGCTGACA
TGTACACCACGCTGCAGGCTTGCCGCGCGTACCTGTACACGGTCGGCAAGAACCTCGACTCACTGGGCCGCGACCACGTG
CGCCAGGTGCGCAAGGACTGCGCCGGCGTGATCCTCTACACCGCCGAGAAGGCCACCTGGATGGCCGGCGAAGCCATCCA
GATCCTGGGCGGCAATGGCTACATCAACGAATTCCCGGTCGGCCGCCTGTGGCGCGACGCCAAGCTGTACGAGATTGGCG
CCGGCACGTCGGAAATCCGCCGCATGCTGATCGGCCGCGAGCTGTACGCAGAGACGATGTAA

Upstream 100 bases:

>100_bases
TCCCGGCACCGCGGTGCCCGCCATAAGCGACGCGCACCGCACAGCGCCAGACCACTGACTAGAGACACCCGCGGCTCGAA
CCGCGCCCAAGGAGACCACC

Downstream 100 bases:

>100_bases
CTGGCGAGAGCAGGCGGGGCTGGGGCACGGGGCCATCAGCCAAACGGATAAGGAGGCGCAACGGTTTCAGGACGCGAACA
CGGTACCGAAGACCCTACAA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MIDLPGLKFDLGEDIEMLRSAVRDWAQGELAPRAGEIDRTDQFPMDAWRKMGELGVLGITVAEEYGGANMGYLAHMIAME
EISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGEWVGALAMSEPNAGSDVVSMKLRAELKGDRYVLNGTK
MWITNGPDCDVLVVYAKTEPELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFENVEVPVENILGQENGGTKV
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKMADMYTTLQACRAYLYTVGKNLDSLGRDHV
RQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEFPVGRLWRDAKLYEIGAGTSEIRRMLIGRELYAETM

Sequences:

>Translated_393_residues
MIDLPGLKFDLGEDIEMLRSAVRDWAQGELAPRAGEIDRTDQFPMDAWRKMGELGVLGITVAEEYGGANMGYLAHMIAME
EISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGEWVGALAMSEPNAGSDVVSMKLRAELKGDRYVLNGTK
MWITNGPDCDVLVVYAKTEPELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFENVEVPVENILGQENGGTKV
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKMADMYTTLQACRAYLYTVGKNLDSLGRDHV
RQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEFPVGRLWRDAKLYEIGAGTSEIRRMLIGRELYAETM
>Mature_393_residues
MIDLPGLKFDLGEDIEMLRSAVRDWAQGELAPRAGEIDRTDQFPMDAWRKMGELGVLGITVAEEYGGANMGYLAHMIAME
EISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKLVSGEWVGALAMSEPNAGSDVVSMKLRAELKGDRYVLNGTK
MWITNGPDCDVLVVYAKTEPELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFENVEVPVENILGQENGGTKV
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKMADMYTTLQACRAYLYTVGKNLDSLGRDHV
RQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEFPVGRLWRDAKLYEIGAGTSEIRRMLIGRELYAETM

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=385, Percent_Identity=63.3766233766234, Blast_Score=497, Evalue=1e-141,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=66.4739884393064, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=39.3139841688654, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=34.9333333333333, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=35.2331606217617, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=35.2331606217617, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI21361497, Length=393, Percent_Identity=36.3867684478371, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=31.701030927835, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI4557235, Length=344, Percent_Identity=35.4651162790698, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI76496475, Length=344, Percent_Identity=35.4651162790698, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=29.9212598425197, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4503943, Length=388, Percent_Identity=32.9896907216495, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=33.9779005524862, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI48976061, Length=288, Percent_Identity=25.3472222222222, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI211971008, Length=288, Percent_Identity=25.3472222222222, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI38505218, Length=285, Percent_Identity=20.7017543859649, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=28.8311688311688, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=27.0341207349081, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=25.0965250965251, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87081702, Length=299, Percent_Identity=25.0836120401338, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=387, Percent_Identity=62.2739018087855, Blast_Score=476, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=34.5744680851064, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=33.7662337662338, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=33.6787564766839, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI17570075, Length=390, Percent_Identity=32.8205128205128, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17508101, Length=383, Percent_Identity=32.3759791122715, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=31.1345646437995, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=35.2112676056338, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71990804, Length=286, Percent_Identity=38.4615384615385, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=39.8268398268398, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=37.1024734982332, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=30.4123711340206, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=32.8467153284672, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=361, Percent_Identity=30.1939058171745, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=361, Percent_Identity=27.9778393351801, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=28.2786885245902, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=22.2222222222222, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=288, Percent_Identity=23.9583333333333, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=289, Percent_Identity=24.2214532871972, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=65.0385604113111, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=40.1574803149606, Blast_Score=284, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=36.745406824147, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24666513, Length=382, Percent_Identity=34.5549738219895, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=34.3669250645995, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI281363737, Length=391, Percent_Identity=33.7595907928389, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI19920834, Length=396, Percent_Identity=31.8181818181818, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24652780, Length=315, Percent_Identity=22.5396825396825, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 43024; Mature: 43024

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLPGLKFDLGEDIEMLRSAVRDWAQGELAPRAGEIDRTDQFPMDAWRKMGELGVLGIT
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEE
VAEEYGGANMGYLAHMIAMEEISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKL
EEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGEWVGALAMSEPNAGSDVVSMKLRAELKGDRYVLNGTKMWITNGPDCDVLVVYAKTEP
HCCCCEEEEEECCCCCCCHHEEEEEHHCCCCCEEEECCEEEEEECCCCCCEEEEEECCCC
ELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFENVEVPVENILGQENGGTKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCCEE
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKMADMYTTLQA
EEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRAYLYTVGKNLDSLGRDHVRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEFPV
HHHHHHHHHCCHHHCCHHHHHHHHHHHCCEEEEECCCCEEECCCEEEEECCCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELYAETM
CHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDLPGLKFDLGEDIEMLRSAVRDWAQGELAPRAGEIDRTDQFPMDAWRKMGELGVLGIT
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEE
VAEEYGGANMGYLAHMIAMEEISRASASVGLSYGAHSNLCVNQIHRNGTAAQKAKYLPKL
EEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
VSGEWVGALAMSEPNAGSDVVSMKLRAELKGDRYVLNGTKMWITNGPDCDVLVVYAKTEP
HCCCCEEEEEECCCCCCCHHEEEEEHHCCCCCEEEECCEEEEEECCCCCCEEEEEECCCC
ELGARGMTAFIVEKGMKGFSVAQKLDKLGMRGSHTGELVFENVEVPVENILGQENGGTKV
CCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHCCCCCCCCEE
LMSGLDYERAVLSGGPIGIMQACMDVVTPYIHDRKQFGQSIGEFQLIQGKMADMYTTLQA
EEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRAYLYTVGKNLDSLGRDHVRQVRKDCAGVILYTAEKATWMAGEAIQILGGNGYINEFPV
HHHHHHHHHCCHHHCCHHHHHHHHHHHCCEEEEECCCCEEECCCEEEEECCCCCCCCCCC
GRLWRDAKLYEIGAGTSEIRRMLIGRELYAETM
CHHHCCCEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]